Clinical trials: Lymph Node Neoplasm
Healthy Volunteers, Rectal Cancer Patients
To Evaluate Dose and Safety of NanoEcho Particle-1 Using NanoEcho Imaging Device Examinations of Rectal Lymph Nodes in Healthy Volunteers and Rectal Cancer Patients.
Clinical nodal staging for rectal cancer tumours in early stages, is today shown to be unreliable and no precise or accurate methods exist.
- Trial name
- NCT06693375
- Testing
- Iron oxide nanoparticles, Rectal Magnetomotoric ultrasound (MMUS)
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- NanoEcho AB
HER2-Positive Primary Breast Cancer, Residual Invasive Breast Cancer
A Study of Trastuzumab Deruxtecan (T-DXd) Versus Trastuzumab Emtansine (T-DM1) in High-risk HER2-positive Participants With Residual Invasive Breast Cancer Following Neoadjuvant Therapy (DESTINY-Breast05)
Patients with HER2-positive primary breast cancer (BC) who do not achieve complete response after appropriate neoadjuvant therapy are at higher risk of disease recurrence.
- Trial name
- NCT04622319
- Testing
- DS-8201a, T-DM1
- Where
- 482 sites in United States, Argentina and 29 more
- Volunteers
- 1,600 people
- Sponsor
- Daiichi Sankyo
Endometrial Cancer
Concurrent Use Lymphoseek & Indocyanine Green in Sentinel Lymph Node Detection in Endometrial Cancer
The goal of this study is to (i) improve detection of sentinel nodes and (ii) reduce additional surgical dissection that is needed in case a sentinel lymph node cannot be detected.
- Trial name
- NCT04511026
- Testing
- Lymphoseek, Single Photon Emission Computed Tomography (SPECT), Indocyanine Green (ICG)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stanford University
Breast Cancer
Regimens Comparison for Breast Cancers of Positive Lymph Nodes
To compare the efficacy and safety of EC-T and ET regimen as adjuvant treatment of breast cancer patients with positive lymph nodes
- Trial name
- NCT01134523
- Testing
- Epirubicin, CTX, Paclitaxel, Epirubicin, Paclitaxel
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chinese Academy of Medical Sciences
Breast Cancer
Sentinel lympH Node Biopsy With Indocyanine Green in Breast Cancer After NEoadjuvant Chemotherapy (SHINE)
This is a prospective, open-label, within-patient clinical trial to determine the accuracy of Indocyanine green (ICG) guided sentinel lymph node biopsy (SLNB) compared to the standard dual-tracer SLNB in breast cancer patients…
- Trial name
- SHINE (NCT06085274)
- Testing
- ICG guided sentinel lymph node biopsy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Hormone Receptor Positive Malignant Neoplasm of Breast
The Impact of the Oncotype DX® Breast Cancer Assay on Treatment Decisions in a Canadian Population
The main goal of this study is to characterize whether the results of the Oncotype DX® assay affect the physician's treatment recommendations for the adjuvant treatment of women with ER-positive (ER+), early breast cancer (EBC)…
- Trial name
- NCT02347449
- Testing
- Questionnaires, Oncotype Dx Assay
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prostatic Neoplasms
Sentinel Lymph Node Detection in Prostate Surgery by Laparoscopy
In this study the investigators want to determine if the detection of lymph node is applicable in prostatectomy by laparoscopy.
- Trial name
- NCT01296217
- Testing
- lymph nod detection
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre René Gauducheau
Endometrial Cancer
A Prospective Study Comparing Three Injection Sites to Detect Sentinel Lymph Nodes in Endometrial Cancer
Uterine cancer is the most common gynecologic malignancy in developed countries. Adenocarcinoma of the endometrium is the most common histologic type of uterine cancer.
- Trial name
- SENNAN (NCT04577950)
- Testing
- Lymphatic drainage of endometrial cancer
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Lung Cancer
Comparison of Gene Mutations in Matched Samples in Advanced Nonsquamous NSCLC Using NGS
The objective of the study was to compare the gene mutation status among the primary tumor, matched metastatic lymph node (LN) and peripheral blood in advanced nonsquamous non-small cell lung cancer (NSCLC) using next-generation…
- Trial name
- NCT02416726
- Testing
- Nextseq500 sequencer
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Jiayuan Sun
Bladder Urothelial Carcinoma, Muscle-invasive Bladder Cancer
Bladder-Sparing Treatment With Disitamab Vedotin and Toripalimab With or Without Pelvic Lymph Node Dissection in Bladder Cancer
This is a prospective, multicenter, randomized controlled superiority study designed to evaluate whether the addition of pelvic lymph node dissection improves bladder-intact event-free survival in patients with cT2-3N0M0 bladder…
- Conditions
- Bladder Urothelial Carcinoma, Muscle-invasive Bladder Cancer, Bladder Cancer
- Trial name
- NCT07756008
- Testing
- Disitamab Vedotin (RC48), Toripalimab, Transurethral Resection of Bladder Tumor
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tianjin Medical University Second Hospital
Breast Cancer
Docetaxel in Node Positive Adjuvant Breast Cancer
The purpose of this study was to compare disease-free survival after treatment with docetaxel in combination with doxorubicin and cyclophosphamide to 5-fluorouracil in combination with doxorubicin and cyclophosphamide in operable…
- Trial name
- TAX316 (NCT00688740)
- Testing
- Docetaxel, 5-fluorouracil, Doxorubicin
- Where
- 20 sites in United States, Argentina and 18 more
- Volunteers
- 1,491 people
- Sponsor
- Sanofi
Head and Neck Squamous Cell Carcinoma
Validation of USPIO-enhanced MRI for Detection of Lymph Node Metastases in Head and Neck Carcinoma
This study evaluates the diagnostic accuracy of USPIO enhanced MRI for the detection of lymph node metastases in head-and-neck squamous cell carcinoma (SCC) using histopathology as a gold standard.
- Trial name
- USPIO-NECK (NCT03817307)
- Testing
- USPIO-enhanced MRI
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Radboud University Medical Center
Uterine Cervical Neoplasms, Uterine Neoplasms
Sentinel Node Mapping in Women With Cervical and Endometrial Cancer
This study aims to evaluate the effect of SLN mapping on the incidence and severity of lymphedema in women with early stage cervical and endometrial cancer.
- Trial name
- SENTIREC I (NCT02825355)
- Where
- 3 sites in Denmark
- Volunteers
- 512 people
- Sponsor
- University of Southern Denmark
Breast Cancer
Photoacoustic Lymph Node Imaging
In this spectroscopic photoacoustic imaging study, the investigators will acquire images (only) to: 1. determine if spectroscopic photoacoustic imaging can acquire high fidelity images in a clinical setting, 2.
- Trial name
- NCT03931655
- Testing
- Spectroscopic photoacoustic imaging
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Geoff Luke
Sentinel Lymph Node, Breast Cancer
A Clinical Feasibility Study of a Photoacoustic Finder
Determining the prognosis of breast cancer relies significantly on axillary staging by sentinel lymph node biopsy (SLNb). The SLNb is generally performed using radioisotopes, blue dyes, or both to improve the false negative rate.
- Trial name
- NCT06412211
- Testing
- Photoacoustic finder
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Seoul St. Mary's Hospital
Lymphoma, Follicular
A Multi-Center Phase 2 Study to Evaluate Efficacy and Safety of Oral Abexinostat as Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma
An open-label, single-arm, multi-center phase 2 study to evaluate the efficacy and safety of oral histone deacetylase (HDAC)-inhibitor abexinostat, as monotherapy in patients with relapsed or refractory follicular lymphoma (FL)
- Trial name
- NCT03934567
- Testing
- Abexinostat
- Where
- 26 sites in China
- Volunteers
- 87 people
- Sponsor
- Xynomic Pharmaceuticals, Inc.
Breast Cancer
Functional Anatomical Examination of Axillary Sentinel Lymph Node Drainage in the Axillary Subregions in Early Breast Cancer
Regional lymph node status is the most important prognostic factor for disease-free and overall survival in breast cancer. Accurate nodal staging can be achieved only by surgery.
- Trial name
- NCT01804309
- Testing
- Sentinel lymph node biopsy (SLNB)
- Where
- Hungary
- Volunteers
- 350 people
- Sponsor
- National Institute of Oncology, Hungary
Breast Cancer
Predictive Model of Axillary Nodal Status After Neoadjuvant Chemotherapy in Breast Cancer Patients
The management of patients diagnosed with breast cancer (BC) with axillary nodal involvement is still a controversial topic. These patients' treatment usually involves the administration of a neoadjuvant chemotherapy (NAC) in…
- Trial name
- LNNEO (NCT05798806)
- Where
- Italy
- Volunteers
- 1,950 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Breast Cancer Lymphedema
Effect of the Axillary Lymphatic /Vein Reflux Ratio on Postoperative Upper Limb Edema and Dysfunction in Breast Cancer
The purpose of this study is to compare the difference in the incidence of upper limb edema and dysfunction between the Preponderant lymphatic reflux group (high ratio of axillary lymphatic reflux to axillary vein reflux) and the…
- Trial name
- PLEDGE-R (NCT05246592)
- Testing
- Branches Sparing, None Branches Sparing
- Where
- 3 sites in China
- Volunteers
- 258 people
- Sponsor
- Xiangyun Zong
Breast Cancer, Axillary Lymph Node Metastasis
A Prospective Multicenter Study of the TuFEst-LN Model for Axillary Lymph Node Status Assessment in Breast Cancer
Through the research of this project, we expect to validate the clinical utility of the TuFEst-LN model in assessing axillary lymph node status in breast cancer patients.
- Trial name
- PRO-TuFEst-LN (NCT07304934)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.