Clinical trials: MACULAR EDEMA
Diabetic Macular Edema
Anterior and Posterior Segment Vascular Changes Following Laser and Anti-Vascular Endothelial Growth Factor (VEGF) Treatment of Diabetic Retinopathy
The study will investigate changes in the structure and function of blood vessels in the front and back of the eye following laser and anti-VEGF treatments for sight-threatening diabetic eye disease.
- Trial name
- VEGF (NCT01196325)
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetic Macular Edema
Safety Study of Bromfenac Ophthalmic Solution in Subjects With Diffuse Diabetic Macular Edema (DME) Refractory to Laser
This is an investigator-sponsored trial (IST), an open-label pilot study, assessing the safety and biologic activity of bromfenac in subjects with diffuse DME refractory to laser.
- Trial name
- NCT00491166
- Testing
- Bromfenac ophthalmic solution
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Boston
Artificial Intelegence, Diabetic Retinopathy Associated With Type 2 Diabetes Mellitus
Application of Artificial Intelligence in Early Detection of Eye Complications in Diabetics
The goal of this pragmatic trial is to test the benefit of using artificial intelligence-based eye screening i.e, a fundus camera device in the early detection of eye complications in diabetics.
- Conditions
- Artificial Intelegence, Diabetic Retinopathy Associated With Type 2 Diabetes Mellitus, Macular Edema Due to Type 2 Diabetes Mellitus
- Trial name
- AI (NCT05655117)
- Testing
- AI based eye screening
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- The New Model of Care, Hail Health Cluster
Diabetic Macular Edema, Macular Edema, Cystoid
Effect of Intravitreal Long Acting Dexamethasone Implant, Ozurdex in Patients With Diabetic Macular Edema
This study is undertaken to determine the effect of intravitreal long acting dexamethasone implant,(Ozurdex®)in patients with diabetic macular edema.Diabetic macular edema is important cause of visual impairment in patients with…
- Conditions
- Diabetic Macular Edema, Macular Edema, Cystoid, Vision Disorders, Clinically Significant Macular Edema
- Trial name
- NCT01698749
- Testing
- long acting intravitreal dexamethasone implant
- Where
- India
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Diabetic Macular Edema
Combined Intravitreal Bevacizumab With Topical Timolol-Dorzolamide Eye Drops in Diabetic Macular Edema
This study is a double-blind randomized clinical trial in Diabetic patients (type 2) over 18 years of age who have diabetic macular edema with involvement of the central 1 millimeter (central macular thickness is more than 300…
- Trial name
- NCT05083689
- Testing
- Injections of 1.25 mg of intravitreal bevacizumab with Timolol and Dorzolamide, Injections of 1.25 mg of intravitreal bevacizumab with artificial tears
- Where
- Iran
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Retinal Edema
Suprachoroidal Injection of Triamcinolone Acetonide in Resistant Diabetic Macular Edema, CRVO, Pseudophakic Cystoid Macular Edema and Diabetic Macular Edema Following Pars Plana Vitrectomy
Prospective interventional study on 60 eyes of resistant diabetic macular edema and central retinal vein occlusion that will receive suprachoroidal injection of Triamcinolone Acetonide (SCTA).
- Trial name
- Resistant (NCT04690608)
- Testing
- Triamcinolone Acetonide 40Mg/Ml Inj,Susp_#1
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanta University
Neovascular Age-related Macular Degeneration
Functional and Structural Outcomes in Neovascular Age-related Macular Degeneration
Several studies during the last years reported the involvement of anti-retinal autoantibodies in ocular disorders, such as AMD. These studies support the growing evidence of an immunological involvement in the pathogenesis of…
- Trial name
- CAPTAIN (NCT02843490)
- Testing
- Ranibizumab
- Where
- Germany
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Diabetic Retinopathy, Diabetic Macular Edema
Comparing Artificial Intelligence for Assisted Diagnosis of Diabetic Retinopathy
This study plans to compare the accuracy of artificial intelligence (AI)-assisted fundus images with other ophthalmic devices such as optical coherence tomography (OCT) and fundus fluorescence angiography (FFA) in the diagnosis…
- Trial name
- NCT06423274
- Testing
- fundus photography, optical coherence tomography, fundus fluorescence angiography
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Retinal Disease, Retinal Detachment
High Resolution Optical Coherence Tomography
Comparison of high-resolution optical coherence tomography (High-Res-OCT) to conventional imaging modalities for the diagnosis of eye diseases
- Conditions
- Retinal Disease, Retinal Detachment, Retinal Vein Occlusion, Retinal Dystrophy
- Trial name
- NCT05130385
- Testing
- High-resolution optical coherence tomography (High-Res-OCT), Standard spectral domain OCT (SD-OCT)
- Where
- Switzerland
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Low Vision, Macular Edema
Smart-TV Application for the Self Examination of the Distance Visual Acuity in Macular Edema Patients
Primary objective of our study is the development and validation of an application for smart-TVs for the self-examination of the distant visual acuity of patients diagnosed with macular edema.
- Conditions
- Low Vision, Macular Edema, Refractive Errors
- Trial name
- NCT04739137
- Testing
- DDiVAT Testing, Distance visual acuity assessment via ETDRS chart
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Retinal Vein Occlusion, Macular Edema
Efficacy of an Intravitreal DEX Implant in Retinal Vein Occlusion Following Treatment With Anti-VEGF Injections.
To test the efficacy of a 0.7 mg intravitreal dexamethasone implant (Ozurdex®) on macular function and recalcitrant macular edema associated with retinal vein occlusion following treatment with 2 or more prior intravitreal…
- Trial name
- NCT01449682
- Testing
- Ozurdex
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Retina Macula Institute
Diabetic Macular Edema, Hard Lipid Exudates
The Effect of Intravitreal Ranibizumab on Visual Acuity and Hard Exudate Resolution in the Treatment of Diabetic Macular Edema With Center Involved Edema and Lipid Exudates
This is an open-label, Phase I/II study of intravitreally administered 0.3mg ranibizumab in subjects with diabetic macular edema and lipid exudates in the central subfield.
- Trial name
- NCT02448446
- Testing
- ranibizumab 0.3mg
- Where
- 4 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- South Coast Retina Center; Carson, McBeath, Boswell, Inc.
Glaucoma, Age-Related Macular Degeneration
Detecting Eye Diseases Via Hybrid Deep Learning Algorithms From Fundus Images
Eye health is of great importance for quality of life. Some eye diseases can progress and cause permanent damage up to vision loss if they are not treated early.
- Conditions
- Glaucoma, Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Retinopathy
- Trial name
- NCT06213896
- Testing
- Mydriatic Agent, Color Fundus Photography, EyeCheckup v2.0
- Where
- Turkey (Türkiye)
- Volunteers
- 1,528 people, healthy volunteers welcome
- Sponsor
- Ural Telekomunikasyon Sanayi Ticaret Anonim Sirketi
Retinopathy, Diabetic
DEXTENZA VS. PREDNISOLONE ACETATE 1% Macular Edema With Diabetic Retinopathy After Cataract Surgery
The complicated schedules for administering topical steroid eye drops combined with forgetfulness and physical difficulties instilling the drops may compromise compliance; which in turn could increase the risk for secondary…
- Trial name
- NCT04362241
- Testing
- Prednisolone Acetate 1% Ophthalmic Suspension [PRED FORTE]
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of the Capital Region
Macular Edema Following Cataract Surgery
Trientine Hydrochloride for the Prevention of Macular Edema After Cataract Surgery in Patients With Type 2 Diabetes Mellitus
The primary purpose of the protocol is to evaluate whether Trientine Hydrochloride, a copper chelator which is an agent that binds with and removes copper, will be effective in minimizing macular edema after cataract surgery in…
- Trial name
- NCT01295073
- Testing
- Trientine Hydrochloride, For Arm B there is no therapeutic intervention other than standard of care, which is cataract surgery.
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of British Columbia
Retinal Vein Occlusion
Intravitreal Ranibizumab Treatment of Central Retinal Vein Occlusion With Macular Edema
The purpose of this study is to examine the effects of Lucentis for active Central Retinal Vein Occlusion with Macular Edema
- Trial name
- NCT00403039
- Testing
- Ranibizumab (Lucentis )
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Vitreous -Retina- Macula Consultants of New York
Cataract, Macular Edema
The Role of Radial Peripapillary Vessel Density in Irvine-gass Syndrome
Pseudophakic cystoid macular edema (PCME), also known as Irvine-Gass syndrome (IGS), is an accumulation of fluid in the macula that occurs after cataract surgery, with an early or late presentation (cut-off 3 months) .
- Trial name
- OCTA and PMCE (NCT06436170)
- Testing
- OCTA
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federico II University
Retinitis Pigmentosa, Macula Off
Transcorneal Electrical Stimulation Therapy for Retinal Disease
Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.
- Conditions
- Retinitis Pigmentosa, Macula Off, Primary Open Angle Glaucoma, Hereditary Macular Degeneration
- Trial name
- NCT00804102
- Testing
- Transcorneal Electrical Stimulation, DTL-electrode attached without energy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Okuvision GmbH
Cystoid Macular Edema, Postoperative, Diabetes Mellitus
Effect of Preoperative Topical Ketorolac on Aqueous Cytokine Levels and Macular Thickness in Cataract Surgery Patients
The purpose of this study is to determine whether there is a relationship between inflammatory cytokines in the aqueous of the eye and thickness of the macula after treatment of topical ketorolac for patients undergoing cataract…
- Trial name
- NCT02646072
- Testing
- Ketorolac tromethamine ophthalmic solution 0.45%
- Where
- Malaysia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Diabetic Macular Edema
Comparative Study of Dexamethasone Implant to Intravitreal Aflibercept in Subjects With Diabetic Macular Edema
This study is an interventional, prospective randomized study comparing the dexamethasone implant to intravitreal aflibercept. Subjects will have an initial single injection of aflibercept and will be randomized if diabetic…
- Trial name
- PRECISION (NCT04411693)
- Testing
- Dexamethasone implant, Aflibercept
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic