Clinical trials: Malaria Prevention
Plasmodium Infection
Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Lao PDR and Cambodia
This stepped-wedge cluster-randomized controlled trial with nested mixed methods study will assess the effectiveness, acceptability, feasibility and cost-effectiveness of a personal protection package to reduce malaria…
- Trial name
- NCT05117567
- Testing
- Personal protection package
- Volunteers
- 5,868 people, healthy volunteers welcome
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Malaria
Comparison of Three Drug Combinations for Intermittent Treatment of Malaria in Children
Intermittent preventive treatment (IPT) offers a way of preventing malaria infection without compromising the development of malaria immunity or encouraging drug resistance.
- Trial name
- NCT00561899
- Testing
- SP, amodiaquine, piperaquine, dihdroartemisinin, intermittent preventive treatment, Du-Cotecxin
- Where
- The Gambia
- Volunteers
- 1,295 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Intermittent Preventive Treatment in Infant in Mali
Studies have shown that Intermittent preventive treatment in infants (IPTi) with Sulfadoxine-pyrimethamine (SP)reduced the incidence of clinical malaria and anemia without modifying infants' serological response to EPI vaccines.
- Trial name
- NCT00766662
- Testing
- Sulfadoxine pyrimethamine
- Where
- Mali
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Bamako
Malaria
Evaluating the Ottawa Malaria Decision Aid
BRIEF SUMMARY Canadians often visit areas with malaria where the preventative drug chloroquine no longer works. This leaves Canadians with the choice to use three different drugs to prevent malaria - atovaquone-proguanil…
- Trial name
- OMDA (NCT01976325)
- Testing
- Ottawa Malaria Decision Aid
- Where
- 3 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Malaria
Hati Salama (Secure Voucher)
The use of long-lasting insecticide treated nets (LLINs) is shown to reduce malaria prevalence. The Tanzania Net Voucher Scheme has been an active component of bed net distribution to pregnant women in Tanzania since 2004.
- Trial name
- NCT02561624
- Testing
- Behaviour change communication via text message
- Where
- Tanzania
- Volunteers
- 5,219 people, healthy volunteers welcome
- Sponsor
- Queen's University
Malaria
Intermittent Preventive Treatment (IPTc) and Home Based Management of Malaria (HMM)in The Gambia
Malaria in African countries remains an important cause of mortality and morbidity among young children. The global malaria control strategies include prompt treatment with an effective antimalarial drug, vector control using…
- Trial name
- NCT00944840
- Testing
- SP plus amodiaquine
- Where
- The Gambia
- Volunteers
- 1,312 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Falciparum
Study of the Impact of Intermittent Preventive Treatment in Schools on Malaria, Anaemia and Education.
This study seeks to establish whether intermittent preventive treatment (IPT) can reduce malaria among school-going children and its consequent impact on school performance.
- Trial name
- NCT00142246
- Testing
- Intermittent preventive treatment (SP and amodiaquine)
- Where
- Kenya
- Volunteers
- 6,758 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Bioavailability
Atoguanil BA Study
This trial aims to characterise the pharmacokinetic (PK) profile and estimate drug exposure from Atoguanil in comparison to Malarone®.
- Trial name
- NCT04866602
- Testing
- Atoguanil, Malarone
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Anaemia, Malaria
Impact of Malaria Prevention on Health and Education in Kenyan Schoolchildren
While malaria represents one of the main health problems afflicting schoolchildren, the evidence base for policy development and programme implementation for school-based malaria control remains inadequate.
- Trial name
- NCT00878007
- Testing
- Intermittent screening and treatment for malaria, Teacher training on literacy instruction, IST plus literacy instruction programme
- Where
- Kenya
- Volunteers
- 5,177 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Severe Malaria
Monoclonal Antibodies in Children With Severe Anaemia or Severe Malaria to Prevent Malaria After Hospital Discharge
Background and rationale: Hospitalised children with severe anaemia remain at high risk of dying or requiring hospital readmission for at least 6 months after discharge.
- Conditions
- Malaria, Severe Malaria, Severe Anaemia, Post Discharge
- Trial name
- L9LS-pd (NCT07082205)
- Testing
- Antimalarial monoclonal antibodies, Dihydroartemisinin - Piperaquine (DP)
- Where
- 2 sites in Kenya
- Volunteers
- 398 people
- Sponsor
- Liverpool School of Tropical Medicine
Neurobehavioral Manifestations
Prophylaxis Against Malaria to Enhance Child Development (PROTECT Study)
Each year, ~85.3 million pregnant women are at risk of becoming infected with Plasmodium falciparum(1). Among women in sub-Saharan Africa, most of whom have some degree of clinical immunity to malaria, malaria infection in…
- Trial name
- PROTECT (NCT02557425)
- Testing
- No intervention in PROTECT
- Where
- Uganda
- Volunteers
- 272 people
- Sponsor
- Indiana University
Malaria, Pregnancy
Impact of IPT With Sulfadoxin Pyrimetamin on Pregnant Women and Their Babies Outcomes in Peri-urban Areas of Bobo-Dioulasso(Burkina Faso)
The purpose of this is to determine the impact of intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) on the morbidities associated with malaria in pregnant women and newborns in rural peri-urban areas of…
- Trial name
- NCT01255605
- Where
- Burkina Faso
- Volunteers
- 772 people
- Sponsor
- Université Polytechnique de Bobo-Dioulasso
Malaria, Anemia
Intermittent Preventive Treatment (IPTi) for the Prevention of Malaria and Anaemia in PNG Infants
In malaria-endemic areas, young children have an especially high risk of malaria morbidity and mortality. Malaria is estimated to cause up to 2 million deaths and 500 million clinical episodes in Africa alone.
- Trial name
- NCT00285662
- Where
- Papua New Guinea
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Papua New Guinea Institute of Medical Research
Malaria
School Based Malaria Control in Ugandan Schoolchildren
The investigators hypothesize that schoolchildren treated with IPT using DP over one year of follow-up will have a different risk of clinical malaria compared to those treated with placebo.
- Trial name
- SBMC (NCT01231880)
- Testing
- Four monthly IPT with dihydroartemisinin Piperaquine (DP), Monthly IPT using DP
- Where
- Uganda
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- Makerere University
Malaria, Anaemia
Intermittent Parasite Clearance (IPC) in Schools: Impact on Malaria, Anaemia and Cognition
Although the risk of malaria is greatest in early childhood, significant numbers of schoolchildren remain at risk from malaria infection, clinical illness and death.
- Trial name
- NCT01454752
- Testing
- Intermittent parasite clearance
- Where
- Senegal
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Prevention of Malaria With Dihydroartemisinine + Piperaquine for Forest Rangers
The purpose of the study is to assess if the antimalarial drugs Dihydroartemisinine + Piperaquine (DP) are effective in preventing malaria infection for forest ranger
- Trial name
- PREMAL (NCT02788864)
- Testing
- Arterakine (DHA/piperaquine)
- Where
- Vietnam
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Pregnancy Complications Parasitic
Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria
The study has two components: component A is a cohort study to determine the in vivo efficacy of SP to clear and prevent malaria parasitaemia in asymptomatic pregnant women and component B is a cross sectional study of women…
- Trial name
- OR1 (NCT01636895)
- Testing
- Efficacy of suphladoxine/pyrimethamine as IPTp
- Where
- Nigeria
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Malaria Consortium, UK
Malaria,Falciparum, Anemia in Children
Comparing Chemoprevention Approaches for School-based Malaria Control
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent screening and treatment (IST) - students will receive treatment if they have a…
- Trial name
- NCT05244954
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine
- Where
- Malawi
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
HIV Infections, Malaria
Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients
Malarone® (atovaquone/proguanil) is frequently used in malaria prophylaxis. Unfortunately, there are indications that certain anti-HIV agents may decrease atovaquone plasma levels by induction of atovaquone metabolism.
- Trial name
- NCT00421473
- Testing
- Atovaquone / Proguanil
- Where
- 5 sites in Netherlands
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Malaria
Innovative Intermittent Preventive Treatment Approaches to Reduce Malaria Burden in School-age Children in Burkina Faso
This will be an open label cluster randomized study with two active intervention and one control arm. A cluster will be defined as a selected village.
- Trial name
- BF-IPTsc (NCT05946642)
- Testing
- Sulphadoxine-Pyrimethamine/Amodiaquine, Dihydroartemisinin/Piperaquine (DP) plus Ivermectin (IVM)
- Where
- Burkina Faso
- Volunteers
- 13,000 people
- Sponsor
- Malaria Consortium