Clinical trials: Mass Drug Administration
Lymphatic Filariasis Elimination by Mass Drug Administration, Monitoring and Evaluation of Mass Drug Administration for Lymphatic Filariasis
East New Britain Province Monitoring & Evaluation
While tremendous progress towards elimination of lymphatic filariasis (LF) has been made in the 20 years since the 1997 Fiftieth World Health Assembly, it is unlikely the goal of eliminating LF as a public health problem by 2020…
- Conditions
- Lymphatic Filariasis Elimination by Mass Drug Administration, Monitoring and Evaluation of Mass Drug Administration for Lymphatic Filariasis, Acceptability of Mass Drug Administration for Lymphatic Filariasis
- Trial name
- ENBP M&E (NCT04124250)
- Testing
- Observational
- Where
- Papua New Guinea
- Volunteers
- 12,930 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Malaria
Repeat Ivermectin Mass Drug Administrations for MALaria Control II
RIMDAMAL II is a double-blind, cluster randomized trial in Burkina Faso designed to test whether repeated ivermectin mass drug administrations, integrated into a monthly delivery platform with standard malaria control measures of…
- Trial name
- RIMDAMAL II (NCT03967054)
- Testing
- Ivermectin
- Where
- Burkina Faso
- Volunteers
- 4,124 people, healthy volunteers welcome
- Sponsor
- Brian Foy
Plasmodium Falciparum Malaria, Plasmodium Vivax Malaria
Targeting High Risk Populations With Enhanced Reactive Focal Mass Drug Administration in Thailand
This study assesses the effectiveness of reactive focal mass drug administration (rfMDA), targeting both village and forest working populations, compared to control for reducing the health promotion hospital-level (sub-district)…
- Trial name
- COMBAT (NCT05052502)
- Testing
- Case Management and Follow-up, Reactive focal mass drug administration (rfMDA)
- Where
- Thailand
- Volunteers
- 14,977 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Childhood Mortality
Mortality Reduction After Oral Azithromycin: Morbidity Study
The long-term goal of this study is to more precisely define the role of mass azithromycin treatments as an intervention for reducing childhood morbidity and increasing growth, and for the potential selection of antibiotic…
- Trial name
- MORDORMorb (NCT02048007)
- Testing
- Azithromycin
- Where
- 6 sites in United States, Malawi and 3 more
- Volunteers
- 72,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ascariasis
Follow-up Assessment of Change in Soil-transmitted Helminths Infection Intensity in Uganda
The goal of this prospective follow-up study nested within an open-label randomized controlled trial is to investigate the unexpectedly high prevalence of Ascaris lumbricoides infection observed 3-4 months after school-based mass…
- Trial name
- FACEIT-FU (NCT07873398)
- Testing
- Albendazole 400mg, Ivermectin 3 mg
- Where
- Uganda
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Helminthiasis, Strongyloides Stercoralis Infection
Management of Soil-transmitted Helminthiasis and Strongyloidiasis
The general purpose of the project is to analyse soil-transmitted helminthiases (STH) in a highly endemic area in northern Argentina with a multidisciplinary approach.
- Trial name
- NCT01308268
- Testing
- Ivermectin + Albendazole
- Where
- Argentina
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Salta
Malaria
Evaluation of Reactive Focal Mass Drug Administration (rfMDA) +/- Reactive Focal Vector Control (RAVC) in Namibia
This is a cluster randomised controlled trial with factorial study design comparing the impact of reactive community-based malaria interventions: 1) presumptive treatment (or rfMDA, reactive focal mass drug administration) versus…
- Trial name
- NCT02610400
- Testing
- RACD, RAVC, rfMDA
- Where
- Namibia
- Volunteers
- 9,845 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Childhood Mortality
Mortality Reduction After Oral Azithromycin: Mortality Study
Our long-term goal is to more precisely define the role of mass azithromycin treatments as an intervention for reducing childhood mortality.
- Trial name
- MORDORIMort (NCT02047981)
- Testing
- Azithromycin
- Where
- 6 sites in United States, Malawi and 3 more
- Volunteers
- 190,238 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lymphatic Filariasis
Optimization of MDA With Existing Drug Regimens for LF: Monitoring Efficacy of Ongoing Treatment Programs in PNG
The standard regimen for elimination of lymphatic filariasis (LF) in PNG is annual administration of two drugs at the same time.
- Trial name
- MDA (NCT03268252)
- Where
- Papua New Guinea
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Mortality
Effects of Mass Drug Administration of Azithromycin on Mortality and Other Outcomes Among 1-11 Month Old Infants in Mali
The LAKANA trial will assess the impact on mortality and other health outcomes of quarterly and biannual azithromycin mass drug administration (MDA) when delivered to 1-11-month (29-364 days) old infants in a high-mortality…
- Trial name
- LAKANA (NCT04424511)
- Testing
- Azithromycin
- Where
- Mali
- Volunteers
- 149,201 people, healthy volunteers welcome
- Sponsor
- Tampere University
Lymphatic Filariasis, Scabies
Better Options for Lymphatic Filariasis Treatment
The goal of this clinical trial is to learn if mass drug administration with moxidectin in combination with diethylcarbamazine, and albendazole (MoxDA) can treat lymphatic filariasis, scabies and strongyloidiasis in children and…
- Conditions
- Lymphatic Filariasis, Scabies, Strongyloidiasis
- Trial name
- BOLT (NCT07159373)
- Testing
- MoxDA - Moxidectin + Diethylcarbamzine (DEC) + Albendazole, IDA - Ivermectin + DEC + albendazole
- Where
- Fiji
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- Medicines Development for Global Health
Plasmodium Vivax Malaria, Malaria
FocaL Mass Drug Administration for Vivax Malaria Elimination
FLAME is an open-label cluster-randomized controlled trial that aims to determine the effectiveness of focal mass drug administration (fMDA) to reduce the incidence of Plasmodium vivax malaria in the Loreto Department in Peru.
- Trial name
- FLAME (NCT05690841)
- Testing
- Focal Mass Drug Administration (fMDA)
- Where
- Peru
- Volunteers
- 7,530 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Trachoma, Chlamydia
Trachoma Amelioration in Northern Amhara (TANA)
The WHO has initiated a program to eliminate trachoma, blinding eye infection caused by Chlamydia trachomatis, in large part by mass distributions of oral azithromycin.
- Trial name
- TANA (NCT00322972)
- Testing
- Mass treatment with oral azithromycin to an entire community
- Where
- Ethiopia
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Malignant Tumor of Cervix, Cervical Intraepithelial Neoplasia
Participation in Screening for Cervical Cancer: Interest of a Self-sampling Device Provided by the General Practitioner
This study evaluates the benefit in women aged from 30 to 65 years, who do not participate to the French opportunistic cervical cancer screening program, of an organized screening with the proposition by the family physician of a…
- Trial name
- PaCUDAHL-Gé (NCT02749110)
- Testing
- Vaginal self-sampling brush
- Where
- France
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Malaria
Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination
This is a community-based cluster-randomized trial in which a novel approach to interrupt residual malaria transmission by mass drug administration (MDA) with ivermectin (IVM) combined with dihydroartemisinin-piperaquine (DP)…
- Trial name
- MASSIV (NCT03576313)
- Testing
- dihydroartemisinin-piperaquine (DP), ivermectin (IVM), standard malaria control interventions only
- Where
- The Gambia
- Volunteers
- 4,939 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA)
The BOHEMIA program consists of a combination of studies organized around a central community prevention mass drug administration protocol and four sub-studies (i.e.; social science, entomology, health economics, and…
- Trial name
- BOHEMIA (NCT04966702)
- Testing
- Albendazole Pill, Ivermectin Pill, Ivermectin Injectable Product
- Where
- 2 sites in Kenya, Mozambique
- Volunteers
- 48,145 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Health Education, Community, Diet, Food, and Nutrition
Change in Child-feeding Knowledge, Attitudes, and Practices With Nutrition Education Mass Media in Ghana
Optimal infant and young child feeding practices are largely inadequate in rural and poor households in Ghana. Child welfare clinics (CWCs) focus on immunization, supplementation, and growth monitoring and promotion (GMP)…
- Conditions
- Health Education, Community, Diet, Food, and Nutrition, Malnutrition, Infant Nutritional Sciences
- Trial name
- NCT02800564
- Testing
- Active mass media approach, Passive mass media approach
- Where
- 4 sites in Canada, Ghana
- Volunteers
- 689 people, healthy volunteers welcome
- Sponsor
- McGill University
Malaria, Soil Transmitted Helminths
Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children
Malaria remains a major health problem, especially in sub-Saharan Africa where more than 90% of the disease and deaths occur in children.
- Conditions
- Malaria, Soil Transmitted Helminths, Schistosomiasis, Integrated Control
- Trial name
- MALHELMIN (NCT05354258)
- Testing
- Albendazole, Praziquantel, Amodiaquine
- Where
- Senegal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria, Malaria, Falciparum
Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia
To quantify the relative effectiveness, cost, and cost-effectiveness of fMDA and MDA with DHAp against no mass treatment for reducing P.
- Trial name
- NCT02329301
- Testing
- MDA with DHAp (Eurartesim), Focal MDA with DHAp (Eurartesim)
- Where
- Zambia
- Volunteers
- 2,430 people, healthy volunteers welcome
- Sponsor
- PATH
Malaria, Soil Transmitted Helminths
Effectiveness and Cost-effectiveness of Integrated Model for Malaria and Helminth Control
Malaria remains a major health problem, especially among children living in sub-Saharan Africa where more than 90% of the disease and deaths occur.
- Conditions
- Malaria, Soil Transmitted Helminths, Schistosomiasis, Seasonal Malaria Chemoprevention
- Trial name
- MALHELMIN (NCT06182176)
- Testing
- Sulphadoxine-pyrimethamine and Amodiaquine
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine