Clinical trials: Malignant Pleural Effusion
Pleural Effusion, Malignant, Pleurodesis
Rapid Pleurodesis Through an Indwelling Pleural Catheter
The primary objective of the study is to evaluate whether the use of a rapid pleurodesis protocol using 10% iodopovidone immediately after tunneled pleural catheter placement improves time to IPC removal compared to patients who…
- Conditions
- Pleural Effusion, Malignant, Pleurodesis, Pleural Diseases
- Trial name
- RAPID (NCT03325192)
- Testing
- Rapid pleurodesis protocol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pennsylvania
Malignant Pleural Effusion, Stage IV Metastatic Cancer
A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion
This is a Phase Ib/II clinical trial to evaluate the feasibility of administering talimogene laherparepvec into the intrapleural space of subjects with malignant pleural effusion through a pleurX catheter.
- Conditions
- Malignant Pleural Effusion, Stage IV Metastatic Cancer, Lung Cancer
- Trial name
- NCT03597009
- Testing
- Talimogene laherparepvec (TVEC), Nivolumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lung Cancer
Single Agent Alimta in Poor Performance Status in Non-small Cell Lung Cancer
The goal of this clinical research study is to learn how effective the drug pemetrexed (ALIMTA®) is in treating advanced NSCLC in patients with poor performance status (PS) (inability to perform every day activities without…
- Trial name
- NCT00508144
- Testing
- Alimta
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer
BAY 43-9006 in Previously Untreated Patients With Non-Small Cell Lung Cancer (NSCLC)
The goal of this study is to find the highest tolerable dose of BAY 43-9006 (sorafenib) and bevacizumab that can be given with paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC).
- Trial name
- NCT00533585
- Testing
- BAY 43-9006, Paclitaxel, Carboplatin
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Pleural Effusion, Malignant, Lung Cancer
Prognostic Factors on Malignant Pleural Effusion
Malignant pleural effusion can occur in up to half of the patients with metastatic disease. It can cause shortness of breath to patients and so far there is no protocol on its management.
- Trial name
- NCT03276715
- Where
- Hong Kong
- Volunteers
- 233 people
- Sponsor
- The University of Hong Kong
Malignant Pleural Effusion, Malignant Ascites
Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites
The objective of this study is to compare the efficacy of Endostar/cisplatin with cisplatin alone or Endostar alone in patients with malignant pleural effusion or ascites.
- Trial name
- NCT01327235
- Testing
- Endostar, Cisplatin
- Where
- 3 sites in China
- Volunteers
- 336 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Malignant Ascites, Malignant Pleural Effusion
Cediranib as Palliative Treatment in Patients With Symptomatic Malignant Ascites or Pleural Effusion
In some patients with cancer there are also cancer cells in the abdominal cavity or between the lung membranes. These cancer cells create too much moisture in the abdominal cavity or between the lung membranes.
- Trial name
- NCT01262612
- Testing
- immediate cediranib, Start cediranib after 28 days Best Supportive Care
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Radboud University Medical Center
Non Small Cell Lung Cancer
Efficacy and Safety Study of Medical Thoracoscope Cryotherapy Combined Standard First-line Treatment of Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion
This study intends to investigate the efficacy and safety of medical thoracoscopic cryotherapy combined with standard first-line treatment of advanced non-small cell lung cancer with malignant pleural effusion through a…
- Trial name
- NCT05291403
- Testing
- Medical thoracoscopic cryotherapy combined with standard first-line therapy for advanced non-cell lung cancer, Sequential intrathoracic injection of cisplatin/erythromycin combined with standard first-line therapy for advanced non-cell lung cancer, Standard first-line therapy for advanced non-cell lung cancer without intrathoracic treatment
- Where
- China
- Volunteers
- 141 people
- Sponsor
- Qianfoshan Hospital
Malignant Pleural Effusion
Safety and Effectiveness of a New Pleural Catheter for Symptomatic, Recurrent, MPEs Versus Approved Pleural Catheter
The purpose of this study is to determine whether a new catheter is safe and effective in treating malignant pleural effusions compared to approve catheter.
- Trial name
- SWIFT (NCT02649894)
- Testing
- Active Comparator: Approved Uncoated PleurX Indwelling Pleural Catheter, Experimental: Silver Nitrate Coated Indwelling Pleural Catheter (SNCIPC)
- Where
- 19 sites in United States, United Kingdom
- Volunteers
- 119 people
- Sponsor
- C. R. Bard
Pleural Effusion, Cancer
Pleuroscopy First Versus Thoracentesis First in Patients With Suspected Malignant Pleural Effusions
This is a randomized control trial of patients with suspected malignant pleural effusions to compare whether patients who have a thoracentesis or pleuroscopy (pleural biopsy) obtain an adequate biopsy, achieve a diagnosis, and…
- Trial name
- PERFECT-MPE (NCT06892691)
- Testing
- Pleuroscopy first, Thoracentesis first
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Malignant Pleural Effusion, Malignant Ascites
Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer
The purpose of this study to find out if tocilizumab can be safely infused into chest or abdominal cavities of patients with malignancy ascites (MA) or malignant pleural effusions (MPE).
- Trial name
- RIOT2 (NCT06016179)
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Advanced Cancers, Malignant Pleural Effusions
Indwelling Pleural Catheter With Either Doxycycline or Saline at Day 7 for Pleurodesis
The goal of this clinical research study is to compare indwelling pleural catheters (IPC) in combination with saline (the current standard of care) versus IPC in combination with doxycycline as treatment for pleural effusions.
- Trial name
- NCT02623959
- Testing
- Questionnaires, Fentanyl Patch, Fentanyl (IV)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Malignant Pleural Effusions (Mpe)- Pleurodesis, Pleurodesis
Thoracoscopic Talc Pleurodesis Versus Bleomycin -Tranxemic Acid Mixture Injection in Chest Tube in Malignant Pleural Effusion
Comparing Two Methods to Treat Fluid Build-up in Chest for Cancer Patients:Talc Powder Surgery versus Chest Tube Medicine.
- Trial name
- NCT06744946
- Testing
- thoracoscope
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mohamed Sabry
Malignant Pleural Effusion, Malignant Peritoneal Effusion
Safety and Efficacy Study of Virus Activated Killer Immune Cells (VAK) for Malignant Pleural and Peritoneal Effusion
Theory of VAK： 1. Immune cells (T cells for example) of cancer subjects may be domesticated by the tumor microenvironment, and have low efficacy to kill cancer cells.
- Trial name
- NCT05565014
- Testing
- Virus Activated Killer immune Cells, Saline
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sheng Hu
Malignant Pleural Effusion
A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion
Malignant pleural effusion (MPE) arises in advanced-stages of malignancies and frequently heralds a poor prognosis.If the underlying malignancy is chemo sensitive (e.g., small-cell carcinoma of lung \& lymphoma), systemic…
- Trial name
- NCT02583282
- Testing
- Doxycycline, Iodopovidine
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
NSCLC
Detection of EGFR Mutation in Malignant Pleural Effusion of Lung Cancer Patients and Cancer Cell Lines Establishment
1. Detection EGFR mutation of cancer cells from malignant pleural effusion. 2. Established the cancer cell lines with without EGFR mutation from malignant pleural effusion.
- Trial name
- EGFR (NCT00752076)
- Testing
- cancer cell lines establishment
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Pleural Effusion, Heart Failure
Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)
To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).
- Conditions
- Pleural Effusion, Heart Failure, Malignant Neoplasm, Fluid Overload
- Trial name
- NCT05797649
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- Chinese University of Hong Kong
Pleural Effusion, Malignant
Cancer Ratio,Pleural Fluid Adenosine Deaminase,Lactate Dehydrogenase, interferonY, Tumor Necrosis Factor,and Interleukins{2,12,18}for Differentiation Between Malignant and Non Malignant Pleural Effusion
To evaluate the ability of cancer ratio and pleural fluid markers to discriminate between malignant and non malignant effusion
- Trial name
- NCT05693727
- Testing
- pleural markers
- Volunteers
- 100 people
- Sponsor
- Assiut University
Non-Small Cell Lung Cancer
Multicenter Observational Study of Advanced Non-small Cell Lung Cancer With Malignant Pleural Effusion
Multicenter observational study for correlation between tumor mutation burden and immunotherapy efficacy of advanced non-small cell lung cancer with malignant pleural effusion
- Trial name
- NCT04263688
- Testing
- Non-Intervention
- Volunteers
- 300 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Lung Cancer, Metastatic Cancer
Identifying Early Lung Cancer Cells in Malignant Pleural Effusion Samples From Patients With Primary Lung Cancer
RATIONALE: Studying samples of pleural fluid in the laboratory from patients with lung cancer may help doctors identify early lung cancer cells. It may also help the study of lung cancer in the future.
- Trial name
- NCT00897143
- Testing
- microarray analysis, mutation analysis, flow cytometry
- Where
- United States
- Sponsor
- Case Comprehensive Cancer Center