Clinical trials: Magnetic Resonance Imaging (MRI)
Healthy, Major Depressive Disorder (MDD)
Neurobiological and Genomic Predictors of Relapse in Depression
The goal of this observational study is to test whether the discontinuation of antidepressant medications for patients with depression can be decided after the normalization of biological parameters.
- Trial name
- MDD (NCT07328373)
- Testing
- Antidepressant Medications
- Where
- Turkey (Türkiye)
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Mehmet Kemal Arikan
Hypertrophic Cardiomyopathy
Comparison of Data Obtained by Echocardiography and Magnetic Resonance Imaging in Hypertrophic Cardiomyopathy
Compare data (structural and functional) obtained by transthoracic rest echocardiography and magnetic resonance imaging (with gadolinium) in 30 patients with hypertrophic cardiomyopathy
- Trial name
- NCT00315783
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Alzheimer Disease, Magnetic Resonance Spectroscopy
New Imaging Biomarkers Predictive of MA Progression
The pathophysiology of AD is complex. In addition to amyloid plaques and neurofibrillary degeneration, there is a metabolic alteration of the energy pathways, oxidative phosphorylation and glycolysis, which are involved in brain…
- Conditions
- Alzheimer Disease, Magnetic Resonance Spectroscopy, Ultra High Field 7T, Progression of Disease
- Trial name
- MR7T-PRADA (NCT05939362)
- Testing
- MRI follow-up
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Poitiers University Hospital
Low Grade Glioma of Brain
Repeatability of Magnetic Resonance Imaging in Patients With IDH1 Mutant Glioma on Ivosidenib
The purpose of this study is to evaluate the repeatability of magnetic resonance imaging (MRI) in patients with isocitrate dehydrogenase 1 (IDH1) mutant (mIDH1) low-grade diffuse glioma [World Health Organization (WHO) grade 2]…
- Trial name
- NCT06648473
- Testing
- MRI Scan
- Where
- United States
- Sponsor
- Duke University
Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
Analysis of Whole Body Magnetic Resonance Imaging and Liquid Biopsy for Early Detection of Cancer in Patients With a Strong Family History of Cancer
This study evaluates patient acceptability of whole body magnetic resonance imaging (WBM) and liquid biopsies (LB) in detecting early stage cancer in patients with a strong family history of cancer.
- Trial name
- NCT05868486
- Testing
- Biospecimen Collection, Genetic Testing for Cancer Risk, Liquid Biopsy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Cognitive Dysfunction, Alzheimer Disease
ALA-enriched Nutrition for Prevention of Cognitive Decline in APOE4 Older Adults
This randomized, double-blind, placebo-controlled pilot trial will evaluate the effects of alpha-linolenic acid (ALA) supplementation on cognitive function, blood-brain barrier integrity, and brain vascular health in older adults…
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Blood-Brain Barrier, Apolipoprotein E, Deficiency or Defect of
- Trial name
- NCT07392723
- Testing
- Alpha-Linolenic Acid (2.6 g/day)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Michal Schnaider Beeri, Ph.D.
Osteoarthritis
Study of Cartilage Relaxometry and Physical Activity in Osteoarthritis
This study is the radiological component of an earlier registered trial under the title: Efficacy of Exercise on Physical Function and Cartilage Health in Patients With Knee Osteoarthritis.
- Trial name
- NCT01797679
- Testing
- Strength Training, Aerobic Exercise
- Where
- Norway
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Advanced Prostate Cancer
Whole Body Magnetic Resonance Imaging Study
In prostate cancer bone is the most common site for cancer spread, causing pain, fractures, nerve compression and death. New therapies are available for treating bone disease from cancer and this means that by maintaining…
- Trial name
- WISE (NCT04117594)
- Testing
- WB-MRI
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Major Depressive Disorder
A Neuroimaging Investigation of Brain Activity in Major Depressive Disorder and Bipolar Disorder
This study employs functional magnetic resonance imaging to compare brain activation patterns during a depressive episode in patients diagnosed with bipolar disorder, major depressive disorder, and a group of healthy control…
- Trial name
- NCT00188942
- Testing
- Fluoxetine+Olanzapine, Olanzapine, Functional Magnetic Resonance Imaging
- Where
- 2 sites in Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Transposition of Great Arteries
Cardiovascular Magnetic Resonance in Adults With SysTemic Right Ventricle (STAR)
The main aim of the study is to explore HFs in SRV, comparing their magnitude and direction with that of subpulmonary RV and systemic LV.
- Trial name
- STAR (NCT05690854)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Cardiovascular Diseases, Hypercholesterolemia
The Combined Portfolio Diet and Exercise Study
The purpose of this study is to determine whether a dietary portfolio of cholesterol-lowering foods (viscous fibres, soy protein, plant sterols and nuts) further enhanced by increased levels of monounsaturated fatty acids (MUFA)…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- PortfolioEx (NCT02481466)
- Testing
- Portfolio diet and structured exercise, DASH-like diet and structured exercise, Portfolio diet and routine exercise
- Where
- 4 sites in Canada
- Volunteers
- 232 people
- Sponsor
- Unity Health Toronto
Glycogen Storage Disease IIIA
Acute Nutritional Ketosis in GSD IIIa
The investigators will study if acute nutritional ketosis in adult GSD IIIa patients can boost muscle mitochondrial function in vivo.
- Trial name
- NCT03011203
- Testing
- physical exercise
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- University Medical Center Groningen
Breast Reconstruction, Contour Irregularities
Immunophenotyping of Fresh Stromal Vascular Fraction From Adipose Derived Stem Cells (ADSC) Enriched Fat Grafts
The purpose of this study is to investigate if there is a relationship between the take of fat grafts with and without ADSCs and the presence of specific surface markers on the cells of the stromal vascular fraction.
- Conditions
- Breast Reconstruction, Contour Irregularities, Volume Insufficiency
- Trial name
- NCT01771913
- Testing
- centrifuged fat graft, ADSCs enriched fat graft
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Heart Failure, Coronary Artery Disease
Dobutamine vs Adenosine CMR Study
This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial coronary artery stenosis in subjects with reduced…
- Conditions
- Heart Failure, Coronary Artery Disease, Cardiac MRI
- Trial name
- DISCORDANCE (NCT03661827)
- Testing
- Stress Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University of Leicester
Atrial Fibrillation
Does the Merged 3D Imaging Improve Contact Force and Long Term Procedure Outcome in Atrial Fibrillation?
The purpose of the study is to investigate whether or not there are the differences in acute procedure and long-term clinical outcome of radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) using the 3D map…
- Trial name
- MICRO-AF (NCT03350581)
- Testing
- FAM 3D map group, FAM-CT 3D map group
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Korea University Guro Hospital
Aortic Stenosis
Cardiac Magnetic Resonance Imaging Versus Computed Tomography to Guide Transcatheter Aortic Valve Replacement
To prove the non-inferiority of TAVR-CMR compared to TAVR-CT to guide TAVR according to clinical efficacy, defined as implantation success based on the VARC-2 criteria.
- Trial name
- TAVR-CMR (NCT03831087)
- Testing
- TAVR-CMR, TAVR-CT
- Where
- Austria
- Volunteers
- 267 people
- Sponsor
- Medical University Innsbruck
Attention-deficit/Hyperactivity Disorder, Autonomic Nervous System Imbalance
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.
Obstructive sleep apnea (OSA) and attention-deficit/hyperactivity disorder (ADHD) are two common, severe disorders in children. Unfortunately, pediatric OSA is closely associated with ADHD, and both diseases can cause cognitive…
- Conditions
- Attention-deficit/Hyperactivity Disorder, Autonomic Nervous System Imbalance, Obstructive Sleep Apnea of Child
- Trial name
- NCT04732572
- Testing
- Sleep and healthy lifestyle education, Other supportive care, Adenotonsillectomy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
MRI
MRI Assessing Clinical Usability of STrategically Acquired Gradient Echo on Human Participants
The study's purpose is to validate STAGE images and, when applicable, their equivalence to conventional MRI through an assessment by a trained certified neuroradiologist in a clinical setting.
- Trial name
- STAGE (NCT04292301)
- Testing
- STrategically Acquired Gradient Echo (STAGE)
- Where
- 5 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- SpinTech, Inc.
Gynecologic Cancer
Brachytherapy Innovations in Gynecologic Cancer
In this pilot study, the investigators will test tools designed to more precisely identify, define and create a radiation treatment plan to tumor remnants as separate from fibrotic or normal tissue in a Magnetic Resonance (MR)…
- Trial name
- NCT04530019
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Myocardial Infarction
Optical Coherence Tomography in Patients With Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease
The purpose of this study is to evaluate the prevalence and morphological features of coronary plaques by means of OCT in patients with acute myocardial infarction but without any significant coronary stenosis at coronary…
- Trial name
- SOFT-MI (NCT02783963)
- Testing
- OCT and CMR imaging
- Where
- Poland
- Volunteers
- 38 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
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