Clinical trials: Major Depressive Disorder \(MDD
Depression
Pulsed Electro Magnetic Fields (PEMF) Treatment in Patients With Treatment-Resistant Major Depression in Ongoing Pharmacological Treatment of Depression
About 30% of patients with major depression are treatment resistant to pharmacological treatment. In the search for new methods to treat depression a great interest has been put into the use of electromagnetic fields.
- Trial name
- NCT00287703
- Testing
- Pulsating Electro-Magnetic Fields
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Hillerod Hospital, Denmark
Major Depressive Disorder
Efficacy of Vortioxetine on Cognitive Dysfunction in Working Patients With Major Depressive Disorder
To assess the efficacy of acute treatment with 10 mg/day vortioxetine versus placebo on cognitive performance (focusing on the aspect concerning speed of processing, executive functioning, attention) in working patients with…
- Trial name
- NCT02279966
- Testing
- Vortioxetine 10 mg, Paroxetine 20 mg
- Where
- 18 sites in Estonia, Finland and 2 more
- Volunteers
- 152 people
- Sponsor
- H. Lundbeck A/S
Major Depression
Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression
40 patients with the diagnosis of major depression are included. There are two interventions: partial sleep deprivation (PSD) and normal night sleep (CTRL).
- Trial name
- NCT00291239
- Testing
- partial sleep deprivation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Zentrum für Integrative Psychiatrie
Major Depressive Disorder
Efficacy and Cost-effectiveness of Internet-delivered CBT for Adolescents With Depression
Adolescent depression is a prevalent and impairing condition that can be effectively treated with Cognitive Behavior Therapy (CBT). However, a majority of adolescents do not have access to CBT.
- Trial name
- IDA (NCT04977856)
- Testing
- Behavioral activation (BA), Regular care within primary or secondary mental health care for children
- Where
- Sweden
- Volunteers
- 219 people
- Sponsor
- Region Stockholm
Major Depressive Disorder (MDD), Female
Gottman Couple Therapy Program in Treatment of Depressed Female Partners
This study aimed to evaluate the effect of Gottman couple therapy program targeted for discordant couples struggling with the negative impact of depression of the female partner and compare between the outcome in case of usual…
- Trial name
- NCT07748845
- Testing
- Gottman couple therapy, treatment as usual for depression
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Major Depressive Disorder
Endogenous Opioid Modulation by Ketamine
Demonstrate the acute effects of ketamine on endogenous µ-opioid neurotransmission in humans.
- Trial name
- NCT03051945
- Testing
- Ketamine Hydrochloride, Normal saline
- Where
- United States
- Sponsor
- University of Utah
Depression, Anxiety
The Safety, Efficacy, and Tolerability of Microbial Ecosystem Therapeutic-2 in People With Major Depression and/or Generalized Anxiety Disorder
This study will measure the effects of MET-2 on symptoms of depression and anxiety using pre- and post-treatment scores for overall depression and anxiety and other symptoms of depression, such as sleep and anhedonia.
- Trial name
- NCT04052451
- Testing
- MET-2
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- NuBiyota
Fibromyalgia, Psychological Trauma
Augmentation of EMDR With tDCS in the Treatment of Fibromyalgia
Fibromyalgia (FM) is a generalized, widespread chronic pain disorder and has an estimated prevalence of 2%-4% in the general population.
- Conditions
- Fibromyalgia, Psychological Trauma, Depressive Symptoms, Anxiety
- Trial name
- NCT04084795
- Testing
- Eye Movement Desensitization and Reprocessing therapy, transcranial Direct Current Stimulation
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Parc de Salut Mar
Major Depressive Disorder
Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive Disorder
The purpose of this study is to predict and visualize sertraline treatment response in major depressive disorder with clinical symptoms, demographic and stress state, personality, eight genetic polymorphisms at baseline.
- Trial name
- AFADTRMDD (NCT01454635)
- Testing
- Sertraline
- Where
- Japan
- Volunteers
- 96 people
- Sponsor
- Showa University
Major Depressive Disorder
Efficacy of Vortioxetine (Lu AA21004) in the Prevention of Relapse of Major Depressive Episodes
This study will evaluate the efficacy of Vortioxetine in the prevention of relapse of major depressive episodes in patients who responded to open-label treatment with Vortioxetine.
- Trial name
- NCT00596817
- Testing
- Vortioxetine (Lu AA21004)
- Volunteers
- 639 people
- Sponsor
- H. Lundbeck A/S
Major Depressive Disorder
SPL026 With or Without SSRIs in Participants With MDD
The main aim of the study is to test the safety and tolerability of single doses of SPL026 (N,N-dimethyltryptamine [DMT] fumarate, a psychedelic tryptamine) in patients currently taking a selective serotonin reuptake inhibitor…
- Trial name
- NCT05553691
- Testing
- SPL026
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- Small Pharma Ltd
Major Depressive Disorder, Remission
Quality of Life in Chinese Working and School Age Population With MDD
Major depressive disorder (MDD) is a common mental illness with high prevalence and global burden. Previous studies revealed that over 70% patients in remission still had decreased quality of life, severe function impairment, low…
- Trial name
- NCT04986124
- Testing
- treatment as usual
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Mental Health Center
Major Depressive Disorder
Safety of Liposom With Citalopram in Elderly Patients With Major Depressive Disorder
The purpose of this study is to determine if Liposom Forte will enhance the response to antidepressant therapy with citalopram in elderly patients suffering from Major Depressive Disorder (MDD).
- Trial name
- NCT04975724
- Testing
- Liposom Forte, Citalopram
- Where
- 12 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Postpartum Depression
The Safety, Tolerability, and Effectiveness of Quetiapine in Postpartum Depression
Postpartum depression is a serious disorder that affects approximately 14% of women who have recently given birth. Postpartum depression is either an episode of major depressive disorder (only low periods) or bipolar disorder…
- Trial name
- NCT04950868
- Testing
- Quetiapine
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Verinder Sharma
Major Depressive Disorder
The Effect of Soluble Epoxide Hydrolase (SEH) on Depression
Depression is the most common mental disease and the second leading cause of chronic disease burden, which is closely related to suicidal behavior.
- Trial name
- NCT05575713
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Major Depressive Disorder, Depression Disorders
Near-infrared Transcranial Laser Therapy in Subjects With Major Depressive Disorder: A Study of Dosing With Laser
Note: This registration is retained as a historical study record. Updated study information and subsequent protocol modifications are available under ClinicalTrials.gov Identifier NCT06934135, which serves as the actively…
- Trial name
- NCT05435820
- Testing
- Near-infrared Transcranial Laser Therapy
- Where
- 3 sites in Peru
- Volunteers
- 50 people
- Sponsor
- Peruvian Clinical Research
Depressive Disorder, Major
Predictors of Treatment Response in Late-onset Major Depressive Disorder
Depression is a common disorder, especially in old age, where it is associated with significant morbidity and mortality. This study will investigate whether there are features of individual patients with major depression that may…
- Trial name
- NCT02546024
- Testing
- Standard care
- Volunteers
- 40 people
- Sponsor
- King's College London
Major Depression
A Family-based Primary Care Intervention to Enhance Older Men's Depression Care
Despite the public health importance of clinical depression, more than 50% of depressed adults receive inadequate or no treatment, with even higher rates of under-treatment in men and minorities.
- Trial name
- NCT02143024
- Testing
- Family-based depression intervention, Usual care plus educational materials
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Davis
Borderline Personality Disorder
Selective Serotonin Reuptake Inhibitors (SSRIs) in Borderline Personality Disorder
The goal of this study is to examine the effectiveness the selective serotonin reuptake inhibitor (SSRI) escitalopram (also known by the trade name "Lexapro") in reducing desire to self-harm and actual self-harming among young…
- Trial name
- NCT01103180
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Chicago
Major Depression
Interpersonal Psychotherapy for Adolescents and Young Adults
The purpose of the project is to study the effectiveness of Interpersonal Psychotherapy (IPT) for adolescents with depression. Specific aims are to analyze the effects, change mechanisms, predictors, and implementation of IPT for…
- Trial name
- NCT05575960
- Testing
- Interpersonal Psychotherapy for Adolescents (IPT-A)
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Linnaeus University