Clinical trials: Lymph Node Neoplasm
Endometrial Cancer
27-Inch Versus 55-Inch Monitors in Women Undergoing Endometrial Cancer Surgery
This study will compare the use of 27-inch and 55-inch endoscopic imaging monitors during minimally invasive surgery for women with endometrial cancer. Participants will be randomly assigned to one of the two monitor groups.
- Trial name
- NCT07882277
- Testing
- 27-Inch Endoscopic Imaging Monitor, 55-Inch Endoscopic Imaging Monitor
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Metehan Uzundal
Breast Cancer
Prospective Pilot Study ANDPrecise
This study aims at providing first evidence that axillary clearance by using an operation technique including the precise LigaSure instrument and closure of dead space of the axilla will result in an operation were a drain is not…
- Trial name
- ANDPrecise (NCT02292407)
- Testing
- LigaSure Precise instrument
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Evaluation of Needle Core Biopsy of Axillary Sentinel Lymph Node in Breast Cancer
The purpose of the study is to determine if it is possible to identify and perform a needle biopsy of the sentinel lymph node. The investigators hope to identify breast cancer cells in the lymph nodes under the arm without making…
- Trial name
- ENCASe (NCT02046057)
- Testing
- PNB of SLN
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Loma Linda University
Prostate Cancer
A Phase 2 Study With MIP-1404 in Men With High-Risk PC Scheduled for RP and EPLND Compared to Histopathology
This was a multicenter, multi-reader, open-label, Phase 2 study assessing the safety and performance characteristics of MIP 1404 imaging in the detection of prostate gland and pelvic lymph node cancer.
- Trial name
- NCT01667536
- Testing
- Drug: 99mTc-MIP-1404
- Where
- 35 sites in United States, Belgium and 6 more
- Volunteers
- 105 people
- Sponsor
- Molecular Insight Pharmaceuticals, Inc.
Papillary Thyroid Cancer, Lymph Node Metastases
Precision Thyroid Cancer Surgery With Molecular Fluorescent Guided Imaging
Almost 50 % of papillary thyroid cancer (PTC) patients have central lymph node metastases (CLNM), which are associated with a high risk of persistent or recurrent disease.
- Trial name
- TARGET (NCT03470259)
- Testing
- IV adminstration of EMI-137, Multispectral Fluorescence Reflectance Imaging, Spectroscopy
- Where
- 2 sites in Netherlands
- Volunteers
- 19 people
- Sponsor
- University Medical Center Groningen
Lung Cancer Metastatic
Clinical and Molecular Findings in Patients With Cervical/Supraclavicular Metastasis From Non-small-cell Lung Cancer (NSCLC)
Despite the availability of highly effective endoscopy-based and computed tomography (CT)-based biopsy procedures, up to 50% of patients with advanced lung cancer potentially eligible for targeted therapies or immunotherapy do…
- Trial name
- ProphetaPro (NCT05706883)
- Testing
- Needle or forceps biopsy of cervical and/or supraclavicular lymph nodes, Needle, forceps or surgical biopsy of any lesion other than cervical and/or supraclavicular lymph nodes
- Where
- Italy
- Volunteers
- 348 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lymph Node Metastases
Irreversible Electroporation(IRE) For Unresectable Lymph Node Metastases(Close to Nerve)
The purpose of this study is to evaluate the safety and efficacy of irreversible electroporation (IRE) for unresectable Lymph Node Metastases.
- Trial name
- IRE (NCT02430766)
- Testing
- Irreversible electroporation (IRE), NanoKnife
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Breast Neoplasms
The Breast Surgery EnLight and LightPath Imaging System Study
This study will correlate the resection margin status of the breast cancer tumour (WLE specimen), cavity shavings (if any) and breast cavity, and the metastatic status of axillary lymph nodes as determined by EnLight, LightPath…
- Trial name
- NCT02151071
- Testing
- EnLight, LightPath
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Lightpoint Medical Limited
Cutaneous Squamous Cell Carcinoma (CSCC)
Testing Whether Skin Cancer Has Spread to Nearby Lymph Nodes
This study is about a type of skin cancer called high-risk cutaneous squamous cell carcinoma (HRcSCC). Although most people with this type of skin cancer are successfully treated, some patients have a higher chance that the…
- Trial name
- CECRE (NCT07746258)
- Testing
- Lymphadenectomy
- Where
- Spain
- Volunteers
- 142 people
- Sponsor
- Germans Trias i Pujol Hospital
Locally Advanced Non-Small Cell Lung Cancer, Stage IIIb Non-small Cell Lung Cancer
Neoadjuvant SBRT Followed by Sintilimab Plus Chemotherapy for N3-Positive NSCLC
This is a Phase II clinical trial evaluating the efficacy and safety of a new treatment approach for patients with locally advanced non-small cell lung cancer (NSCLC) that has spread to lymph nodes on the opposite side of the…
- Conditions
- Locally Advanced Non-Small Cell Lung Cancer, Stage IIIb Non-small Cell Lung Cancer, Stage IIIC Non-Small Cell Lung Cancer
- Trial name
- SACTION 2501 (NCT07309952)
- Testing
- Sintilimab, Paclitaxel, Carboplatin (AUC 5)
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Yang Hong
Sentinel Lymph Node, Breast Cancer
A Clinical Feasibility Study of a Photoacoustic Finder
Determining the prognosis of breast cancer relies significantly on axillary staging by sentinel lymph node biopsy (SLNb). The SLNb is generally performed using radioisotopes, blue dyes, or both to improve the false negative rate.
- Trial name
- NCT06412211
- Testing
- Photoacoustic finder
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Seoul St. Mary's Hospital
Indocyanine Green, Gastric Cancer
Randomized Controlled Trial on Effect of Lymph Node Mapping by Indocyanine Green Via Submucosal or Subserosal Injection
The purpose of this study was to evaluate whether submucosal or subserous injection of indocyanine green during laparoscopic lymphadenectomy for patients with gastric cancer was different.
- Conditions
- Indocyanine Green, Gastric Cancer, Injection Site
- Trial name
- NCT04219332
- Testing
- Subserosa injection of indocyanine green, submucosal injection of indocyanine green
- Where
- China
- Volunteers
- 266 people
- Sponsor
- Fujian Medical University
Colon Cancer
Sentinel Lymph Node Mapping and Analysis in Colon Cancer Using Indocyanine Green Dye
Approximately 20-30 % of colon cancer patients who have no metastasis in lymph nodes after definitive colectomy have recurrence with distant metastasis.
- Trial name
- NCT04351009
- Testing
- sentinel lymph node mapping
- Where
- India
- Volunteers
- 48 people
- Sponsor
- Asian Institute of Gastroenterology, India
Breast Cancer
Regional Anesthesia for Modified Radical Mastectomy With Axillary Lymph Node Dissection
local and regional anesthesia have been introduced with the goal of reducing the side effects associated with general anesthesia and IV opioid analgesia.our hypothesis is that ultrasound-guided interscalene brachial plexus block…
- Trial name
- NCT04239716
- Testing
- regional anesthesia
- Where
- Egypt
- Volunteers
- 13 people
- Sponsor
- Tanta University
Endometrial Cancer Stage I, Sentinel Lymph Node
Sentinel Node Biopsy in Endometrial Cancer
Endometrial cancer (EC) is the most common gynaecological cancer. Current treatment of EC typically includes removal of the uterus and to determine the extent of the disease (removal of fallopian tubes, ovaries \& if required a…
- Conditions
- Endometrial Cancer Stage I, Sentinel Lymph Node, Surgery
- Trial name
- ENDO-3 (NCT04073706)
- Testing
- TH BSO with SNB Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted, TH BSO without retroperitoneal node dissection Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted
- Where
- 23 sites in United States, Argentina and 5 more
- Volunteers
- 760 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Ovarian Cancer, Sentinel Lymph Node
Mapping Sentinel Lymph Node in Initial Stages of Ovarian Cancer
Epithelial ovarian cancer (EOC) diagnosed in the initial stage (stage I-II) require complete staging surgery to histologically assess the possible existence of peritoneal or lymph node disease.
- Trial name
- MELISA (NCT05184140)
- Testing
- Sentinel node detection
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Breast Cancer, Axillary Lymph Node Dissection
Nomogram to Predict Breast Cancer Related Lymphedema
It has been hypothesized that damaged arm lymphatic drainage is associated with the arm lymphedema after axillary lymph node dissection (ALND).
- Conditions
- Breast Cancer, Axillary Lymph Node Dissection, Breast Cancer Related Lymphedema, Axillary Reverse Mapping
- Trial name
- NCT04665882
- Testing
- Axillary surgery based on lymphedema prediction nomogram
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Wuhan University
Breast Cancer Early Stage Breast Cancer (Stage 1-3)
A Dose-Image Optimization Trial Evaluating Mannitol and Voluven as Adjuncts for Indocyanine Green
The goal of this clinical trial is to exploring the use of Mannitol 20% as a solvent to prepare ICG solution, combining with Voluven, forming a hybrid small-large molecular weight solvent for protecting ICG in monomer form and…
- Trial name
- ICGMV (NCT06768268)
- Testing
- Voluven-assisted Indocyanine green fluorescence guided sentinel lymph node biopsy for breast cancer, Mannitol (20%)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer
Selective Avoidance of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy In HER-2 Positive/Triple Negative Breast Cancer Patients With Excellent Radiologic Response to the Breast and Axilla, Prospective, Multi-center, Single-arm (ASLAN) Study
The aims of this study is to evaluate 5 year recurrence free survival when omit sentinel lymph node biopsy after neoadjuvant chemotherapy in triple negative or HER-2 positive breast cancer patients when physical examination…
- Trial name
- ASLAN (NCT04993625)
- Testing
- avoid axillary sentinel lymph node biopsy after neoadjuvant chemotherapy
- Where
- South Korea
- Volunteers
- 178 people
- Sponsor
- Jeong Eon Lee
ESCC, Lymph Node Metastasis
Lymph Node Metastasis in Early Esophageal Squamous Cell Carcinoma
This study aims to develop a predictive model using deep learning and radiomics to assess the likelihood of lymph node metastasis in patients with early-stage esophageal squamous cell carcinoma (ESCC).
- Conditions
- ESCC, Lymph Node Metastasis, Radiomics
- Trial name
- NCT07050576
- Testing
- The prediction model of lymph node metastasis in early esophageal squamous cell carcinoma
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
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