Clinical trials: Lymph Node Neoplasm
Lung Disease, Inflammation
Study of Biologic Materials From the Mediastinal Lymph Nodes From Patients With Lung Disease.
The purpose of this protocol is to obtain biologic materials from the mediastinal lymph nodes from patients with lung disease and mediastinal lymph node involvement in order to: (1) develop a better understanding of the cause and…
- Conditions
- Lung Disease, Inflammation, Lung Cancer, Sarcoidosis
- Trial name
- NCT02168036
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Weill Medical College of Cornell University
Breast Cancer (Early Breast Cancer), Sentinel Lymph Node Biopsy
NAUTILUS-04: No Axillary Surgical Treatment in Low-Risk Clinically Node-Negative Breast Cancer Without Whole-Breast Radiotherapy
The safety of omitting sentinel lymph node biopsy (SLNB) has been established only in patients undergoing breast-conserving surgery with whole-breast radiotherapy, as demonstrated in the prior randomized trials.
- Trial name
- NAUTILUS-04 (NCT07841704)
- Testing
- Omission of axillary surgery, Sentinel lymph node biopsy
- Where
- South Korea
- Volunteers
- 1,520 people
- Sponsor
- Wonshik Han
Melanoma, Skin
Omitting Therapeutic Lymph Node Dissection in Patients With Melanoma (Stage 3) and Major Pathological Response in the Index Lymph Node
Rationale: The randomized trial NADINA has demonstrated that neoadjuvant treatment with nivolumab with ipilimumab improves event-free survival (EFS) in patients with macroscopic resectable stage III melanoma.
- Trial name
- OMIT (NCT06754904)
- Testing
- Omitting TLND, Index node procedure
- Where
- Netherlands
- Volunteers
- 213 people
- Sponsor
- D.J. (Dirk) Grünhagen
Nasopharyngeal Carcinoma
Individualized Elective Neck Irradiation in NPC Patients
To evaluate whether individualized elective neck irradiation for nasopharyngeal carcinoma based on the vertebral level of metastatic lymph nodes can reduce the incidence of radiation-related adverse effects and improve patients'…
- Trial name
- NCT06241612
- Testing
- Individualized Elective Neck Irradiation
- Where
- China
- Volunteers
- 470 people
- Sponsor
- Sun Yat-sen University
Uterine Cervical Neoplasms, Uterine Neoplasms
Early Feasibility Study of the "Easy Light" Fluorecence Imaging System
This is an early feasibility study to evaluate the device functionality of an open-field handheld wireless fluorecence imaging system for detection of sentinel lymph nodes in women with cervical and uterine cancers who underwent…
- Trial name
- NCT05004623
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Breast Cancer
Sentinel Lymph Node Biopsy With Hybrid Technique in Breast Cancer
Sentinel lymph node (SLN) biopsy is the gold standard method to stage axilla in breast cancer. The aim of the study is to compare the efficiency of various methods to identify SLN is breast cancer patients.
- Trial name
- NCT04274946
- Testing
- Sentinel lymph node biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Breast Cancer
The Impact of the Gene Recurrence Score on Chemotherapy Prescribing in ER Positive, Lymph Node Positive Early Stage Breast Cancer
This study examines the impact of an additional tumour test called the 21 gene Recurrence Score (OncotypeDx®), a commercially available test on a Medical Oncologist's decision to recommend chemotherapy.
- Trial name
- NCT03843346
- Where
- 10 sites in Ireland
- Volunteers
- 87 people
- Sponsor
- Cancer Trials Ireland
Bladder Cancer
Lymph Node Dissection Before or After Cystectomy
The purpose of this study is to compare different ways of performing surgery for bladder cancer. Specifically, the goal is to determine whether it is better to remove the lymph nodes before removing the bladder or after removing…
- Trial name
- LBOACP (NCT05939856)
- Testing
- Lymph node dissection before bladder resection, Lymph node dissection after bladder resection
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Invasive Breast Cancer, Ipsilateral Recurrence
Sentinel Lymph Node Procedure in Ipsilateral Invasive Breast Cancer Relapse
Sentinel lymph node biopsy (SLNB) has become the standard procedure for staging of patients with clinically node-negative breast cancer.
- Conditions
- Invasive Breast Cancer, Ipsilateral Recurrence, Sentinel Lymph Node Biopsy
- Trial name
- FIGARO (NCT03630653)
- Testing
- Sentinel LN in breast cancer recurrence
- Where
- 9 sites in France
- Volunteers
- 50 people
- Sponsor
- Institut Cancerologie de l'Ouest
Lung Cancer Metastatic
Clinical and Molecular Findings in Patients With Cervical/Supraclavicular Metastasis From Non-small-cell Lung Cancer (NSCLC)
Despite the availability of highly effective endoscopy-based and computed tomography (CT)-based biopsy procedures, up to 50% of patients with advanced lung cancer potentially eligible for targeted therapies or immunotherapy do…
- Trial name
- ProphetaPro (NCT05706883)
- Testing
- Needle or forceps biopsy of cervical and/or supraclavicular lymph nodes, Needle, forceps or surgical biopsy of any lesion other than cervical and/or supraclavicular lymph nodes
- Where
- Italy
- Volunteers
- 348 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer
Sentinel Lymph Node Biopsy Versus no Axillary Surgery in Early Breast Cancer
The VENUS trial is a prospective, multicenter, noninferiority, randomized, controlled clinical trial that compares sentinel lymph node biopsy versus no axillary surgery in women with early breast cancer (tumor <5cm) and…
- Trial name
- VENUS (NCT05315154)
- Testing
- No axillary surgery, SLNB
- Where
- 18 sites in Brazil
- Volunteers
- 800 people
- Sponsor
- University of Campinas, Brazil
Carcinoma, Non-Small-Cell Lung
Durvalumab With Stereotactic Body Radiation Therapy (SBRT) vs Placebo With SBRT in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients/ Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR Mutation
This is a Phase III, randomized, placebo-controlled, double-blind, multi-center study assessing the efficacy and safety of durvalumab with SoC SBRT versus placebo with SoC SBRT in patients with unresected clinical Stage I/II…
- Trial name
- PACIFIC-4 (NCT03833154)
- Testing
- Durvalumab, (Osimertinib cohort, single-arm, open-label separate cohort)
- Where
- 209 sites in United States, Australia and 18 more
- Volunteers
- 724 people
- Sponsor
- AstraZeneca
Breast Cancer
Preoperative and Intraoperative Quantification of Axillary Tumoral Load
At present, patients diagnosed of a breast cancer with infiltration of the axillary lymph-nodes are submitted to axillary lymph-node dissection (ALND).
- Trial name
- NCT02197949
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Parc de Salut Mar
Breast Cancer, Invasive Breast Cancer
Sentinel Node Biopsy Following NeoAdjuvant Chemotherapy in Biopsy Proven Node Positive Breast Cancer
Title of Study: Sentinel node biopsy following neoadjuvant chemotherapy in biopsy proven node positive breast cancer. Objectives of the study: Primary objective 1.
- Trial name
- SN-FNAC (NCT00909441)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Canada
- Volunteers
- 153 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Esophageal Cancer
Effect of Cervical Paraesophageal Lymph Node Metastasis Versus Supraclavicular Lymph Node Metastasis on the Overall Survival of Patients With Thoracic Esophageal Squamous Cell Carcinoma: An Observational Study
The goal of this observational study is to learn about in health conditions of ESCC. The main question[s] it aims to answer are: •Lymph node metastasis(LNM) in cervical paraesophageal or supraclavicular which influence OS more.
- Trial name
- ECPLNMvsSLNM (NCT06165094)
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Lymph Node Metastases
Lymph Node Metastases and Arterial Ligation in Rectal Cancer Surgery
Lymph node status is of major prognostic importance in non-metastatic rectal cancer. For oncological reasons, central arterial ligation of the inferior mesenteric artery (IMA) is suggested.
- Trial name
- NCT03314961
- Volunteers
- 151 people
- Sponsor
- Region Västmanland
Oral Cancer, Lymph Node Metastasis
Neck Observation or Elective Neck Dissection in cT1N0M0 OSCC
To evaluate the clinical outcomes of 2-year lymph node metastasis rate, disease-free survival, overall survival, and health-related quality of life in the patients with cT1N0M0 oral squamous cell carcinoma, who receive primary…
- Trial name
- NCT06623266
- Testing
- Neck management
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
Gastric Cancer
Trial for Application of Laparoscopic Total Gastrectomy With Lymph Node Dissection for Gastric Cancer (KLASS-06)
Although Laparoscopic gastrectomy for both early and locally advanced gastric cancer has gained popularity, the use of laparoscopic total gastrectomy for proximal advanced gastric cancer is still limited to some experienced…
- Trial name
- NCT03385018
- Testing
- Radical total gastrectomy with D2 (D2 - #10) lymph node dissection by laparoscopic approach, Radical total gastrectomy with D2 (D2 - #10) lymph node dissection by open conventional approach
- Where
- South Korea
- Volunteers
- 772 people
- Sponsor
- Yonsei University
Breast Cancer, Sentinel Lymph Node
Omission of Axillary Surgery in Breast Cancer Patients
The treatment and prognosis of breast cancer (BC) are dependent on its molecular subtype and nodal burden. In early BCs with favourable molecular subtype, the incidence of axillary node involvement is low.
- Conditions
- Breast Cancer, Sentinel Lymph Node, Breast Neoplasms
- Trial name
- NCT06259513
- Testing
- omission of SLNB in SentiOMIT or omission of ALND in SentiMACRO
- Where
- Singapore
- Volunteers
- 350 people
- Sponsor
- KK Women's and Children's Hospital
Cancer of the Urinary Tract
Merits of Performing a Modified Template Retroperitoneal Lymph Node Dissection
The primary objective is to show that performing a lymph node dissection may detect occult nodal metastasis in this patient population whereby providing important diagnostic information, with potential therapeutic benefits in…
- Trial name
- NCT00751140
- Testing
- Lymph Node Dissection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
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