Clinical trials: Management
Safety, Tolerability
A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD9977 After Single Ascending Doses to Healthy Males
This study will be a randomized, single-blind, placebo-controlled first-in-human study in healthy male subjects to assess the safety, tolerability and pharmacokinetics of single ascending doses of AZD9977.
- Conditions
- Safety, Tolerability, Pharmacokinetics, Healthy Subjects
- Trial name
- NCT02484729
- Testing
- AZD9977, oral suspension, AZD9977, oral solution
- Where
- United Kingdom
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Post-operative Pain
Post-operative Oral Morphine Versus Ibuprofen
Children 5-17 years of age who have undergo orthopedic day surgical procedures for definitive management of fractures, tendon release, etc.
- Trial name
- NCT01686802
- Testing
- oral morphine, Ibuprofen
- Where
- Canada
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Venous Thrombosis
A Study of MK-2060 in Healthy Participants (MK-2060-016)
The goal of the study is to learn about the safety of MK-2060 and if people tolerate it when MK-2060 is given in different forms.
- Trial name
- NCT06582602
- Testing
- MK-2060
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Age-Related Macular Degeneration
Personalized Shared Eye-care Identification of Age-related Macular Degeneration Using Artificial Intelligence and Telemedicine by Matching Optometrist Office-based Sites With Clinical Supervision
Office-based optometrist centres equipped with low-cost OCT devices can be used for screening of age-related macular degeneration.
- Trial name
- PYRENEES (NCT06465212)
- Testing
- TopCon Maestro 2 OCT
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Infertility
Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles
This is a randomized, double-blind, single center clinical trial study to compare oocyte competence and risk of ovarian hyperstimulation syndrome (OHSS) after receiving the standard dose of human chorionic gonadotropin (hCG)…
- Trial name
- NCT02310919
- Testing
- Low dose hCG plus FSH co-trigger, Standard dose of hCG
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Fasted State
Pharmacokinetic Study With Levodopa-carbidopa Fixed-dose Products in Healthy Subjects After Oral Administration
The study is carried-out to describe and compare the plasma pharmacokinetics of levodopa and carbidopa after oral single-dose administration of 100 mg levodopa plus 25 mg carbidopa by means two fixed combination products (test…
- Trial name
- LCD18K (NCT02116465)
- Testing
- Levodopa Carbidopa immediate release tablets
- Where
- Bulgaria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Desitin Arzneimittel GmbH
Educational Activities
A Comparison of Clinical Simulation and Classical Learning for Airway Management in Medical Students
Multiple studies have shown clinical simulation benefits over classical learning method. Research on simulation of airway management has focused on endotracheal intubation training, while research on ventilation via facemask is…
- Trial name
- NCT03071367
- Testing
- Clinical Simulation
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Fundación Santa Fe de Bogota
Healthy
To Evaluate the Pharmacokinetic Characteristics and Safety in Healthy Volunteers
The objective is to evaluate the safety and pharmacokinetic characteristics after co-administration of JW0202 and C2202 and co-administration of C2205 and JW0201 in healthy volunteers under fasting conditions
- Trial name
- NCT06361277
- Testing
- Reference Drug or Test Drug
- Where
- South Korea
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- JW Pharmaceutical
Healthy
A Study in Healthy People to See How Zongertinib is Taken up Into the Blood When Given as Tablets Made by Two Different Manufacturers
The main objective of this trial is to establish the bioequivalence of zongertinib tablet from manufacturer 1 (Test, T) compared with zongertinib tablet from manufacturer 2 (reference, R) following oral administration.
- Trial name
- NCT06360081
- Testing
- Zongertinib manufacturer 1, Zongertinib manufacturer 2
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Endometriosis
Characterization of Immune Cells and Their Secreted Cytokines in Endometriosis Patients
The EUmetriosis project aims to address the most important unmet needs of endometriosis sufferers to advance patient care. The objectives cover all main aspects of disease management, including elucidating the pathogenesis…
- Trial name
- EUmetriosis (NCT06897436)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Compression Fracture
QOCA®-Image Medical Platform - Smart VCF Risk Management System
This project aims to develop and validate an automatic detection and classification system for vertebral compression fractures on computer tomography (CT) images using an artificial intelligence (AI) system (named Smart Bone) by…
- Trial name
- NCT04384211
- Testing
- Computer Assisted Detection Software For Vertebral Fractures
- Where
- Taiwan
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Comparative Bioavailability
Bioequivalence Study of Gliclazide 120 mg Modified Release Tablets
The main purpose of this study is to assess comparative bioavailability of two test formulations of Gliclazide 120 mg Modified Release tablets (120 mg gliclazide per modified release tablet) Manufactured By Indeus Life Sciences…
- Trial name
- NCT02980757
- Testing
- Gliclazide 120 mg MR Tablets Formula A, Gliclazide 120 mg MR Tablets, Gliclazide 120 mg MR Tablets Formula B
- Where
- Jordan
- Volunteers
- healthy volunteers welcome
- Sponsor
- Disphar International B.V.
Pharmacokinetics of ASP015K, Drug Interactions
Pharmacokinetic Interaction Study to Assess the Effect of ASP015K on Tacrolimus in Healthy Volunteers
This study characterizes the pharmacokinetic effects of ASP015K on Tacrolimus in healthy volunteers.
- Conditions
- Pharmacokinetics of ASP015K, Drug Interactions, Healthy Subjects
- Trial name
- NCT01430065
- Testing
- ASP015K, Tacrolimus
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Bioequivalence
The Bioequivalence Study of Two Different Formulations of Candesartan Cilexetil After a Single Oral Dose Administration Under Fasting Conditions
This single dose study was designed in accordance with EMA (the European Medicines Agency) regulatory guidelines, with the aim of characterizing the bioavailability of candesartan in the two formulations in healthy subjects.
- Trial name
- NCT04012307
- Testing
- Candesartan Cilexetil 32mg, Atacand® PROTECT
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pharmtechnology LLC
Pain Management
MBCT for Cancer Patients in Follow-Up
The objectives of the present study are: 1) to executing the practical implementation in an oncology department of MBCT for patients who have completed their primary treatment and experience significant cancer- and…
- Trial name
- NCT03591237
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- 2 sites in Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Non-alcoholic Steatohepatitis
A Thorough QTC Study to Assess the Effect of Cotadutide on Cardiac Repolarization in Healthy Participants
This study will investigate the effect of multiple doses of cotadutide on the cardiac activity (QTc interval) of healthy participants.
- Trial name
- NCT05668936
- Testing
- Cotadutide, Moxifloxacin
- Where
- Germany
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Dental Trauma
Awareness of Parents About Management of Dental Avulsion
Aim of the study: assessment of level of awareness of parents about emergency management of permanent teeth avulsion in children
- Trial name
- NCT05815277
- Where
- Egypt
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Cairo University
Type 2 Diabetes
Type 2 Diabetes Self-management Intervention for Low-income Women
The purpose of this study is to assess the extent to which a culturally appropriate, self-management intervention that combines patient education with a patient outreach liaison strategy improves outcomes associated with type-2…
- Trial name
- NCT01284465
- Testing
- Education and patient liaison combination, Control group
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Malaria
Impact of Malaria Mass Drug Administration on Malaria Prevalence in Under 15 Children and Pregnant Women
This is a clinical trial being done to find better ways to reduce malaria in the community. Malaria is caused by a parasite that is spread by mosquitoes.
- Trial name
- NCT07358767
- Testing
- Artemether-lumefantrine (AL)
- Where
- Ghana
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Noguchi Memorial Institute for Medical Research
Analgesia, Anxiety
Analgesic and Anxiety Efficacy of Preemptive Pregabalin
Effective postoperative pain control after arthroscopic shoulder surgery optimizes postoperative rehabilitation, reduces anxiety, and can increase patient satisfaction and postoperative healing by providing amnesia and sedation.
- Conditions
- Analgesia, Anxiety, Arthroscopic Shoulder Surgery
- Trial name
- NCT04675671
- Testing
- Preoperative and postoperative anxiety measurement [Spielberger's State Anxiety Scale (STAI-S)] and [ Spielberg's State-Trait Anxiety Inventory (STAI-T) ]
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Selcuk University
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