Clinical trials: Medicine
Drug Absorption
Effect of Gamma-cyclodextrin on the Bioavailability of Ginsenosides
This study will evaluate the relative bioavailability of ginsenosides Rg5, Rk1, and Ck of Red ginseng HRG80 preparations containing gamma-cyclodextrin (GCD) in the blood plasma of healthy subjects after oral administration of two…
- Trial name
- NCT04932265
- Testing
- HRG80™ Red Ginseng, HRG80™ Red Ginseng + gamma cyclodextrin
- Where
- 4 sites in Armenia, Sweden
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- EuroPharma, Inc.
Abortion Early
Auriculotherapy During Medication Abortion
This randomized trial will evaluate the effect of adding auriculotherapy (i.e. acupuncture applied to the ear) using either gold beads or Pyonex needles in addition to usual care for the relief of pain and anxiety during…
- Trial name
- NCT03900728
- Testing
- Auriculotherapy with needles, Auriculotherapy with beads
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Columbia University
Depressive Disorder, Major, Suicidal
A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide
The purpose of the study is to evaluate the efficacy, safety, and tolerability of SLS-002 (intranasal racemic ketamine) in addition to standard of care on symptoms of Major Depressive Disorder (MDD) and suicidality, in…
- Trial name
- NCT04669665
- Testing
- SLS-002, Standard of care, Intranasal device
- Where
- 21 sites in United States
- Volunteers
- 164 people
- Sponsor
- Seelos Therapeutics, Inc.
Atherosclerosis
Study to Determine the Effect of Repeated Administration of Diltiazem on the Pharmacokinetics of Darapladib (Sb-480848).
Darapladib (SB-480848) is a novel, selective, orally active inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2) currently under clinical development by GlaxoSmithKline as a potential anti-atherosclerosis agent for…
- Trial name
- NCT01852565
- Testing
- Darapladib, Diltiazem
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stroke, Ischemic
The Association Between Obesity-Related Indicators and Adverse Outcomes in Ischemic Stroke Patients
This study encompasses two cohorts: a retrospective cohort derived from a genuine clinical environment and a national multicenter prospective cohort for secondary analysis.
- Trial name
- NCT06165107
- Testing
- No intervention
- Where
- China
- Volunteers
- 18,374 people
- Sponsor
- Qin Zhang
Coronary Artery Disease
Drug-Eluting Stent Implantation Versus Optimal Medical Treatment in Patients With Chronic Total Occlusion (DECISION-CTO)
The purpose of this study is to compare the safety and effectiveness of drug-eluting stent implantation compared to optimal medical treatment in patients with chronic total occlusion.
- Trial name
- NCT01078051
- Testing
- Cypher, xience, Endeavor, Taxus, optimal medical therapy
- Where
- 26 sites in India, Indonesia and 3 more
- Volunteers
- 840 people
- Sponsor
- Seung-Jung Park
Thumb Osteoarthritis
Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection
The goal of this clinical trial is to evaluate whether platelet-rich plasma (PRP) injections improve pain and function in adults with thumb base osteoarthritis (CMC-I OA).
- Trial name
- Thumbs-up (NCT07491302)
- Testing
- Platelet-Rich Plasma (PRP) Injections, Saline (0.9% NaCl)
- Where
- Netherlands
- Volunteers
- 88 people
- Sponsor
- Goed Medisch Centrum
Partial Epilepsies
Determine Safety and Efficacy of Long-term Oral Lacosamide in Patients With Partial Seizures
The purpose of this trial is to determine whether lacosamide is safe and effective for long-term use in patients with partial-seizures from epilepsy
- Trial name
- NCT00522275
- Testing
- lacosamide
- Where
- 60 sites in United States
- Volunteers
- 308 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Unruptured Intracranial Aneurysm, Stents
Application of Platelet Function Test in Prevention of Ischemic Events After Stent Placement in Intracranial Aneurysms
This study was designed to identify high platelet reactivity (HPR) who might have in-stent thrombosis in unruptured aneurysm with intracranial stent placement with light transmittance platelet aggregometry (LTA).
- Conditions
- Unruptured Intracranial Aneurysm, Stents, Antiplatelet Drugs
- Trial name
- APISIA Trail (NCT03989557)
- Testing
- Aspirin and clopidogrel/Ticagrelor, Light transmittance aggregometry
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Beijing Neurosurgical Institute
Plaque Type Psorisis
Study Comparing Tapinarof Cream 1% To VTAMA ® (Tapinarof Cream 1%) In the Treatment of Plaque Psoriasis
To compare the safety and efficacy of the test (Tapinarof Cream 1%), placebo (vehicle cream) and reference VTAMA® (Tapinarof Cream 1%) treatments to demonstrate clinical equivalence in patients with plaque psoriasis.
- Trial name
- NCT06742957
- Testing
- Tapinarof Cream 1%, VTAMA®
- Where
- 26 sites in United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA
Diabetes Mellitus
Comparison of the Patients With Diabetes Mellitus Using Either Insulin or Oral Antidiabetic Drug In Terms Of Difficult Laryngoscopy
Diabetes Mellitus is known to be a risk factor for difficult laryngoscopy. Several studies showed that diabetes mellitus is responsible for 30% of difficult laryngoscopy.Insulin and oral antidiabetic drugs are two main current…
- Trial name
- NCT05040412
- Testing
- difficult laryngoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
MUSIC THERAPY, Premenstrual Syndrome
Music and Premenstrual Symptoms and Quality of Life
Premenstrual syndrome is an important health problem affecting women of childbearing age. This study is a prospective, single-blinded randomized controlled trial. Participants were randomized into music, and control groups.
- Trial name
- NCT04955912
- Testing
- music medicine
- Where
- Turkey (Türkiye)
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Dyslipidemia, Diabetes
Meta-analyses of Dietary Pulses and Cardiometabolic Risk
Dietary pulses, more commonly known as "legumes", are generally recognized as healthy components of the diet. Canada's Food Guide encourages consumptions of meat alternatives, such as beans "more often"; and the dietary…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01594567
- Testing
- Dietary pulses
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Kidney Transplant Failure and Rejection
AGe-adapted Benefits of Envarsus Versus Twice-daily Tacrolimus ImmunosuppressioN druGs After Kidney Transplantation
The proportion of elderly patients with end-stage kidney disease undergoing renal replacement therapy (RRT) is steadily increasing.
- Trial name
- AGEING (NCT03005236)
- Testing
- ENVARSUS, Standard twice daily tacrolimus
- Volunteers
- 40 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Early-stage Breast Cancer
Cardioprotective Effect of Acute Exercise in Breast Cancer Patients
Cardiotoxicity is one of the most significant adverse effects in breast cancer patients treated with anthracyclines (a type of chemotherapy), so we propose to determine whether acute training (i.e., 24h before each chemotherapy…
- Trial name
- CardioProtEx (NCT05467111)
- Testing
- Acute Exercise
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Technical University of Madrid
Epilepsy, Chronic Pain
Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use
This study aims to evaluate the influence of genetic polymorphisms of OCTN1 and OCT2 and other possible covariates on the kinetic disposition of GAB in patients undergoing GAB chronic treatment.
- Trial name
- NCT02977208
- Testing
- Sparse blood sampling, Urine sampling, DNA extraction
- Where
- Brazil
- Volunteers
- 66 people
- Sponsor
- São Paulo State University
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Hypercholesterolemia, HMG COA Reductase Inhibitor Adverse Reaction
Statin Therapy to Improve Medication Adherence
The purpose of this pilot study is to examine if using genetics can improve statin adherence in patients who should be taking statins but are not because of prior side effects with statins.
- Trial name
- NCT01894217
- Testing
- Genetic testing and reporting for SLCO1B1*5 allele
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Duke University
Stroke, Transient Ischemic Attacks
Atrial Fibrillation as a Cause of Stroke and Intracranial Hemorrhage Study (The FibStroke Study)
The aim of this study is to evaluate the role of atrial fibrillation (AF) and its treatment in relation to thromboembolic events (stroke, and transient ischemic attacks) and intracranial hemorrhage.
- Conditions
- Stroke, Transient Ischemic Attacks, Intracranial Hemorrhage, Atrial Fibrillation
- Trial name
- FibStroke (NCT02146040)
- Where
- 4 sites in Finland
- Volunteers
- 5,885 people
- Sponsor
- University of Turku
Schizophrenia
A Clinical Study to Evaluate the Long-term Safety and Tolerability of an Investigational Drug in People With Schizophrenia
This is a clinical trial to determine the long-term safety and tolerability of an investigational drug in people with schizophrenia. Participants in the study will receive the drug being studied.
- Trial name
- NCT04109950
- Testing
- SEP-363856
- Where
- 78 sites in United States, Bulgaria and 6 more
- Volunteers
- 463 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
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