Clinical trials: Meibomian Gland Dysfunction
GVHD, Meibomian Gland Dysfunction (Disorder)
Autologous Serum Obtained by a Closed-Circuit Collection Device
Autologous serum eye drops (ASED) are an established therapy for ocular surface diseases; however, their preparation can be costly and may not be available due to the need for germ-free conditions.
- Conditions
- GVHD, Meibomian Gland Dysfunction (Disorder), Stevens-Johnson Syndrome, Limbal Keratoconjunctivitis
- Trial name
- NCT07014059
- Testing
- Autologous Serum 20%
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- GIANCARLO FATOBENE
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Effect of a Dietary Supplement on Gut Microbiota and Ocular Surface Outcomes in Dry Eye Disease
This prospective clinical study investigates whether a dietary supplement product can modulate the gut microbiota and improve ocular surface outcomes in patients with dry eye disease.
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Dry Eye Disease (DED), Dry Eye Disease, Meibomian Gland Disease
- Trial name
- NCT07148271
- Testing
- Dietary Supplement Product
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Varol TUNALI
Dry Eye Disease (DED), Meibomian Gland Dysfunction (Disorder)
Effect of Oral Isotretinoin on Ocular Surface and Meibomian Glands
The aim of the study was to evaluate meibomian gland morphology using non-contact meibography and ocular surface changes in patients with acne vulgaris treated with isotretinoin as indicators of dry eye, which is known to be a…
- Conditions
- Dry Eye Disease (DED), Meibomian Gland Dysfunction (Disorder), Acne Vulgaris
- Trial name
- NCT07753811
- Testing
- isotretinoin
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Benha University
Meibomian Gland Dysfunction
Efficacy and Safety of Thermic Devices in the Treatment of Meibomian Gland Dysfunction
Dry eye syndrome is a common eye disease that affects 1 to 2 out of 10 persons around the planet. One common cause of this disease is the meibomian gland dysfunction.
- Trial name
- NCT03767530
- Testing
- Mibo Thermoflo, Warm compresses and eyelid massage
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Meibomian Gland Dysfunction, Dry Eye Syndromes
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients
This observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07810569
- Volunteers
- 150 people
- Sponsor
- Assiut University
Dry Eye, Evaporative Dry Eye Disease
Microbiome-Focused Food Supplement for Evaporative Dry Eye Due to Meibomian Gland Dysfunction
Dry eye disease (DED) is a common chronic condition characterized by ocular surface discomfort and tear film instability. Evaporative DED associated with meibomian gland dysfunction (MGD) is a frequent phenotype and is often…
- Conditions
- Dry Eye, Evaporative Dry Eye Disease, Meibomian Gland Dysfunction (Disorder)
- Trial name
- NCT07453212
- Testing
- Dietary Supplement: Microbiome-targeted oral supplement
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Varol TUNALI
Demodex Blepharitis, Meibomian Gland Dysfunction (MGD)
Effectiveness of Low Level Light Therapy and Intense Pulse Light on Mite Count as Adjuntive Therapies in Demodex Blepharitis Using Artificial Intelligent Program (Ai-Demodex)
Primary Objective: To evaluate the efficacy of LLLT, IPL, and IPL + LLLT in re ducing demodex count in patients with Demodex Blepharitis.
- Trial name
- Ai-Demodex (NCT07169461)
- Testing
- The blue MY MASK-E, IPL, Mechanical with pharmacological treatment
- Where
- Thailand
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Dry Eye Disease (DED), MGD-Meibomian Gland Dysfunction
The Effect of Eyelid Support Plate Assisted Eyelid Massage on Meibomian Gland Dysfunction: a Randomized Controlled Trial
This study aims to conduct a randomized controlled clinical trial to compare the efficacy of a new type of massage device - eyelid support plate and glass rod assisted eyelid massage in improving MGD related dry eye symptoms, and…
- Trial name
- NCT07633938
- Testing
- eyelid support plate assisted eyelid massage, glass rod assisted eyelid massage
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Meibomian Gland Dysfunction (MGD)
Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction
This research study evaluates a prescription eye drop called Vevye® (cyclosporine 0.1%) for adults who have meibomian gland dysfunction (MGD), a common eye condition that can cause dry, irritated, or burning eyes.
- Trial name
- NCT07224529
- Testing
- Vevye(Cyclosporine 0.1% Ophthalmic Solution)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Alabama at Birmingham
Meibomian Gland Dysfunction
Intense Regulated Pulsed Light Vs Standard of Care for the Treatment of Meibomian Gland Dysfunction
This study is to evaluate the effectiveness of E>EYE intense regulated pulsed light (IRPL) treatment compared to the current standard of care using a daily warm compress
- Trial name
- NCT04920396
- Testing
- E>Eye IRPL, Warm compress
- Where
- Canada
- Sponsor
- Aston University
Meibomian Gland Dysfunction (Disorder)
TearCare MGX™ System With and Without Warming Hold
TearCare is an office-based thermal therapeutic eyelid technology cleared by the US Food and Drug Administration for the treatment of evaporative dry eye disease due to meibomian gland dysfunction.
- Trial name
- XTEND (NCT07365735)
- Testing
- localized heat therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Sight Sciences, Inc.
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Meibomian Gland Changes in Ocular Prosthesis Users
This observational cross-sectional study aims to evaluate meibomian gland loss and dry eye symptoms in patients using unilateral ocular prostheses.
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Anophthalmic Socket Syndrome, Ocular Prostheses
- Trial name
- MGPRO (NCT07621952)
- Testing
- Oculus Keratograph 5M
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Dry Eye, MGD-Meibomian Gland Dysfunction
Comparative Effects of USB-Powered Warm Compress and Self-Heating Eye Mask in the Management of Meibomian Gland Dysfunction
Why was this study done? People with Meibomian Gland Dysfunction (MGD) often have dry, irritated eyes because the tiny oil glands in their eyelids do not work properly.
- Trial name
- NCT07618169
- Testing
- USB-Powered Warm Compress, Self-Heating Eye Mask
- Where
- Saudi Arabia
- Volunteers
- 15 people
- Sponsor
- King Saud University
Dry Eye, Meibomian Gland Dysfunction
Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment
The purpose of this study is to examine the impact of nasal spray treatment on Meibomian gland function and ocular surface health in symptomatic dry eye patients with mild to moderate Meibomian gland dysfunction (MGD).
- Trial name
- NCT07606625
- Testing
- Varenicline 0.03Mg/Spray Nasal Soln
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Berkeley
Dry Eye Disease, Meibomian Gland Dysfunction
Preoperative iLux on Cataract Surgery Derived Dry Eye Disease Due to Meibomian Gland Dysfunction
This prospective study will investigate the effect of pre-operative Systane iLux system administration in treated cataract induced dry eye disease.
- Conditions
- Dry Eye Disease, Meibomian Gland Dysfunction, Cataract Senile, Dry Eye Syndromes
- Trial name
- NCT06483750
- Testing
- Systane iLux Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- George Washington University
Meibomian Gland Dysfunction (Disorder)
TearCare in Young Adults
This study is a non-randomized, open-label, interventional trial of TearCare® eyelid warming and manual meibomian gland expression in young adults with clinically significant meibomian gland dysfunction (MGD).
- Trial name
- NCT07579156
- Testing
- TearCare®
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Dry Eye Syndromes, Meibomian Gland Dysfunction
Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD
The goal of this prospective, 24-week, double-masked, randomized, sham-controlled clinical trials to compare clinical efficacy and safety of RF and MGX with MGX alone in patients with meibomian gland dysfunction-related dry eye…
- Trial name
- NCT06220474
- Testing
- The Thermage FLX System
- Where
- 2 sites in Hong Kong
- Volunteers
- 112 people
- Sponsor
- The University of Hong Kong
Meibomian Gland Dysfunction
Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD
Meibomian gland dysfunction (MGD), closely associated with Dry Eye Disease (DED), is a chronic condition where terminal ducts are obstructed and/or glandular secretion changes. The efficacy of traditional treatment options, e.g.
- Trial name
- NCT05577910
- Testing
- Vectored thermal pulsation (VTP) therapy, Intense pulsed light with meibomian gland expression (IPL+MGX) therapy, Eyelid Warm Compress Therapy (EW)
- Where
- 4 sites in Hong Kong
- Volunteers
- 374 people
- Sponsor
- Chinese University of Hong Kong
Dry Eye Syndromes, Meibomian Gland Dysfunction (Disorder)
Blink Reminders and Meibomian Gland Loss in Digital Screen Users
This randomized clinical trial aims to evaluate if a blink reminder program ('BlinkEasy') reduces the progression of Meibomian gland loss in intensive digital screen users over three months , using infrared meibography as the…
- Trial name
- NCT07430137
- Testing
- Digital Blink Reminder Software (BlinkEasy), Visual Hygiene Education (20-20-20 Rule).
- Volunteers
- 28 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Dry Eye Syndromes, Meibomian Gland Dysfunction
Mechanisms of Light-based Therapies for Dry Eye Disease
Dry eye disease is a common condition affecting millions worldwide and costing millions in healthcare due to reduced work productivity and quality of life.
- Trial name
- MOLT (NCT06004895)
- Testing
- Actual IPL, LLLT
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Aston University