Clinical trials: Lymph Node Involvement
Endometrial Cancer, Endometrial Carcinoma (EC)
Prognosis and Therapeutic Implications in Molecular High-Risk Non-Myoinvasive Endometrial Cancer
This multicenter retrospective observational cohort study aims to evaluate the prognosis of patients with non-myoinvasive endometrial cancer harbouring high-risk molecular features by determining the rate of lymph node…
- Conditions
- Endometrial Cancer, Endometrial Carcinoma (EC), p53abn
- Trial name
- MyoNone (NCT07838207)
- Where
- Spain
- Volunteers
- 350 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Lymphadenopathy, Lung Cancer
Prevalence and Malignant Involvement of Calcified Intrathoracic Lymph Nodes in Patients Undergoing Endosonography
The presence of calcifications, which is a relatively common feature in intrathoracic lymph nodes, typically contributes to confer them a heterogeneous aspect during endosonographic B-mode examination, but their prevalence and a…
- Conditions
- Lymphadenopathy, Lung Cancer, Sarcoidosis, Tuberculosis
- Trial name
- NCT04743583
- Testing
- Endosonography B-mode examination
- Where
- Italy
- Volunteers
- 362 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer
Sentinel Lymph Node Total Tumoral Load as a Predictor of Non Sentinel Node Involvement in Early Breast Cancer
This is a retrospective, multicentric cohort study of patient cases with cT1-3, N0 early breast cancer, who previously had intraoperative sentinel lymph node (SLN) evaluation by one-step nucleic acid amplification (OSNA) assay…
- Trial name
- SOLO-1 (NCT01669265)
- Where
- 9 sites in Spain
- Volunteers
- 701 people
- Sponsor
- SOLTI Breast Cancer Research Group
Breast Cancer
Adjuvant Stage 2-3A Breast Cancer With Positive Lymph Nodes
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as filgrastim may increase the number of immune cells found in bone marrow or…
- Trial name
- NCT00007904
- Testing
- filgrastim, cyclophosphamide, doxorubicin hydrochloride
- Where
- 3 sites in United States
- Volunteers
- 16 people
- Sponsor
- Case Comprehensive Cancer Center
Endometrial Cancer, Sentinel Lymph Node
Cervical and Endometrial Injection for Sentinel Lymph Node Detection in Endometrial Cancer
The investigators think that trans-cervical endometrial tracer injection will cause more paraaortic sentinel lymph node detection. Also, this application is easy, cost-effective and safer than hysteroscopic method.
- Trial name
- NCT03900104
- Testing
- Transcervical endometrial injection of technetium 99 m-labeled human albumin colloid particles, Cervical injection of technetium 99 m-labeled human albumin colloid particles
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Kocaeli University
Endometrial Cancer
Pre-operative Studies for Prediction of Lymph Nodes Involvement in Endometrial Cancer Patients
The study evaluates pre-operative prediction of the risk for lymph nodes involvement in endometrial cancer patients. Patients will undergo ultrasound exam (bi and three dimensional) and biomarker test - Ca 125, in addition to…
- Trial name
- NCT02560571
- Testing
- ultrasound, blood test
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Rectal Cancer
Management of LLN Metastasis in Locally Advanced Rectal Cancer: A Prospective Radiation Dose Escalation Study
In this study, locally advanced rectal cancer (LARC) patients with lateral lymph node (LLN) metastasis would be enrolled. The LLNs with short axis (SA) ≥ 5 mm are considered metastatic.The safety of neoadjuvant…
- Trial name
- NCT04991090
- Testing
- escalation dose of LLNs
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node
Clinical Impact of EUS Elastography Mean Strain Histograms (SH) and Contrast Peak-enhancement in Focal Pancreatic Masses and Lymph Nodes
The study protocol is based on a multi-center semi-quantitative approach of EUS elastography data in combination with contrast-enhanced EUS, consisting of measuring SR and SH for focal pancreatic masses and lymph nodes, as well…
- Conditions
- Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node, Benign Neoplasm of Lymph Nodes, Benign Pancreatic Tumors
- Trial name
- ADVEUS (NCT02459041)
- Testing
- Elastography, contrast enhancement
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Rectal Cancer
Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer
This prospective, single-center, randomized controlled trial evaluates whether online adaptive radiotherapy (ART) with a sequential boost to both the primary rectal tumor and clinically involved lymph nodes improves pathologic…
- Trial name
- NCT06246344
- Testing
- Online Adaptive Radiotherapy With Sequential Boost, Conventional Non-Adaptive IMRT, Capecitabine
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Shandong Cancer Hospital and Institute
Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
Intensity Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Treating Patients With Lymph-Node Positive Breast Cancer
This phase II trial studies the shoulder morbidity in patients with lymph-node positive breast cancer receiving intensity modulated radiation therapy or 3-dimensional conformal radiation therapy.
- Conditions
- Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8, Anatomic Stage IIB Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT03786354
- Testing
- 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer
Hormone Therapy in Treating Postmenopausal Women With Receptor-Positive Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002646
- Testing
- fenretinide, tamoxifen citrate
- Where
- 85 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Eastern Cooperative Oncology Group
Lung Neoplasms, Pulmonary Neoplasms
Feasibility of Fluorescence Imaging With Bevacizumab-800CW During Bronchoscopy
In this feasibility study, bronchoscopy will be combined with fluorescence molecular imaging using the near-infrared fluorescence (NIRF) tracer bevacizumab-800CW for assessment of pulmonary lesions and/or lymph nodes considered…
- Conditions
- Lung Neoplasms, Pulmonary Neoplasms, Lymph Node Involvement, Pulmonary Nodule
- Trial name
- DEFLECT I (NCT06809946)
- Testing
- injection with 15 mg bevacizumab-800CW before bronchoscopy, injection with 25 mg bevacizumab-800CW before bronchoscopy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Melanoma of Unknown Primary, Metastatic Malignant Neoplasm in Lymph Node
Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement
This phase II trial studies how well encorafenib and binimetinib work before surgery in treating patients with BRAF V600-mutated stage IIIB-D melanoma that has spread to the lymph nodes.
- Conditions
- Melanoma of Unknown Primary, Metastatic Malignant Neoplasm in Lymph Node, Pathologic Stage IIIB Cutaneous Melanoma AJCC v8, Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
- Trial name
- NCT04221438
- Testing
- Binimetinib, Conventional Surgery, Encorafenib
- Where
- 10 sites in United States
- Volunteers
- 3 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Breast Cancer
SWOG-8814 Tamoxifen With or Without Combination Chemotherapy in Postmenopausal Women Who Have Undergone Surgery for Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the use of estrogen by the tumor cells.
- Trial name
- NCT00929591
- Testing
- cyclophosphamide, doxorubicin hydrochloride, endocrine therapy
- Volunteers
- 1,558 people
- Sponsor
- SWOG Cancer Research Network
Breast Cancer, Breast Neoplasms
Axillary Management After Neoadjuvant Chemotherapy
The standard treatment for locally advanced and node-positive breast cancer is surgery following neoadjuvant chemotherapy (NAC).
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Cancer Female
- Trial name
- NCT06096545
- Testing
- Axillary sentinal lymph node biopsy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Medipol University
Endometrial Cancer
Different Risk Stratification Models for Prediction of Lymph Node Involvement in Endometrial Carcinoma
Endometrial cancer is the most common malignant disease of the female genital tract and the seventh most common cause of cancer death in women in Western countries.
- Trial name
- NCT04120649
- Testing
- hysterectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Cancer
Multicentric Retrospective Review of Extracapsular Lymph Node Involvement After Esophagectomy
It is well known that lymph node metastasis is one of the most important prognostic factors in oesophageal carcinoma. The investigators want to determine the influence of lymph node characteristics, being either intracapsular or…
- Trial name
- ECLNI-MC (NCT01837173)
- Where
- Belgium
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Gasthuisberg
Breast Cancer
S9623, Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill…
- Trial name
- NCT00002772
- Testing
- filgrastim, carboplatin, carmustine
- Where
- United States
- Volunteers
- 602 people
- Sponsor
- SWOG Cancer Research Network
Breast Cancer Female
A Novel Method of Clipped Axillary Lymph Node Localization Post Neoadjuvant Chemotherapy in Breast Cancer Patients .
to determine the feasibility of a novel technique of localization of clipped LN post neoadjuvant chemotherapy
- Trial name
- NCT03878017
- Testing
- skin marking of clip axillary lymph node for localisation
- Where
- Singapore
- Volunteers
- 15 people
- Sponsor
- KK Women's and Children's Hospital
Gastric Cancer, Lymph Node Metastasis
Staging LaParoscopy to Assess Lymph NOde InvoLvement in Advanced GAstric Cancer
Staging LaParscopy to Assess Lymph NOde InvoLvement in Advanced GAstric Cancer (POLA) study aims to investigate the safety and feasibility of ICG-guided SN retrieval in GC patients undergoing multimodal treatment.
- Trial name
- POLA (NCT05720598)
- Testing
- Sentinel Node Assessment, Staging laparoscopy, Gastroscopy with indocyanine green (ICG) injection
- Where
- Poland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin