Clinical trials: Lymphatic Edema
Head and Neck Neoplasms, Head and Neck Cancer
A Pilot Study to Evaluate the Feasibility and Potential Effectiveness of the Flexitouch System Head and Neck Treatment
The study will evaluate the feasibility and potential effectiveness of the Flexitouch head and neck treatment plus standard home care compared to standard home care regimen alone.
- Conditions
- Head and Neck Neoplasms, Head and Neck Cancer, Head and Neck Lymphedema
- Trial name
- NCT03332160
- Testing
- Flexitouch head and neck lymphedema treatment system, Standard home lymphedema care
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Tactile Medical
Edema, Hypoproteinemia
Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial
Critically ill patients usually require intravenous fluids to correct low blood pressure and improve blood flow to vital organs.
- Trial name
- FADE (NCT02055872)
- Testing
- Intravenous albumin, Normal saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Hamilton Health Sciences Corporation
Secondary Lymphedema
Imaging Biomarkers of Lymphatic Dysfunction
Persons with secondary arm and/or upper quadrant lymphedema following cancer therapies commonly are prescribed complete decongestive therapy as a course of management of their lymphedema.
- Trial name
- NCT03760744
- Testing
- CDT with Negative Pressure, CDT alone
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University Medical Center
Lymphedema, Edema
Prospective Evaluation of a Surgical Solution for Breast Cancer-Associated Lymphedema
To investigate whether addition of the Biobridge scaffold to the standard surgery for vascularized lymph node transfer will improve the outcome of surgical treatment in lymphedema of the upper arm.
- Trial name
- Biobridge (NCT02734979)
- Testing
- Biobridge and lymph node transfer
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Lymphedema
A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer
The major purpose of this study is to determine if a new drug called pazopanib decreases lymphedema in subjects previously treated for cancer.
- Trial name
- NCT00827372
- Testing
- Pazopanib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kathy Miller
Breast Cancer Related Lymphoedema, Lymphoedema
LYT-100 in Patients With BCRL
This is a trial of up to 6-months duration for safety, tolerability, clinical efficacy assessments, PK and biomarkers analysis in breast carcinoma patients with secondary lymphoedema
- Trial name
- NCT04243837
- Testing
- LYT-100 BCRL
- Where
- 8 sites in United States, Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PureTech
Breast Cancer, Lymphedema
LLLT Combined With CDT in Breast Cancer-Related Lymphedema
This study aims to explore the effects of Low Level Laser Therapy (LLLT) on breast cancer-related lymphedema when utilized in conjunction with Complex Decongestive Therapy (CDT) when compared to CDT treatment alone.
- Trial name
- NCT01351376
- Testing
- Low Level Laser Therapy, Low Level Laser
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- NYU Langone Health
Breast Cancer Lymphedema
Study Evaluating Flexitouch Plus With Connectivity on Compliance in 30 Patients With Breast Cancer-Related Lymphedema.
The objective of this study is to demonstrate the feasibility of using the Flexitouch Plus with Cellular Connectivity (FT-CC) to monitor device use data to determine if reminders to patients impact compliance, and to identify the…
- Trial name
- NCT04432727
- Testing
- Flexitouch Plus with Cellular Connectivity (FT-CC)
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- Tactile Medical
Lymphedema
Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema
This is a randomized, controlled, parallel group, open label, clinical trial to evaluate the effectiveness of intermittent, gradient, pneumatic compression (IPC)on the healing of venous ulcers in subjects diagnosed with chronic…
- Trial name
- NCT01079299
- Testing
- Intermittent, gradient, pneumatic compression device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Calvary Hospital, Bronx, NY
Breast Cancer Related Lymphedema, Covid19
Patient Experiences With the COVID-19 Vaccination After Breast Cancer Treatment
This study aims to elicit patient experiences, choices, and side effects associated with the COVID-19 vaccine after breast cancer surgery.
- Trial name
- LymphVAX (NCT04872738)
- Testing
- Survey
- Where
- United States
- Volunteers
- 714 people
- Sponsor
- Massachusetts General Hospital
Lymphatic Filariasis
Moxidectin for LF, Cote d'Ivoire (DOLF)
The purpose of this study is to determine whether moxidectin (Mox) will be more effective than ivermectin (IVM) when used in single-dose combination therapies for lymphatic filariasis (LF).
- Trial name
- NCT04410406
- Testing
- Ivermectin, Diethylcarbamazine, Albendazole
- Where
- Côte d’Ivoire
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Breast Cancer
Evaluation of BIS for Quantification of Lymphedema
The purpose of this study is to determine whether measuring the fluid in your arms using Bioimpedance Spectroscopy is as effective at detecting and monitoring lymphedema as measurements with the Perometer.
- Trial name
- NCT01544335
- Testing
- Bioimpedance Spectroscopy
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Massachusetts General Hospital
Non-filarial Elephantiasis
An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis
An RCT (n=193) in two podoconiosis clinics in Ethiopia to evaluate the effectiveness of a research based skin management regimen compared to the current regimen.
- Trial name
- NCT02839772
- Testing
- Current skin care regimen plus 2% glycerine added to soaking water, Current skin care regimen
- Volunteers
- 193 people
- Sponsor
- University of Hull
Lymphedema
Low Level Laser Treatment and Breast Cancer Related Lymphedema
Manual Lymphatic Drainage (massage therapy) with compression (wearing a tight sleeve on the arm) is the current standard of treatment for breast cancer related lymphedema (arm swelling).
- Trial name
- NCT00852930
- Testing
- laser and MLD combined, laser alone, manual lymphatic drainage
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University
Lymphedema
Ubenimex in Adult Patients With Lymphedema of The Lower Limb (ULTRA)
This proof-of-concept study is designed as a randomized, double-blind, placebo-controlled study comparing ubenimex at 150 mg, 3 times daily (total daily dose of 450 mg) with placebo for 6 months treatment period in patients with…
- Trial name
- NCT02700529
- Testing
- ubenimex
- Where
- 4 sites in United States, Australia
- Volunteers
- 54 people
- Sponsor
- Eiger BioPharmaceuticals
Head and Neck Neoplasms, Head and Neck Lymphedema
Response to Intermittent Pneumatic Compression Therapy in Head and Neck Cancer-Related Lymphedema
Assessment of lymphatic structure and function pre- and post- treatment and during recovery in head and neck cancer related lymphedema patients using NIR fluorescence lymphatic imaging: Response to ICD therapy in HNC Patients.
- Conditions
- Head and Neck Neoplasms, Head and Neck Lymphedema, Head and Neck Cancer
- Trial name
- NCT02946021
- Testing
- Head and neck garments for pneumatic compression device, NIRFLI with ICG
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Tactile Medical
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group
Lymphedema
Two Pneumatic Compression Devices in the Treatment of Lower Extremity Lymphedema
The treatment of lymphedema has been a major focus of attention for physicians and scientists for several decades. At this time, no successful techniques have been developed to prevent lymphedema, and therefore, a great deal of…
- Trial name
- ACE (NCT01239160)
- Testing
- Flexitouch System, Hydroven FPR
- Where
- 22 sites in United States, Australia and 1 more
- Volunteers
- 238 people
- Sponsor
- Tactile Medical
Lymphedema, Breast Cancer
Lymphedema Prophylaxis in Breast Cancer Survivors Who Show Early Evidence of High-risk Status
To compare the effectiveness of usual treatments for lymphedema [massage and elastic compression sleeve, instituted at-risk and before the development of swelling (lymphedema)], compared to the use of a newly-marketed device, the…
- Trial name
- NCT00383500
- Testing
- Flexitouch, Class 1 compression garment
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Stanford University
Lymphedema, Musculoskeletal Complications
Image-Guided Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Shoulder, Arm, Hip, or Leg
RATIONALE: Image-guided radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a lower dose of radiation directly to the tumor may kill more tumor cells and cause less damage to…
- Conditions
- Lymphedema, Musculoskeletal Complications, Radiation Fibrosis, Radiation Toxicity
- Trial name
- NCT00589121
- Testing
- Chemotherapy, Radiation therapy, Surgery
- Where
- 17 sites in United States, Canada
- Volunteers
- 98 people
- Sponsor
- Radiation Therapy Oncology Group