Clinical trials: Management
Hyperlipidemia, Diabetes
Point-of-Care Testing (POCT) Detection and Management of Metabolic Syndrome in Patients With Mental Illness
The study was a 12-month, multi-centered, quasi-experimental design to assess point-of-care (POCT) screening/monitoring of subjects on antipsychotic agents for metabolic syndrome.
- Conditions
- Hyperlipidemia, Diabetes, Hypertension
- Trial name
- NCT02029989
- Testing
- Glucose and lipids, Glycosylated Hemoglobin A1c, Blood Pressure and Heart Rate
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Depression
Global CALM Implementation Study
This study seeks to evaluate the implementation of the Managing Cancer and Living Meaningfully (CALM) Program in diverse cultural settings, including its feasibility, fidelity, and acceptability.
- Trial name
- Global CALM (NCT04499690)
- Testing
- Managing Cancer and Living Meaningfully
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Healthy
Drug-Drug Interaction Study of Esomeprazole (D961H) Capsule and Loxoprofen Tablet After Repeated Oral Administration in Japanese Males
The purpose of this study is to evaluate the pharmacokinetic profile of Esomeprazole (D961H) during repeated oral administration with and without co-administration of loxoprofen and the pharmacokinetic profile of loxoprofen…
- Trial name
- NCT00676117
- Testing
- Esomeprazole (D961H), Loxoprofen
- Where
- Japan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity, Weight Loss
Implementation of Medical Weight Management by Telemedicine
As the prevalence and associated healthcare costs of obesity continue to increase, the need for obesity treatments that contribute to weight loss maintenance are needed.
- Conditions
- Obesity, Weight Loss, Telemedicine
- Trial name
- NCT03283618
- Testing
- Video Conferencing Group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- California State University, Long Beach
Healthy Volunteers
Phase I Study to Evaluate the Safety of Dexibuprofen 200mg Under Fasting and Fed Conditions
Phase I Study to Evaluate the Safety of Dexibuprofen 200mg (Apsen Pharmaceuticals A / S.) After a Single and Multiple Dose Oral Administration in Healthy Participants of Both Sexes Under Fasting and Fed Conditions.
- Trial name
- NCT02956525
- Testing
- Dexibuprofen
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Apsen Farmaceutica S.A.
Reproductive Physiological Phenomena
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.
The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration across the pubertal stages and adult group…
- Trial name
- NCT03286517
- Testing
- Kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany)
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ghulam Nabi
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Dry Eye Disease
Management of the Ocular Surface With Preservative-Free Lubricants in Patients With Dry Eye
Observational and prospective cohort study that seek to evaluate the epidemiological characteristics and changes in the ocular surface of patients diagnosed with dry eye disease who are treated with preservative-free lubricating…
- Trial name
- NCT06162442
- Testing
- Preservative-free sterile ophthalmic solution, with 0.3% propylene glycol and 0.4% polyethylene glycol (400)
- Where
- Colombia
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tecnoquimicas
Atopic Dermatitis (AD), Asthma
Post-authorization Safety Study in North America to Monitor Pregnancy and Infant Outcomes Following Administration of Dupilumab During Planned or Unexpected Pregnancy
The objective is to evaluate the potential effect of exposure to dupilumab in pregnancy compared to the primary comparison group of disease-matched pregnant women who are not exposed to dupilumab, and the secondary comparison…
- Trial name
- NCT04173442
- Testing
- dupilumab
- Where
- United States
- Volunteers
- 581 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Healthy Volunteers
A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers
The purpose of this study is to assess the influence of simultaneous CYP3A4 and p-glycoprotein inhibition on lenvatinib pharmacokinetics following a single oral dose of 5 mg lenvatinib.
- Trial name
- NCT02198170
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Obesity
The Effect of 5-Hydroxytryptophan (5-HTP) on Satiety
The aim of the study is to show evidence of the efficacy of 5-HTP to induce satiety and to reduce food intake (confirmatory study).
- Trial name
- NCT00328913
- Testing
- 5-hydroxytryptophan (food supplement)
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Exercise, Hypoxia
Effect of Oral Ketone and Sodium Bicarbonate Administration During Endurance Exercise in Hypoxia
This study is investigating the effects of oral ketone and sodium bicarbonate administration on physiological and metabolic parameters during cycling endurance exercise in hypoxia.
- Trial name
- NCT04579770
- Testing
- Ketone ester, Sodium bicarbonate
- Where
- Belgium
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jozef Stefan Institute
Post Operative Pain
Pre-incision Versus Lapaorscopic-assisted Transversus Abdominis Plane (TAP) and Rectus Sheath Block for Post-Cholecystectomy Pain
The goal of this clinical trial is to compare pre-incision vs laparoscopic assisted Transversus abdominis plane and rectus sheath block in patients undergoing laparoscopic cholecystectomy.
- Trial name
- NCT05856682
- Testing
- Laparoscopic-assisted TAP block(LATAP) and Rectus Sheath block
- Where
- Pakistan
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Patel Hospital, Pakistan
Pelvic Pain, Symphysis Pubis Dysfunction
Single Centre Blinded Randomized Controlled Trial Evaluating the Effectiveness of Two Pelvic Support Garments
This blinded randomized comparative trial aims to determine the effectiveness of a customized Dynamic Elastomeric Fabric Orthoses (DEFO) compared to a standard pelvic belt in: a) reducing pregnancy-related pelvic girdle pain…
- Trial name
- MAPS (NCT01820013)
- Testing
- Customised Dynamic Elastomeric fabric Orthoses, Serola Sacroiliac Belt
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Measles, Mumps
Immunogenicity and Safety of Concomitant Administration of MMR™ rHA and VARIVAX® by Intramuscular Versus Subcutaneous Route (V205C-011)
Primary objective: To compare if, when given concomitantly with VARIVAX® by the same route at 12-18 months of age using separate injection sites, a single dose of M-M-RTMII administered by IM route is as immunogenic as a single…
- Conditions
- Measles, Mumps, Varicella
- Trial name
- NCT00432523
- Testing
- M-M-R™II manufactured with recombinant Human Albumin (rHA) and VARIVAX®
- Where
- 2 sites in France, Germany
- Volunteers
- 752 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Healthy
Impact of Stress and Sleep Management on Emergency Professionals
The investigators hypothesize that a recovery management program could have an impact on emergency nurses and physicians by improving their sleep and reducing their psychological and physiological responses when dealing with…
- Trial name
- REST (NCT05251246)
- Testing
- recovery management program
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Tetanus, Acellular Pertussis
Evaluation of the Immunogenicity, Safety and Reactogenicity of the Combined DTPa-IPV Vaccine in Healthy Infants
DTPa and IPV vaccines are recommended for immunization of infants in Korea. The use of combination vaccines simplifies routine paediatric vaccination.
- Conditions
- Tetanus, Acellular Pertussis, Diphtheria
- Trial name
- NCT00290342
- Testing
- DTPa-IPV, DTPa, IMOVAX Polio®
- Where
- 9 sites in South Korea
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Infections, Rotavirus
To Test 2 Doses of GSK Biologicals' Oral Live Attenuated Human Rotavirus (HRV) Vaccine in Healthy Infants in Co-administration With Specific Childhood Vaccines
The main objectives of this study is to determine vaccine efficacy against any rotavirus (RV) gastroenteritis (GE) during the first efficacy period.
- Trial name
- NCT00140686
- Testing
- Rotavirus (vaccine)
- Where
- 101 sites in Czechia, Finland and 4 more
- Volunteers
- 3,994 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Subjects
Co-Administration Of Fosamprenavir With Methadone: A Drug Interaction Study.
To assess the combined effects of fosamprenavir 700mg BID + ritonavir 100mg BID + standardized dose of methadone, on plasma total and unbound methadone enantiomer pharmacokinetics (PK), opiate pharmacodynamic (PD) measures, and…
- Trial name
- NCT00481182
- Testing
- fosamprenavir + ritonavir + methadone
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Vaginal Infection
Interventional Study to Evaluate the Effect of the Oral Administration of L.Plantarum on Vaginal Microbiota
Vaginal microbiota is abundantly colonized by Lactobacillus genera. When vaginal microbiota gets altered, opportunistic microorganisms may proliferate and become abundant species giving rise to dysbiosis.
- Trial name
- NCT04461782
- Testing
- Lactobacillus plantarum
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AB Biotics, SA
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