Clinical trials: Malaria Falciparum
Malaria,Falciparum, Malaria Recrudescence
TES of Artemether-lumefantrine for Pf in the Philippines in 2015
Artemether-lumefantrine has been used as a first-line treatment for uncomplicated Plasmodium falciparum infection since 2009 in the Philippines.
- Trial name
- TES (NCT05958693)
- Testing
- Artemether-lumefantrine, Primaquine
- Volunteers
- 82 people
- Sponsor
- Research Institute for Tropical Medicine, Philippines
Plasmodium Falciparum Malaria
Immunization With Different Doses of Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis
Malaria is one of the major infectious diseases in the world with a tremendous impact on the quality of life significantly contributing to the ongoing poverty in endemic countries.
- Trial name
- ZonMw1 (NCT01218893)
- Testing
- Chloroquine prophylaxis, Immunization, Plasmodium falciparum challenge
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Plasmodium Falciparum Infection
Dose Ranging Study of Ferroquine With Artesunate in African Adults and Children With Uncomplicated Plasmodium Falciparum Malaria
Primary objective: To assess the Day 28 efficacy defined as the percentage of patients with no parasitic recrudescence, of 3 treatment groups - 3 dose levels of ferroquine associated with artesunate - for a 3-day treatment.
- Trial name
- FARM (NCT00988507)
- Testing
- Ferroquine (SSR97193), artesunate
- Where
- 10 sites in Benin, Burkina Faso and 4 more
- Volunteers
- 440 people
- Sponsor
- Sanofi
Falciparum Malaria
A Bioequivalence Study Comparing Camoquin® Suspension (Pfizer) To Flavoquine® Tablets (Sanofi Aventis) In Healthy Subjects
The purpose of this study is to determine bioequivalence of amodiaquine suspension ( Pfizer) and the WHO approved reference product Flavoquine® tablet ( Sanofi Aventis).
- Trial name
- NCT00859807
- Testing
- Flavoquine®, Camoquin® Suspension
- Where
- India
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Pfizer
Malaria, Falciparum
Efficacy and Safety of Pyronaridine-artesunate for the Treatment in Uncomplicated Falciparum Malaria
This study is a prospective, single arm, open-labelled clinical trial. The total number subjects will be 145 patients to receive Pyronaridine-artesunate once daily for 3 days. Dosing will be according to the body weight.
- Trial name
- NCT02389439
- Testing
- Pyronaridine-artesunate
- Where
- 3 sites in Cambodia
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Falciparum, Anemia
The Community Effectiveness of IPTi in Southern Tanzania
The safety and efficacy of Intermittent Preventive Treatment for malaria and anaemia control in Infants (IPTi) have already been documented in Southern Tanzania, affording an opportunity to gain operational experience in…
- Trial name
- NCT00152204
- Testing
- Sulfadoxine-pyrimethamine used for IPTi, IPTi
- Where
- Tanzania
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Malaria (Uncomplicated)
Efficacy of Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium Falciparum Malaria in Children Under 12 Years at Four Sentinel Sites in Mozambique
This is a classical in vivo clinical trial, following World Health organization's recommendations, ran as a multisite study within Mozambique trying to assess the efficacy and safety in four sites of artemether-lumefantrine (AL)…
- Trial name
- NCT06970600
- Testing
- Artemether-lumefantrine (Coartem)
- Where
- 4 sites in Mozambique
- Volunteers
- 352 people
- Sponsor
- Centro de Investigacao em Saude de Manhica
Malaria, Plasmodium Falciparum Malaria
CQSP in Malawi: Chloroquine and Sulfadoxine-pyrimethamine Efficacy for the Treatment of Malaria in Malawi
The purpose of this research study is to find out how well chloroquine works as a drug to treat malaria in children, compared to the standard malaria treatment in Malawi.
- Trial name
- NCT00125489
- Testing
- chloroquine sulfate, sulfadoxine/pyrimethamine
- Where
- Malawi
- Volunteers
- 210 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Falciparum Malaria
Nitrite Infusion in Children With Malaria
The purpose of this study is to assess the safety of intravenous sodium nitrite in African children who have moderately severe malaria.
- Trial name
- NCT04289558
- Testing
- Sodium Nitrite
- Where
- Tanzania
- Sponsor
- Duke University
Falciparum Malaria
Evaluation of the Gametocytocidal Efficacy and Safety of Primaquine in Uncomplicated Falciparum Malaria in Uganda
The purpose of this study is to evaluate the safety and efficacy of lower doses of primaquine compared to the dose recommended by the WHO for reducing P.
- Trial name
- NCT01365598
- Testing
- Primaquine
- Where
- Uganda
- Volunteers
- 468 people
- Sponsor
- London School of Hygiene and Tropical Medicine
P. Falciparum Malaria
Re-exposure of EHMI-8 Human Volunteers to Live Malaria Sporozoites
In the EHMI-8 study (CMO 2006/207) the investigators induced sterile protection against P. falciparum challenge in healthy Dutch volunteers by repeated exposure to infected mosquitoes whilst under chloroquine prophylaxis.
- Trial name
- NCT00757887
- Testing
- Exposure to 5 P. falciparum infected mosquitoes
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria, Malaria,Falciparum
A Study to Compare Two Dosing Regimens for a New Malaria Vaccine
Malaria is a major public health problem. There were around 240 million cases of malaria and 627,000 deaths worldwide in 2020. Most of the deaths are in children under five living in Africa.
- Conditions
- Malaria, Malaria,Falciparum, Protozoan Infections, Parasitic Disease
- Trial name
- NCT06141057
- Testing
- Matrix M with RH5.1
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
A Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ439 in Healthy Subjects With Induced Blood Stage Plasmodium Falciparum or Plasmodium Vivax Infection
Part A -Cohort 1 DSM265 will be administered as a single dose (400 mg). For cohort 1 only, an additional single dose (400 mg) of DSM265 may be given if gametocytemia develops.
- Trial name
- DSMOZ-2 (NCT02573857)
- Testing
- DSM265, OZ439
- Where
- Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Malaria, Vivax, Malaria, Falciparum
Therapeutic Efficacy Study of Pyrimethamine/Sulfdoxine (Fansidar®) for the Treatment of Uncomplicated Falciparum Malaria in the Peruvian Amazon
The purpose of this study is to determine the efficacy of pyrimethamine/sulfdoxine (Fansidar®) for the treatment of uncomplicated falciparum malaria in the Peruvian Amazon.
- Trial name
- NCT00951106
- Testing
- Pyrimethamine/sulfdoxine (Fansidar)
- Where
- Peru
- Sponsor
- Walter Reed Army Institute of Research (WRAIR)
Malaria
Laboratory Evaluation of Pregnancy Malaria Vaccine Candidates/In-vitro Testing of Pregnancy Malaria Vaccine Candidates
Background: Malaria is a disease that affects many people in African countries. It is caused by germs that are spread by mosquito bites. It can be fatal if not diagnosed and treated right away.
- Trial name
- NCT02471378
- Where
- Mali
- Volunteers
- 7,476 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria,Falciparum
Safety, Immunogenicity and ex Vivo Efficacy of Pfs25-IMX313/Matrix-M in Healthy Volunteers in Bagamoyo, Tanzania.
A phase Ib age de-escalation and dose escalation open label clinical trial of the safety, immunogenicity and ex-vivo efficacy of a candidate malaria vaccine Pfs25-IMX313/Matrix-M administered intramuscularly in healthy adults and…
- Trial name
- NCT04271306
- Testing
- Pfs25-IMX313 (10ug)/Matrix-M (50ug), Pfs25-IMX313 (50ug)/Matrix-M (50ug), Pfs25-IMX313 (50ug)/Matrix-M (50ug) & Pfs25-IMX313 (10ug)/Matrix-M (50ug)
- Where
- Tanzania
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria
A Study to Assess Safety, Immunogenicity and Parasite Growth Inhibition of an Asexual Blood Stage Vaccine for P. Falciparum Malaria
Malaria is a parasite, infection with which kills over 2 million people each year. It is a major problem for those who live in endemic areas and for travellers. There is a great need for a safe effective malaria vaccine.
- Trial name
- NCT00984763
- Testing
- AMA1-C1/Alhydrogel® + CPG 7909
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria, Asymptomatic Malaria
Dihydroartemisinin-piperaquine With Low Dose Primaquine to Reduce Malaria Transmission
Primaquine (PQ) is currently the only available drug that can clear the mature transmission stages of P. falciparum parasites. PQ was previously shown to clear gametocytes that persist after artemisinin-combination therapy.
- Conditions
- Malaria, Asymptomatic Malaria, Plasmodium Falciparum
- Trial name
- DAPPI (NCT02259426)
- Testing
- Dihydroartemisinin-piperaquine combination (Artekin), Primaquine
- Where
- Kenya
- Volunteers
- 120 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria,Falciparum
Evaluation of Insecticide-treated Eave Nets and Window Screens for Malaria Control in Tanzania.
This is a household randomized trial of a new tool for house modification, Insecticide-Treated Eave nets (ITENs) in combination with insecticide-treated window screens (ITWS), coated with a dual active ingredient (dual AI)…
- Trial name
- ITENs (NCT05125133)
- Testing
- ITENs + ITWS
- Where
- Tanzania
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Ifakara Health Institute
Malaria, Falciparum, G6PD Deficiency
Safety and Tolerability of Low Dose Primaquine
In Cambodia, falciparum is becoming more difficult to treat because drugs are becoming less effective. The investigators can help to try to prevent the spread of this resistant malaria by adding a drug that will make it more…
- Trial name
- NCT02434952
- Testing
- Dihydroartemisinin piperaquine (DHA PP), Primaquine
- Where
- Cambodia
- Volunteers
- 109 people
- Sponsor
- Malaria Consortium