Clinical trials: Maturity-onset Diabetes of the Young
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Type 2 Diabetes
Determining the Minimal Amount of Exercise to Improve Glycaemic Control
In 2015, there were 415 million adults worldwide with type II diabetes and by 2040, typeII diabetes will affect one in ten adults worldwide.
- Trial name
- MiniEx (NCT04129268)
- Testing
- Cycle ergometry exercise at 60% VO2max
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Obesity, Type II Diabetes Mellitus
Yellow Pea Protein and Fibre and Short Term Food Intake
It is hypothesized that yellow pea protein and fiber will reduce short-term food intake, subjective appetite and glycemic response.
- Conditions
- Obesity, Type II Diabetes Mellitus, Metabolic Syndrome
- Trial name
- NCT01255085
- Testing
- yellow pea protein, yellow pea fiber, Control Tomato Soup
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes Mellitus (T2DM), Diabetes-related Distress
Digital Self-Management Education and Support for Young Adults With Type 2 Diabetes (DSMESYAT2DM)
This randomized controlled trial will evaluate the effect of a nurse-led digital self-management education and support program on self-management behaviors, glycemic control, and diabetes-related distress in young adults with…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Diabetes-related Distress, Diabetes Distress
- Trial name
- DSMESYAT2DM (NCT07325838)
- Testing
- Digital Nurse-Led DSMES Program, Usual Care Plus Standard Digital Education
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Recep Turan
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE
The study aims to investigate the validity of 2 hour post-prandial UCPCR test in paediatric and adult patients with diabetes duration greater than 2 and 5 years, respectively, for the purposes of distinguishing between patients…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Maturity-onset Diabetes of the Young
- Trial name
- NCT03607604
- Testing
- Next generation sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Type 2 Diabetes, Diabetes Mellitus, Type 2
Comparative Bioavailability - Gender Effect - Single and Multiple Ascending Dose Safety and Pharmacokinetic Study of GFT505
The Sponsor, Genfit, has developed a new formulation of GFT505 (60 mg). The objective is to compare the relative bioavailability between the new GFT505 formulation (capsule dosed at 60 mg GFT505) and the old GFT505 formulation…
- Conditions
- Type 2 Diabetes, Diabetes Mellitus, Type 2, Metabolic Diseases, Cardiovascular Diseases
- Trial name
- NCT01474161
- Testing
- GFT505 120mg - old formulation, GFT505 120mg - new formulation, GFT505 180mg - new formulation
- Where
- France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Genfit
Type 1 Diabetes Mellitus, Maturity-Onset Diabetes of the Young, Type 2
Contribution of Hyperinsulinemia vs. Hyperglycemia to Insulin Resistance in Type 1 Diabetes and Maturity Onset Diabetes of the Young, Type 2 (MODY2)
The purpose of this study is to determine the key factors influencing insulin sensitivity in type 1 diabetes (T1DM) and maturity onset diabetes of the young, type 2 (MODY2).
- Conditions
- Type 1 Diabetes Mellitus, Maturity-Onset Diabetes of the Young, Type 2, MODY2, Insulin Resistance
- Trial name
- NCT02971202
- Testing
- Hyperinsulinemic, euglycemic clamp, 20% dextrose
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Covid19
AZD1656 in Diabetic Patients Hospitalised With Suspected or Confirmed COVID-19
The ARCADIA Trial is a randomised, double-blind, placebo-controlled clinical trial to assess the safety and efficacy of AZD1656 in patients with either Type 1 or Type 2 diabetes, hospitalised with COVID-19.
- Trial name
- ARCADIA (NCT04516759)
- Testing
- AZD1656
- Where
- 30 sites in Czechia, Romania and 1 more
- Volunteers
- 170 people
- Sponsor
- St George Street Capital
Gestational Diabetes, GDM
Genetic Causes of Gestational Diabetes in the Emirati Population
The study aims to identify the number of MODY patients to be found among Emirati women with GDM as the incidence and prevalence of monogenic diabetes among this group of patients is unknown.
- Conditions
- Gestational Diabetes, GDM, Maturity-onset Diabetes of the Young, MODY
- Trial name
- NCT03589092
- Testing
- Next generation sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 600 people
- Sponsor
- Imperial College London Diabetes Centre
Diabetes Mellitus, Type 2, Cardiovascular Disease
Moderate Alcohol Consumption, Fat and Carbohydrate Metabolism and Insulin Sensitivity
Moderate alcohol consumption is associated with a decreased risk of diabetes type 2. This association could be mediated by an improvement of insulin sensitivity with moderate alcohol consumption.
- Trial name
- NCT00364767
- Testing
- A, B
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- TNO
Maturity-onset Diabetes of the Young
The Effects of GLP-1 in Maturity-Onset Diabetes of The Young (MODY)
The purpose of this study is to evaluate the treatment potential of GLP-1-analogues in patients with Maturity Onset Diabetes of the Young (MODY) compared to common treatment.
- Trial name
- NCT01610934
- Testing
- liraglutide, Glimepiride
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Neonatal Diabetes, Monogenic Diabetes
China Monogenic Diabetes Registry
This observational study aims to establish a digital registry, screening platform for patients with monogenic diabetes using internet-based and mobile application technologies.
- Conditions
- Neonatal Diabetes, Monogenic Diabetes, Maturity Onset Diabetes of the Young
- Trial name
- CMDR (NCT07492004)
- Testing
- No Interventions
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Tianjin Medical University General Hospital
Maturity-Onset Diabetes of the Young (MODY), Type 2 Diabetes
Optimized Diagnosis and Precision Medicine of MODY
The goal of this observation is to establish a complete registry for the clinical manifestations, environment, genetic, and other related gene variation information of young-onset diabetic patients.
- Conditions
- Maturity-Onset Diabetes of the Young (MODY), Type 2 Diabetes, Diabetes Complications
- Trial name
- NCT06111833
- Where
- Taiwan
- Volunteers
- 1,500 people
- Sponsor
- Taichung Veterans General Hospital
Type 2 Diabetes Mellitus, Obesity
Form of Dairy Products on Satiety, Food Intake and Post-meal Glycaemia in Young and Older Adults
The proposed study is planned to determine the potential role for regular fat dairy products in short-term metabolic control in younger and older adults and the metabolic flexibility in response to food components, which are…
- Trial name
- NCT02491801
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity
Exenatide and Brown Adipose Tissue
The obesity epidemic has led to a enormous increase in the prevalence of type 2 diabetes mellitus (T2D), dyslipidemia and cardiovascular events.
- Trial name
- exe01 (NCT03002675)
- Testing
- Bydureon
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Obesity, Diabetes Mellitus, Type 2
Dairy and Non-Dairy Alternatives Comparative on Metabolic Outcomes
The purpose of this study is to compare the acute effects of a single serving of dairy and non-dairy alternatives on post-treatment and post-meal glycemia, appetite, plasma amino acid concentrations, and gastrointestinal hormones…
- Trial name
- NCT05919667
- Testing
- Dairy and plant-based dairy beverages and solids
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 1 Diabetes, MODY
Usefulness of Continuous Glucose Monitoring in MODY Diagnosis
Observational study about usefulness of intermittently scanned continuous glucose monitoring (isCGM) in the diagnosis of maturity-onset of the young (MODY) patients.
- Trial name
- UCMODY (NCT05918484)
- Testing
- Intermittenly scanned continuous glucose monitoring, MODY genetic diagnostic test
- Where
- 9 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Castilla-La Mancha Health Service
Healthy
A Study in Healthy People to Test How Empagliflozin is Taken up in the Body When Taken as a Whole Tablet or Dissolved in Water and Mixed With Food
This trial is conducted to test how empagliflozin is taken up in the body when taken as a whole tablet or dissolved in water and mixed with food.
- Trial name
- NCT06962826
- Testing
- Empagliflozin
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Type 1 Diabetes (T1D), Type 2 Diabetes (T2D)
Safety Evaluation of MODI, an Insulin Titration Algorithm, in Adults With Diabetes
A 13-week multi-center single-arm trial, preceded by a 2-week standard therapy phase, will be conducted to assess the safety of MODI, an insulin titration algorithm, in adults with type 1 diabetes (T1D) who use multiple daily…
- Trial name
- MODIUS (NCT07599982)
- Testing
- MODI Algorithm
- Where
- 6 sites in United States
- Volunteers
- 102 people
- Sponsor
- DreaMed Diabetes
Obesity, Insulin Resistance
The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults
The primary aim of this study is to evaluate the effect of exenatide on daily glycemic excursions obtained by continuous glucose monitoring system (CGMS).
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Cardiovascular Disease
- Trial name
- NCT00845559
- Testing
- Exenatide
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University