Clinical trials: Mechanism
Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents
A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935
The purpose of this study is to determine the brain cholesterol 24S-hydroxylase (CH24H) enzyme occupancy of TAK-935 after single oral dose in healthy participants using the positron emission tomography (PET) ligand [18F]MNI-792…
- Trial name
- NCT02497235
- Testing
- TAK-935, [18F]MNI-792 (tracer)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Takeda
Behavior and Behavior Mechanisms, Communication
COVID-19 Resource Offers Among Rent and Utility Assistance Applicants in St. Louis
The purpose of this study is to evaluate health messaging strategies that help individuals with a high degree of housing-related needs engage in COVID-19 vaccination and testing behaviors.
- Trial name
- NCT05451511
- Testing
- Door-In-The-Face Technique, Foot-In-The-Door Technique
- Where
- United States
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Mechanisms, Defense
The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex (GP-SPI) on Gut Microbiota
The overall purpose of this study is to evaluate the effect of nutritional supplementation with a well-characterized preparation of Concord grape polyphenol-soy protein isolate (GP-SPI) on the composition of the gut microbiota.
- Trial name
- NCT04018066
- Testing
- GP-SPI
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Behavior and Behavior Mechanisms
Translational Research to Inform Interventions for Challenging Behavior
This project is meant to identify relations between the reinforcement histories of 80 adults with intellectual and developmental disabilities (IDD) and the prevalence of extinction bursts.
- Trial name
- NCT04842500
- Testing
- Demand Informed Moderator Analysis
- Where
- 5 sites in United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Drug Mechanism, Healthy
Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique
The main objective is to assess whether a novel electrochemical tool is reliable in detecting concentration of paracetamol in fingerprick- , saline-, urine-, and serum samples. We will recruit 12 healthy volunteers aged 18-45.
- Trial name
- NCT04690673
- Testing
- Paracetamol, Paracetamol concentration measurements and lipidomic assessment
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johanna Kujala
Stroke, Gait, Hemiplegic
Gait Training Combined With Behavioral Strategies for People With Stroke
A variety of rehabilitation techniques focused on improving disability after stroke have shown significant changes on walking speed, and endurance. Also, the administration of combined techniques showed better results.
- Conditions
- Stroke, Gait, Hemiplegic, Behavior and Behavior Mechanisms
- Trial name
- NCT04546217
- Testing
- Treadmill training + transfer package (TT+TP), Treadmill training (TT)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Alabama at Birmingham
Binge Drinking, Alcohol Drinking in College
Balanced Lifestyle for Undergraduate Excellence - Mobile (Project BLUEM)
The purpose of this study is to evaluate a text-message delivered approach for improving college adjustment and experience and reducing risky alcohol use in young adult college students.
- Conditions
- Binge Drinking, Alcohol Drinking in College, Behavior, Drinking, Behavior and Behavior Mechanisms
- Trial name
- BLUEM (NCT04105725)
- Testing
- Brief Motivational Intervention+Substance-Free Activity Session, Alcohol + Nutrition Education Session
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Memphis
Basic Science Study of the Mechanisms of Attentional Enhancement by Compounds Acting on the Nicotinic Receptor
Low-Dose Galantamine to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine
The aim of this study is to test whether the attention-enhancing effects of low-dose nicotine can be enhanced by the drug galantamine, FDA-approved for the treatment of Alzheimer's disease.
- Trial name
- GalaNic (NCT02420327)
- Testing
- Nicotine patch and galantamine capsule
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore