Clinical trials: Magnetic Resonance Imaging (MRI)
Arthritis, Arthritis, Rheumatoid
An MRI-guided Treatment Strategy to Prevent Disease Progression in Patients With Rheumatoid Arthritis
The purpose of this study is to examine whether an magnetic resonance imaging (MRI) -guided treatment strategy based on a predefined treatment algorithm can prevent progression of erosive joint damage, increase remission rate and…
- Conditions
- Arthritis, Arthritis, Rheumatoid, Joint Diseases, Musculoskeletal Diseases
- Trial name
- IMAGINE-RA (NCT01656278)
- Testing
- Magnetic resonance imaging (MRI), Conventional biochemical and clinical examinations
- Where
- 9 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Professor of Rheumatology, MD, DMSci, Kim Horslev-Petersen
Major Depressive Disorder
Imaging Neural Correlates of Ketamine Using PET/MR
The purpose of this randomized, placebo-controlled study is to investigate pharmacodynamic differences between racemic ketamine and esketamine using functional fluorodeoxyglucose ([18F]FDG) positron emission tomography/magnetic…
- Trial name
- RSKet (NCT04587778)
- Testing
- Ketamine Hydrochloride, Esketamine, Pilot study II: Esketamine
- Where
- Austria
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Myopathy, HMG COA Reductase Inhibitor Adverse Reaction
Evaluation of Ubiquinol on Mitochondrial Oxidative Capacity in Statin Patients Using 31PMRS
It is our primary hypothesis that statin drugs impair skeletal muscle mitochondrial function and that ubiquinol (the reduced active form of CoQ10) supplementation will block impairment of PCr recovery kinetics in patients using…
- Conditions
- Myopathy, HMG COA Reductase Inhibitor Adverse Reaction, Hypercholesterolemia
- Trial name
- NCT01702987
- Testing
- ubiquinol, statin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hemodialysis Access Failure
Three-dimensional (3D) Printed Hemodialysis Vascular Model
Infiltration of a surgically-placed hemodialysis vascular access (HVA) is recognized as a major contributor to the high hospital re-admission rate in dialysis-dependent patients.
- Trial name
- NCT05096416
- Testing
- The three-dimensional (3D) printed hemodialysis vascular model
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Alzheimer's Disease
Biomarkers and Early Alzheimer's Disease
The main goal of this project is to use imaging and biomarkers to identify cognitively normal elderly people who are at increased risk for developing mild cognitive impairment (MCI).
- Trial name
- NCT00094952
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Cardiac Surgery, Cardiopulmonary Bypass
Mri characterIzation of Troponin Elevation After Cardiac Surgery
Cardiac surgery under cardiopulmonary bypass (CPB) induces myocardial ischemia-reperfusion injury. This myocardial attack is a well-identified independent prognostic factor of postoperative morbidity and mortality.
- Trial name
- MITEC (NCT04490785)
- Testing
- MRI, Postoperative dosage of released troponin
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Advanced Cancer, Bone Metastases
Correlation of MR Thermal Imaging to Actual Size of Ablation During Laser Ablation Therapy
The goal of this clinical research study is to learn how well magnetic resonance thermal imaging (MRTI) can check the amount of tumor being destroyed using a therapy called laser ablation (a procedure that uses lasers to create…
- Trial name
- NCT00688038
- Testing
- Laser Ablation, Magnetic Resonance Thermal Imaging
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- M.D. Anderson Cancer Center
Major Depressive Disorder, Anxiety
The Effects of Vilazodone on Glutamate in the Anterior Cingulate Cortex in Anxious Unipolar Depressives
The purpose of this study is to determine whether vilazodone is more effective than citalopram for the treatment of anxious depression.
- Conditions
- Major Depressive Disorder, Anxiety, Comorbidity
- Trial name
- NCT02028026
- Testing
- Vilazodone, Citalopram
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Eye Cancer
MRI in Diagnosing Solid Tumors of the Eye and Orbit
This study is being done due to a new imaging method that may help others in the future to improve evaluation of diseases in the eye and eye socket and to help make a decision concerning best treatment of the disease.
- Trial name
- NCT01653080
- Testing
- dynamic contrast-enhanced MRI
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Developmental Dysplasia of the Hip (DDH), Developmental Dysplasia of the Hip
Computer-Assisted Comparison of Hip Socket Volume and Surface Shape After Pediatric Acetabular Osteotomies
The goal of this observational study is to learn how four acetabular osteotomy techniques change the shape of the hip socket in children and adolescents with developmental dysplasia of the hip or residual acetabular dysplasia.
- Conditions
- Developmental Dysplasia of the Hip (DDH), Developmental Dysplasia of the Hip, Acetabular Dysplasia
- Trial name
- PAVMS (NCT07581717)
- Testing
- Salter osteotomy, Dega osteotomy, San Diego osteotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Istanbul University
Parkinson Disease
The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity.
- Trial name
- NCT04472325
- Where
- Taiwan
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Major Depressive Disorder
Creatine Augmentation for Adolescent Females With Treatment-Resistant Major Depressive Disorder
The primary hypothesis is that compared to placebo, 10g of daily creatine monohydrate for eight weeks will be associated with significant increases in frontal lobe phosphocreatine and beta-nucleoside triphosphate (β-NTP)…
- Trial name
- NCT02134808
- Testing
- Creatine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Perry Renshaw
Alzheimer's Disease
Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease
Recent data show that marked cell damage precedes the clinical manifestation of Alzheimer's disease (AD). Hence, targeting populations at risk with pharmacological interventions is a possible strategy to lessen the burden of the…
- Trial name
- NCT00933608
- Testing
- memantine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Pain
Applications of Realtime Functional Magnetic Resonance Imaging (fMRI )
The goal of this research program is to determine the potential effectiveness of real-time fMRI training in improving mental control over pain.
- Trial name
- NCT01111617
- Testing
- Real-time fMRI feedback
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Stanford University
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
Magnetic Resonance Guided Focal Stereotactic Body Radiation Therapy for Localized Prostate Cancer
This pilot clinical trial studies magnetic resonance (MRI)-guided focal stereotactic radiosurgery (SRS) in treating patients with low- or intermediate-risk localized prostate cancer.
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage I Prostate Cancer, Stage IIA Prostate Cancer
- Trial name
- NCT02163317
- Testing
- stereotactic radiosurgery, magnetic resonance imaging, quality-of-life assessment
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Case Comprehensive Cancer Center
Retinal Artery Occlusion, Magnetic Resonance Imaging
Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO)
Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke at the retinal level. They share the same risk factors and common pathology.
- Conditions
- Retinal Artery Occlusion, Magnetic Resonance Imaging, Diagnosis, Etiology
- Trial name
- I-RECANAL (NCT03313817)
- Testing
- Additional MRI sequences
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Healthy Volunteer, Major Depressive Disorder
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Background: Most medications that treat depression take weeks or months to work. Researchers want to develop fast-acting treatments. One dose of ketamine has a rapid antidepressant effect.
- Conditions
- Healthy Volunteer, Major Depressive Disorder, Depression
- Trial name
- NCT03065335
- Testing
- Ketamine, Cobot TS MV robotic arm for TMS, NeurOptics PLRTM-30000 Pupillometer
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Ventricular Tachycardia, Cardiac Arrhythmia
MRI Assessment of Arrythmia Ablation Lesions
This study will evaluate the feasibility of visualization and characterization of arrhythmia ablation lesions by MRI immediately following standard ablation techniques.
- Trial name
- NCT02761343
- Testing
- MRI scan
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's National Research Institute
Depressive Disorder, Major, Post Traumatic Stress Disorder
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
The proposed study will assess the combined effect of perampanel and ketamine on the anti-depressant response in individuals with treatment resistant depression.
- Conditions
- Depressive Disorder, Major, Post Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT03367533
- Testing
- Ketamine, Perampanel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Healthy
Magnetic Resonance Imaging of Human Supraclavicular Brown Adipose Tissue - MIBAT Study
Brown adipose tissue (BAT) is unique in its capability to convert chemical energy directly into heat. Active BAT increases energy expenditure and can thereby counteract obesity and insulin resistance.
- Trial name
- MIBAT (NCT02682706)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
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