Clinical trials: Medicine
Anti-Glaucoma Medications
Preoperative Visual Aids on Glaucoma Surgical Patients
This study aims to evaluate the impact of preoperative visual aids on anxiety and pain management in patients with low educational backgrounds undergoing glaucoma filtration surgery.
- Trial name
- NCT06478095
- Testing
- Visual aids
- Where
- China
- Volunteers
- 133 people
- Sponsor
- Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong
Healthy Volunteers
A Study to Evaluate the Drug Levels of Cendakimab Delivered Subcutaneously in Healthy Participants
The purpose of this study is to evaluate the drug levels of cendakimab delivered subcutaneously in healthy participants.
- Trial name
- NCT05337345
- Testing
- Cendakimab
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis (RA)
Masitinib in Refractory Active Rheumatoid Arthritis
The objective is to compare efficacy and safety of masitinib at 3 and 6 mg/kg/day to methotrexate, with a randomisation 1:1:1, in treatment of patients with active rheumatoid arthritis with inadequate response to 1.
- Trial name
- NCT01410695
- Testing
- masitinib 3 mg, masitinib 6.0 mg, methotrexate
- Where
- Czechia
- Volunteers
- 324 people
- Sponsor
- AB Science
Inflammatory Bowel Disease, Perianal Fistula
Perianal Fistula (PAF) Validation and Burden of Illness Study
The purpose of this study is to gain a better understanding of the disease burden and unmet need of perianal fistulas within Crohn's disease (CD) in Ontario.
- Conditions
- Inflammatory Bowel Disease, Perianal Fistula, Crohns Disease
- Trial name
- NCT03981939
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 3,032 people
- Sponsor
- Takeda
Stroke
The Effectiveness and Safety of Acupuncture for Elderly Patients of Stroke
Stroke and its sequelae are a major indication for acupuncture. The specific aims of this study are to assess the feasibility of pragmatic clinical trial on acupuncture in primary care setting and evaluate the effectiveness and…
- Trial name
- NCT04971603
- Testing
- Acupuncture
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Hong Kong Baptist University
Atopic Dermatitis, Eczema
Defining the Skin and Blood Biomarkers of Pediatric Atopic Dermatitis
Atopic dermatitis (AD), also known as eczema, is the most common inflammatory skin disorder of children, affecting 10-20% of children and 1-2% of adults.
- Trial name
- NCT01782703
- Where
- 4 sites in United States
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hypertension
Study to Compare the Safety and Pharmacokinetics of CKD-330 8/5mg With Coadministration of the Two Separate Drugs
The purpose of this study is to compare the safety and pharmacokinetics of CKD-330 (fixed-dose combination of Candesartan Cilexetil 8 mg and Amlodipine 5 mg) with coadministration of the two separate drugs in healthy male…
- Trial name
- NCT02548286
- Testing
- Candesartan 8mg, Amlodipine 5mg, CKD-330 8/5mg
- Where
- South Korea
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Pain
Effect of Acupuncture and Pain Medication on Radicular Pain Using QST
In this aim, we propose to conduct a double blinded, placebo-controlled, and randomized clinical trial to compare the clinical effectiveness of radicular pain relief by either acupuncture therapy or a course of pain medication…
- Trial name
- NCT01678586
- Testing
- Acupuncture, Gabapentin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Generic Drug Quality, Generic Formulation Interchangeability
Generic Formulations of Commonly-used Oral Drugs in Saudi Arabia:Interchangeability & Post-marketing Quality
Generic formulations of prescription drugs can, through their relatively lower cost, improve healthcare as long as they maintain their registration-quality and public trust.
- Trial name
- NCT01344070
- Testing
- one of the 15 drugs listed below
- Where
- Saudi Arabia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Tuberculosis
Self-verification and Support Via Mobile Phones Drastically Improves Tuberculosis Treatment Success in LMIC Settings
Each year, 10.4 million patients are diagnosed with and 1.8 million people die from Tuberculosis (TB). Despite the availability of highly effective and accessible medications in the developing world where TB is endemic, the 6-18…
- Trial name
- NCT03135366
- Testing
- Keheala, Standard of Care
- Volunteers
- 1,190 people
- Sponsor
- Yale University
Cardiovascular Diseases
Nudges for Statin Prescribing in Primary Care
The objective of the study is to evaluate the effect of nudges to clinicians, patients, or both to initiate statin prescriptions for patients that meet national guidelines.
- Trial name
- NCT04307472
- Testing
- Clinician Nudge, Patient Nudge
- Where
- United States
- Volunteers
- 4,131 people
- Sponsor
- University of Pennsylvania
Gastric Cancer, Signet Ring Cell Carcinoma
Mechanism of Gastric Signet Ring Cell Carcinoma Based on Microproteomics
Gastric signet ring cell carcinoma (GSRCC) possesses unique epidemiology and pathogenesis in the field of cancer, but its incidence is low.
- Trial name
- NCT05985577
- Testing
- Without any intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhejiang Cancer Hospital
Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs)
Impact of Pharmacotherapy Optimization in Polymedicated Lebanese Older Adults in Primary Health Care Centers
Why are the researchers doing this study? Many older adults take five or more medicines every day. Some of these medicines may no longer help them. Some may even cause harm, such as falls, confusion or tiredness.
- Conditions
- Older Adults (65 Years and Older), Polypharmacy (People Under Treatment With 5 or More Drugs), Primary Health Care, Social Determinants of Health (SDOH)
- Trial name
- PHARMACT-PHC (NCT07866677)
- Testing
- Structured pharmacotherapy optimization, Usual Care
- Where
- Lebanon
- Volunteers
- 452 people
- Sponsor
- National Institute of Public Health, Clinical Epidemiology, and Toxicology-Lebanon (INSPECT-LB)
Yaws
Evaluation of an Intensive 3-round MDA Strategy Towards Yaws Eradication
The current principle of yaws eradication (the Morges strategy) is based on single round mass drug administration (MDA) of azithromycin (AZI) called total community treatment (TCT) followed by targeted treatment of active cases…
- Trial name
- NCT03490123
- Testing
- R1-Total community treatment with azithromycin, R2-Total community treatment with azithromycin, R3-Total community treatment with azithromycin
- Where
- Papua New Guinea
- Volunteers
- 56,000 people, healthy volunteers welcome
- Sponsor
- Lihir Medical Centre
Peripheral Artery Disease
Evaluating the Safety and Efficacy of the G-stream® Drug-Eluting Stent in the Above-the-Knee Femoropopliteal Artery
A multicenter, randomized, controlled, superiority clinical trial to evaluate the efficacy and safety of drug-eluting peripheral arterial stent system（G-stream） in the treatment of femoropopliteal artery stenosis or occlusion.
- Trial name
- G-streamPAD (NCT05780359)
- Testing
- Drug eluting stent, drug coating balloon
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Coronary Heart Disease, Stable Angina
Efficacy and Safety of Xueshuanxinmaining Tablet for the Treatment of Stable Angina Pectoris
This study is a randomized, double-blind, placebo-controlled, parallel clinical trial in Chinese population with stable angina pectoris.
- Trial name
- NCT04270279
- Testing
- Xueshuanxinmaining tablet, Nitroglycerin tablets
- Volunteers
- 120 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Healthy Participants
A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants
The purpose of this study is to assess the effects on the single-dose drug levels of mavacamten in healthy participants.
- Trial name
- NCT05658146
- Testing
- Mavacamten Capsule 1, Mavacamten Capsule 2, Mavacamten Capsule 3
- Where
- 3 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Vision and Hearing Loss, Vision Impairment
SENSE-Brain Health Pro for Older Adults With Sensory Loss
The goal of this study is to learn about the outcomes, usability, and accessibility of the online Brain Health Pro program for older adults with hearing difficulties, vision difficulties, or both.
- Conditions
- Vision and Hearing Loss, Vision Impairment, Hearing Impairment, Vision Difficulty
- Trial name
- SENSE-BHPro (NCT07856888)
- Testing
- Brain Health Pro
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Université de Montréal
Glaucoma; Drugs
Evaluation of Adherence to Clinical Treatment of Glaucoma
Evaluation of adherence to clinical treatment of glaucoma in patients of a Reference Ophthalmological Hospital in Goiânia using Morisky Adhesion scale as a validated questionary.
- Trial name
- NCT03338088
- Where
- 2 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto de Olhos de Goiania
Parkinson Disease
Markers of Disease Progression and Gait Within the Parkinsonian Population
The aim of the project is to evaluate disease progression of patients with Parkinsonian syndrome of various severity through regular home-based gait parameters analysis. We identified several steps in this project: 1.
- Trial name
- Gait'N'Park (NCT04653688)
- Testing
- The FeetMe® Evaluation, the PKG® Watch,, MRI
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
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