Clinical trials: Marker Screening
Lung Cancer, Pulmonary Nodule
Improving Detection of Early Lung Cancer in a Diverse Population (IDEAL) Study
The goal of this trial is to (a) identify people at high risk of lung cancer who would benefit from LDCT screening but are currently ineligible based on current lung cancer screening criteria (b) provide the framework to manage…
- Trial name
- IDEAL (NCT06628102)
- Testing
- Chest CT Scan
- Where
- Canada
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Lung Cancer
Early Lung Cancer Detection in High Risk Individuals
The MILD project is a randomized lung cancer screening trial whose primary aim is to evaluate the impact on mortality of early lung cancer detection through LDCT (low-dose computed tomography) in 2 groups: a control group…
- Trial name
- MILD (NCT02837809)
- Testing
- Low dose CT
- Where
- Italy
- Volunteers
- 4,099 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Intracerebral Hemorrhage
Biomarkers and Imaging Markers for ICH
Intracerebral hemorrhage (ICH) is a subtype of stroke associated with high mortality and disability. Basic and clinical research has contributed to our understanding of the complex pathophysiology in ICH.
- Trial name
- NCT06462274
- Testing
- body sample collection and imaging scan
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Southwest Hospital, China
Periodontitis, Diagnosis
Self-detection and Professional Screening Strategies for Early Detection of Periodontal Disease
The majority of the burden of periodontal diseases in the population remain undetected. Self-detection and confirmation with simple, non-clinical tests may improve early case detection and access to the needed level of care.
- Conditions
- Periodontitis, Diagnosis, Self-Assessment
- Trial name
- NCT05513599
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Pre-Eclampsia
Study for Improving Maternal, Pregnancy and Child Outcomes
The overall aims of this proposal are to improve, facilitate, optimize and equalize the existing screening system for adverse pregnancy outcomes in early pregnancy in order to limit adverse consequences for both the mother and…
- Trial name
- IMPACT (NCT03831490)
- Testing
- history
- Where
- 9 sites in Sweden
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Lung Cancer
Circulating and Imaging Biomarkers to Improve Lung Cancer Management and Early Detection
Validation of biomolecular markers in the circulation and radiomic features are the focus of this project.The aim is to assess the role of molecular and cellular biomarkers (exosomes antigens, Circulating tumor cells - CTCs…
- Trial name
- SMAC-2 (NCT04315753)
- Testing
- LDCT (Low Dose CT)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Nasopharyngeal Carcinoma
Screening Nasopharyngeal Carcinoma With EBV Associated Biomarkers in Zhongshan City
The study includes two cohorts: (1) a serological screening cohort; (2) a serological and EBV DNA screening cohort. All participants will be tested for EBNA1-IgA, VCA-IgA, BNLF2b total antibodies (P85-Ab), with additional plasma…
- Trial name
- NCT04085900
- Testing
- Blood and saliva, P85-Ab, EBNA1-IgA, VCA-IgA, Consecutive EBV DNA testing
- Where
- 2 sites in China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Gestatiaonl Diabetes Mellitus, Early Pregnancy
Biomarkers for Early Screening of Gestational Diabetes Mellitus
Gestational Diabetes Mellitus (GDM) refers to the abnormal glucose metabolism first detected during pregnancy. It is estimated that approximately 7% of pregnant women worldwide and their offspring are affected by GDM.
- Trial name
- NCT05142020
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Colorectal Cancer
PRESEPT Study: Evaluation of SEPT9 Biomarker Performance for Colorectal Cancer Screening
The purpose of this study is to collect blood specimens and clinical data from screening guideline eligible individuals designated by their physician to receive a screening colonoscopy, and to evaluate the performance of a…
- Trial name
- PRESEPT (NCT00855348)
- Testing
- All eligible subjects will provide blood for SEPT9 biomarker testing
- Where
- 23 sites in United States, Germany
- Volunteers
- 7,929 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
Neoplasms, Solid Tumor
Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in Colombia
DNA methylation changes occur early and broadly during carcinogenesis. Methylscape is a rapid assay that detects global DNA methylation patterns in body fluids (blood, urine, and saliva) and may detect a cancer signal and predict…
- Conditions
- Neoplasms, Solid Tumor, Breast Neoplasms, Lung Neoplasms
- Trial name
- METHYLSCAPE-CO (NCT07741435)
- Testing
- Methylscape DNA methylation assay
- Where
- Colombia
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Type 2 Diabetes, Diabetes (DM)
Detecting Type 2 Diabetes From Voice
The goal of this observational study is to learn if computer analysis of voice recordings can detect Type 2 diabetes in adults. The main questions it aims to answer are: Can advanced voice analysis accurately identify…
- Conditions
- Type 2 Diabetes, Diabetes (DM), T2DM, T2DM (Type 2 Diabetes Mellitus)
- Trial name
- NCT07421921
- Where
- United Kingdom
- Volunteers
- 7,319 people, healthy volunteers welcome
- Sponsor
- Thymia Limited
Chronic Obstructive Pulmonary Disease
Exhaled Breathing Condensate (EBC) Features and Lung Function Decline in Chinese Adults
Chronic obstructive lung disease (COPD) is a worldwide leading and still increasing cause of chronic morbidity and mortality. The important issue of COPD is its delayed diagnosis.
- Trial name
- NCT02037828
- Where
- China
- Volunteers
- 2,440 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Colon Cancer, Rectal Cancer
Validation of Colon Biomarkers for the Early Detection of Colorectal Adenocarcinoma
The investigators are undertaking a multi-center, 13000 subject validation study of several biomarkers for early detection of colon cancer.
- Trial name
- GLNE010 (NCT01511653)
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Alzheimer's Disease
A Community-Based Screening Program to Identify Participants at High Risk for Amyloid Pathology
The primary purpose of this study is to identify participants with or without symptoms of Alzheimer's Disease (AD) that are at high risk for brain amyloid pathology using blood-based biomarkers.
- Trial name
- NCT06043700
- Testing
- No Intervention
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Eisai Limited
Lupus Nephritis
Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN)?
Introduction and background : Glomerulonephritis and auto-immune diseases are often associated. Lupus nephritis (LN) is one of the major clinical manifestations of systemic lupus erythematosus (SLE) which have a severe impact on…
- Trial name
- GOODLUPUS (NCT03664908)
- Testing
- Detection of circulating anti-GBM antibodies (using chemiluminescence method and indirect immunofluorescence (IIF) method).
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Gastrointestinal Cancers
A Multicenter Prospective Observational Cohort Study for Digestive Tract Tumor Screening Using Multi-Target Blood and Fecal Biomarkers
This project aims to evaluate the sensitivity and specificity of combined blood multi-gene methylation and fecal biomarkers for pan-digestive tract cancer screening, so as to establish a novel technical system for the early…
- Trial name
- NCT07769892
- Where
- 7 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Lung Cancer
NanoSpectrometer Biomarker Discovery and Confirmation Study
This study will evaluate exhaled volatile organic compounds (VOC's) in the breath of participants with stage 1 lung cancer, their house-mates, and matched controls.
- Trial name
- NCT03275688
- Testing
- Breath Analysis
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Breast Benign, Malignant Neoplasm of Breast
Low-field MRI for Breast Cancer Screening
This research study wants to learn more about improving the attainable image quality for ultra-low field MRI of the breast using new data acquisition methods(also called MRI pulse sequences) and image reconstruction algorithms.
- Conditions
- Breast Benign, Malignant Neoplasm of Breast, Breast Malignant Tumor
- Trial name
- NCT05486520
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colonic Polyp
Study of a Screening Blood Test to Determine Patients' Potential Risk of Adenomatous or Advanced Colon Polyps (ACPs)
The aim of this study is to develop a blood test to determine which patients are at risk for pre-cancerous colon polyps (ACPs: Advanced Colon Polyps).
- Trial name
- NCT01062035
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Health
Research Plan for Early Disease Screening Biomarkers in Healthy Individuals
The establishment of reference intervals for biomarkers in healthy populations relies on large-scale, standardized cohort data. However, current baseline data for hematology, liver and kidney function, and multi-omics (genomics…
- Trial name
- NCT07569094
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Zhonghao Fang