Clinical trials: Mechanisms, Defense
Bacterial Infection in COPD
Mechanisms of Lung Defense and Their Relationship With Airway Infection in Chronic Obstructive Pulmonary Disease (COPD)
Study hypothesis: Chronic Obstructive Pulmonary Disease (COPD) patients with chronic bacterial colonization have lower levels of mucins and antimicrobial peptides in their airways
- Trial name
- NCT01976130
- Testing
- Bronchoscopy
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Single Cell Sequencing Technology, Gene Expression Profiling
Host Response to Infection by Direct Analysis of Leukocyte Single Cell-type Gene Expression/transcript Abundance, Direct LS-TA. a Prospective Study Will Evaluate the Performance of Direct LS-TA in Triage Febrile Patients Into Major Categories of Infections: Viral, Bacterial or Active Tuberculosis.
Febrile illness is a common condition and it is crucial to have an early triage of patients according to various aetiologies to enable appropriate treatment.
- Conditions
- Single Cell Sequencing Technology, Gene Expression Profiling, Gene Expression, Infection
- Trial name
- NCT06846645
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Atopic Dermatitis, Hidradenitis Suppurativa
Linking Epidermal Barrier Function With Anti-Oxidant Defense Mechanisms in Skin Conditions
Investigators will sample the skin and blood of patients with chronic skin conditions (including but not limited to atopic dermatitis (AD), contact dermatitis, hidradenitis suppurativa (HS), and psoriasis) to study the expression…
- Conditions
- Atopic Dermatitis, Hidradenitis Suppurativa, Contact Dermatitis, Psoriasis
- Trial name
- NCT03198390
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Fibromyalgia, Chronic Migraine, Headache
Personality, Defences, Central Sensitization, and Trauma in Women With Chronic Migraine, Fibromyalgia, and Vulvodynia
Chronic pain (CP) is a substantial healthcare challenge with considerable economic costs. Recently, the term Nociplastic Pain (NP) has been introduced as a third descriptor of mechanisms related to CP.
- Conditions
- Fibromyalgia, Chronic Migraine, Headache, Vulvodynia
- Trial name
- PSYCHOFIBRO (NCT06138171)
- Testing
- Psychological self-reported measures assesment (questionnaire)
- Where
- Italy
- Volunteers
- 1,006 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Mechanisms, Defense
The Effect of Concord Grape Polyphenol-soy Protein Isolate Complex (GP-SPI) on Gut Microbiota
The overall purpose of this study is to evaluate the effect of nutritional supplementation with a well-characterized preparation of Concord grape polyphenol-soy protein isolate (GP-SPI) on the composition of the gut microbiota.
- Trial name
- NCT04018066
- Testing
- GP-SPI
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Host Defense Mechanisms
Molecular Basis of Human Phagocyte Interactions With Bacterial Pathogens
Human phagocytic cells such as polymorphonuclear leukocytes (PMNs) are readily mobilized to sites of infection and ingest microorganisms by a process known as phagocytosis.
- Trial name
- NCT00339287
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Liver Diseases
Study of Psychological Defense Mechanisms Used by Liver Transplant Patients
Organ transplantation has a special place in the medical field. It symbolizes a medicine whose limits always seem to be repelled.
- Trial name
- GHEPA (NCT01458756)
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Lille
Bronchiectasis
Role of Innate Immunity in Non-Cystic Fibrosis Bronchiectasis
The purpose of this study is to demonstrate that 1) the secretion of mucins, antimicrobial peptides and Toll-like receptors is altered in certain patients with non-CF bronchiectasis, which makes them more susceptible to be…
- Trial name
- NCT02163642
- Testing
- Cyranose® 320
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Major Depressive Disorder (MDD)
Effect of TMS Treatment on Defense Mechanisms and Functionality in Patients With Depression
This prospective observational study aims to evaluate changes in psychological defense mechanisms in patients with non-psychotic major depressive disorder (MDD) undergoing repetitive Transcranial Magnetic Stimulation (rTMS)…
- Trial name
- NCT07853989
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Namik Kemal University
Takayasu Arteritis, Mechanisms, Defense
The Registry Study of Takayasu Arteritis in East China
The Takayasu arteritis (TA) is a rare inflammatory large vessel arteritis which often occurs women in Aisa, one of which is China.
- Conditions
- Takayasu Arteritis, Mechanisms, Defense, Pregnancy Related, Treatment Refusal
- Trial name
- NCT03893136
- Testing
- Tocilizumab, Leflunomide
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Chronic Periodontitis, Diabetes Mellitus, Type 2
White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis
White blood cell membrane and surface structures are affected by the metabolic disorders and complications found in diabetes mellitus.
- Trial name
- DMS (NCT01848379)
- Testing
- ADT+FD, FD
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zentrum fuer Zahn-, Mund- und Kieferheilkunde
Pneumonia
The Effect of Leukocyte Dna mEthylation and micRoBIOME Diversity on Host Defense Mechanisms During Community-acquired Pneumonia (ELDER-BIOME)
Community-acquired pneumonia (CAP) represents a major health care problem and mortality and morbidity associated with severe pneumonia remain considerable, despite state of the art care.
- Trial name
- ELDER-BIOME (NCT02928367)
- Testing
- rectal swab, nasopharyngeal swab, blood draw
- Where
- Netherlands
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mindfulness, Psychoeducation
Mindfulness-based Psychoeducation and Defense Mechanisms, Mindful Awareness
Purpose: Nowadays, it is seen that there is an increasing interest in mindfulness-based therapies. Such practices can be beneficial by contributing to the personal and professional development of nursing students.
- Conditions
- Mindfulness, Psychoeducation, Defense Mechanisms, Awareness
- Trial name
- NCT05712499
- Testing
- mindfulness-based psychoeducation program, ongoing life
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Agri Ibrahim Cecen University