Clinical trials: Management
Alzheimer's Disease
Relative Bioavailability Study in Healthy Subjects to Evaluate the Pharmacokinetics of HTL0009936 After One Dose of Prototype Formulation
The purpose of this study is to find a modified release oral tablet formulation for this drug, which will be safe and well tolerated.
- Trial name
- NCT02710188
- Testing
- HTL0009936 modified release, HTL0009936 immediate release
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Nxera Pharma UK Limited
Gestational Age and Weight Conditions, Health Knowledge, Attitudes, Practice
Pregnancy Weight Management Health Literacy Questionnaire
Worldwide obesity has continued to increase over the past decades. Among the adult women, the overweight and obesity rates in Taiwan are much higher than that of women in nearby Asian countries.
- Trial name
- PWMHLQ (NCT05042427)
- Testing
- Pregnancy Weight Management Health Literacy Questionnaire
- Where
- Taiwan
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Chao-Hui, Lee
Neurogenic Bowel
Electrical Stimulation of Abdominal Muscles for Bowel Management in People With Spinal Cord Injury
A well-managed bowel program is an essential part of daily life for many people with a SCI. Nevertheless, constipation is frequently reported (42-95%).
- Trial name
- BOWMAN (NCT04307303)
- Testing
- abdominal functional electrical stimulation
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Salisbury NHS Foundation Trust
Neonatal Resuscitation, Clinical Competence
POV Video and Mental Practice Training for Neonatal LMA Insertion
This prospective, randomized, single-blind simulation study aims to evaluate and compare the educational efficacy of a hybrid instructional modality-combining point-of-view (POV) video training and structured mental practice…
- Conditions
- Neonatal Resuscitation, Clinical Competence, Simulation Training, Airway Management
- Trial name
- NCT07678424
- Testing
- Standard Instructor Demonstration, POV Video and Mental Practice
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Streptococcus Pneumoniae Infection
Clinical Trial of the 24-valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/Tetanus Toxoid)
This clinical trial consists of Phase I and Phase II. The objective is to evaluate the safety and immunogenicity of the 24-valent pneumococcal polysaccharide conjugate vaccine (CRM197/tetanus toxoid) in individuals aged 2 months…
- Trial name
- NCT07600983
- Testing
- 24-valent pneumococcal polysaccharide conjugate vaccine (CRM197/tetanus toxoid) (referred to as PCV24) (dose M), PCV24 vaccine (dose H), PCV24 vaccine (dose M)
- Where
- 2 sites in China
- Volunteers
- 854 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Obesity, Overweight
Balance: A Pragmatic Trial of a Digital Health Intervention to Prevent Weight Gain in Primary Care
Up to 50% of obese patients are not interested in, or ready for, weight loss. Clinical practice guidelines clearly recommend that these patients avoid gaining weight.
- Conditions
- Obesity, Overweight, Overnutrition, Nutrition Disorders
- Trial name
- D0479 (NCT03003403)
- Testing
- Intervention Program
- Where
- United States
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy
A Study of Darunavir in the Presence of Cobicistat When Administered as a Fixed Dose Combination Under Fed Conditions
The purpose of this study is to evaluate the single-dose Pharmacokinetic (PK) and bioequivalence of darunavir (DRV) in the presence of cobicistat (COBI) when administered as a scored fixed dose combination (FDC) tablet (DRV/COBI)…
- Trial name
- NCT04718805
- Testing
- Darunavir, Cobicistat, Darunavir/Cobicistat FDC
- Where
- Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Dilated Cardiomyopathy
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants.
The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of AZD0233 following single and multiple ascending dose (SAD and MAD) administration in healthy participants.
- Trial name
- NCT06381466
- Testing
- AZD0233
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Satiety
Effects of Mixed Nut Consumption on Satiety and Weight Management
The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management.
- Trial name
- NCT03375866
- Testing
- Pretzels, Mixed nuts
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Cervical Intraepithelial Neoplasia
Feasibility of the Management of Severe Cervical Dysplasia in a Single Visit
1. Implement a single-visit program (SVP) for cervix cancer prevention in clinics serving a multi-ethnic population of women; 2.
- Trial name
- NCT00237562
- Testing
- Large loop electrosurgical excision
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Irvine
Chronic Hepatitis B
GLS4/RTV and TAF Drug-drug Interaction
The purpose of this study is to evaluate the drug-drug-interaction (DDI), pharmacokinetics (PK) and tolerability of GLS4/RTV combined with TAF in healthy subjects.
- Trial name
- NCT04551261
- Testing
- GLS4, RTV, TAF
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Irreversible Pulpitis
Post Operative Pain and Oral Health Related Quality of Life Following Pulpotomy VS Extraction of Permanent First Molar
The goal of this clinical trial is to compare between post operative pain and oral health related quality of life in participants receiving two treatments for first permanent mandibular molars with poor prognosis.
- Trial name
- NCT06420583
- Testing
- MTA pulpotomy, Extraction
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mood
Mood Management Effects of Brief Unsupported Internet Interventions
The main goal of this study was to compare the effect of a one-session unsupported Internet intervention on participants' clinical symptoms (depressive and anxiety symptoms) and related variables (mood, confidence and motivation).
- Trial name
- NCT02748954
- Testing
- Thoughts, Activities., Assertiveness.
- Volunteers
- 765 people, healthy volunteers welcome
- Sponsor
- i4Health
Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy
This clinical trial tests how well a geriatric assessment (GA) with GA-directed treatment recommendations, compared to GA with usual care, works in identifying risk factors, reducing chemotherapy radiation toxicity and functional…
- Trial name
- NCT06139627
- Testing
- Best Practice, Biospecimen Collection, Communication Intervention
- Where
- 3 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Plasmodium Falciparum Malaria, Malaria
Effect of Plasmodium Falciparum Exposure and Sickle Cell Trait on Infection Rates and Kinetics After IV Administration of PfSPZ Challenge
The study is designed to establish infectivity of Plasmodium falciparum sporozoites (PfSPZ) via intravenous (IV) administration in three groups with different malaria immunity-status: 1.
- Trial name
- NCT02237586
- Testing
- PfSPZ Challenge
- Where
- Gabon
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sanaria Inc.
Sentinel Lymph Node Biopsy, MRI
The Combination of Preoperative MRI and SLN in the Surgical Management of CC and EC
The aim of the study was to evaluate the diagnostic value of MRI and/or SLN mapping alone or in combination in cervical (CC) and endometrial cancer (EC) patients.
- Trial name
- NCT05942170
- Testing
- ICG/ blue dye
- Where
- China
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Buckle Fracture, Patient Satisfaction
Home Management of Pediatric Buckle Fractures
The goal of this clinical trial is to determine if a home management plan incorporating video education can effectively replace in-person visits for children aged 7-17 diagnosed with distal radius buckle fractures.
- Trial name
- HM-PBF (NCT06633094)
- Testing
- Educational videos
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Gut Health, Body Composition
A Clinical Trial to Evaluate the Effects of Cowboy Colostrum on Gut Health, Body Composition, Hair Growth, and Skin Appearance
This study evaluates the effects of Cowboy Colostrum bovine colostrum powder on gut health, body composition, hair growth, and skin appearance in generally healthy adults aged 21-47 with concerns in these areas.
- Conditions
- Gut Health, Body Composition, Hair Growth, Skin Appearance
- Trial name
- NCT07756866
- Testing
- Cowboy Colostrum
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cowboy Colostrum
Methemoglobinemia, Anemia, Iron-Deficiency
Ferric Carboxymaltose Methemoglobinemia Study
Anemia that develops due to iron deficiency is called iron deficiency anemia. This common condition is treated with iron supplements taken either orally or given through an intravenous (IV) infusion.
- Conditions
- Methemoglobinemia, Anemia, Iron-Deficiency, Parenteral Iron Therapy, Ferric Carboxymaltose
- Trial name
- FerMet (NCT06958822)
- Testing
- Ferric Carboxymaltose (FCM)
- Where
- 23 sites in Turkey (Türkiye)
- Volunteers
- 977 people, healthy volunteers welcome
- Sponsor
- Ordu University
Diabetes Mellitus, Gestational
Gestational Diabetes Management Based on Planned Behavior Theory
Our study was planned as a randomized controlled trial in order to determine the effect of Planned Behavior Theory based training model on diabetes management and pregnancy outcomes in women with Gestational Diabetes Mellitus.
- Trial name
- NCT04874922
- Testing
- Gestational Diabetes Training Intervention based on Planned Behavior Theory, Gestational Diabetes Training Intervention based on standart
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Koç University
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