Clinical trials: Malaria, completed
Malaria
A Trial of Intermittent Treatment in the Prevention of Malaria in Senegalese Children
In countries of the Sahel and sub-Sahel, malaria transmission is highly seasonal with nearly all infections occurring during a few months of the year.
- Trial name
- NCT00132561
- Testing
- Sulfadoxine/pyrimethamine and artesunate
- Where
- Senegal
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Effectiveness of Artemether-Lumefantrine for Malaria Treatment of Children at Community Level in Tanzania
The purpose of this clinical trial is to assess the effectiveness of artemether-lumefantrine (Coartem®) treatment provided by community health workers against uncomplicated malaria in children under 5 years of age in Kibaha…
- Trial name
- C3 (NCT00454961)
- Testing
- artemether-lumefantrine
- Where
- Tanzania
- Volunteers
- 200 people
- Sponsor
- Karolinska University Hospital
Malaria
LLIN Evaluation in Uganda Project
In Uganda, the National Malaria Control Division (NMCD) and implementing partners plan to deliver long-lasting insecticidal nets (LLINs) nationwide in 2020-21, through a mass distribution campaign supported by generous…
- Trial name
- LLINEUP2 (NCT04566510)
- Testing
- long lasting insecticidal nets with alpha-cypermethrin + pyriproxyfen (PPF LLIN, Royal Guard)), long lasting insecticidal nets with deltamethrin + piperonyl butoxide (PBO LLIN, PermaNet 3.0)), Social behaviour change communication
- Where
- Uganda
- Volunteers
- 32,895 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria
Evaluation of Rapid Diagnosis Tests in Imported Malaria
The annual number of cases of clinical malaria worldwide is estimated to be 300-500 million leading to 1.5 million deaths. Delayed care and frequent drug resistance of Plasmodium falciparum (Pf), the most frequent form of…
- Trial name
- TDR-PALU (NCT00451269)
- Testing
- Rapid diagnosis test for malaria
- Where
- France
- Volunteers
- 1,297 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Malaria
Efficacy, Safety, Tolerability and Pharmacokinetics of KAF156 in Adult Patients With Acute, Uncomplicated Plasmodium Falciparum or Vivax Malaria Mono-infection
This study will assess efficacy, safety , tolerability and PK in uncomplicated adult malaria patients with P. vivax or P. falciparum infection after 3 day dosing with KAF156 at 400 mg/day (Part 1) and single dosing with KAF156 at…
- Trial name
- NCT01753323
- Testing
- KAF156
- Where
- 5 sites in Thailand, Vietnam
- Volunteers
- 43 people
- Sponsor
- Novartis Pharmaceuticals
Plasmodium Falciparum, Malaria
Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia
To assess the efficacy of both first-line antimalarial medications used for the treatment of uncomplicated Plasmodium falciparum malaria infections in two geographic regions in Liberia.
- Conditions
- Plasmodium Falciparum, Malaria, Uncomplicated Malaria
- Trial name
- NCT06300970
- Testing
- Amodiaquine-artesunate (ASAQ), Artemether+Lumefantrine (AL)
- Where
- 2 sites in Liberia
- Volunteers
- 352 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria
Piperaquine Granule Formulation Relative Bioavailability and Food Effect Study in Healthy Volunteers.
This trial aims to characterise the pharmacokinetic (PK) profile and estimate drug exposure of a single oral dose of piperaquine (PQP) in a dispersible granule formulation compared to the PQP hard tablet formulation in the fasted…
- Trial name
- PedPQP(BA/FE) (NCT05930782)
- Testing
- Piperaquine Tetraphosphate uncoated tablets, Piperaquine Tetraphosphate dispersible granules
- Where
- Tanzania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Safety and Efficacy of Methylene Blue Combined With Artesunate or Amodiaquine for Malaria Treatment in Children of Burkina Faso: a Pilot Study
The primary objective of this trial is to study the safety of the combination methylene blue (MB)-artesunate (AS) and MB-amodiaquine (AQ) in treating malaria among children compared to the safety of an AS-AQ regimen.
- Trial name
- NCT00354380
- Testing
- Methylene blue, Artesunate, Amodiaquine
- Where
- Burkina Faso
- Sponsor
- Heidelberg University
Malaria
Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkina Faso
The purpose of this study is to evaluate the safety of a malaria vaccine, Ad35.CS.01, and how the body reacts to vaccination. Participants will include 48 Berkinabè healthy males and females ages 18-45 years in Burkina Faso.
- Trial name
- NCT01018459
- Testing
- Ad35.CS.01 Circumsporozoite Malaria Vaccine
- Where
- Burkina Faso
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
A Trial of Four Drug Regimens for the Prevention of Malaria in Senegalese Children
A recent study has shown that the administration of a single dose of sulfadoxine/pyrimethamine plus artesunate to Senegalese children on three occasions during a short malaria transmission season reduced the incidence of clinical…
- Trial name
- NCT00132548
- Testing
- Pyrimethamine/sulfadoxine, Amodiaquine, Artesunate
- Where
- Senegal
- Volunteers
- 2,200 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Plasmodium Falciparum Malaria, Plasmodium Vivax Malaria
DSM265 Phase IIa Investigation Treating Plasmodium Falciparum or Vivax
This will be a Proof-of-concept / Phase IIa, open label study to examine the efficacy of DSM265 in uncomplicated Plasmodium vivax and Plasmodium falciparum blood-stage malaria in adult patients.
- Trial name
- NCT02123290
- Testing
- DSM265 400mg, DSM265 xmg, DSM265 ymg
- Where
- Peru
- Volunteers
- 45 people
- Sponsor
- Medicines for Malaria Venture
Uncomplicated Plasmodium Falciparum Malaria
Phase II Efficacy Study of Artefenomel & Piperaquine in Adults & Children With P. Falciparum Malaria.
A randomised, double-blind single-dose study to determine the efficacy, safety, tolerability and pharmacokinetics of OZ439 (artefenomel) in combination with piperaquine (PQP) in patients > 0.5 years and <= 70 years of age with…
- Trial name
- NCT02083380
- Testing
- Artefenomel 800mg: piperaquine 640mg, Artefenomel 800mg: piperaquine 960mg, Artefenomel 800mg: piperaquine 1440mg
- Where
- 9 sites in Benin, Burkina Faso and 5 more
- Volunteers
- 448 people
- Sponsor
- Medicines for Malaria Venture
Malaria, Febrile Illness
A Randomised Trial of Rapid Diagnostic Tests in the Diagnosis of Malaria in Tanzania
There is clear evidence diagnosis of malaria in much of Africa is sub-optimal and this has a negative impact on patient care. Many of those treated for malaria do not have it.
- Trial name
- NCT00146796
- Testing
- Rapid diagnostic test for malaria
- Where
- Tanzania
- Volunteers
- 2,400 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Plasmodium Falciparum, Malaria
DSM265 Chemoprophylaxis of Plasmodium Falciparum Malaria
Study to evaluate the efficacy of DSM265 as a causal prophylactic in a standardized and validated Human Challenge model using direct venous inoculation of aseptic, purified, cryopreserved, vialed Plasmodium falciparum sporozoites.
- Trial name
- NCT02450578
- Testing
- DSM265 400mg, Plasmodium falciparum sporozoite challenge, Malarone
- Where
- Germany
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria
Target Antigens Induced by Plasmodium Falciparum Sporozoite Immunization Under Chemoprophylaxis
Malaria, a disease caused by the parasite Plasmodium, is one of the world's major infectious diseases. With approximately 627.000 deaths a year, there is desperate need for an effective vaccine.
- Trial name
- BMGF1 (NCT02080026)
- Testing
- CPS-immunization, Controlled Human Malaria Infection, chloroquine
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria, Malaria Vaccine, Insecticide-treated Bednets
RTSS Vaccine and PBO Net Impact on Malaria Infection and Transmission in Malawi
The overall goal of this study is to assess the impact of RTS,S (malaria) vaccination and PBO nets on malaria infection and transmission, independently and how they interact when they are introduced together.
- Trial name
- RTSS/PBO (NCT04327440)
- Testing
- RTS,S/AS01 malaria vaccine, PBO bed nets
- Where
- Malawi
- Volunteers
- 1,691 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Malaria
Computerized Cognitive Rehabilitation in Children After Severe Malaria
Brain training exercises will be provided to children who survived an episode of severe malaria. These children will be given assessments for cognition, behaviour and executive functions before and after the brain training…
- Trial name
- CM_CCRT (NCT01743417)
- Testing
- Computerised cognitive rehabilitation training
- Where
- Uganda
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Makerere University
Malaria
Safety of KAE609 in Adults With Uncomplicated Plasmodium Falciparum Malaria.
KAE609 will be evaluated primarily for hepatic safety of single and multiple doses in sequential cohorts with increasing doses.This study aims to determine the maximum safe dose of the investigational drug KAE609 in malaria…
- Trial name
- NCT03334747
- Testing
- KAE609, Coartem
- Where
- 9 sites in Gabon, Ghana and 3 more
- Volunteers
- 188 people
- Sponsor
- Novartis Pharmaceuticals
Plasmodium Falciparum Malaria
Safety and Preliminary Protective Efficacy of Genetically Attenuated GA2 Parasites.
This study will consist of two phases and be aimed at assessing the safety and tolerability of the new genetically attenuated GA2 malaria parasite (Phase 1) and its preliminary protective efficacy against controlled human malaria…
- Trial name
- NCT04577066
- Testing
- GA2, GA1
- Where
- Netherlands
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Malaria in Pregnancy
TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study
The main objective of this study is to monitor SP resistance via molecular markers in the context of the TIPTOP project implementation of community distributed SP for women during pregnancy.
- Trial name
- TIPTOP-DRS (NCT03998839)
- Testing
- Community distribution of Sulfadoxine-pyrimethamine (SP)
- Where
- 4 sites in Democratic Republic of the Congo, Madagascar and 2 more
- Volunteers
- 7,200 people
- Sponsor
- Jhpiego
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