Clinical trials: Measure of Nociception
Pain
The Medasense Study
Despite various efforts there is still the need for adequate monitoring of pain and nociception during anesthesia. In a previous protocol the investigators measured pain responses during anesthesia based on single end-points, eg…
- Trial name
- NCT01912118
- Testing
- Propofol, Remifentanil
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- Leiden University Medical Center
Pain Measurement
Performance Evaluation of ANI in Patients Under General Anesthesia With Remimazolam
The purpose of this study is to determine whether Analgesia Nociception Index (ANI) can effectively reduce the dose of opioid in patients who underwent general anesthesia using remimazolam.
- Trial name
- NCT06432894
- Testing
- Analgesia Nociception Index, remimazolam
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Catholic Kwandong University
Nociceptive Pain, Pupillary Light Reflex Lost
Clinical Trial Using Pupillometry to Measure Nociception in Healthy Volunteers.
Pupillometry has been used in healthy volunteers to investigate the usefulness of the pupil light reflex as an indicator of pain intensity on pressure as a nociceptive stimulus.
- Conditions
- Nociceptive Pain, Pupillary Light Reflex Lost, Healthy, Pain, Procedural
- Trial name
- NCT04864340
- Testing
- CE marked medical device, Algometer, Comparator
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Intubated Brain Injured
Psychometric Measurements of Three Nociception Assessments Methods in Intubated Brain Injured Critical Care Patients
Nociception in intensive care unit is frequently evaluated with some tools such as BPS (Behavioral Pain scale) and NCS (Nociception coma scale). These scales were not validated in intubated and brain injured ICU patients.
- Trial name
- D co réa (NCT02830256)
- Testing
- NCS-I (Nociception Coma Scale adapted intubated patients)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Pain Measurement, Children
Pain Management in Pediatric Intensive Care by Studying the Autonomic Balance
Fighting against the pain caused by the disease or by the diagnostic and therapeutic procedures for children is a daily and essential concern of health care in the pediatric sector.
- Conditions
- Pain Measurement, Children, Child, Hospitalized
- Trial name
- ANI-DOL (NCT02769598)
- Testing
- ANI Index for Hospitalized children
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Pain, Pediatric ALL
Validation of the ANI in Perpubescent Patients in Pediatric Intensive Care Unit.
The ANI monitor is a medical device allowing to measure the response of the autonomic nervous system to a painful stimulus. In the pediatric population under general anesthesia, the ANI score can detect failure of locoregional…
- Trial name
- ANI-EP (NCT04913038)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Measure of Nociception
Composite Variability Index and Propofol Remifentanil Anesthesia
The purpose of the study is to determine if the new Composite Variability Index (CVI) is capable of detecting changing effect compartment concentrations of remifentanil.
- Trial name
- NCT01234194
- Testing
- rising remifentanil concentrations, falling remifentanil concentrations
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University Hospital, Bonn
Critical Illness
The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.
The aim of the study was to describe the feasibility of the nociception flexion reflex and the pupillary dilatation reflex as objective pain assessment tools in the Intensive Care Unit (ICU).
- Trial name
- NCT02916004
- Testing
- Measurement of NFR and PDR
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Pain, Tachycardia
Usefulness and Predictive Capacity of ANI and SPI of the Hemodynamic Response
The primary objective of this study is to investigate the influence of a standardized noxious stimulus on the ANI, SPI and hemodynamic parameters during standard propofol and sufentanil TCI and to see if the ANI and SPI are…
- Conditions
- Pain, Tachycardia, Hypertension
- Trial name
- NCT02608775
- Testing
- Metrodoloris Medical System, Aisys® care station, Acertys
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitair Ziekenhuis Brussel
Pain
BIS and Entropy Nociception Monitoring
Reports have been appearing in literature over the past years of various nociception-antinociception monitors, introduced and promoted from major manufactures.
- Trial name
- BIS4 (NCT02585466)
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Infant, Newborn, Infant, Premature
Effect of a Vibratory Stimulus on Mitigating Nociception-specific Responses to Skin Puncture in Neonates
The assessment and treatment of pain in neonates remains a challenge. In an effort to improve the quality of care while limiting opioid-related adverse effects, this study aims to determine the efficacy of a non-pharmacological…
- Conditions
- Infant, Newborn, Infant, Premature, Pain Perception, Pain Measurement
- Trial name
- NCT04050384
- Testing
- Baby GentleStick
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Lance M Relland, MD, PhD
Ovarian Neoplasm
Impact of Specific Monitoring of Intraoperative Analgesia Under General Anesthesia on Chronic Pain After Ovarian Cancer Surgery
This is a single-center, randomized, phase II, non-comparative, single-blind clinical study that will determine whether morphine reduction through intraoperative monitoring by ANI (Analgesia Nociception Index) significantly…
- Trial name
- MONIALC (NCT04906187)
- Testing
- Arm A : intraoperative ANI monitoring of nociception, Arm B : no specific monitoring of nociception
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Institut Bergonié