Clinical trials: Medicine, Emergency
Dyspnea
Feasibility and Functionality Test of Ada's DDSS Prototype
This study is to explore with a feasibility and functionality test the potential of the Ada DDSS prototype with cases of dyspnea patients using the data collected at the Emergency Department (ED) and the ward of Internal medicine…
- Trial name
- Ada4dyspnoe (NCT04827342)
- Testing
- data collection in the Ada DDSS prototype
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Basel, Switzerland
Healthy Volunteers
Ultrasound to View Abdominal Wall Muscle Layers
The American College of Emergency Physicians (ACEP) views ultrasound-guided nerve blocks to be a core skill for emergency medicine physicians.
- Trial name
- NCT06955013
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Corewell Health South
Polytrauma
Comparing Trauma Severity Scores Injury Severity Score "ISS", Rapid Emergency Medicine Score "REMS" and Kampala Trauma Score "KTS"
Trauma is defined as a physical injury from an external source of sudden onset and severity, which require immediate medical attention.Despite improvements in trauma systems worldwide, trauma continues to be one of the leading…
- Trial name
- NCT05544773
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Assiut University
HIV Infections
Rapid HIV Testing for Emergency Department Patients
The purpose of this study is to test data collection options in emergency departments (EDs) and to enhance ED patient awareness of the risk of HIV infection.
- Trial name
- NCT00676481
- Testing
- HIV risk education
- Where
- United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Acute Apical Abscess
Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening
This study is aimed to evaluate the efficacy of valacyclovir in reducing postoperative pain following emergency chamber opening for acute apical abscess .
- Trial name
- Antiviral (NCT06344195)
- Testing
- Valacyclovir 500 mg, Naproxen Sodium 550mg
- Where
- Pakistan
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Medication Errors, Pediatric Medication Error
Augmenting the On-Scene Medic (ATOM): A Randomized, Controlled, Multicenter Study to Assess the Effectiveness of Augmented Reality Software on Prehospital Pediatric Medication Administration Accuracy
The primary objective of this research study is to use simulated pediatric emergencies to test the effectiveness of a drug dosing safety system for EMS providers by comparing usual care to use of an augmented reality device.
- Trial name
- ATOM (NCT07504211)
- Testing
- Augmented reality software for pediatric drug dosing
- Where
- United States
- Volunteers
- 312 people
- Sponsor
- Western Michigan University School of Medicine
Drug Addiction
Importance of Drug User Detection
1. Identify the illicit drugs (morphine, cannabinoids, benzodiazepines, barbiturates, tramadol, cocaine, amphetamine, alcohol, synthetic cannabinoids). 2.
- Trial name
- NCT05803044
- Volunteers
- 200 people
- Sponsor
- Assiut University
Chronic Back Pain, Degenerative Disc Disease Lumbar
CELZ-201-DDT for the Treatment of Chronic Lower Back Pain
CELZ-201-DDT is an investigational (experimental) cell therapy currently being studied for people with degenerative disc disease who have chronic lower back pain.
- Trial name
- ADAPT (NCT07137559)
- Testing
- CELZ-201-DDT
- Sponsor
- Creative Medical Technology Holdings Inc
Frailty, Emergency Department Visit
Association Between Geriatric Frailty and Medication Related Problems in the Emergency Department to Help Clinical Pharmacists Prioritise Patients
The healthcare systems are under increasing pressure due to a rise in emergency consultations, staff shortages, an ageing population and rising costs.
- Conditions
- Frailty, Emergency Department Visit, Elderly, Drug Drug Interaction
- Trial name
- DISARMED (NCT07282379)
- Testing
- Pharmaceutical analysis based on the Electronic Patient Record
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Pharmacie des Hopitaux de l'Est Lemanique
Charcoal, Decontamination, Poisoning
Activated CHARcoal in Poisoned Patient - Pilot Trial
The goal of this clinical pilot trial is to determine the feasibility of the clinical trial. Then the large-scale CHARPP will be conducted in order to determine the efficacity of activated charcoal as a treatment for acute…
- Trial name
- CHARPP-Pilot (NCT05471479)
- Testing
- Activated Charcoal, No activated charcoal
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Drug Interactions
Emergency Department (ED) Drug Interaction in Emergency Department Patients
This study examines how hepatic cytochrome CYP2D6 drug interactions affects the efficacy of oxycodone, hydrocodone, and ondansetron in Emergency Department (ED) patients.
- Trial name
- NCT01859715
- Testing
- Oxycodone, Hydrocodone, Ondansetron
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- University of Colorado, Denver
Medical Education
Critical Appraisals at Play
Pre and Post assessment of knowledge and attitudes on critical appraisal of biomedical literature in Emergency Medicine practice in a cohort of residents with implementation of a competition based educational format.
- Trial name
- NCT07126314
- Testing
- Competition based Education Format
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Community Medical Center, Toms River, NJ
Drug Overdose
Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use
Overdose with potential deadly outcome is a serious problem among opioid abusers, not least in Norway. The annual death toll from overdose is about 250, higher than road traffic accidents.
- Trial name
- OPI-14-001 (NCT02307721)
- Testing
- Intranasal naloxone, Intramuscular naloxone, Remifentanil
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Cardiac Arrest
Effectiveness of an Interactive Cognitive Support Tablet App to Improve the Management of Pediatric Cardiac Arrest
Pediatric cardiac arrest (PCA) has a high mortality and morbidity. Its management is complex and often deviates from guideline recommendations leading to patients' worse clinical outcomes.
- Trial name
- PediAppRREST (NCT04619498)
- Testing
- PediAppRREST, AHA-PALS pocket reference card
- Where
- 4 sites in Italy
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of Padova
Laceration of Skin, Anxiety
IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED
Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to optimize patient and family experience and allow for…
- Conditions
- Laceration of Skin, Anxiety, Discharge Time
- Trial name
- NCT05934669
- Testing
- Intranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Analgesics, Opioid, Delivery of Health Care
A Quality Improvement Project to Investigate Individual Provider Variation in Opioid Prescribing From the Emergency Department
This is a study of emergency physicians' prescribing patterns related to opioid (narcotic) medications. We are trying to determine whether giving providers access to their own prescribing data influences their prescribing…
- Conditions
- Analgesics, Opioid, Delivery of Health Care, Drug Prescribing, Over Prescribing
- Trial name
- NCT02665429
- Testing
- Individual prescribing data profile and self-assessment
- Where
- 3 sites in United States
- Volunteers
- 109 people
- Sponsor
- University of Massachusetts, Worcester
Dementia
Deprescribing Potentially Inappropriate Medications in the Emergency Department for Persons Living With Dementia
Aim 1: To demonstrate the feasibility by determining proportion of completed medication reconciliation, Central Nervous System active Potentially Inappropriate Medication (CNS PIM) use among patients with Alzheimer's Disease and…
- Trial name
- IMPACT (NCT06273917)
- Testing
- PRIDE
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- National Institute on Aging (NIA)
Intussusception, Emergencies
Point-of-Care Ultrasonography for Intussusception
Pediatric emergency medicine (PEM) physicians are increasingly utilizing point-of-care ultrasound (POCUS). There is currently limited data regarding POCUS evaluation for intussusception in pediatric patients.
- Trial name
- NCT03360643
- Testing
- Point-of-care ultrasound prior to radiology ultrasound, Radiology-performed ultrasound
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Heat Illness, Heat Stroke
Heat Emergency Awareness and Treatment (HEAT)
Investigators propose an intervention trial of a comprehensive education and treatment bundle designed to reduce morbidity and mortality associated with heat-related illness for low resource settings.
- Conditions
- Heat Illness, Heat Stroke, Heat Exhaustion, Heat Exposure
- Trial name
- HEAT (NCT03513315)
- Testing
- Implementation of Community-based Home Heat Bundle, Regular Community Healthcare provision
- Where
- 2 sites in Pakistan
- Volunteers
- 16,973 people
- Sponsor
- Johns Hopkins University
Fatigue, Shift Work Type Circadian Rhythm Sleep Disorder
Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts
Emergency Medicine (EM) requires 24/7 staff coverage resulting in healthcare workers' circadian rhythm disruptions that impair clinical and cognitive performance, physical recovery, and contribute to burnout.
- Trial name
- NCT06100809
- Testing
- Personalized coaching, Nutrition handout
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester