Clinical trials: Major Abdominal Surgeries
Acute Kidney Injury
Effects of BRS and LRS on Postoperative Acute Kidney Injury
1. Title: Effects of Sodium Bicarbonate Ringer's Injection and Sodium Lactated Ringer's Injection on postoperative acute kidney injury in patients undergoing major abdominal surgery: a randomized, controlled, open-label clinical…
- Trial name
- BRS/LRS (NCT04835038)
- Testing
- Sodium Bicarbonate Ringer's Injection, Sodium Lactated Ringer's Injection
- Where
- China
- Volunteers
- 3,400 people
- Sponsor
- Tongji Hospital
Postoperative Pain
A Pharmacokinetic (PK) Study of Extended-Release Epidural Morphine in Upper Abdominal Surgery
The primary purpose of this study is to evaluate the effects of lidocaine/epinephrine test dose administration on the PK profile of a single epidural dose of DepoDur (extended-release epidural morphine) in patients undergoing…
- Trial name
- NCT00728832
- Testing
- DepoDur (extended-release epidural morphine)
- Volunteers
- 39 people
- Sponsor
- EKR Therapeutics, Inc
Postoperative Acute Kidney Injury
Processed Electroencephalography-guided General Anesthesia and Outcomes in Major Abdominal Surgery
This study aims to evaluate whether the reduction in the amount of intraoperative norepinephrine required to prevent hypotension, facilitated by processed electroencephalography (pEEG) -guided general anesthesia, will lead to a…
- Trial name
- NCT06753409
- Testing
- Processed electroencephalography (pEEG) Guided General Anesthesia, Non-pEEG-Guided General Anesthesia (with blinded pEEG monitoring)
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Assiut University
Surgery, Temperature Change, Body
Intraoperative Body Core Temperature Monitoring: Oesophageal Probe vs Heated Controlled Servo Sensor
Monitoring of intraoperative core temperature is essential for patient safety, reducing the risk of perioperative hypothermia. A recently developed measuring system, SpotOn® (3M, St.
- Trial name
- ESOSPOT (NCT03820232)
- Testing
- temperature monitoring
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Careggi Hospital
Major Abdominal Surgery
Individualized Goal-directed Sufentanil Administration Versus Standard Therapy in Patients Undergoing Major Abdominal Surgery
To determine whether a treatment strategy targeting an individualized sufentanil administration based on the Analgesia Nociception Index (ANI) could reduce the total dose of sufentanil during major abdominal surgery, as compared…
- Trial name
- PHOENIX (NCT03166644)
- Testing
- Analgesia Nociception Index (ANI)-guided sufentanil administration
- Where
- France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Clermont-Ferrand
Abdominal Surgery
Pre-operative Physiotherapy to Prevent Post-operative Complications
The purpose of this study is to assess the roll of pre-operative chest physiotherapy, in addition to the usual care given after major abdominal surgery, in the prevention of post-operative respiratory complications.
- Trial name
- NCT01389648
- Testing
- Pre Operative
- Where
- Israel
- Volunteers
- 157 people
- Sponsor
- Rambam Health Care Campus
Intra-abdominal and Intrapelvic Surgery
Comparison of Intravenous Anesthetics to Volatile Anesthetics on Postoperative Cognitive Dysfunction
Post-operative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon. Most patients will receive general anesthesia during surgery. Two groups of general anesthetics are used for this purpose.
- Trial name
- NCT01809041
- Testing
- Sevoflurane, propofol, remifentanil
- Where
- China
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Hypovolemia, Surgery
Focused Assessed Echocardiography to Predict Fluid Responsiveness
The aims of the study are: 1. To evaluate the feasibility of echocardiography monitoring in postoperative unit; 2. To assess diagnostic value of different focussed echocardiography parameters to define fluid responsiveness for…
- Conditions
- Hypovolemia, Surgery, Hypotension
- Trial name
- fluidres (NCT03044405)
- Testing
- Fluid challenge, Focused transthoracic echocardiography
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Postoperative Pain
Combined Intrathecal Morphine and Dexmedetomidine Analgesia
The current study investigated the effect of adding dexmedetomidine to intrathecal morphine for postoperative analgesia in cancer patients undergoing major abdominal surgery.
- Trial name
- ITMandDEX (NCT02435537)
- Testing
- Dexmedetomidine (Precedex), Bupivacaine, Morphine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Surgical Complications From General Anesthesia, Hypertension
Monitoring Hypertensive Patients's Cerebral Oxygen Saturation
The purpose of this study is to determine whether there is a significant decrease in cerebral oxygen saturation in hypertensive patients undergoing major abdominal surgery and their correlation with standard monitoring parameters.
- Conditions
- Surgical Complications From General Anesthesia, Hypertension, Cerebral Ischemia, Cerebral Anoxia
- Trial name
- MHPCOS (NCT02147275)
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Huazhong University of Science and Technology
Major Upper or Lower Abdominal Surgery
A Multicenter, Randomized, Placebo-Controlled Phase 2 Study to Evaluate the Clinical Efficacy, Safety, and Tolerability of ARX-F01 Sublingual Sufentanil in Patients Undergoing Major Abdominal Surgery
The purpose of this study is to evaluate dosages of ARX-F01 (opioid pain medication) versus a placebo (or sugar pill) for the treatment of post-operative pain in subjects following abdominal surgery.
- Trial name
- NCT00718081
- Testing
- Oral sufentanil
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Talphera, Inc
Opioid Use
Efficacy of Erector Spinae Plane (ESP) Block in Patients With Inflammatory Bowel Disease (IBD)
This will be a prospective, double-blind randomized controlled clinical trial. There will be two arms of treatment: intervention and control group.
- Trial name
- NCT06230003
- Testing
- Ropivacaine, normal saline
- Where
- Canada
- Volunteers
- 67 people
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Abdominal Sepsis, Abdominal Infection
Closed or Open Abdomen for the Management of Abdominal Sepsis
This is a prospective randomized clinical study. The study will comprise the randomized decision to either A) primarily close the fascia after laparotomy for intra-abdominal infection (CLOSED); or B) leave the fascia open after…
- Trial name
- NCT03163095
- Testing
- Open Abdomen Management with ANPPT dressing, Closed Abdomen Management
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- University of Calgary
Postoperative Acute Kidney Injury, Postoperative Complications
Hypotension Prediction Index-guided Hemodynamic Optimization Trial to Reduce Postoperative Acute Kidney Injury (HYT).
MAIN AIM OF THE STUDY To establish whether hemodynamic management guided by the hypotension prediction index (HPI) guided by the administration of intravenous fluids and vasoactive drugs in patients undergoing elective major…
- Trial name
- HYT (NCT05569265)
- Testing
- Intraoperative hemodynamic management
- Where
- 26 sites in Spain
- Volunteers
- 958 people
- Sponsor
- Maria José Clara Colomina Soler
Abdominal Surgery
Impact of NOL Index Intraoperative Guided Remifentanil Analgesia
The Physiological Monitoring Device (PMD-200™) system is comprised of a monitor and a designated finger probe containing 4 sensors.
- Trial name
- Eu-MultiNOL (NCT04402242)
- Testing
- Bispectral index, Bispectral index + NOL index
- Where
- 3 sites in France
- Volunteers
- 90 people
- Sponsor
- Hopital Foch
Protein Malnutrition
Comparison of Clinical Outcomes According to High-protein Provision in Critically Ill Patients After Abdominal Surgery
Protein malnutrition in critically ill patients is a global concern due to its association with prolonged hospital stays, and higher morbidity rates.
- Trial name
- NCT06458387
- Testing
- Active protein supplementation, Conventional protein supplementation
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Seoul St. Mary's Hospital
Parenteral Nutrition, Nutritional Status
Effects of Preoperative Parenteral Nutrition With Omega-3 Fish Oil Lipid Emulsion on Postoperative Outcomes in Patients Undergoing Major Abdominal Surgery
The goal of this study is to explore if preoperative ω-3 fish oil lipid emulsion parenteral nutrition (PN) can improve postoperative outcomes in patients undergoing major abdominal surgery.
- Conditions
- Parenteral Nutrition, Nutritional Status, Major Abdominal Surgery
- Trial name
- NCT07878468
- Testing
- ω-3 fish oil lipid emulsion, Conventional lipid without ω-3 fish oil
- Where
- 7 sites in China
- Volunteers
- 158 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Lung Injury, Pulmonary Complication
Intraoperative Mechanical Power and Ventilation-Associated Lung Injury: Assessing Complications
This study investigates the relationship between intraoperative mechanical power and postoperative pulmonary complications in patients undergoing major abdominal surgery.
- Trial name
- NCT06375980
- Testing
- Intraoperative Mechanical Ventilation Strategies
- Where
- Turkey (Türkiye)
- Volunteers
- 207 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Pain, Postoperative
Comparison Between Two Different Doses of Nulbuphine _bupivacaine in TAP Block in Cancer Abdominal Surgeries
To compare the analgesic effect of two different doses of nulbuphine (10 mg and 20 mg) added to bupivacaine in bilateral subcostal single injection in ultrasound-guided TAP block for abdominal surgeries.
- Trial name
- NCT05090579
- Testing
- Group I (BN10), Active Comparator:Group ll (BN20), Active Comparator:Group lll (B)
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pulmonary Complications
Postoperative Pulmonary Complications in Major Abdominal Surgery
Incidence of Postoperative Pulmonary Complications (PPCs) varies from 2% to 19%, according to the population under examination and the criteria used to define pulmonary complications. There is no univocal definition of PPCs.
- Trial name
- NCT01701908
- Where
- 40 sites in Italy
- Volunteers
- 1,542 people
- Sponsor
- University of Udine