Clinical trials: Mechanically Ventilated Patients
Ventilator Dependent
Short Effects of SIMT and EM in Prolonged Mechanically Ventilated Patients
Using mechanical ventilation for more than 18 hours can affect respiratory muscle and postural muscle control, making it difficult to wean off the ventilator and reducing mobility. The aim of this study is to: 1.
- Trial name
- NCT06368089
- Testing
- Inspiratory muscle training (IMT) group, Early mobilization (EM) group
- Where
- Thailand
- Volunteers
- 46 people
- Sponsor
- Prince of Songkla University
Respiratory Failure, Acute Hypoxemic Respiratory Failure
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen…
- Conditions
- Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia
- Trial name
- NCT06501118
- Testing
- Education, Epic notification alert
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- University of Colorado, Denver
Nutritional Deficiency, Cachexia
Optimal Protein Supplementation and Early Exercise In Mechanically Ventilated Patients
A Pilot Randomized Controlled Trial (RCT) will be conducted where where mechanically ventilated patients will be randomized to optimal protein (Achieve 80% protein supplementation adequacy with daily titration) versus standard…
- Trial name
- NCT05603585
- Testing
- Optimal protein supplementation to achieve 80% protein adequacy.
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Tracheostomy Complication, Covid19
A Cohort Study of Mechanically Ventilated COVID-19 Patients Undergoing Tracheostomy
COVIDTrach aims to assess the outcomes of tracheostomy in mechanically ventilated patients with COVID-19. The use of personal protective equipment and incidence of COVID-19 amongst operators is also recorded.
- Conditions
- Tracheostomy Complication, Covid19, Ventilator Lung
- Trial name
- COVIDTrach (NCT04572438)
- Testing
- Tracheostomy
- Where
- United Kingdom
- Volunteers
- 2,234 people
- Sponsor
- University College, London
Patient/Ventilator Asynchrony
Study to Measure the Prevalence of Asynchrony In Mechanically Ventilated Patients
This study will examine the prevalence of patient-ventilator asynchrony and its determinants. Mechanically ventilated trauma patients often experience asynchrony when their pattern of breathing does not match the triggering of a…
- Trial name
- Asynchrony (NCT01049958)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury
A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function
This is a prospective randomized controlled pilot study in traumatic brain injury (TBI) patients who are sedated with either propofol or midazolam to compare the cytokine response and neuropsychological outcomes with and without…
- Trial name
- NCT01712477
- Testing
- Intravenous sedation using propofol, Intravenous sedation with midazolam
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Michigan State University
Gastric Emptying, Mechanically Ventilation
Metoclopramide on Gastric Emptying in Mechanically Ventilated Patients
The aim of this study is to evaluate the prokinetic effect of metoclopramide on gastric emptying in critically ill mechanically ventilated patients .
- Conditions
- Gastric Emptying, Mechanically Ventilation, Randomized Controlled Trial, Metoclopramide
- Trial name
- NCT05641051
- Testing
- Metoclopramide
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Acute Respiratory Distress Syndrome, Mechanical Ventilation, Respiratory Mechanics, Ventilator-induced Lung Injury
A Modified Mathematical Model to Calculate Power Received by Mechanically Ventilated Patients With Different Etiologies
Ventilator-induced lung injury is a common complication. The latest and most noticeable theory of its pathogenesis is called 'ergotrauma' by Gattinoni in 2016.
- Trial name
- NCT04046380
- Testing
- work of breath measurement and calculation
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Changhua Christian Hospital
Ventilator-induced Diaphragm Dysfunction, VIDD
Evaluation of heepSync, a Novel Algorithm for Transcutaneous Electrical Stimulation of Respiratory Muscles in Mechanically Ventilated Patients.
Up to 76% of ICU patients on mechanical ventilation develop significant respiratory muscle atrophy within the first 24 hours, contributing to prolonged ventilation, increased morbidity, and higher healthcare costs.
- Conditions
- Ventilator-induced Diaphragm Dysfunction, VIDD, Weaning Failure
- Trial name
- NCT07363902
- Testing
- Heecap
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Tesai Care SL
Sedation
Expanded Access for Inhaled Isoflurane Delivered Via the Sedaconda ACD-S for Sedation of Difficult-to-Sedate Adult Mechanically Ventilated Intensive Care Unit Patients
The purpose of this Expanded Access Protocol is to provide access to inhaled isoflurane delivered via the Sedaconda ACD-S device for sedation of adult patients in the ICU that are mechanically ventilated and are difficult to…
- Trial name
- NCT07457593
- Testing
- Isoflurane, Sedaconda ACD-S
- Sponsor
- Sedana Medical
Electrical Impedance Tomography
Evaluation of Postoperative Ventilation Distribution With Electrical Impedance Tomography
Postoperative patients require respiratory management . It is known that the intrapulmonary ventilation distribution becomes uneven due to dorsal atelectasis and ventral hyperinflation during mechanical ventilation management…
- Trial name
- NCT05389735
- Where
- Japan
- Volunteers
- 130 people
- Sponsor
- Osaka University
COVID-19 Acute Respiratory Distress Syndrome
Is Prolonged Period of Prone Position Effective and Safe in Mechanically Ventilated Patients With SARS-COV-2?
the aim of the study is to assess safety and efficacy of prone position ventilation beyond the usual 16 hrs in patients with SARS-COV-2
- Trial name
- NCT05109624
- Testing
- prolonged prone position ventilation
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Ain Shams University
Airway Morbidity
Comparison of ProSeal Laryngeal Mask Airway, LTS-D and I-gel in Mechanically Ventilated Patients
The Aim of the study is to compare the clinical performance of p-LMA, i-gel and LTS-D in terms of the efficacy and safety in anaesthetized patient on Mechanical ventilation undergoing elective surgical procedure.
- Trial name
- NCT02877940
- Testing
- ProSeal Laryngeal mask airway, Laryngeal Tube Suction- Disposable, i-gel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Government Medical College, Haldwani
Mechanical Ventilation, Critical Illness
Acupressure for Agitation, Pain, and Sleep in Mechanically Ventilated ICU Patients
Mechanically ventilated intensive care unit (ICU) patients commonly experience agitation, pain, and sleep disturbances, which may negatively affect recovery and increase the need for sedative medications.
- Conditions
- Mechanical Ventilation, Critical Illness, Agitation, Pain
- Trial name
- CALM-ICU (NCT07619326)
- Testing
- Acupressure, Light Touch
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Yang Yun Shiuan
Critically Injured Mechanically Ventilated Trauma Patients
Protective Manual Hyperinflation in Acute Mechanically Ventilated Trauma Patients
This single-blinded randomized study aims to compare two methods of manual hyperinflation (protective - moderate tidal volumes with positive end expiratory pressure) and non-protective (large tidal volume and no positive end…
- Trial name
- NCT01366274
- Testing
- Protective manual hyperinflation, Usual method of MHI
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- The University of Queensland
Obesity Associated Disorder
Respiratory and Hemodynamics Parameters Response to Positive End-Expiratory Pressure
In this study, the sixty mechanically ventilated class I obese patients were divided into two equal groups A and B. group A received RTP position + PEEP protocol, while group B underwent RTP position protocol only.
- Trial name
- Respiratory (NCT05508997)
- Testing
- respiratory parameters on mechanical ventilator (PEEP)
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Heidy F. Ahmed
Mechanically Ventilated Patients
Early Directed Physical Therapy in the Management of Mechanically Ventilated Patients in a Medical Intensive Care Unit
To study all ICU patients with an independent baseline functional status, who experience a critical illness requiring intubation and mechanical ventilation, evaluating the role of protocol-directed, early physical and…
- Trial name
- NCT00322010
- Testing
- early PT OT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Chicago
Trauma, Traumatic Injury
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in…
- Conditions
- Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
- Trial name
- EPO-TRAUMA (NCT04588311)
- Testing
- Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9%
- Where
- 41 sites in Australia, Belgium and 7 more
- Volunteers
- 2,500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Pneumonia
Safety, Tolerability and Pharmacokinetics of Aerosolized Amikacin in Intubated and Mechanically-ventilated Patients With Nosocomial Pneumonia
This study is to understand how the inhaled form of amikacin is spread throughout the human body and how it is eliminated from the body and to make sure that giving an inhaled form of Amikacin to patients is safe and well…
- Trial name
- NCT01021436
- Testing
- Amikacin inhalation solution (BAY41-6551)
- Where
- 6 sites in United States, France
- Volunteers
- 30 people
- Sponsor
- Bayer
Respiratory Failure, Re-intubation Rate
High Flow Nasal Cannula Versus Non Invasive Positive Pressure Ventilation in Reducing The Rate of Reintubation
This is study aim to compare between high flow nasal canula (HFNC) and non invasive positive pressure ventilation (NIPPV) in reducing the rate of reintubation in mechanically ventilated patient with successful weaning
- Trial name
- NCT06029699
- Testing
- high flow nasal cannula, non invasive positive pressure ventilation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University