Clinical trials: Mechanical Stress
Left Ventricular Assist Device
Exercise Tolerance in Patients With Implanted Left Ventricular Assist Device
To evaluate the concept of dynamic pump speed optimization based on the echocardiographic assessment of aortic valve opening during cardiopulmonary exercise test.
- Trial name
- NCT05063006
- Testing
- Cardiopulmonary exercise tests with maintained baseline optimal pump speed settings., Cardiopulmonary exercise test with gradually increased pump speed depending on live echocardiographic imaging.
- Where
- Poland
- Volunteers
- 22 people
- Sponsor
- Karol Wierzbicki
Dexmedetomidine, Propofol
Dexmedetomidine and Propofol in Mechanically Ventilated Patients by Using Salivary Alpha-amylase as a Stress Marker
The aim of this study is to compare the efficacy of dexmedetomidine and propofol on decreasing stress in mechanically ventilated patients by using salivary alpha-amylase as a stress marker.
- Conditions
- Dexmedetomidine, Propofol, Mechanical Ventilation, Salivary Alpha Amylase
- Trial name
- NCT06098209
- Testing
- Dexmedetomidine, Propofol
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Acute Ischemic Stroke
Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation Thrombectomy
Ischemic stroke accounts for a relatively high proportion of strokes. In recent years, intravenous thrombolysis and endovascular therapy have significantly improved the revascularization rate in patients with large vessel…
- Trial name
- NCT05845372
- Where
- 19 sites in China
- Volunteers
- 2,592 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Obesity
Effect of Shock Wave Therapy Without Biological and Immuno-histochemical Analysis.
Informative Summary: Extracorporeal shockwave therapy (ESWT) is a new method for treating aesthetic disorders within the field of aesthetic medicine, its mechanisms of action and physiological effects promise to combat localized…
- Trial name
- ESWT (NCT05017636)
- Testing
- shock wave therapy
- Where
- Brazil
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indústria Brasileira Equipamentos Médicos - IBRAMED
ARDS, Mechanical Power
Ventilatory Parameters in Predicting Outcomes in ARDS Patients
This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes…
- Trial name
- OCTANE (NCT06400095)
- Testing
- Poccl, Time constant, driving pressure
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- CentraCare
Critical Illness, Hyperglycemia
Effects of a Complete Diet in Critically Ill Patients With Stress Hyperglycemia
The aim of the study is to evaluate the beneficial effects of the administration of a complete diet rich in monounsaturated fatty acids (MUFA) and slow absorption carbohydrate in patients with stress hyperglycemia(T-Diet Plus…
- Conditions
- Critical Illness, Hyperglycemia, Dietary Modification, Metabolic Stress Hyperglycemia
- Trial name
- NCT01233726
- Testing
- T-Diet plus Diabet IR, ISOSOURCE PROTEIN FIBRE, GLUCERNA SELECT
- Where
- 2 sites in Spain
- Volunteers
- 159 people
- Sponsor
- Vegenat, S.A.
Respiratory Insufficiency
Music Therapy for Patients Being Weaned From Mechanical Ventilation
The purpose of the study is to determine whether Music Therapy interventions can be used as supportive therapy for patients undergoing weaning from mechanical ventilation.
- Trial name
- NCT00178139
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Rochester
Urinary Incontinence
Transcutaneous Mechanical Nerve Stimulation (TMNS) by Vibration in the Treatment of Incontinence
During transcutaneous mechanical nerve stimulation in spinal cord injured men an increase in pressure was observed in the external urethral sphincter along with an increase in bladder capacity.
- Trial name
- TMNS (NCT00695058)
- Testing
- Transcutaneous mechanical nerve stimulation by A medical vibrator (FERTI CARE personel, Multicept A/S, Albertslund, Danmark)
- Where
- 3 sites in United States, Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital at Herlev
Patellar Tendinopathy / Jumpers Knee
Long-Hold Yielding Isometric Exercise for Patellar Tendinopathy in Weightlifting Athletes
The goal of this clinical trial is to evaluate whether a long-hold yielding isometric exercise program improves pain, tendon vascularity, mechanical properties, and functional performance in weightlifting athletes with patellar…
- Trial name
- QuantFlow (NCT07361848)
- Testing
- Long-Hold Yielding Isometric Exercise Program, Usual-Care Training Condition
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Universidad Complutense de Madrid
Mechanical Ventilation Complication
Cross-sectional, Observational, Prospective and Analytical Study:MECHANICAL POWER DAY (MPDay)
Recently the new concept of "mechanical power" has been proposed. It refers to the amount of energy per minute that is transferred to the lung by the ventilator.
- Trial name
- MPDay (NCT03936231)
- Testing
- NO Intervention
- Where
- Spain
- Volunteers
- 2,000 people
- Sponsor
- Hospital Universitario Marqués de Valdecilla
Acute Respiratory Distress Syndrome
Stress Index to Individualize Mechanical Ventilation in ARDS
Acute respiratory distress syndrome (ARDS) is a widely prevalent and morbid disease for which the current standard treatment is supportive care and avoidance of complications with lung-protective ventilation.
- Trial name
- NCT02871102
- Testing
- Recruitment Maneuver with PEEP and Tidal Volume Optimization
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University
Analgesia, Sedation
Surgical Stress Index as a Tool for Monitoring Analgesia and/or Sedation in Critically Ill Patients
The hypothesis of the study is: Does the Surgical Stress Index (SSI) correlate with the Behavioral Pain Scale (BPS), the Ramsay Sedation Scale (RSS)and/or the Behavioral Pain Scale(BPV) and can therefore be used to monitor the…
- Conditions
- Analgesia, Sedation, Mechanical Ventilation, Pain
- Trial name
- NCT00789412
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Schleswig-Holstein
Critical Illness, Hyperglycemia
Prognostic Value of Stress Hyperglycemia Ratio in Critically Ill Patients
Critically ill patients admitted to intensive care units (ICUs) frequently develop elevated blood sugar levels (hyperglycemia) as a result of acute illness-related stress, even if they do not have diabetes.
- Conditions
- Critical Illness, Hyperglycemia, Acute Kidney Injury, Multiple Organ Failure
- Trial name
- NCT07853911
- Volunteers
- 230 people
- Sponsor
- Assiut University
Stress Urinary Incontinence
Urethral Rotation Angles and Foot Pronation Mechanical Changes in Postmenopausal Women
Stress urinary incontinence (SUI) occur secondary to increased intra abdominal pressure, that directed the researchers to study the mechanical changes in urethra and bladder that associated with it.
- Trial name
- NCT06576791
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mechanical Ventilation Weaning From Mechanical Ventilation Extubation Failure Critical Illness
Delta Pocc During Spontaneous Breathing Trial to Predict Extubation Failure in Mechanically Ventilated Adults (DELTA-EXT)
This prospective observational single-center study will evaluate whether dynamic respiratory stress estimated by delta airway occlusion pressure deflection (Delta Pocc) during a standardized spontaneous breathing trial can…
- Trial name
- DELTA-EXT (NCT07634783)
- Testing
- Delta Pocc Measurement During Spontaneous Breathing Trial
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Sanatorio Parque, Argentina
Leg Discrepancy
Influence of Mechanical Stimulus on Distraction Osteogenesis
a further step of our current one-year NSC project, aiming to bridge the above-mentioned gap by continuously monitoring the mechanical stimuli applied to the limb and callus, both through experimental measurements and FEM…
- Trial name
- NCT00154856
- Testing
- Detect the variation of limb lengthening
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Respiratory Distress Syndrome
Assessment of Occult Lung Stress During Lung Protective Mechanical Ventilation
The present study will utilize esophageal manometry to measure the presence and magnitude of persistent patient effort during lung protective ventilation, allowing identification and mitigation of occult lung stress.
- Trial name
- NCT05675696
- Testing
- Esophageal Catheter
- Where
- United States
- Sponsor
- NYU Langone Health
Recovery, Mechanical Stress
Effects of Hot Baths Prior or After a Damaging Protocol on Muscle Function and HSP70 Expression
Muscle lengthening contractions lead to physiological responses such as strength loss, soreness, immune cell infiltration, and CK production, along with elevated heat shock proteins (HSPs), which protect and regenerate cells.
- Conditions
- Recovery, Mechanical Stress, Heat Stress, HSP70
- Trial name
- Prehotemp (NCT07559344)
- Testing
- Immersion, NIRS, isokinetic dynamometer
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
ARDS, Driving Pressure
Effects of Different Driving Pressure on Lung Stress, Strain and Mechanical Power in Patients With Moderate to Severe ARDS
ARDS is the most common acute respiratory failure in the ICU and the mortality rate is still as high as 40%. Mechanical ventilation(MV) is the major supportive treatment for ARDS, but inappropriate ventilator setting could lead…
- Conditions
- ARDS, Driving Pressure, Strains, Mechanical Power
- Trial name
- NCT03616704
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jianfeng Xie
Stress Disorders, Post-Traumatic, Depression
Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on PTSD
Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation.
- Conditions
- Stress Disorders, Post-Traumatic, Depression, Anxiety
- Trial name
- NCT02040649
- Testing
- Non-sedation, Control, sedation (propofol, midazolam)
- Where
- Denmark
- Volunteers
- 205 people
- Sponsor
- Palle Toft