Clinical trials: Maternal Death
Cause of Mortality, Cause of Neonatal Death
Defining Causes of Deaths in South and Southeast Asia
Brief Summary: Mortality data are important in low and middle-income countries to assess the population health status and trends.
- Conditions
- Cause of Mortality, Cause of Neonatal Death, Cause of Child Death, Cause of Maternal Death
- Trial name
- SEACTN-VA (NCT04595656)
- Testing
- verbal autopsy interview
- Where
- 5 sites in Bangladesh, Burma and 3 more
- Volunteers
- 3,413 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Preeclampsia
Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia
Preeclampsia (PE) complicates 2-8% of pregnancies. It is associated with an increased risk of adverse maternal (death, eclampsia, abruptio placenta, HELLP syndrome) and perinatal (perinatal death, growth restriction, prematurity)…
- Trial name
- HEPEPE (NCT00986765)
- Testing
- Lovenox® (enoxaparin), Aspegic ® (Aspirin)
- Where
- France
- Volunteers
- 257 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Death, Infant, Morbidity;Infant
Trial to Compare Two Strains of BCG
The trial will be a two-year outcome assessor-blinded RCT at the maternity ward of hospital Simão Mendes (HNSM) in urban Bissau, Guinea-Bissau to compare BCG-Japan versus BCG-Russia 1:1 in 15,000 infants with respect to…
- Trial name
- STRAIN III (NCT04383925)
- Testing
- BCG-Japan, BCG-Russia
- Where
- Guinea-Bissau
- Volunteers
- 16,390 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Asphyxia Neonatorum
First Breath: Neonatal Resuscitation in Developing Countries
In developing countries, neonatal death from birth asphyxia is a major problem. This study will be conducted in several countries to determine if the combined Neonatal Resuscitation Program/Essential Newborn Care Program compared…
- Trial name
- NCT00136708
- Testing
- Neonatal Resuscitation
- Where
- 7 sites in Argentina, Guatemala and 4 more
- Volunteers
- 120,009 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Perinatal Death, Respiratory Distress Syndrome, Newborn
Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities
Hyperoxygenation for resuscitation of abnormal fetal heart rate tracings has been routine obstetric practice. However, there have not been any studies to support this practice.
- Conditions
- Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure
- Trial name
- NCT03996317
- Testing
- Room air
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Sudden Infant Death
The Effect of Video-Assisted Sudden Infant Death Syndrome Prevention Training Program and Counseling Practice on Mothers' Knowledge Level and Self-efficacy: Randomized Controlled Study
Sudden Infant Death Syndrome (SIDS) is one of the leading causes of infant mortality in the postneonatal period, but it can be prevented and its incidence can be reduced by creating a safe sleep environment with modifiable risk…
- Trial name
- NCT05823051
- Testing
- VASIDS-TP and Counseling Practice
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dilara Aydin Tozlu
Perinatal Depression
Preventing Perinatal Depression
The goal of this pilot study is to evaluate the acceptability, feasibility, mechanisms of action, and efficacy of Center M. Center M is a group-based, mindfulness-based Cognitive Behavioral Therapy (CBT) intervention to treat…
- Trial name
- NCT06525922
- Testing
- Center M
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Sleep, Pregnancy
Halifax PrenaBelt Trial
Back and right-sided sleeping position in pregnant women has recently emerged as a potential risk factor for low birthweight (LBW) and stillbirth (SB) in the medical literature.
- Conditions
- Sleep, Pregnancy, Stillbirth, Infant, Low Birth Weight
- Trial name
- NCT02377817
- Testing
- PrenaBelt
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Allan Kember
Prevention of Sudden Death
Training Mothers of Infants in Infant Cardiopulmonary Resuscitation (CPR)
This research will be a prospective, cohort study to determine if mothers of infants/newborns are more willing to complete CPR training using a 22-minute instructional DVD and infant manikin versus traditional four hour didactic…
- Trial name
- NCT00570869
- Testing
- CPR Anytime
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Lehigh Valley Hospital
Neonatal SEPSIS, Perinatal Mortality
Outcomes in Spontaneous and ART Twin Pregnancies
During the last decades, assisted reproductive technique has been transformed from a miracle to real and has become widely used for treatment human infertility. this was associated with increased the rate of twin pregnancies
- Conditions
- Neonatal SEPSIS, Perinatal Mortality, Maternal Morbidity
- Trial name
- NCT03590483
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Hawler Medical University
Stillbirth, Obstetric Complication
Improving Intrapartum Care for Saving Life at Birth in Ethiopia Through PartoMa Approach
Overall Objective To introduce PartoMa approach (locally agreed and achievable intrapartum guidelines and a continual in-house training program) to Ethiopian context through continuous fetal heart rate (FHR) monitoring using MOYO…
- Conditions
- Stillbirth, Obstetric Complication, Maternal Death, Perinatal Death
- Trial name
- PartoMa-Eth (NCT06273007)
- Testing
- PartoMa intervention(Locally achievable intrapartum care guideline), in house LDHF trainings
- Where
- 2 sites in Ethiopia
- Volunteers
- 500 people
- Sponsor
- Haramaya Unversity
Post Partum Haemorrhage
Outcomes and Perceptions of the Implementation of the JADA Device in a Stage II Postpartum Hemorrhage Management Protocol in Referral Hospitals of the Colombian Pacific Region
This study focuses on postpartum hemorrhage (PPH), a condition that stands out as the leading cause of global maternal mortality. Annually, about 14 million women experience PPH, resulting in approximately 70,000 deaths.
- Trial name
- JADAValle (NCT06843265)
- Testing
- Vacuum- Induce Hemorrhage Control
- Volunteers
- 24 people
- Sponsor
- Fundacion Clinica Valle del Lili
COVID19, Coronavirus Infection
Northeast COVID-19 and Pregnancy Study Group
A prospective and retrospective cohort study. The objective will to determine the frequency of COVID-19 in pregnant and postpartum women hospitalized with flu syndrome, to evaluate clinical and laboratory predictors of COVID-19…
- Conditions
- COVID19, Coronavirus Infection, Pregnancy Disease, Severe Acute Respiratory Syndrome
- Trial name
- NCOVIP (NCT04462367)
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Maternal Mortality
Effectiveness of the Education Program on Increasing the Competency Level of Health Cadres in Indonesia
Ending preventable maternal mortality (EPMM): By 2030, every country should reduce its maternal mortality ratio (MMR) by at least two-thirds from the 2010 baseline.
- Trial name
- NCT06134518
- Testing
- The education program, the initial orientation from the PHCs
- Where
- Indonesia
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
¨Maternal Morbidity¨, ¨Perinatal Mortality¨
A Study to Measure the Effectiveness of an Intervention Package Aiming to Decrease Perinatal Mortality and Increase Institution-based Obstetric Care Among Indigenous Populations in Guatemala
A matched pair cluster-randomized trial of this intervention package will be conducted in four rural and indigenous districts (Huehuetenango, Quiche, Alta Verapaz and San Marcos) of the Republic of Guatemala, using the health…
- Trial name
- NCT01653626
- Testing
- package of 3 interventions
- Where
- Guatemala
- Volunteers
- 1 people
- Sponsor
- Hospital San Juan de Dios Guatemala
External Causes of Morbidity and Mortality, Stillbirth
Linking Facility-based Mortality Audits With Community Engagement in Gilgit-Baltistan, Pakistan
Pakistan is one of the countries in South Asia where neonatal mortality rates remain stagnant. Babies born in Pakistan encounter the highest risk of dying; of every 1,000 babies born, 46 die before the end of their first month…
- Conditions
- External Causes of Morbidity and Mortality, Stillbirth, Neonatal Death
- Trial name
- NCT03904706
- Testing
- Audits only, Audits with community feedback
- Where
- Pakistan
- Volunteers
- 1,871 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Cervical Pregnancy, Maternal Care for Late Fetal Death
Medical Management of Late Intrauterine Death.
The purpose of this study is to assess the therapeutic efficacy and safety of isosorbide dinitrate-oxytocin in combination in the management of late intrauterine foetal death.
- Trial name
- INPer (NCT02488642)
- Testing
- Isosorbide Dinitrate, Misoprostol, Oxytocin
- Volunteers
- 60 people
- Sponsor
- National Institute of Perinatology
Contraception Behavior, Contraceptive Usage
A Cluster-RCT to Increase the Uptake of LARCs Among Adolescent Females and Young Women in Cameroon.
The study investigators propose to test various supply-side approaches to increase the numbers of both SARCs (short-acting reversible contraceptives, i.e.
- Conditions
- Contraception Behavior, Contraceptive Usage, Contraceptive Method Switching, Contraception
- Trial name
- NCT03725358
- Testing
- Training, App, Control
- Sponsor
- World Bank
Preterm Infant, Hypothermia, Newborn
Early Kangaroo Mother Care in Gambian Hospitalised Unstable Neonates
The mortality effect of kangaroo mother care in stable newborns <2000g is well established but mortality effect in unstable newborns is not conclusively known.
- Conditions
- Preterm Infant, Hypothermia, Newborn, Death, Kangaroo Mother Care
- Trial name
- eKMC (NCT03555981)
- Testing
- Early Kangaroo Mother Care, Standard care
- Where
- The Gambia
- Volunteers
- 279 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Fetal Distress, Perinatal Asphyxia
Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings
The PRISM pilot feasibility study consists of two phases to determine: 1) to delivery practices, rates of primary and secondary outcomes, and feasibility of enrollment rates, and 2) to assess the feasibility and acceptability of…
- Conditions
- Fetal Distress, Perinatal Asphyxia, Birth Asphyxia, Stillbirth
- Trial name
- PRISM (NCT05946681)
- Where
- Zambia
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health