Clinical trials: Maternal Complications
Postpartum Hemorrhage (Primary), Hemorrhage
U-CaVIT Versus Standard of Care for Prevention of Atonic Postpartum Hemorrhage After Cesarean Section in High-risk Women.
This pilot study aims to assess performance, safety and feasibility of U-CaVIT method (Uro-Catheter Vacuum Induced Tamponade), using the Rüsch® Brillant Silicone Balloon Catheter, an urological catheter, for the prevention of…
- Conditions
- Postpartum Hemorrhage (Primary), Hemorrhage, Postpartum Complication, Delivery ,Complications,Maternal
- Trial name
- UCaVIT Pilot (NCT07019623)
- Testing
- Rüsch® Balloon Catheter Ch. 24, Ultrasonography
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Christian Haslinger
Pregnancy Complications, Maternal Care Patterns
Melanated Group Midwifery Care (MGMC)
This study is being conducted to determine if a multi-level intervention for delivering maternity care can improve patient trust and engagement among Black birthing people.
- Conditions
- Pregnancy Complications, Maternal Care Patterns, Patient Engagement
- Trial name
- MGMC (NCT05365815)
- Testing
- Melanated Group Midwifery Care
- Where
- United States
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Maternal Complications, Pregnancy Complication
Pregnancy Surveillance Program of Patients Exposed to Epidiolex/Epidyolex During Pregnancy
The purpose of this study is to evaluate pregnancy-related health outcomes in participants who are exposed to Epidiolex/Epidyolex during pregnancy and their infant up to 12 months of life.
- Conditions
- Maternal Complications, Pregnancy Complication, Birth Outcomes, Adverse, Pregnancy
- Trial name
- NCT06113237
- Testing
- Epidiolex
- Where
- 3 sites in United States, Germany and 1 more
- Volunteers
- 50 people
- Sponsor
- Jazz Pharmaceuticals
Pregnancy, Post Partum
Deconstructing Maternal Burdens: Doulas and the Community Unite for Health
This study is a randomized controlled trial comparing two models of doula support for pregnant individuals enrolled in Medicaid: an enhanced doula support model, in which support starts earlier in pregnancy, occurs more…
- Conditions
- Pregnancy, Post Partum, Doula Care, Postpartum Depression (PPD)
- Trial name
- UNITE (NCT07799805)
- Testing
- Doula, Standard (non-enhanced) Medicaid doula support
- Where
- United States
- Volunteers
- 516 people
- Sponsor
- University of Florida
Maternal Health, Child Health
Boston Birth Cohort Study
Early life exposures may lead to adverse effects on health in later life. The Boston birth Cohort study is designed to study a broad array of early life factors and their effects on maternal and child health outcomes across the…
- Conditions
- Maternal Health, Child Health, Pregnancy Complications, Birth Outcome, Adverse
- Trial name
- NCT03228875
- Where
- United States
- Volunteers
- 24,000 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Newborn Health Complications, Maternal Health Complications
Encouraging Pregnant Women to Use Skilled Birth Attendants and Its Effects on Maternal and Newborn Health in Rural Bangladesh
The goal of this clinical trial is to learn whether encouraging pregnant women in rural Bangladesh to use a skilled birth attendant during childbirth can improve the health of mothers and newborns.
- Trial name
- NCT07804069
- Testing
- Skilled Birth Attendant Encouragement Intervention
- Where
- Bangladesh
- Volunteers
- 504 people
- Sponsor
- Hiroshima University
Postpartum Complication
IMPACT: Improving Maternal Postpartum Access to Care Through Telemedicine
The purpose of this study is to compare two complex, multi-component evidence-based postpartum interventions in underserved populations of lower socioeconomic status in an effort to reduce maternal morbidity and mortality.
- Trial name
- IMPACT (NCT06218355)
- Testing
- Intensive Education, Enhanced Virtual Care
- Where
- 2 sites in United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Maternal Death During Childbirth, Pregnancy Complications
Wireless Physiologic Monitoring in Postpartum Women
To estimate the clinical effectiveness of wireless physiologic monitoring of women in the first 24 hours after cesarean delivery at Mbarara Regional Referral Hospital
- Trial name
- WIMS (NCT04060667)
- Testing
- Wireless physiologic monitoring
- Where
- Uganda
- Volunteers
- 3,191 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pregnancy Complications, Maternal Distress
Providing an Optimized and Empowered Pregnancy for You (POPPY) Aim 3: Randomized Controlled Trial
The PᵌOPPY study is designed to support the American Heart Association's mission to improve maternal/infant health outcomes and address inequities in maternal/infant health care.
- Conditions
- Pregnancy Complications, Maternal Distress, Adverse Birth Outcomes, Infant Conditions
- Trial name
- P3OPPY (NCT06510075)
- Testing
- Digital Health intervention, Community Health Worker, Digital Health Intervention plus Community Health Worker
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Alabama at Birmingham
Pregnancy Complication, Aortic Dissection
PregnAncy-Related Aortic DISsEction in China
A multicenter observational study on pregnancy-related aortic dissection
- Conditions
- Pregnancy Complication, Aortic Dissection, Marfan Syndrome, Loeys-Dietz Syndrome
- Trial name
- PARADISE (NCT07672210)
- Testing
- Intervention strategies including medication or surgery
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- DeltaHealth Hospital · Shanghai
Maternal Death, Maternal Complication of Pregnancy
Assessing the Maternal Outcome Monitoring Systems
Pregnancy-related death is a growing public health issues, which are of particular concern to minority groups, including African-Americans and Spanish-speaking Latinas.
- Trial name
- MOMS (NCT06415942)
- Testing
- Maternal Outcome Monitoring and Support system
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pregnancy Related, Hypotension
The Effect of HPI to Reduce Intraoperative Hypotension in Caesarean Sections
During caesarean section, blood pressure variations especially a reduction in blood pressure (or hypotension) can bring harmful effects to mother and baby. This usually occurs after spinal anaesthesia is administered.
- Conditions
- Pregnancy Related, Hypotension, Maternal-Fetal Relations, Cesarean Section Complications
- Trial name
- NCT06892665
- Testing
- Hypotension prediction index, Non invasive Blood Pressure Monitoring
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- National University of Malaysia
Vasa Previa, Pregnancy Complications
Fetoscopic Laser Photocoagulation in Management of Vasa Previa
In this research study, the investigators want to learn more about the safety and effectiveness of a fetal surgery, known as fetoscopic laser photocoagulation (FLP), for the treatment of a pregnancy condition called vasa previa…
- Conditions
- Vasa Previa, Pregnancy Complications, Maternal; Procedure, In Utero Procedure Affecting Fetus or Newborn
- Trial name
- FLUMEN (NCT06290232)
- Testing
- Fetoscopic Laser Photocoagulation
- Where
- United States
- Sponsor
- Boston Children's Hospital
Preeclampsia, Pregnancy Complications
Climate-Safe Pregnancy Intervention for Women With Preeclclampsia
This randomized controlled trial aims to evaluate the effectiveness of a climate-related nursing intervention in improving pregnancy-specific climate change knowledge, health beliefs, and protective behaviors among pregnant women…
- Conditions
- Preeclampsia, Pregnancy Complications, Climate Change and Maternal Health
- Trial name
- NCT07564856
- Testing
- Climate-Related Nursing Intervention, Routine Antenatal Care
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Benha University
Genetic Disease, Genetic Syndrome
Ensuring Patients' Informed Access to Noninvasive Prenatal Testing
Noninvasive prenatal genetic testing (NIPT) is an important new screening test option provided to pregnant women in the first trimester of pregnancy.
- Conditions
- Genetic Disease, Genetic Syndrome, Prenatal Disorder, Prenatal Maternal Abnormality
- Trial name
- NEST (NCT03420274)
- Testing
- NEST, Usual care
- Where
- 2 sites in United States
- Volunteers
- 691 people
- Sponsor
- The Cleveland Clinic
Hemophilia A, Hemophilia A, Severe
Hemophilia A Research Program
This study longitudinally observes the intergenerational (mother-child) continuum in hemophilia A from pregnancy through early childhood.
- Conditions
- Hemophilia A, Hemophilia A, Severe, Factor VIII (FVIII), FVIII Deficiency
- Trial name
- HARP (NCT07414511)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
Postpartum Complication, Maternal Hypertension
Safest Choice of Antihypertensive Regimen for Postpartum Hypertension
The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.
- Conditions
- Postpartum Complication, Maternal Hypertension, High Blood Pressure
- Trial name
- SCARPH (NCT05551104)
- Testing
- Oral Nifedipine, Oral Labetalol
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Loma Linda University
Advanced Maternal Age Pregnancy, Premature
Pregnancies Outcomes in Advanced Maternal Age Women
Pregnancies occurring in advanced maternal age (AMA) have become more common over the last few decades for a variety of reasons.
- Conditions
- Advanced Maternal Age Pregnancy, Premature, Labor Complication, Delivery Complication
- Trial name
- POIAMA (NCT06528340)
- Testing
- spontaneous delivery
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Maternal Sepsis, Infections
EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis (Aim 1)
Sepsis is the second leading cause of maternal death in the U.S. Labor and postpartum are particularly vulnerable risk periods. The goal of this multi-center, multidisciplinary study is to evaluate a maternal sepsis safety bundle.
- Trial name
- NCT06145724
- Testing
- Maternal Sepsis Safety Bundle
- Where
- 4 sites in United States
- Volunteers
- 33,183 people, healthy volunteers welcome
- Sponsor
- Columbia University
Maternal Sepsis, Infections
EnCoRe MoMS: Engaging Communities to Reduce Morbidity From Maternal Sepsis (Aim 2)
Sepsis is the second leading cause of maternal death in the U.S. For racial and ethnic minoritized birthing people, especially those who are Black, living in poverty, and from underserved communities, labor and postpartum are…
- Trial name
- NCT06148532
- Where
- United States
- Volunteers
- 400,000 people
- Sponsor
- Columbia University