Clinical trials: Malignant Gastric Outlet Obstruction
Gastric Outlet Obstruction
Magnetic Anastomosis Device Relief of Malignant Gastric Outlet Obstruction
The purpose of this study is to determine if the Cook Magnetic Anastomosis Device can be used to safely and successfully create a patent gastrojejunal anastomosis in subjects requiring treatment of gastric outlet obstruction…
- Trial name
- MAD (NCT00487552)
- Testing
- Cook Magnetic Anastomosis Device (MAD) with Stent
- Where
- 4 sites in Belgium, Italy and 1 more
- Volunteers
- 18 people
- Sponsor
- Cook Group Incorporated
Gastric Outlet Obstruction
EUS-GE vs ES for Palliation of Gastric Outlet Obstruction
Gastric outlet obstruction (GOO) is a common complication of luminal malignancies which is associated with substantial morbidity.
- Trial name
- NCT03259763
- Testing
- Lumen-apposing metal stent, Self-expandable metal stent
- Where
- 9 sites in United States, Canada and 5 more
- Volunteers
- 112 people
- Sponsor
- Johns Hopkins University
B Cell Lymphoma, NHL, Adult
SynKIR-310 for Relapsed/Refractory B-NHL
This first-in-human (FIH) trial is designed to assess the safety, feasibility and preliminary efficacy of a single intravenous (IV) dose of SynKIR-310 administered to participants with relapsed/refractory B-NHL.
- Conditions
- B Cell Lymphoma, NHL, Adult, Mantle Cell Lymphoma, Relapsed Non-Hodgkin Lymphoma
- Trial name
- NCT06544265
- Testing
- SynKIR-310
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Verismo Therapeutics
Gastric Outlet Obstruction
EUS-guided Versus Laparoscopic Gastrojejunostomy for Malignant Gastric Outlet Obstruction
Gastric outlet obstruction (GOO) is a common complication of various types of malignancy arising from the pancreas, bile ducts, retroperitoneum and distal stomach.
- Trial name
- EATING (NCT05605327)
- Testing
- EUS-guided gastroenterostomy, Laparoscopic gastroenterostomy
- Volunteers
- 120 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastric Outlet Obstruction
EPASS Versus Uncovered Duodenal Stent for Unresectable Malignant Gastric Outlet Obstruction.
Surgical gastrojejunostomy is the conventional treatment for palliating patients suffering from of inoperable malignant gastric outlet obstruction (GOO).
- Trial name
- NCT03823690
- Testing
- EUS-guided gastrojejunstomy, The pyloro-duodenal stent
- Where
- Hong Kong
- Volunteers
- 97 people
- Sponsor
- Chinese University of Hong Kong
Stomach Neoplasms, Gastric Outlet Obstruction
Malignant Gastric Outlet Obstruction Study With Stomach Partitioning (GO-PART)
The goal of this clinical trial is to evaluate whether stomach-partitioning gastrojejunostomy (SPGJ) more effectively reduces postoperative delayed gastric emptying (DGE) compared to conventional gastrojejunostomy (CGJ) in…
- Trial name
- GO-PART (NCT07749326)
- Testing
- Conventional Gastrojejunostomy, Stomach-Partitioning
- Where
- South Korea
- Volunteers
- 144 people
- Sponsor
- Gyeongsang National University Hospital
Malignant Gastric Outlet Obstruction
Roux-en-Y Gastric Bypass Versus Loop Gastrojejunostomy for Malignant Gastric Outlet Obstruction
This study is intended to investigate whether roux-en-y bypass surgery is superior to conventional loop gastrojejunostomy for Malignant gastric outlet obstruction in terms of tolerance to solid food intake.
- Trial name
- NCT05986890
- Testing
- Roux-en-Y Bypass, gastrojejunostomy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Corewell Health West
Gastric Cancer, Gastric Outlet Obstruction
Stomach-Partitioning Versus Conventional Gastrojejunostomy for Malignant Gastric Outlet Obstruction: A Multicenter Randomized Controlled Trial
Gastric outlet obstruction (GOO) complicates locally advanced or metastatic gastric cancer and severely impairs oral intake, nutritional status, and quality of life.
- Trial name
- NCT07561073
- Testing
- stomach-partitioning gastrojejunostomy, conventional gastrojejunostomy
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- Guangxi Medical University
Unresectable Malignant Gastric Outlet Obstruction
Partially Covered Versus Uncovered Pyloro-duodenal Stents for Unresectable Malignant Gastric Outlet Obstruction. A Double Blinded Randomised Controlled Trial.
To compare the efficacy of a novel partially covered (PC) versus uncovered (UC) pyloro-duodenal stents (DS) in unresectable malignant gastric outlet obstruction.
- Trial name
- NCT03223831
- Testing
- Partially covered pyloro-duodenal stent, Uncovered pyloro-duodenal stents
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Chinese University of Hong Kong
Anaplastic Astrocytoma, Anaplastic Ependymoma
SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
Approximately 90% of children with malignant brain tumors that have recurred or relapsed after receiving conventional therapy will die of disease.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Ependymoma, Anaplastic Ganglioglioma, Anaplastic Meningioma
- Trial name
- NCT03434262
- Testing
- Gemcitabine, ribociclib, sonidegib
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- St. Jude Children's Research Hospital
Jaundice
Biliary Drainage in Patients With Duodenal Metal Stent
This is a retrospective study to evaluate the outcomes of endoscopic biliary drainage according to the timing of distal malignant biliary obstruction (MBO) in relation to gastric outlet obstruction (GOO) and the location of GOO.
- Trial name
- NCT02376907
- Testing
- Biliary drainage
- Where
- 25 sites in China, Hong Kong and 7 more
- Volunteers
- 200 people
- Sponsor
- Tokyo University
Diffuse Large B-cell-lymphoma, DLBCL, Nos Genetic Subtypes
Clinical Study of C402-CD19-CAR Treatment in Subjects With Relapsed or Refractory B-cell Lymphoma
This study is to investigate the safety and tolerability of C402-CD19-CAR treatment in subjects with relapsed or refractory large B-cell lymphoma and further determine the recommended Phase 2 dose of C402-CD19-CAR.
- Conditions
- Diffuse Large B-cell-lymphoma, DLBCL, Nos Genetic Subtypes, Follicular Lymphoma Grade 3B, PMBL
- Trial name
- C402 (NCT06830031)
- Testing
- C402-CD19-CAR
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Exuma Biotechnology Ltd.
Glioblastoma Multiforme, Anaplastic Astrocytoma
INCB7839 in Treating Children With Recurrent/Progressive High-Grade Gliomas
This is a multicenter phase 1 trial of INCB7839 for children with recurrent or progressive high-grade gliomas, including, but not limited to, diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs), after…
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, DIPG
- Trial name
- NCT04295759
- Testing
- INCB7839
- Where
- 11 sites in United States
- Volunteers
- 13 people
- Sponsor
- Pediatric Brain Tumor Consortium
Malignant Gastric Outlet Obstruction
Endoscopic Ultrasound-Guided Gastroenterostomy for Malignant Gastric Outlet Obstruction
Malignant gastric outlet obstruction is a very disabling complication of patients with gastric, duodenal, ampullary, pancreatic, or bile duct cancer and worsens their prognosis.
- Trial name
- NCT04810377
- Testing
- EUS-guided gastroenterostomy
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Gastric Outlet Obstruction
Clinical Trial of EPASS With Hot AXIOS System
A prospective, multi-center, single-arm study for unresectable malignant gastric outlet obstruction with EUS-guided double-balloon-occluded gastrojejunostomy bypass (EPASS)
- Trial name
- PASSAGE (NCT05644951)
- Testing
- Hot AXIOS system used for EPASS
- Where
- 6 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Boston Scientific Corporation
Duodenal Obstruction, Gastric Outlet Obstruction
EVOLUTION® Duodenal Stent for Duodenal or Gastric Outlet Obstruction Caused by Malignant Neoplasms
The objective of this investigation is to compile clinical experience on the use of the Evolution® Duodenal Stent (Cook Ireland), a CE marked device intended for the palliative treatment of duodenal or gastric outlet obstruction…
- Trial name
- NCT00991614
- Testing
- EVOLUTION® Duodenal Stent
- Where
- 6 sites in Australia, Canada and 3 more
- Volunteers
- 110 people
- Sponsor
- Cook Group Incorporated
Malignant Gastric Outlet Obstruction
Comparing Endoscopic Ultrasound vs Surgical Gastrojejunostomy for Management of GOO.
The goal of this interventional study is to learn about the outcomes between two options for the management of malignant gastric outlet obstruction.
- Trial name
- RESTORE (NCT06128018)
- Testing
- Surgical gastrojejunostomy (S-GJ), EUS-guided gastrojejunostomy (EUS-GJ)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- AdventHealth
Malignant Gastric Outlet Obstruction
Endoscopic Ultrasound-guided Versus Surgical Gastroenterostomy for Malignant Gastric Outlet Obstruction
Gastric outlet obstruction (GOO), defined by a mechanical obstruction of the duodenum, pylorus, or antrum, may result from various diseases.
- Trial name
- NCT05564143
- Testing
- EUS-guided gastroenterostomy (EUS-GE), Laparoscopic gastroenterostomy (LGE)
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Malignant Small Bowel Obstruction, Malignant Gastric Outlet Obstruction
AspireAssist for Palliative Venting Gastrostomy in Malignant Bowel Obstruction Patients
Individuals with cancer causing an intestinal or stomach obstruction often require gastric drainage to prevent symptoms of nausea, vomiting, and to prevent aspiration.
- Trial name
- NCT04375462
- Testing
- AspireAssist device, Standard decompressive PEG tube, gastric outlet obstruction scoring system (GOOSS) questionnaire
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center
Biliary Intervention, Altered Anatomy
EUS-directed Transenteric ERCP (EDEE) in Patients With Benign and Malignant Underlying Conditions and Inaccessible Papilla/Biliodigestive Anastomosis (BDA)
Safety and efficacy of EDEE (EUS-directed transenteric ERCP)
- Conditions
- Biliary Intervention, Altered Anatomy, Malignant Gastric Outlet Obstruction, EUS Guided Enteroenteric Anastomosis
- Trial name
- NCT07096895
- Testing
- EDEE (EUS-directed transenteric ERCP)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Evangelisches Krankenhaus Düsseldorf