Clinical trials: Medicine
Healthy Volunteers
A STUDY TO EVALUATE THE EFFECT OF PF-06651600 ON PHARMACOKINETICS OF SINGLE DOSE SUMATRIPTAN IN HEALTHY PARTICIPANTS.
Study to evaluate the effect of pf-06651600 on pharmacokinetics of single dose sumatriptan.
- Trial name
- NCT04355845
- Testing
- Sumatriptan, PF-06651600
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pfizer
Malaria
Mass Drug Administrations of DHA-PQP to Accelerate Towards Malaria Elimination in Magude District, Southern Mozambique
In line with the global and regional efforts towards malaria elimination, a five year program was established to assist the NMCP in adopting targeted evidence-based elimination plans through a 'learn by doing' strategy.
- Trial name
- MDAM (NCT02914145)
- Testing
- Dihydroartemisinin-piperaquine
- Volunteers
- 240,502 people, healthy volunteers welcome
- Sponsor
- Centro de Investigacao em Saude de Manhica
Psoriasis
This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis
To assess the influence of risankizumab on kinetics of cytochrome P450 (CYP) probe drugs as a means of predicting drug-drug interactions.
- Trial name
- NCT02772601
- Testing
- Caffeine, Warfarin, Omeprazole
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- AbbVie
Pharmacokinetics, Drug Interactions
Pharmacokinetic Drug Interaction Between Ezetimibe and Sirolimus After Single Dose Administration in Healthy Subjects
The purpose of this study is to confirm a significant influence of ezetimibe and sirolimus on each others pharmacokinetics
- Conditions
- Pharmacokinetics, Drug Interactions, Hypercholesterolemia, Immunosuppression
- Trial name
- NCT00621101
- Testing
- 1 tablet Ezetrol(R) (ezetimibe), MSD Sharp & Dohme GmbH, Germany, 1 tablet Rapamune(R) (sirolimus), Wyeth Pharma, Germany, 1 tablet Ezetrol(R) + 1 tablet Rapamune(R)
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Alzheimer Dementia, Dementia Disorders
Medication Repurposing to Stop Cognitive Decline in Dementia
Dementia creates a great personal and societal burden and there are currently no treatments to stop memory loss. Many patients with dementia take medications to treat other conditions, e.g. high blood pressure and cholesterol.
- Trial name
- NCT05817188
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 100,000 people
- Sponsor
- Karolinska Institutet
Neutropenia, Thrombocytopenia
Effects of Levetiracetam Monotherapy on Various Hematological Parameters in Adult Patients Suffering of Epilepsy
Low therapeutic index of established antiepileptic drugs (AEDs) coupled with better understanding of the pathophysiology of seizure has encouraged the development of several novel AEDs.
- Conditions
- Neutropenia, Thrombocytopenia, Aplastic Anemia, Anemia
- Trial name
- NCT06491303
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease
Austrian Multivessel Taxus-Stent Registry
The aim of AUTAX study is to investigate the frequency of MACCE in patients with multivessel disease and multiple Taxus stent implantations in the "real world" stenting at 30 days, 6 and 12 months at 2 year follow-up.
- Trial name
- AUTAX (NCT00738686)
- Testing
- Intracoronary stent implantation
- Where
- 7 sites in Austria
- Volunteers
- 441 people
- Sponsor
- Medical University of Vienna
Kidney Transplant
Perceptions of Kidney Transplant Recipients Regarding the Role of Artificial Intelligence in Medicine
The AITX study is an international, multicenter survey exploring how kidney transplant recipients perceive artificial intelligence (AI) in medicine and, specifically, a system that predicts graft loss risk.
- Trial name
- AITX (NCT07600541)
- Where
- 2 sites in France
- Volunteers
- 1,000 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Diabetes Mellitus, Type 2
Integrative Group Program for Type 2 Diabetes Mellitus (T2DM)
This is an open, randomized, controlled trial to determine the impact of an integrative group program on metabolic control and wellbeing perception of patients with T2DM.
- Trial name
- NCT05888454
- Testing
- Integrative Group Program, Conventional treatment for T2DM
- Where
- 2 sites in Mexico
- Volunteers
- 120 people
- Sponsor
- TecSalud Investigación Clínica
Neoplasms, Heart Failure
Ivabradine to Prevent Anthracycline-induced Cardiotoxicity
Anthracyclines are associated with cardiotoxic effects. Previous studies suggest that enalapril, and or carvedilol, protect against cardiovascular effects of these drugs.
- Conditions
- Neoplasms, Heart Failure, Cardiotoxicity, Chemotherapy Effect
- Trial name
- IPAC (NCT03650205)
- Testing
- Ivabradine
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- University of Sao Paulo
Uncontrolled Hypertension
EuroNetrod HTN OFF-Med Study of Renal Denervation With NetrodTM Six-electrode Radiofrequency RDN System
This randomized controlled investigation aims to evaluate the efficacy and safety of the Netrod™ RDN system in patients with uncontrolled primary hypertension in the absence of antihypertensive medication, comparing the outcomes…
- Trial name
- EuroNetrod (NCT06722651)
- Testing
- Netrod™ six-electrode radiofrequency renal denervation system
- Where
- Switzerland
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Chronic Hepatitis c
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients
The hepatitis C virus is a major cause of chronic liver diseases, including cirrhosis and hepatocellular carcinoma, and infects approximately 3 % of the world population (150-170 million).
- Trial name
- NCT03687229
- Testing
- A)microribonucleic acid-122(miRNA-122), B) Hepatitis C virus Real Time Polymerase chain Reaction (HCV RT-PCR), A)fasting serum glucose, B)Fasting serum insulin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pediatric Emergency Medicine, Therapeutic Turnaround Time
Effectiveness of a Mobile App in Reducing Therapeutic TAT in an Emergency Department
This study is a single center, non-equivalent comparison group, pre-post study in a tertiary pediatric emergency department in Switzerland.
- Trial name
- NCT05557331
- Testing
- PIMPmyHospital (mobile app)
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Hypertension, COVID
ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, enters type II pneumocytes using angiotensin-converting enzyme 2 (ACE2).
- Trial name
- NCT04467931
- Testing
- ACEI/ARB, Non-ACEI/ARB, ACEI
- Where
- United States
- Volunteers
- 22,213 people
- Sponsor
- University of Utah
Schizophrenia
A Study to Determine the Maximum Tolerated Dose of an Investigational Drug in Subjects With Schizophrenia
A study to determine the maximum tolerated dose of an investigational drug in subjects with schizophrenia
- Trial name
- NCT03627195
- Testing
- DSP-1349M
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sumitomo Pharma America, Inc.
Hodgkin Disease, Lymphoma, T-Cell, Peripheral
A Safety Study of PF-08046044/SGN-35C in Adults With Advanced Cancers
This clinical trial is studying lymphoma. Lymphoma is a cancer that starts in the blood cells that fight infection. There are several types of lymphoma.
- Conditions
- Hodgkin Disease, Lymphoma, T-Cell, Peripheral, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Large-Cell, Anaplastic
- Trial name
- NCT06254495
- Testing
- PF-08046044/SGN-35C
- Where
- 33 sites in United States, Denmark and 4 more
- Volunteers
- 58 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Motivational Interviewing, Schizophrenia Spectrum Disorder
Effects of Adherence Therapy on Medication Adherence in Patients With Schizophrenia Spectrum Disorder
This study will explore the effect of Adherence Therapy(AT) on medication adherence in patients with schizophrenia spectrum disorder.
- Conditions
- Motivational Interviewing, Schizophrenia Spectrum Disorder, Medication Adherence
- Trial name
- NCT04022577
- Testing
- Adherence Therapy, control group
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Yang Ming Chiao Tung University
Bilateral Vestibular Hypofunction, Bilateral Vestibular Deficiency
Long Term Outcomes After Vestibular Implantation
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural…
- Conditions
- Bilateral Vestibular Hypofunction, Bilateral Vestibular Deficiency, Bilateral Vestibulopathy, Gentamicin Ototoxicity
- Trial name
- NCT06500975
- Testing
- Labyrinth Devices MVI™ Multichannel Vestibular Implant System
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease
The PICCOLETO IX PHENO Study
To investigate whether pre-procedural OCT-derived de novo coronary lesion phenotype (lipid-rich, fibrotic, calcific; and ACS mechanisms such as plaque rupture/erosion/calcified nodule) is associated with clinical outcomes after…
- Trial name
- PIX-PHENO (NCT07390994)
- Volunteers
- 600 people
- Sponsor
- Fondazione Ricerca e Innovazione Cardiovascolare ETS
HIV Infections
Daclizumab to Treat HIV-Infected Patients
This study will examine the safety and effectiveness of daclizumab (also called Zenapax or anti-CD25) in reducing viral replication in patients with HIV infection.
- Trial name
- NCT00080431
- Testing
- Daclizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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