Clinical trials: Macular Edema
Diabetic Macular Edema
Microperimetry and Optical Coherence Tomography (OCT) With Lucentis for Diabetic Macular Edema (DME)
Diabetic maculopathy is the leading cause of visual impairment in the working-age population in developed countries. Diabetic macular edema can cause impaired visual acuity and so far is treated by laser, vitreous surgery, and…
- Trial name
- MORE (NCT00885794)
- Testing
- Ranibizumab
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
VEGFA-targeting Gene Therapy to Treat Retinal and Choroidal Neovascularization Diseases
Patients who respond to anti-VEGF therapy but with refractory retinal and choroidal neovascularization diseases including neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein…
- Conditions
- Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT05099094
- Testing
- BD311
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Shanghai BDgene Co., Ltd.
Diabetic Retinopathy
PST/Laser v. Laser Alone for CSME
Prospective randomized clinical trial comparing Laser Alone v. Laser and posterior sub-tenon injection of triamcinolone acetonide for primary and refractory clinically significant macular edema.
- Trial name
- NCT00229918
- Testing
- triamcinolone acetonide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Edward Hines Jr. VA Hospital
Diabetic Macular Edema
Safety and Effect of Intravitreal Injection of a Derivative of Nucleoside Reverse Transcriptase Inhibitor in Subjects with Diabetic Macular Edema
This study is designed to assess the safety and initial evidence of efficacy of the novel compound SOM-401 (K8), a derivative of a nucleoside reverse transcriptase inhibitor, in subjects with untreated, clinically significant…
- Trial name
- NCT05699759
- Testing
- K8
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Michelle Abou-Jaoude
Diabetic Macular Edema
Efficacy of Fluocinolone Acetonide Intravitreal Implant in Diabetic Macular Edema
This was a multi-center, randomized, masked, parallel-group, controlled study in patients with diabetic macular edema, comparing RetisertTM (0.59 mg) with control therapy (standard of care (SOC) - repeat macular grid laser or…
- Trial name
- NCT00502541
- Testing
- fluocinolone acetonide, Standard of Care
- Volunteers
- 196 people
- Sponsor
- Bausch & Lomb Incorporated
Cystoid Macular Edema, Cataract
PRevention of Macular EDema After Cataract Surgery
Cystoid macular edema (CME) is a common cause of vision loss after cataract surgery. In the last few years, several new treatments have been tried to address the problem of CME after cataract surgery in diabetic and non-diabetic…
- Conditions
- Cystoid Macular Edema, Cataract, Diabetes Mellitus
- Trial name
- PREMED (NCT01774474)
- Testing
- Bromfenac, Dexamethasone, Bevacizumab
- Where
- 16 sites in Austria, Belgium and 5 more
- Volunteers
- 1,127 people
- Sponsor
- Maastricht University Medical Center
Diabetic Macular Edema
Intravitreal Aflibercept InjectiOn in Vitrectomized Eyes for Treatment of Diabetic Macular Edema
This a non-interventional retrospective study on the efficiency and the tolerance of intravitreal injections of Aflibercept on vitrectomized eyes in the diabetic macular oedema
- Trial name
- MODEVA (NCT02874859)
- Where
- 8 sites in France
- Volunteers
- 49 people
- Sponsor
- Lille Catholic University
Diabetic Macular Edema
Pilot and Phase 2 Study of the Efficacy of a Treatment Protocol With Dexamethasone Implant Loading Dose in Patients With Diabetic Macular Edema (LOADEX)
Nowadays, steroids and anti-VEGF are the first line treatment for diabetic macular edema. Ozurdex is the most frequently used steroid and has label for both first and second line treatment.
- Trial name
- LOADEX (NCT04116398)
- Testing
- Dexamethasone with 2 loading doses followed by PRN regimen.
- Where
- 16 sites in France
- Volunteers
- 53 people
- Sponsor
- Hospices Civils de Lyon
Neovascular Age-related Macular Degeneration, Age-related Macular Degeneration
SD-OCT Angiography
The objective of this study is to image retinal vascular alterations in patients with retinal disease using the AngioVue OCT-A system and understand the information these images provide.
- Conditions
- Neovascular Age-related Macular Degeneration, Age-related Macular Degeneration, Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- NCT02510885
- Testing
- AngioVue SD-OCT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Duke University
Diabetic Macular Edema
Evaluation of RC28-E Injection in Diabetic Macular Edema
This is a non-randomized, open-label, multicenter, 48-week study to investigate the efficacy, safety and pharmacokinetics of RC28-E injection in the treatment of patients with diabetic macular edema.
- Trial name
- NCT04782115
- Testing
- intravitreal injection of RC28-E, Conbercept
- Where
- 37 sites in China
- Volunteers
- 156 people
- Sponsor
- RemeGen Co., Ltd.
Diabetic Macular Oedema
A Study to Evaluate the Efficacy and Safety of IBI302 inSubjects With Diabetic Macular Edema（DME）
The study is designed for multi-center,randomized,double-masked,active-contralledstudy to evaluate effective and security of intravitrealinjection of IBI302 in subjects with Diabetic Macular Oedema.
- Trial name
- NCT06908876
- Testing
- IBI302, Faricimab
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Innovent Biologics Technology Limited (Shanghai R&D Center)
Diabetic Macular Edema
Aflibercept Plus Micropulse Laser Versus Aflibercept Monotherapy for Diabetic Macular Edema
Purpose: To evaluate the role of adjuvent micropulse laser with Aflibercept injections in the management of treatment naïve centre involving DME, looking at decreased treatment burden and increased efficacy as outcomes.
- Trial name
- NCT04014556
- Testing
- micropulse laser, Aflibercept
- Volunteers
- 40 people
- Sponsor
- University of Alexandria
Diabetic Macular Edema
Safety Study of Bromfenac Ophthalmic Solution in Subjects With Diffuse Diabetic Macular Edema (DME) Refractory to Laser
This is an investigator-sponsored trial (IST), an open-label pilot study, assessing the safety and biologic activity of bromfenac in subjects with diffuse DME refractory to laser.
- Trial name
- NCT00491166
- Testing
- Bromfenac ophthalmic solution
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Boston
Diabetic Retinopathy, Macular Edema
20- Versus 23- Gauge System for Pars Plana Vitrectomy
The aim of the present study is to compare the functional and clinical differences and advantages between a standard operating system and a newly developed even smaller system for pars plana vitrectomy.
- Conditions
- Diabetic Retinopathy, Macular Edema, Postoperative Complications, Vitreous Hemorrhage
- Trial name
- NCT00411970
- Testing
- 20- and 23 gauge vitreoretinal surgery systems
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Diabetic Retinopathy
Photobiomodulation for the Treatment of Diabetic Macular Edema
The current application proposes to conduct a prospective, clinical trial in diabetic subjects with diabetic macular edema (DME) to evaluate the therapeutic efficacy of 670 nm photobiomodulation on validated clinical outcome…
- Trial name
- PTDME (NCT02457975)
- Testing
- 670nm PBM, intravitreous VEGF-inhibitors
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical College of Wisconsin
Macular Edema, Retinal Vein Occlusion
Safety and Effectiveness of Bevacizumab Intravitreal Injections in the Treatment of Macular Edema Secondary to Retinal Vein Occlusion
Lack of an effective treatment for macular edema secondary to central retinal vein occlusion and the bad response to grid laser treatment in patients with macular edema secondary to branch retinal vein occlusion, together with…
- Trial name
- EBOVER (NCT00970957)
- Testing
- Avastin Intravitreal Injection
- Where
- 13 sites in Spain
- Volunteers
- 107 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Diffuse Diabetic Macular Edema
POSTERIOR SUB-TENON'S Avastin
Posterior sub-tenon's injection of bevacizumab decreased diffuse diabetic macular edema
- Trial name
- NCT00567372
- Testing
- bevacizumab (Sub-tenon´s injection)
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Diabetic Macular Edema
Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular Edema
This pilot prospective, interventional, longitudinal study, aims to evaluate the potential benefits of the probiotic supplement Lactobacillus plantarum 299v in patients with diabetic macular edema (DME).
- Trial name
- NCT07383701
- Testing
- Lactobacillus plantarum 299v
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Visual Impairment Due to Diabetic Macular Edema
24 Week Study to Compare Systemic VEGF-levels of Ranibizumab and Aflibercept in DME.
The purpose of the study is to compare the effect of intravitreal injections of ranibizumab and aflibercept on systemic VEGF levels in DME patients in a detailed time course.
- Trial name
- TIDE DME (NCT02878681)
- Testing
- Ranibizumab, Aflibercept
- Sponsor
- Novartis Pharmaceuticals
Diabetic Macular Edema, Diabetic Retinopathy
ADVM-022 Intravitreal Gene Therapy for DME
A Phase 2, Multi-Center, Randomized, Double-Masked*, Active Controlled Study of ADVM-022 (AAV.7m8-aflibercept) in Subjects with Diabetic Macular Edema [INFINITY]
- Trial name
- INFINITY (NCT04418427)
- Testing
- 6E11 vg/eye of ADVM-022, 2E11 vg/eye of ADVM-022, Aflibercept
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 36 people
- Sponsor
- Adverum Biotechnologies, Inc.