Clinical trials: MINS
Myocardial Injury After Noncardiac Surgery (MINS), Hypotension During Surgery
Study on the Correlation Between Intraoperative Hypotension and Postoperative Myocardial Injury
The investigators are conducting an important study aimed at better understanding and predicting a potential complication after non-cardiac surgery: myocardial injury.
- Trial name
- NCT07094321
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- China-Japan Friendship Hospital
GI Endoscopy
Evaluation of the Incidence of Myocardial Damage Following Upper and Lower Gastrointestinal Endoscopy in High-risk Patients
Hypoperfusion occurs following anaesthesia induction as a result of: 1. a reduction in venous return and cardiac output subsequent to the dilatation of the venous reservoir, and 2.
- Trial name
- NCT07179549
- Volunteers
- 120 people
- Sponsor
- European Society of Anaesthesiology
Intervertebral Disc Herniation, Stiffness; Spine
Cervical Changes by 4h of Hyper-buoyancy Flotation and Followed by 15 Mins 1g Re-loading
Study with the aim to see the effect on a space ground anaologue, Hyperbuoyancy Floatation (HBF) on cervical column.
- Trial name
- NCT05296200
- Testing
- Hyperbuoyancy Floatation
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Universidad Autonoma de Madrid
Cardiovascular Risk Factor
Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients
This is a prospective randomised trial investigating the effect of a preemptive administration of levosimendan on postoperative cardiac NT-proBNP concentrations.
- Trial name
- IMPROVE (NCT04329624)
- Testing
- Levosimendan
- Where
- Austria
- Volunteers
- 230 people
- Sponsor
- Medical University of Vienna
Hyperoxia, Myocardial Infarction
Intraoperative Hyperoxia and MINS
Oxygen therapy is administered to all patients during general anesthesia to maintain tissue oxygenation and prevent hypoxia and ischemia.
- Conditions
- Hyperoxia, Myocardial Infarction, Myocardial Injury
- Trial name
- NCT04540276
- Testing
- Inspiratory oxygen fraction
- Where
- 8 sites in United States, Canada and 6 more
- Volunteers
- 7,700 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Myocardial Injury After Noncardiac Surgery (MINS), Myocardial Ischemia
Ivabradine for Prevention of Myocardial Injury After Noncardiac Surgery Trial (PREVENT-MINS)
This study is a multicentre, randomized controlled trial of ivabradine versus placebo.
- Trial name
- PREVENT-MINS (NCT05279651)
- Testing
- Ivabradine
- Where
- 26 sites in Poland
- Volunteers
- 2,146 people
- Sponsor
- Jagiellonian University
Pancreas Disease, Troponin T
Cardiac Cycle Efficiency and Postoperative Troponin
Knowing how intraoperative anesthesia management and cardiac cycle monitoring affect postoperative cardiac outcomes in patients undergoing pancreatic surgery can help develop a protocol for future cases.
- Conditions
- Pancreas Disease, Troponin T, Hemodynamic Monitoring, MINS
- Trial name
- NCT07778914
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Istanbul Saglik Bilimleri University
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Myocardial Injury, Non-cardiac Surgery
Hemodynamics and Myocardial Injury After Non-cardiac Surgery
The incidence of myocardial injury after non-cardiac surgery (MINS) is approximately 12-15% and is associated with an increased risk of 30-day mortality, 1-year mortality, and 2-year major vascular events.
- Conditions
- Myocardial Injury, Non-cardiac Surgery, Complication,Postoperative, High-sensitivity Troponin
- Trial name
- MINS (NCT05188001)
- Testing
- Not an Interventional Study
- Where
- Canada
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
MINS, Myocardial Injury After Noncardiac Surgery
Comparison of Myocardial Injury After Noncardiac Surgery (MINS) Incidence in Supine vs. Prone Positioning During Percutaneous Nephrolithotomy (PNL)
This prospective cohort study aims to compare the incidence of Myocardial Injury after Noncardiac Surgery (MINS) in patients undergoing percutaneous nephrolithotomy (PNL) for kidney stones in supine versus prone positioning.
- Conditions
- MINS, Myocardial Injury After Noncardiac Surgery, Myocardial Injury After Noncardiac Surgery (MINS), Renal Calculi
- Trial name
- NCT06944301
- Testing
- blood sampling
- Volunteers
- 400 people
- Sponsor
- Medipol University
Myocardial Injury After Noncardiac Surgery (MINS)
SecondarY Prevention and maNagement of Myocardial Injury aftER Noncardiac surGerY (SYNERGY) Pilot Trial
Cardiac complications, particularly myocardial injury after noncardiac surgery (MINS), significantly contribute to 30-day mortality, affecting about 1 in 10 patients after noncardiac surgery.
- Trial name
- NCT06768034
- Testing
- Intervention Group
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Myocardial Infarction Postoperative, Myocardial Injury
Preoperative BNP: Epidemiological Patterns, Management Strategies and Cost Analysis of Care
Recently, the use of preoperative BNP as a preoperative risk stratifcation tool was added to the Canadian Cardiovascular Society (CCS) guidelines (4) on perioperative cardiac risk assessment and management for patients who…
- Conditions
- Myocardial Infarction Postoperative, Myocardial Injury, Death, Cardiac
- Trial name
- NCT04077294
- Testing
- Cardiac risk stratification using preoperative BNP measurement, followed by postoperative cardiac monitoring, Use of traditional perioperative cardiac risk stratification only
- Where
- Canada
- Volunteers
- 333 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Myocardial Injury, Surgery
Chronic Kidney Disease and Myocardial Injury After Non Cardiac Surgery
Investigators will conduct a retrospective chart review, examining the impact of chronic kidney disease on risk of myocardial injury after non cardiac surgery (MINS).
- Conditions
- Myocardial Injury, Surgery, Chronic Kidney Diseases
- Trial name
- MINS (NCT05248451)
- Testing
- Not an Interventional Study
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Myocardial Injury After Noncardiac Surgery (MINS)
Myocardial Injury Noncardiac Surgery in Geriatric Patients
In inpatients aged 45 years and older, the approximate peri-operative mortality rate after non-cardiac surgery is around 1% to 2%. Half of these deaths are attributed to cardiovascular complications of surgery.
- Trial name
- NCT06957106
- Where
- Turkey (Türkiye)
- Volunteers
- 117 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS)
Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2
VISION-2 is an international, multi-site, prospective observational cohort study of 20,000 patients undergoing noncardiac surgery.
- Conditions
- Myocardial Injury After Noncardiac Surgery (MINS), Bleeding Independently Associated With Mortality After Noncardiac Surgery (BIMS), Sepsis, Infection Without Sepsis
- Trial name
- VISION-2 (NCT07300579)
- Testing
- Continuous vital signs measurement device
- Where
- 3 sites in Canada
- Volunteers
- 20,000 people
- Sponsor
- Hamilton Health Sciences Corporation
MINS
Association Between Ambient Temperature and Myocardial Injury After Noncardiac Surgery in Adults
This single-center retrospective cohort study enrolled patients aged ≥18 years who underwent noncardiac surgery between January 2014 and December 2023.
- Trial name
- NCT07079891
- Testing
- MINS
- Volunteers
- 143,095 people, healthy volunteers welcome
- Sponsor
- Hao Li
Geriatric Patients, Postoperative Complications
PREDICTING MINS WITH FRAILTY AND BIOMARKERS IN GERIATRIC SURGERY
The primary objective of this study is to develop and validate a machine learning model that integrates preoperative clinical data, biomarkers, and modified frailty indices (mFI-5) to accurately predict myocardial injury after…
- Conditions
- Geriatric Patients, Postoperative Complications, Frailty, Myocardial Ischemia
- Trial name
- NCT07566013
- Testing
- Preoperative Risk Assessment and Machine Learning Modeling
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- DİLEK KALAYCI
Abdomen, Acute, Myocardial Injury
MINS, AKI and Pulmonary Pathology in Patients Undergoing Acute Abdominal Surgery
Explorative study to investigate potential predictors of myocardial injury, acute kidney injury and pulmonary disorder after acute high-risk abdominal surgery.
- Conditions
- Abdomen, Acute, Myocardial Injury, Acute Kidney Injury, Pulmonary Disease
- Trial name
- NCT04681508
- Testing
- Chest CT without contrast enhancement and chest X-ray
- Where
- Denmark
- Volunteers
- 600 people
- Sponsor
- Nordsjaellands Hospital
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery
The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury
In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery.
- Conditions
- Myocardial Injury After Non-cardiac Surgery, Hypotension During Surgery, Anesthesia, General, Anesthesia, Spinal
- Trial name
- NCT06343259
- Testing
- General Anesthesia, Spinal Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital