Clinical trials: Lymph Node Involvement
Wilms Tumor
Treatment of Newly Diagnosed Patient's With Wilm's Tumor Requiring Abdominal Radiation Delivered With Proton Beam Irradiation
Participants are being asked to take part in this clinical trial, a type of research study, because the participants have a Wilms Tumor cancer.
- Trial name
- NCT04968990
- Testing
- Proton Beam Radiation (PBRT), DD-4A Chemotherapy Regimen, Complete Surgical Resection
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- St. Jude Children's Research Hospital
SARS CoV-2, Kawasaki Disease
Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)
Human Endogenous Retroviruses (HERVs) are ancient sequences that became integrated into our DNA during evolutionary processes. The significance of their presence in DNA is still being studied, but HERVs appear to be involved in…
- Conditions
- SARS CoV-2, Kawasaki Disease, Retrovirus Infection
- Trial name
- HERV_COVID (NCT06775457)
- Testing
- sample collection
- Where
- 5 sites in Italy
- Volunteers
- 120 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pancreatic Cancer
Evaluation of Complete microscopicE Resection Margin (R0) and Lymph Node Involvement After Standard Pancreatosplenectomy (SPS) Versus Radical Anterograde Modular Pancreatosplenectomy
Resection with negative margins (R0) followed by adjuvant chemotherapy is today the standard of care and the only chance of cure for patients with pancreatic ductal adenocarcinoma (PDA).
- Trial name
- REMIND-01 (NCT03679169)
- Testing
- pancreatosplenectomy
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Institut Paoli-Calmettes
ALND, Sentinel Lymph Node Biopsy (SLNB)
Upfront Targeted Axillary Dissection for Luminal Breast Cancer With Limited Axillary Involvement
The present study aims to avoid axillary lymph node dissection (ALND) in patients with an Ultrasound (US) detected positive preoperative lymph node involvement (1 or 2 suspicious lymph-nodes) and a needle histology/cytology…
- Conditions
- ALND, Sentinel Lymph Node Biopsy (SLNB), Targeted Axillary Dissection (TAD)
- Trial name
- UTAD (NCT07278726)
- Testing
- Upfront Targeted Axillary Dissection (UTAD)
- Where
- 14 sites in Italy, Switzerland
- Volunteers
- 150 people
- Sponsor
- European Institute of Oncology
Endometrial Cancer, Endometrial Carcinoma (EC)
Prognosis and Therapeutic Implications in Molecular High-Risk Non-Myoinvasive Endometrial Cancer
This multicenter retrospective observational cohort study aims to evaluate the prognosis of patients with non-myoinvasive endometrial cancer harbouring high-risk molecular features by determining the rate of lymph node…
- Conditions
- Endometrial Cancer, Endometrial Carcinoma (EC), p53abn
- Trial name
- MyoNone (NCT07838207)
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Breast Cancer
Hormone Therapy in Treating Postmenopausal Women With Receptor-Positive Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002646
- Testing
- fenretinide, tamoxifen citrate
- Where
- 85 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Eastern Cooperative Oncology Group
Secondary Malignant Neoplasm of Lymph Node, Prostatic Neoplasms
Lymph Node Involvement Using Extended Pelvic Lymphadenectomy in Clinically Localized Prostate Cancer
Prostate cancer is considered the fourth most common malignancy cancer in America. However, in Colombia the incidence is higher, and it is considered the second cause of death among men for malignance diseases.
- Trial name
- LNIEPLCLPC (NCT02156414)
- Testing
- Radical Prostatectomy, Extended Lymphadenectomy
- Where
- 3 sites in Colombia
- Volunteers
- 135 people
- Sponsor
- Javeriana University
Breast Cancer
Adjuvant Stage 2-3A Breast Cancer With Positive Lymph Nodes
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as filgrastim may increase the number of immune cells found in bone marrow or…
- Trial name
- NCT00007904
- Testing
- filgrastim, cyclophosphamide, doxorubicin hydrochloride
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Case Comprehensive Cancer Center
Pancreatic Neoplasms, Pancreatic Adenocarcinoma
The Prognostic Impact of Extracapsular Lymph Node Involvement in Ductal Pancreatic Adenocarcinoma
Extracapsular lymph node involvement (ECLNI) has been identified as a pathological variable associated with worse outcome in esophageal, gastric and colorectal cancer.
- Trial name
- ECLNI DPAC (NCT00644254)
- Testing
- Pancreatic resection
- Where
- Belgium
- Volunteers
- 145 people
- Sponsor
- KU Leuven
Intrahepatic Cholangiocarcinoma (Icc), Adjuvant Chemoradiotherapy
A Prospective Phase II Study of Postoperative Concurrent Chemoradiotherapy in Patients With Intrahepatic Cholangiocarcinoma
This is a single-arm prospective phase II clinical trial to investigate the efficacy and safety of adjuvant concurrent chemoradiotherapy with simultaneous integrated boost following hepatectomy for intrahepatic cholangiocarcinoma…
- Conditions
- Intrahepatic Cholangiocarcinoma (Icc), Adjuvant Chemoradiotherapy, Narrow Margin, Lymph Node Involvement
- Trial name
- NCT07063888
- Testing
- Adjuvant Concurrent Chemoradiotherapy with Simultaneous Integrated Boost
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Endometrial Cancer
Pre-operative Studies for Prediction of Lymph Nodes Involvement in Endometrial Cancer Patients
The study evaluates pre-operative prediction of the risk for lymph nodes involvement in endometrial cancer patients. Patients will undergo ultrasound exam (bi and three dimensional) and biomarker test - Ca 125, in addition to…
- Trial name
- NCT02560571
- Testing
- ultrasound, blood test
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Rectal Cancer
Management of LLN Metastasis in Locally Advanced Rectal Cancer: A Prospective Radiation Dose Escalation Study
In this study, locally advanced rectal cancer (LARC) patients with lateral lymph node (LLN) metastasis would be enrolled. The LLNs with short axis (SA) ≥ 5 mm are considered metastatic.The safety of neoadjuvant…
- Trial name
- NCT04991090
- Testing
- escalation dose of LLNs
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Melanoma of Unknown Primary, Metastatic Malignant Neoplasm in Lymph Node
Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement
This phase II trial studies how well encorafenib and binimetinib work before surgery in treating patients with BRAF V600-mutated stage IIIB-D melanoma that has spread to the lymph nodes.
- Conditions
- Melanoma of Unknown Primary, Metastatic Malignant Neoplasm in Lymph Node, Pathologic Stage IIIB Cutaneous Melanoma AJCC v8, Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
- Trial name
- NCT04221438
- Testing
- Binimetinib, Conventional Surgery, Encorafenib
- Where
- 10 sites in United States
- Volunteers
- 3 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Endometrial Cancer, Sentinel Lymph Node
Cervical and Endometrial Injection for Sentinel Lymph Node Detection in Endometrial Cancer
The investigators think that trans-cervical endometrial tracer injection will cause more paraaortic sentinel lymph node detection. Also, this application is easy, cost-effective and safer than hysteroscopic method.
- Trial name
- NCT03900104
- Testing
- Transcervical endometrial injection of technetium 99 m-labeled human albumin colloid particles, Cervical injection of technetium 99 m-labeled human albumin colloid particles
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Kocaeli University
Nasopharyngeal Cancers
Induction Chemotherapy and Chemoradiotherapy in Nasopharyngeal Cancers
This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy to concurrent chemoradiotherapy alone, in…
- Trial name
- NPC2006 (NCT00828386)
- Testing
- Induction chemotherapy + concurrent radiochemotherapy vs. concurrent radiochemotherapy
- Where
- 5 sites in France, Morocco and 2 more
- Volunteers
- 83 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node
Clinical Impact of EUS Elastography Mean Strain Histograms (SH) and Contrast Peak-enhancement in Focal Pancreatic Masses and Lymph Nodes
The study protocol is based on a multi-center semi-quantitative approach of EUS elastography data in combination with contrast-enhanced EUS, consisting of measuring SR and SH for focal pancreatic masses and lymph nodes, as well…
- Conditions
- Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node, Benign Neoplasm of Lymph Nodes, Benign Pancreatic Tumors
- Trial name
- ADVEUS (NCT02459041)
- Testing
- Elastography, contrast enhancement
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
Intensity Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Treating Patients With Lymph-Node Positive Breast Cancer
This phase II trial studies the shoulder morbidity in patients with lymph-node positive breast cancer receiving intensity modulated radiation therapy or 3-dimensional conformal radiation therapy.
- Conditions
- Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT03786354
- Testing
- 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Uterine Cervical Neoplasms
Oncological Outcome After Completing or Abandoning (Radical) Hysterectomy in Patients With Cervical Cancer and Intraoperative Detection of LN Positivity
The ABRAX trial is multicentre retrospective cohort study. Included are patients with negative LN in clinical staging, in whom LN involvement is detected intraoperatively.
- Trial name
- ABRAX (NCT04037124)
- Testing
- Cervical procedure
- Where
- Czechia
- Volunteers
- 718 people
- Sponsor
- General University Hospital, Prague
Endometrial Cancer
Different Risk Stratification Models for Prediction of Lymph Node Involvement in Endometrial Carcinoma
Endometrial cancer is the most common malignant disease of the female genital tract and the seventh most common cause of cancer death in women in Western countries.
- Trial name
- NCT04120649
- Testing
- hysterectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Breast Cancer
SWOG-8814 Tamoxifen With or Without Combination Chemotherapy in Postmenopausal Women Who Have Undergone Surgery for Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the use of estrogen by the tumor cells.
- Trial name
- NCT00929591
- Testing
- cyclophosphamide, doxorubicin hydrochloride, endocrine therapy
- Volunteers
- 1,558 people
- Sponsor
- SWOG Cancer Research Network