Clinical trials: Management
Abdominal Hypertension, Abdominal Compartment Syndrome
Updated Abdominal Compartment Society Consensus Definitions
An international team of experts is working on a project called updated WSACS consensus definitions. The goals of this study are to: 1. To generate expert consensus on the definitions and classification of IAH and ACS. 2.
- Trial name
- WSACS (NCT07563842)
- Testing
- Delphi study
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Fetal Movement Perception
Use of Glucose and Saline for Fetal Movement Perception
The purpose of this study is to investigate the hypothesis that glucose administration increases fetal movement perception by the pregnant woman.
- Trial name
- NCT01308359
- Testing
- IV glucose 5%, saline
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Antimicrobial Agent, Cephalosporins
Effect of Ceftobiprole on Human Intestinal Microflora
The purpose of the study is to investigate the effect of ceftobiprole treatment on intestinal microflora in healthy volunteers.
- Conditions
- Antimicrobial Agent, Cephalosporins, Drug Resistance
- Trial name
- NCT00965042
- Testing
- Ceftobiprole
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Injection Pain, Local Anesthesia
Efficacy of Virtual Reality in Reducing Injection Pain and Anxiety During Local Anesthesia in Children
The aim of this study is to determine the efficacy of a virtual reality (VR) device in reducing injection pain and anxiety associated with local anesthesia in pediatric dental patients.
- Trial name
- NCT03772483
- Testing
- Local anesthesia with conventional syringe, Local anesthesia with conventional syringe + VR device
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Overweight, Obesity
A Controlled Study to Evaluate the Effects of a Supplement on Weight Loss, Blood Sugar, and Appetite Suppression
This is a randomized, controlled, hybrid clinical trial evaluating the effects of the Evolv GLP-1 supplement on weight loss, blood sugar regulation, and appetite suppression over 12 weeks.
- Conditions
- Overweight, Obesity, Blood Sugar Regulation, Appetite Suppression
- Trial name
- NCT07889570
- Testing
- Evolv GLP-1 Group, Control Group
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Evolv
Healthy, Behavior Management
Effect of Vibrasthetic Device on Pain Reduction During Local Anesthesia in Pediatric Patients
The goal of this clinical trial is to test if children aged between 6 and 14 years who are receiving a dental injection will feel less pain by using a vibration device applied to the injection site during the injection compared…
- Trial name
- NCT07306650
- Testing
- Vibrating device, Manual vibration
- Where
- Saudi Arabia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Acute Pain
ANI Versus Standard Care in Surgical Patients Receiving Balanced Sevoflurane-Fentanyl Anesthesia
This study aims to be a randomized, controlled study of ANI-guided opioid administration versus standard clinical practice in surgical patients undergoing general anesthesia with balanced sevoflurane-fentanyl.
- Trial name
- NCT03684590
- Testing
- ANI-guided opioid administration, Standard opioid administration
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Renal Colic
Acupuncture Versus IV Morphine in the Treatment of Acute Pain in ED
Renal colics are a common cause af acute intense pain in medical emergency settings requiring often the use of high level antalgics (opioid) to relief the patient.
- Trial name
- AcuMoPE (NCT02152410)
- Testing
- acupuncture, Morphine
- Where
- 2 sites in Tunisia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Obesity
Integrated Obesity Care Management System
Obesity is an important public health problem that is taking epidemic proportions worldwide. Indeed, nearly 50% of Canadians are obese and their number has increased dramatically in the last 20 years.
- Trial name
- NCT01385397
- Testing
- Preceptorship and virtual community
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Healthy
Investigation of Pharmacokinetics of BIBX 245 CL and Safety in Healthy Subjects
Aim of this trial is to investigate the single dose pharmacokinetics and the effect of food on single dose of 160 mg 245 CL (two 80 mg tablets) as well as its safety
- Trial name
- NCT02264197
- Testing
- BIBX 245 CL - fed, BIBX 245 CL- fasted
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Fuel Management
Elderberries and Obesity
Previous studies in humans indicate that anthocyanin-rich berries can positively alter fat oxidation and insulin sensitivity. This study will determine if this is also true with elderberries, which are a more concentrated source…
- Trial name
- NCT05723497
- Testing
- Elderberry juice
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Washington State University
Healthy Subjects
Comparison of Two Dose Strengths of Selexipag in Healthy Adults
Clinical study in healthy adult subjects to compare the adult tablet of selexipag with the tablet developed for children.
- Trial name
- NCT02745860
- Testing
- Selexipag (adult formulation), Selexipag (pediatric formulation)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Actelion
Heart Transplant Failure and Rejection, Heart Failure
HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
Heart transplantation is a life saving therapy for people with end stage heart failure. Acute rejection, a process where the immune system recognizes the transplanted heart as foreign and mounts a response against it, remains a…
- Conditions
- Heart Transplant Failure and Rejection, Heart Failure, Heart Diseases, Heart Failure，Congestive
- Trial name
- HEARTBiT (NCT03575910)
- Where
- 4 sites in United States, Canada
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Emotional Regulation, Examining the Emotion Regulation Effectiveness to be Given to Adolescents
Emotional Management in Adolescents
This study aims to give information about the content of the school-based emotion regulation program study designed for adolescent children to develop their emotion regulation skills.
- Trial name
- NCT06849310
- Testing
- Group that will receive emotional regulation training
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara Medipol University
Nursing Education
An e-Learning Program for Nurses on Evidence-Based Prevention of CKD
Electronic training course to help Syrian nurses prevent chronic kidney disease Why are the investigators doing this study? Chronic kidney disease (CKD) is common in Syria, yet many nurses have not received up-to-date training on…
- Trial name
- NCT07256990
- Testing
- CKD-prevention e-learning course (Your Kidney... our priority)
- Where
- Syria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
Healthy
Study of Safety, Tolerability and PK, PD of HPG1860 in Healthy Subjects
This is a randomized, double-blind, placebo-controlled, single and multiple ascending dose Phase 1study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and food effect of HPG1860 orally administered in…
- Trial name
- NCT04480697
- Testing
- HPG1860
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Hepagene (Shanghai) Co., Ltd.
Renal Insufficiency
Phase 1 Renal Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride
Twenty-four subjects were divided into three groups: subjects with mild renal insufficiency, subjects with moderate renal insufficiency and subjects with normal renal function, with 8 subjects in each group.Subjects with mild…
- Trial name
- NCT06747520
- Testing
- ET-26HCl
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ahon Pharmaceutical Co., Ltd.
Influenza
Assessment of CR6261, a Monoclonal Antibody Against the Influenza A Virus
The purpose of this study is to assess in healthy subjects the safety, tolerability, pharmacokinetics and immunogenicity of single escalating doses of CR6261, a monoclonal antibody against influenza A viruses.
- Trial name
- NCT01406418
- Testing
- CR6261 2 mg/kg, CR6261 5 mg/kg, CR6261 15 mg/kg
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
Laparoscopic Cholecystectomy
Dexamethasone-Enhanced TAP Block in Lapchole
The transversus abdominis plane (TAP) block is widely used as part of analgesia for abdominal surgeries such as laparoscopic cholecystectomy. While bupivacaine is commonly used for TAP blocks with reported success.
- Trial name
- NCT07182110
- Testing
- Dexamethasone enhanced TAP Block, Marcaine- 0.25%
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Myocarditis, Ventricular Arrhythmia
Role of Endomyocardial Biopsy and Aetiology-based Treatment in Pediatric Patients with Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOPED)
Myocarditis is a complex inflammatory disease, usually occurring secondary to viral infections, autoimmune processes or toxic agents.
- Conditions
- Myocarditis, Ventricular Arrhythmia, Inflammatory Cardiomyopathy, Genetic Predisposition
- Trial name
- MYOPED (NCT06591260)
- Testing
- support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Scientific Institute San Raffaele
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