Clinical trials: Macrovascular Disease
Cardiac Allograft Vasculopathy
Early Post Transplant Cardiac Allograft Vasculopathy
Heart transplantation is an effective life-saving treatment for patients with end-stage heart disease. After a transplant, the new heart may develop narrowing in the arteries, causing heart failure, heart attacks and abnormal…
- Trial name
- ECAV (NCT03217786)
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Ottawa Heart Institute Research Corporation
PAOD (Peripheral Arterial Obstructive Disease)
Micro- and Macrovascular Adaptations in Patients With Peripheral Arterial Disease During Supervised Exercise Therapy
Given that previous studies demonstrated the feasibility of the required MRI techniques, we propose to study the macro- and microvascular adaptations in PAOD patients undergoing supervised exercise therapy.
- Trial name
- VAPAV (NCT00675402)
- Testing
- supervised treadmill exercise program
- Where
- Netherlands
- Volunteers
- 117 people
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Cancer
Diabetes Prevention Program Outcomes Study
The Diabetes Prevention Program (DPP) was a multi-center trial examining the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population due to the presence of impaired…
- Conditions
- Diabetes Mellitus, Cancer, CVD
- Trial name
- DPPOS (NCT00038727)
- Testing
- DPPOS Group Lifestyle, Metformin, DPPOS Boost Lifestyle
- Where
- United States
- Volunteers
- 2,779 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes Mellitus With Complication
Comparison of Micro- and Macrovascular Disease(s) in People With T2D, Who Have Moderate to Severe Acanthosis Nigricans vs. Those Who do Not Have Acanthosis Nigricans
Hypothesis: Moderate to severe acanthosis nigricans in people with T2D is associated with higher magnitude of complication than people who do not have acanthosis nigricans.
- Trial name
- NCT06386939
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Hepatocellular Carcinoma
Radioembolization for Hepatocellular Carcinoma With Portal Vein Tumoral Thrombosis
In patients with hgepatocellular carcinoma (HCC) and portal vein tumoral thrombosis (PVTT), Sorafenib represents the treatment of choice but more recently, trans-arterial radioembolization (TARE) with yttrium-90 has been also…
- Trial name
- NCT04771988
- Testing
- yttrium-90 radioembolization
- Volunteers
- 17 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hepatocellular Carcinoma
Sorafenib vs.TransArterial Chemoembolization Plus RadioTherapy in Hepatocellular Carcinoma With Macrovascular Invasion
To evaluate and compare the efficacy and safety of sorafenib versus trans-arterial chemoembolization plus external beam radiation therapy in patients with hepatocellular carcinoma invading major intrahepatic vessels
- Trial name
- START (NCT01901692)
- Testing
- TACE+External beam RT, Sorafenib
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Asan Medical Center
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Evolution of Effectiveness of Diabetes Medical Care in Russia
The main aim of the present study is to evaluate the prevalence of individual microvascular and macrovascular complications among diabetes mellitus patients and to determine the percentage of diabetes mellitus patients achieved…
- Trial name
- NCT02574195
- Where
- Russia
- Volunteers
- 599 people
- Sponsor
- Endocrinology Research Centre, Moscow
Type 2 Diabetes Mellitus
Effects of Food Advanced Glycation Endproducts on Vascular Function in Diabetes
Recent evidence supports detrimental effects of advanced glycation endproducts (AGE) on vascular function (VF). Though, the effect of AGE-modified proteins alone on vascular function remained unknown.
- Trial name
- NCT01456026
- Testing
- Glycated beta-lactoglobulins., Non-glycated beta-lactoglobulins
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Cardiovascular Diseases, Diabetes Mellitus
Markers and Mechanisms of Macrovascular Disease in IDDM
To elucidate the biochemical, metabolic, and genetic markers and mechanisms of macrovascular disease in insulin dependent diabetes mellitus (IDDM).
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Atherosclerosis, Heart Diseases
- Trial name
- NCT00005474
- Volunteers
- 1,063 people
- Sponsor
- Medical University of South Carolina
Diabetes Mellitus, Type 2, Peripheral Arterial Disease
REducing Diabetic MacrovascUlar Complications DuE to Peripheral Arterial Disease- REDUCE-PAD
This is a Phase IIa, multi-centre study conducted at 3 sites in Singapore (SGH and NUHS, KTPH). 70 patients with diabetes mellitus (DM) and peripheral arterial disease (PAD) will be randomised in a ratio 1:1 to receive normal…
- Trial name
- REDUCE-PAD (NCT05912218)
- Testing
- MEI6570
- Where
- Singapore
- Volunteers
- 70 people
- Sponsor
- National Heart Centre Singapore
Diabetes Mellitus
Nippon Ultra-Rapid Insulin and Diabetic Complication Evaluation-Study (NICE-Study)
For the purpose of comparing efficacy of intensive therapy between 1) ultrarapid-acting type insulin (insulin aspart) and 2) conventional rapid-acting type insulin (R), a Multicenter Open Label Randomized Controlled Trial was…
- Trial name
- NCT00575172
- Where
- Japan
- Volunteers
- 346 people
- Sponsor
- Osaka Saiseikai Nakatsu Hospital
Macular Degeneration
Noninvasive Imaging Biomarkers of Treatable Macrovascular Disease in Age-related Macular Degeneration.
The purpose of this prospective study is to investigate whether ophthalmic artery stenosis (narrowing of the ophthalmic artery) contributes to the development and progression of geographic atrophy (GA), an advanced form of dry…
- Trial name
- NCT07798323
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Scott Raymond
Hepatocellular Carcinoma, Hepatocellular Cancer
Atezolizumab Plus Bevacizumab Alone or Combined with External Beam Radiotherapy for HCC with Macrovascular Invasion
The recent global IMbrave150 study evaluated the combination of atezolizumab and bevacizumab versus sorafenib in 501 patients with advanced or metastatic Hepatocellular Carcinoma (HCC).
- Conditions
- Hepatocellular Carcinoma, Hepatocellular Cancer, Hepatocellular Carcinoma Non-resectable, Hepatocellular Carcinoma Stage IV
- Trial name
- ALERT-HCC (NCT05992220)
- Testing
- Atezolizumab plus bevacizumab, combined EBRT to vascular invasion, Atezolizumab plus bevacizumab
- Where
- South Korea
- Volunteers
- 138 people
- Sponsor
- Asan Medical Center
Hepatocellular Carcinoma (HCC), Macrovascular Invasion
Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant
The goal of this clinical trial is to learn if locoregional therapy and immunotherapy can be used together to help patients with hepatocellular carcinoma (HCC) and macrovascular invasion achieve liver transplantation.
- Conditions
- Hepatocellular Carcinoma (HCC), Macrovascular Invasion, Liver Transplant Surgery, Downstaging
- Trial name
- MacroTrans (NCT06725121)
- Testing
- Atezolizumab & Bevacizumab, Yttrium-90 (Y-90), Stereotactic body radiotherapy (SBRT)
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes
TODAY2 Phase 2 Follow-up
The primary objective of T2P2 is to track the progression of T2D and related comorbidities and complications in the TODAY cohort as they transition to young adulthood.
- Trial name
- T2P2 (NCT02310724)
- Testing
- TODAY cohort
- Where
- 15 sites in United States
- Volunteers
- 517 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Thyroid Associated Orbitopathy
Changes in Orbital Macrovascular and Intraocular Microvascular Blood Flow After Orbital Decompression Surgery in Patients With Thyroid Eye Disease
This study aims to evaluate the effects of balanced orbital decompression surgery in patients with inactive thyroid-associated orbitopathy.
- Trial name
- BOD-VASC (NCT07393230)
- Testing
- Balanced Orbital Decompression Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Coronary Artery Disease
Study of the Vascular Effects of Serelaxin
This was a mechanistic study in patients with coronary artery disease on the effects of Serelaxin on micro- and macrovascular function.
- Trial name
- NCT01979614
- Testing
- Serelaxin
- Where
- 3 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- Novartis Pharmaceuticals
Hepatocellular Carcinoma (HCC)
HAIC Plus Lenva and PD-1 for Advanced HCC With Macrovascular or Biliary Invasion
The combination of HAIC with systemic therapy can provide superior efficacy compared to systemic therapy alone or local therapy alone for patients with advanced HCC complicated by vascular invasion, regardless of whether they…
- Trial name
- NCT07466225
- Testing
- HAIC, Lenvatinib, PD-1 Inhibitors
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University
Diabetes Mellitus Type 2
Effect of Dapagliflozin on Microvascular and Macrovascular Circulation and Total Body Sodium Content
Dapagliflozin leads to improved vascular function in the micro- and macrocirculation by action on various cardiovascular risk factors, in particular by effectively controlling hyperglycemia, arterial hypertension and reducing…
- Trial name
- Dapa (NCT02383238)
- Testing
- Dapagliflozin
- Where
- Germany
- Volunteers
- 59 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Type 2 Diabetes
A Cohort Study of Morning Home Blood Pressure Measurement in Type 2 Diabetic Patients
Previous cross-sectional studies have demonstrated that blood pressure (BP) measurements at home (HBP) in the morning offer stronger predictive power for micro- and macrovascular complications in patients with type 1 and 2…
- Trial name
- NCT00760110
- Testing
- blood pressure measurements based on HBP or CBP
- Volunteers
- 400 people
- Sponsor
- Nagaoka Red Cross Hospital