Clinical trials: Malaria, completed
Malaria
Cluster Randomized Trial of Peer Health Education in Malaria in The Gambia
Health promotion in schools aims to improve the health and well being of students by empowering them with the knowledge, skills and confidence to take responsibility for their own health.
- Trial name
- NCT00269178
- Testing
- Peer Health Education Programme
- Where
- The Gambia
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Baseline Cohort Malaria Morbidity Study
The BLOOMy study is a longitudinal prospective cohort study of healthy children to assess the incidence of clinical malaria over the main transmission season.
- Trial name
- BLOOMy (NCT04601714)
- Where
- Burkina Faso
- Volunteers
- 459 people
- Sponsor
- Groupe de Recherche Action en Sante
Malaria
Randomised Trial of 3 Artemisinin Combination Therapy for Malaria in Pregnancy
This is a randomised, open label trial, comparing standard dose of dihydroartemisinin-piperaquine (DP) with standard fixed artesunate-mefloquine regimen (MAS3) and with a longer regimen of artemether-lumefantrine (ALN+) in the…
- Trial name
- DMA (NCT01054248)
- Testing
- dihydroartemisinin-piperaquine, Artesunate-mefloquine, arthemeter-lumefantrin
- Where
- Thailand
- Volunteers
- 511 people
- Sponsor
- University of Oxford
Malaria, Anemia
Perennial Malaria Chemoprevention (PMC) in Côte d'Ivoire
The Plus Project will assess the impact, operational feasibility, efficacy, effectiveness, and cost-effectiveness of PMC. Specifically, the impact evaluation will involve monitoring a passive cohort of all children in the study…
- Trial name
- NCT05856357
- Testing
- Sulfadoxine pyrimethamine
- Where
- Côte d’Ivoire
- Volunteers
- 1,381 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria
The purpose of this study is to compare the efficacy and safety of the fixed combination of pyronaridine artesunate (Pyramax®, PA) (180:60 mg) with that of standard chloroquine therapy in children and adults with acute…
- Trial name
- NCT00440999
- Testing
- Pyronaridine artesunate, Chloroquine
- Where
- 5 sites in Cambodia, India and 2 more
- Volunteers
- 456 people
- Sponsor
- Medicines for Malaria Venture
Malaria, Plasmodium Falciparum
Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
The purpose of the study is to determine the safety and tolerability of ID administration of PfSPZ Challenge to volunteers taking chloroquine chemoprophylaxis (an approach called PfSPZ-CVac).
- Trial name
- NCT01728701
- Testing
- PfSPZ Challenge, Normal Saline (NS)
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Malaria
Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...
Background: Malaria is a severe infection caused by a parasite. People can get malaria if a mosquito that carries the parasite bites them.
- Trial name
- NCT02511054
- Testing
- Chloroquine (CQ), Pyrimethamine (PYR), Sanaria PfSPZ Challenge (NF54)
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
A Randomized, Double-blind, Placebo-controlled Evaluation of Increasing Doses of Weekly Tafenoquine for Chemosuppression of Plasmodium Falciparum
This was a randomised, double-blind, placebo-controlled study to compare the efficacy of a range four weekly doses of tafenoquine, and weekly mefloquine, with placebo as chemosuppression of P. falciparum malaria.
- Trial name
- NCT02488902
- Testing
- Tafenoquine 25mg, Tafenoquine 50mg, Tafenoquine 100 mg
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Malaria
Prevention of Malaria in HIV-uninfected Pregnant Women and Infants
This will be a double-blinded randomized controlled phase III trial of 782 HIV uninfected pregnant women and the children born to them.
- Trial name
- PROMOTE-BC3 (NCT02793622)
- Testing
- Monthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy, Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy
- Where
- Uganda
- Volunteers
- 782 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malaria, Respiratory Infections
A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children
The primary objective of this study is to determine whether addition of azithromycin (AZ) to Seasonal Malaria Chemoprevention (SMC) using sulphadoxine/pyrimethamine (SP) +amodiaquine (AQ) will provide an additional reduction in…
- Trial name
- SMCAZ (NCT02211729)
- Testing
- Sulphadoxine-Pyrimethamine+ Amodiaquine+ Azithromycin
- Where
- 2 sites in Burkina Faso, Mali
- Volunteers
- 22,090 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Feasibility, Acceptability and Costs of a Multiple First-lines Artemisinin-based Combination Therapies
A simultaneous deployment of multiple first line therapies (MFT) for uncomplicated malaria using artemisisin based combination therapies as showed by theoretical models, may extend the useful therapeutic life of the current…
- Trial name
- NCT04265573
- Where
- Burkina Faso
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- Groupe de Recherche Action en Sante
Malaria
Safety and Efficacy Study of Artesunate and Mefloquin in Children With Uncomplicated Malaria
The present study aims to investigate and to assess possible neurological and neuropsychiatric events in young children in west Africa with uncomplicated P.
- Trial name
- NCT00978172
- Testing
- artesunate and mefloquine
- Where
- Cameroon
- Volunteers
- 220 people
- Sponsor
- Mepha Ltd.
Malaria
Efficacy and Safety of Azithromycin and Artesunate in Pregnant Women
The purpose of this study is to compare the efficacy and safety of three treatment regimens for the prevention of malaria during pregnancy.
- Trial name
- NCT00287300
- Testing
- Sulfadoxine-Pyrimethamine, Azithromycin, Artesunate
- Where
- Malawi
- Volunteers
- 141 people
- Sponsor
- University of North Carolina
Falciparum Malaria
A Bioequivalence Study Comparing Camoquin® Suspension (Pfizer) To Flavoquine® Tablets (Sanofi Aventis) In Healthy Subjects
The purpose of this study is to determine bioequivalence of amodiaquine suspension ( Pfizer) and the WHO approved reference product Flavoquine® tablet ( Sanofi Aventis).
- Trial name
- NCT00859807
- Testing
- Flavoquine®, Camoquin® Suspension
- Where
- India
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Pfizer
Malaria
Azithromycin + Artesunate v Artemether-lumefantrine in Uncomplicated Malaria.
This trial sets out to determine whether the combination of azithromycin and artesunate (AZ+AS) is as good as the current standard treatment for uncomplicated malaria in Tanzania, artemether-lumefantrine (AL).
- Trial name
- CAZAMS (NCT00694694)
- Testing
- azithromycin + artesunate, artemether-lumefantrine
- Where
- Tanzania
- Volunteers
- 261 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Estimating the Malaria Prevention Impact of New Nets: Observational Analyses to Evaluate the Evidence Generated During Piloted New Net Distributions in Burkina Faso
The use of insecticide-treated bed nets (ITN) has contributed to the substantial reduction in malaria cases and deaths. This progress is threatened by increasing resistance commonly used insecticides in mosquito populations.
- Trial name
- NCT04157894
- Testing
- Standard long-lasting insecticidal net, Chlorfenapyr insecticide treated net, Piperonyl butoxide long-lasting insecticidal net
- Where
- Burkina Faso
- Volunteers
- 5,606 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria, Plasmodium Falciparum
A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21
This is a Phase Ib multi-stage Plasmodium falciparum malaria vaccine study to assess the safety and immunogenicity of the blood-stage vaccine candidate RH5.2 virus-like particle (VLP) in Matrix-MTM and the pre-erythrocytic stage…
- Trial name
- NCT05357560
- Testing
- Matrix-M with RH5.2 VLP and/or R21
- Where
- The Gambia
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Plasmodium Falciparum Malaria
Hyperphenylalaninemia in Cerebral Malaria
The purpose of this study is to see if children, who develop coma from malaria, are not making enough of a vitamin-like chemical, tetrahydrobiopterin (BH4), which is required for the brain to function normally.
- Trial name
- NCT00338520
- Where
- Tanzania
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pregnancy, Malaria in Pregnancy
Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa
This study evaluates the efficacy and safety of monthly intermittent preventive treatment using dihydroartemisinin piperaquine (DP) alone or in combination with azithromycin (AZ) compared to sulphadoxine-pyrimethamine (SP) for…
- Conditions
- Pregnancy, Malaria in Pregnancy, Malaria
- Trial name
- IMPROVE (NCT03208179)
- Testing
- dihydroartemisinin-piperaquine, sulphadoxine-pyrimethamine, dihydroartemisinin-piperaquine plus azithromycin
- Where
- 7 sites in Kenya, Malawi and 1 more
- Volunteers
- 4,680 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Malaria
Intermittent Preventive Treatment in Infant in Mali
Studies have shown that Intermittent preventive treatment in infants (IPTi) with Sulfadoxine-pyrimethamine (SP)reduced the incidence of clinical malaria and anemia without modifying infants' serological response to EPI vaccines.
- Trial name
- NCT00766662
- Testing
- Sulfadoxine pyrimethamine
- Where
- Mali
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Bamako
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