Clinical trials: Mechanism
Ischemic Preconditioning
The Biology of Chronic Preconditioning: Genomic and Physiologic Mechanisms of Response
The purpose of this study is to assess the effects of repeated RIPC and exercise, on exercise performance, skeletal muscle responses and circulating cellular and humoral biology in humans
- Trial name
- NCT01164618
- Testing
- Remote ischemic preconditioning (RIPC), Exercise
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Obsessive - Compulsive Disorder
Neural Mechanisms of the Sensorymotor Circuit in Sensory Phenomena in OCD
The goal of this clinical study is to investigate the neural mechanisms of abnormal sensory phenomena in patients with Obsessive-Compulsive Disorder and to evaluate whether modulation of the insula-supplementary motor area…
- Trial name
- NCT07480408
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Peritoneal Carcinomatosis
Register Study of Patients With Peritoneal Carcinomatosis Treated With PIPAC (Pressurized Intra-peritoneal Aerosol-Chemotherapy)
The study will follow up patients with peritoneal carcinomatosis from colorectal, ovarian, gastric, pancreatic cancers and primary peritoneal tumors and undergoing a diagnostic laparoscopy / laparotomy, a PIPAC as single dose or…
- Trial name
- PIPAC_01 (NCT03100708)
- Testing
- PIPAC
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Administrative Staff in Hospital of Taiwan
The Impact of Internationalize Medical Services to localPeople Seeking Medical Care
Recently The Department of Health of Taiwan has launched the "Internationalize Medical Services Flagship Program", expecting to promote Taiwan's high-quality of medical services to the international market, and anticipating…
- Trial name
- NCT01123720
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University WanFang Hospital
Analgesia
The Analgesic Effect of Auditory Inputs and Its Relation to Psychological and Neurobiological Mechanisms
The study investigates the analgesic effect of different auditory inputs. Employing a within-subject design, the study includes healthy participants that are exposed to thermal stimuli while listening to three different auditory…
- Trial name
- NCT03410563
- Testing
- Auditory inputs
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Depression, Hypertension
Biological CVD Risk Factors in Older Depressed Patients
The purpose of this study is to determine if improvements in mood will ameliorate autonomic dysregulation, HPA dysfunction and typical (e.g.
- Conditions
- Depression, Hypertension, Hypercholesterolemia
- Trial name
- NCT00318864
- Testing
- Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Prehabilitation, Breast Cancer
Prehabilitation With Resistance-exercise Training for Breast Cancer Neoadjuvant Therapy
Breast cancer stands as the foremost cause of cancer-related deaths among women worldwide, with the highest incidence of any cancer type.
- Conditions
- Prehabilitation, Breast Cancer, Postmenopause, Resistance Training
- Trial name
- NEO STRONG (NCT06309290)
- Testing
- Prehabilitation with resistance-exercise training, Usual care program
- Where
- 2 sites in Chile
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de La Frontera
Choledochal Cyst
Host-Microbe Interactions in Biliary Dilatation
This study is an observational cohort study aimed at continuously enrolling patients with biliary dilatation and healthy controls.
- Trial name
- NCT07152496
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Prediabetes, Insulin Resistance
Pilot Study on Metabolic Effects of Fish Peptides and Vitamin D
The overall goal of this study is to investigate the effects and the mechanisms of action of a fish peptide and vitamin D on glucose metabolism, insulin secretion, and cardiometabolic risk profile in overweight men.
- Trial name
- BONITO (NCT02668159)
- Testing
- Fish peptide supplement, Vitamin D supplement, Fish peptide + Vitamin D3 supplements
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Laval University
Fibromyalgia, Pain, Chronic
Psychobiological Mechanisms Underlying Chronic Pain
Pain is a powerful motivator of behavior and it is more than the perception of nociceptive input. It is a complex experience that comprises different components: sensory discriminative, emotional-motivational and cognitive…
- Conditions
- Fibromyalgia, Pain, Chronic, Chronic Pain, Widespread
- Trial name
- NCT04674670
- Testing
- Bromocriptine Mesylate Capsules, Amisulpride 400 MG
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- susanne becker
Acute Promyelocytic Leukemia
Role of Microparticles in the Coagulopathy of Acute Promyelocytic Leukemia
Although the clinical application of differentiation therapy has made great success in the treatment of acute promyelocytic leukemia (APL), early fatal bleeding remains an unsolved problem which accounts for the main reason of…
- Trial name
- NCT02991066
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Tobacco Use Disorder, Schizophrenia
Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia
The objective of this study is to investigate the relative contributions of nicotine replacement and sensorimotor replacement (i.e., smoking denicotinized cigarettes) on abstinence-induced smoking urges, withdrawal-related…
- Trial name
- NCT01213524
- Testing
- sensorimotor replacement, 42 mg transdermal nicotine replacement, usual brand smoking
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Brown University
Dyslexia, Developmental
Neural Mechanisms of Successful Intervention in Children With Dyslexia
Dyslexia, an impairment in accurate or fluent word recognition, is the most common learning disability affecting roughly ten percent of children.
- Trial name
- NCT04323488
- Testing
- Lindamood-Bell Seeing Stars
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Stanford University
Behavior and Behavior Mechanisms, Information Literacy
A Women-Focused PrEP Intervention
Many women at high risk for acquiring HIV infection are not aware of preexposure prophylaxis (PrEP), an efficacious, self-administered, woman-controlled, HIV prevention product.
- Trial name
- Just4Us (NCT03699722)
- Testing
- Education + Activities, Information
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cancer Screening, Lung Cancer
Precision Navigation to Improve Community Cancer Screening Participation
This study will evaluate whether a precision navigation intervention can help community residents at high risk for cancer complete recommended cancer screening.
- Conditions
- Cancer Screening, Lung Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT07676383
- Testing
- Precision Navigation Intervention, Usual Health Education
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Hunan Cancer Hospital
ADHD - Attention Deficit Disorder With Hyperactivity, ADHD
Research on the Development, Implementation Effect and Neural Mechanism of a Physical Intervention Program for College Students With ADHD Based on the Characteristics of Balance Dysfunction
Background: Attention deficit/hyperactivity disorder is a common neurodevelopmental disorder. Its core symptoms and related executive function, emotional and motor coordination problems often persist into adulthood, significantly…
- Conditions
- ADHD - Attention Deficit Disorder With Hyperactivity, ADHD, ADHD - Combined Type, ADHD - Inattentive Type
- Trial name
- NCT07499427
- Testing
- Aerobic Treadmill Training, Progressive Balance Training, Cognitive-Balance Dual-Task Training
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Wuhan Sports University
IUD; Complications, Mechanical, Menstrual Cup
Pilot Study of Suction as a Mechanism of IUD Expulsion With Concomitant Menstrual Cup Use
This study will provide pilot data examining suction as a mechanism of IUD displacement with menstrual cup use. The investigator hypothesize that manufacturer-recommended menstrual cup insertion and removal by breaking the seal…
- Trial name
- NCT05254041
- Testing
- Menstrual Cup Removal
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Post-Traumatic Headache
Investigate the Mechanisms, Predictors, and Prevention of Persistent Post-Traumatic Headache
This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild traumatic brain injury, and identify methods…
- Trial name
- NCT04369729
- Where
- 5 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic