Clinical trials: Manipulation
End Stage Renal Disease
Reducing Arrhythmia in Dialysis by Adjusting the Rx Electrolytes/Ultrafiltration, Study A
The primary purpose of this study is to test the feasibility of trials which change the dialysate (dialysis bath prescription) of potassium and bicarbonate according to a standardized algorithm and according to the results of…
- Trial name
- RADAR-A (NCT03519347)
- Testing
- Potassium Removal Maximization, Potassium Gradient Minimization, Alkalosis Avoidance
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- NYU Langone Health
Cocaine Use, Unspecified
Behavioral Effects of Drugs (Inpatient): 38
The specific aim of this project is to demonstrate that the decisional analysis/craving regulation aspects of CBT reduce cocaine self-administration in subjects with cocaine use disorder through diminished craving responses.
- Trial name
- NCT03954938
- Testing
- Craving Manipulation, Cocaine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- William Stoops
Neck Pain, Posterior
The Effect of Manipulation of the Cervical Spine on Pain Biomarkers
This study evaluates the effect of high-velocity low-amplitude thrust (HVLAT) manipulation to the cervical spine on neuropeptide expression as determined by the plasma concentration of oxytocin, neurotensin, orexin A and…
- Trial name
- HVLAT (NCT03176654)
- Testing
- HVLAT manipulation
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Neck Pain
Preventive Care of Chronic Cervical Pain and Disabilities
The aim of this study is to determine which of tertiary prevention spinal manipulative therapy (SMT) or a home exercise program is the more efficient approach to reduce pain and increase functional capacity, quality of life and…
- Trial name
- NCT00566930
- Testing
- spinal manipulation, Spinal manipulation + exercises
- Where
- Canada
- Volunteers
- 117 people
- Sponsor
- Université du Québec à Trois-Rivières
Low Back Pain
The Mechanisms of Manual Therapy in the Treatment of Low Back Pain
The purpose of this study is to determine whether a novel placebo for comparison to spinal manipulation is believable and creates similar expectation for treatment effectiveness as the studied spinal manipulation technique.
- Trial name
- NCT01168999
- Testing
- spinal manipulation
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Florida
Low Back Pain, Patient Acceptance of Health Care
Veterans Response to Dosage in Chiropractic Therapy
This study evaluates how Veterans with chronic low back pain (cLBP) respond to varying doses of chiropractic therapy and how health services utilization are impacted as a result. There are 2 phases in this study.
- Conditions
- Low Back Pain, Patient Acceptance of Health Care, Veterans Health
- Trial name
- VERDICT (NCT04087291)
- Testing
- Chiropractic Care
- Where
- 4 sites in United States
- Volunteers
- 766 people
- Sponsor
- Palmer College of Chiropractic
Acute Pain, Low Back Pain, Mechanical
Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain
This is a study of adults with acute low back pain flare-up at risk of becoming chronic and disabling. The study tests how well spinal manipulation and guided selfcare work compared to standard medical care.
- Trial name
- PACBACK (NCT03581123)
- Testing
- Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Stiffness Following Total Knee Arthroplasty
MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty
Compare the outcome following manipulation under anesthesia for stiffness in a randomized controlled fashion with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving…
- Trial name
- MUA (NCT02739035)
- Testing
- Dexamethasone, Celecoxib
- Where
- 16 sites in United States
- Volunteers
- 130 people
- Sponsor
- Mayo Clinic
Prostate Cancer
Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy
The purpose of this study is to look at the effect that the study drug OPC has on AGE levels in patients with prostate cancer.
- Trial name
- NCT02946996
- Testing
- Metformin, OPC
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Medical University of South Carolina
Low Back Pain
Patient Response to Spinal Manipulation - Pilot Study
In collaboration with the University of Iowa, the Palmer Center for Chiropractic Research will conduct a pilot study for the purposes of testing equipment, finalizing data collection protocol, and training study personnel before…
- Trial name
- PRiSM (NCT01562756)
- Testing
- HVLA-SM
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Palmer College of Chiropractic
Hypertension
Chiropractic for Hypertension in Patients
The investigators propose a prospective randomized 2 arm parallel observer-blinded phase II clinical study comparing a distinct method of upper cervical chiropractic manipulation to a sham technique in 50 individuals with stage I…
- Trial name
- CHiP (NCT01020435)
- Testing
- Spinal Manipulation
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Palmer College of Chiropractic
Multiple Sclerosis, Relapsing-Remitting
Effects of Chiropractic Care on Cytokine Levels in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory autoimmune disease associated with an imbalance between pro- and anti-inflammatory markers (cytokines) resulting in a demyelinating and neurodegenerative disease.
- Trial name
- NCT04972929
- Testing
- Spinal Manipulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Alabama at Birmingham
Spinal Manipulation
The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
The objective of the present study is to determine if spinal manipulations with a constant rate of force application but with different peak force and time to peak force lead to similar responses in healthy adults.
- Trial name
- NCT02550132
- Testing
- Spinal manipulation, Apparatus used to deliver spinal manipulations
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Carpal Tunnel Syndrome
Safety and Efficacy of a Novel Carpal Tunnel Tissue Manipulation Device in Treating Carpal Tunnel Syndrome
A single-center, prospective, non-randomized study to evaluate the safety and efficacy of a novel carpal tunnel tissue manipulation device in treating symptoms and decreased physical function in subjects previously diagnosed with…
- Trial name
- NCT02534493
- Testing
- Carpal Tunnel Tissue Manipulation Device (CTMD)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Pressure Profile Systems, Inc.
Back Pain
Spinal Manipulation and Spinal Mobilization Effects in Participants With and Without Back Pain
The objective of the present study is to compare the neuromechanical responses to spinal manipulation and spinal mobilization in participants with chronic nonspecific middle back pain.
- Trial name
- NCT02660801
- Testing
- Spinal manipulation, Spinal mobilization
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Capsule Endoscopy
The Second-Generation MCCG for Upper Gastrointestinal Tract.
The aim of this study is to evaluate the clinical application of the second-generation MCCG with higher image resolution and frame rate for upper gastrointestinal tract compared with the first-generation.
- Trial name
- NCT03977935
- Testing
- the second-generation MCCG
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Low Back Pain
The McKenzie Method Versus Manipulation for Patients With Chronic Low Back Pain
Introduction: The McKenzie method as well as spinal manipulation is commonly used for the treatment of low back pain throughout the western world.
- Trial name
- NCT00939107
- Testing
- spinal manipulation, McKenzie exercises
- Where
- Denmark
- Volunteers
- 350 people
- Sponsor
- Back and Rehabilitation Center, Copenhagen
Concussion Injury of Cerebrum, Cranial Osteopathic Medicine
Cranial Osteopathic Manipulative Medicine as an Adjunct Treatment for Concussion
Patients who have concussions exhibit an array of symptoms, also known as post-concussive symptoms, including headaches, feeling slowed down or foggy and difficulty with concentration.
- Trial name
- NCT03225599
- Testing
- Cranial Osteopathic Manipulative Medicine
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Low Back Pain
Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial
The purpose of this study is to determine whether osteopathic manipulative treatment (a type of spinal manipulative therapy used by osteopathic physicians) and ultrasound physical therapy are effective in the treatment of chronic…
- Trial name
- NCT00315120
- Testing
- A. Active OMT and active UST
- Where
- United States
- Volunteers
- 455 people
- Sponsor
- University of North Texas Health Science Center
Physiological Measurements of Response and Reaction Times
Assessment of Chiropractic Treatment Using Reaction and Response Times in Members of the Special Operation Forces (ACT2)
This study is a randomized controlled trial designed to evaluate changes in reaction times (RTs) and response times (RespTs) following chiropractic treatment compared to controls in the Special Forces Qualified (SFQ) population…
- Trial name
- NCT02168153
- Testing
- Chiropractic Manipulative Therapy, Wait-list
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- RAND