Clinical trials: Maximal Exercise Capacity
Cystic Fibrosis, Fibrosis
The Alfred Step Test Exercise Protocol (A-STEP), for Adults With Cystic Fibrosis.
Exercise testing has become clinically important in the management and ongoing evaluation of patients with Cystic Fibrosis (CF) with higher rates of exercise tolerance and participation previously linked to lower mortality risk…
- Conditions
- Cystic Fibrosis, Fibrosis, Lung Diseases, Respiratory Diseases
- Trial name
- A-STEP (NCT02717650)
- Testing
- A-STEP, A-STEP (New Protocol), Comparator: CPET cycle ergometer (Gold Standard)
- Where
- Australia
- Volunteers
- 7 people
- Sponsor
- The Alfred
Congestive Heart Failure
Testosterone Improves Exercise Oxygen Uptake, Insulin Resistance and Muscle Strength in Elderly Patients With Chronic Heart Failure
Background: Patients with congestive heart failure (CHF) show muscle mass wasting and decreased testosterone levels. Long-term testosterone supplementation improves walking distance and glucose metabolism of patients CHF.
- Trial name
- NCT00512408
- Testing
- testosterone
- Where
- Italy
- Sponsor
- IRCCS San Raffaele
Healthy
Exercise-induced Changes in DNA-methylation
The purpose of the study was to investigate whether regular moderate- or high-intensity interval training can change the DNA methylation in a long-lasting state, and whether these changes affect the gene expression.
- Trial name
- NCT01931072
- Testing
- High-intensity interval training, Moderate training
- Where
- Norway
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
The Effect of Additive On-Demand Sildenafil vs. Dextrose Candy on Maximum Exercise Capacity in Pulmonary Arterial Hypertension
The goal of this clinical study is to investigate whether the additional intake of sildenafil 20mg on top of standard medical treatment results in a benefit on maximum exercise workload (Wmax) in patients with pulmonary arterial…
- Trial name
- Pocket-PH (NCT07824674)
- Testing
- Dextrose, Sildenafil 20mg
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich
Duchenne Muscular Dystrophy
Stacking Exercises Aid the Decline in FVC and Sick Time
Duchenne Muscular Dystrophy is complicated by weak breathing muscles and lung infections. "Lung volume recruitment" is a technique performed using a face mask or mouthpiece and a hand-held resuscitation bag to stack breaths…
- Trial name
- STEADFAST (NCT01999075)
- Testing
- Lung Volume Recruitment (LVR), Conventional Treatment
- Where
- 9 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Children's Hospital of Eastern Ontario
Cystic Fibrosis
Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF
Cystic fibrosis has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-AOX (NCT02690064)
- Testing
- Acute Antioxidant, Chronic Antioxidant
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Augusta University
Coronary Artery Bypass Surgery
Exercise Training in Patients After Bypass Surgery
Based on clinical experience both physical condition and psychological recovery after surgery are individually variable. Exercise training plays an important part, has been recommended for CABS patients in order to enhance…
- Trial name
- NCT05188352
- Testing
- Chest physiotherapy, Aerobic exercise training
- Volunteers
- 30 people
- Sponsor
- Bezmialem Vakif University
Lung Transplant, Inspiratory Muscle Training
The Effects of IMT on Exercise Capacity, Dyspnea and Lung Functions in LTx
Inspiratory Muscle Training (IMT), which is used to strengthen the respiratory muscles, is one of the techniques used in PR. It is mostly used in patients with chronic obstructive pulmonary disease, and has been shown to be…
- Trial name
- NCT03505697
- Testing
- inspiratory muscle training, Pulmonary rehabilitation
- Volunteers
- 34 people
- Sponsor
- Istanbul Medipol University Hospital
Heart Failure, Heart Failure and Reduced Ejection Fraction
Comparative Effects of Different Inspiratory Muscle Training Modalities in Patients With Heart Failure.
The purpose of this study is to compare the effects of three different modalities of inspiratory muscle training (IMT) in patients diagnosed with chronic heart failure who exhibit reduced or mid-range left ventricular ejection…
- Conditions
- Heart Failure, Heart Failure and Reduced Ejection Fraction, Heart Failure and Mildly Reduced Ejection Fraction, Muscle Weakness
- Trial name
- IMT-HF-COMPARE (NCT07688863)
- Testing
- Mechanical Pressure-Threshold IMT Device, PowerBreathe KH2 Electronic IMT Device
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- Universidad Nacional Andres Bello
Sleep Deprivation
Sleep and Maximal Fat Oxidation
Introduction: Despite the awareness of the importance of sleep in our lives, especially for athletes, the consequences of poor rest on sports performance are not well understood.
- Trial name
- Sleep&Fat (NCT07015008)
- Testing
- Sleep deprivation, Sleep place
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Alcala
Schizophrenia, Cardiovascular Disease
Treatment Effects From Aerobic Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia
This study investigates treatment effects from aerobic endurance training, maximal strength training and computer game on aerobic capacity, work efficiency and psychiatric symptoms in patients suffering from schizophrenia.
- Trial name
- NCT00286299
- Testing
- Aerobic high-intensity interval training (AIT), Computer game training (CG), Maximal strength training
- Where
- Norway
- Volunteers
- 33 people
- Sponsor
- Norwegian University of Science and Technology
Heart Transplantation
L-arginine Supplementation and Exercise; L-arginine Supplementation and Renal Function
exercise capacities are still altered after heart transplantation partly due to peripheral endothelial dysfunction cyclosporin-induced renal dysfunction may be due to renal endothelial dysfunction and can be reversed in an animal…
- Trial name
- NCT00213915
- Testing
- 12 g of L-arginine glutamate during 6 weeks twice a day
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Exercise Training, Respiratory Muscle Training
Effects of High Intensity Interval Training (HIIT) vs. Inspiratory Muscle Training on the Recovery After a Maximal Apnea.
The aim of this randomized cross-over controlled study was to assess the effects of an 4-week exercise program on the recovery capacity after a voluntary maximal apnea.
- Conditions
- Exercise Training, Respiratory Muscle Training, High-Intensity Interval Training, Apnea
- Trial name
- (HIIT) (NCT04084535)
- Testing
- High intensity interval training, Inspiratory muscle training
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Breast Cancer, Upper Extremity
Arm Exercise Capacity and Maximal Oxygen Consumption With Breast Cancer
Breast cancer is the most common type of cancer among women worldwide. The incidence rate has reached approximately 16%. According to 2016 data from the Ministry of Health, the incidence of breast cancer in Turkey is 46.8 per…
- Conditions
- Breast Cancer, Upper Extremity, Oxygen Consumption, Healthy
- Trial name
- NCT06018038
- Testing
- Arm Exercise Capacity, Peak Oxygen Consumption (VO2peak), Muscle oxygenation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Chronic Venous Insufficiency
Long-term Effects of Inspiratory Muscle Training in Chronic Venous Insufficiency
The long-term effectiveness of inspiratory muscle training, which is known in the literature to help venous return by increasing the pump effect of the diaphragm muscle, remains unclear in individuals with chronic venous…
- Trial name
- NCT05982405
- Testing
- Training group: Inspiratory muscle training, Control group: Thoracic expansion exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Democracy University
Stem Cell Transplantation
Physical Impairments in Allogeneic-HSCT
Pulmonary functions, exercise capacity and muscle strength deteriorate in survived hematopoietic stem cell transplantation (HSCT) recipients due to toxic effects of chemotherapy, radiotherapy, conditioning regimens and/or…
- Trial name
- NCT03448627
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Gazi University
Athlete
The Effect of Inspiratory Muscle Warm-up on Decreased Diffusing Capacity for Carbon Monoxide After Maximal Exercise in Athletes
This study aims to examine the effects of inspiratory muscle warm-up (IMW) on the gas exchange capacity of the lungs (DLCO) and its potential contribution to recovery and athletic performance in elite athletes from various…
- Trial name
- NCT06751511
- Testing
- General warm-up, Inspiratory muscle warm-up (%40 IMW)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Emre Karaduman
Physical Activity After Organ Transplantation
High-intensity Training Safely Improves Exercise Capacity in Heart, Lung, Kidney, and Liver Transplant Recipients: a Comparative Study
The investigators will investigate whether high-intensity exercise training can safely improve physical performance in long-term stable heart, kidney, lung, and liver transplant recipients.
- Trial name
- NCT03329586
- Testing
- High-intensity training
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Near-Infrared Spectroscopy
Comparison of Intercostal and Quadriceps Femoris Muscle Oxygenation in Women and Men
The differences in physiological responses due to gender during exercise tests have recently begun to be investigated. The oxygen use of respiratory muscles and lower extremity muscles may differ during upper and lower extremity…
- Trial name
- NCT06896838
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Single Ventricle Heart Disease After Fontan Surgery
Pharmacokinetic/Pharmacodynamic Study of Udenafil in Adolescents
To determine the pharmacokinetic profile and safety of udenafil in adolescents with Fontan physiology and to assess the short-term pharmacodynamic effect of udenafil on pharmacodynamic measures of exercise capacity, ventricular…
- Trial name
- NCT02201342
- Testing
- Udenafil
- Where
- 6 sites in United States, Canada
- Volunteers
- 36 people
- Sponsor
- Mezzion Pharma Co. Ltd