Clinical trials: Membranous
Extracorporeal Membrane Oxygenation
Feasibility and Prognosis of Early Rehabilitation in Patients With ECMO
ECMO is increasingly used in critically ill patients with severe circulatory and/or respiratory failure. Because of the catheterization of the femoral artery and femoral vein, usage of sedatives, and occasionally with…
- Trial name
- NCT05083624
- Testing
- rehabilation therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- JinyanXing
Tympanic Membrane Perforation
Insulin Intratympanic Application
The objective of the present study was to study the impact of insulin insitu-gel formulation on healing progress after surgical procedures for treatment of dry tympanic membrane perforation for at least three consecutive months.
- Trial name
- NCT07535827
- Testing
- Insulin (Humulin), foam
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Deraya University
Peri-Implantitis
Regenerative Outcomes for Peri-implant Bony Defects Using Amnion-chorion Barrier vs. Collagen Membrane
The purpose of this study is to compare the clinical and radiographic outcomes of two different barrier membranes-amnion-chorion membranes (ACM) and conventional collagen membranes-used in guided bone regeneration (GBR)…
- Trial name
- NCT07032259
- Testing
- BioXclude Amnion Chorion Membrane, Collagen Membrane
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Efficacy and Safety of Synchronized Cardiac Support in Cardiogenic Shock Patients
The study aims to investigate the safety and efficacy of the Synchronized Cardiac Support treatment wit the icor kit and the Xenios console with modified sensor box ECG and Software Version 3.2.4
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, ECLS, VA ECMO
- Trial name
- PulseSE (NCT05106491)
- Testing
- Synchronized Cardiac Support with the icor kit
- Where
- 2 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Xenios AG
Wound Healing, Palate; Wound
Manufacturing, Characterization and Evaluation of the Effect of Silk Fibroin Membranes, Loaded or Not With Neurotensins on Open Wounds in the Palate
The aim of the present study will be to manufacture and characterize silk fibroin membranes loaded or not with neurotensin and to evaluate clinical, patient-centered and immunological parameters the effect of using these…
- Trial name
- NCT05191082
- Testing
- Palatal Wound, Palatal Wound treated with Silk Fibroin Film, Palatal Wound treated with Neurotensin-loaded Silk Fibroin Film
- Where
- Brazil
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Vertical Alveolar Bone Loss
Comparing the Efficacy and Morbidity of Two Vertical Ridge Augmentation Techniques
The proposed study design is a randomized controlled trial, split mouth design, to compare the two different vertical augmentation procedures: Titanium mesh (Ti-mesh) technique and Guided Bone Regeneration (GBR) technique with a…
- Trial name
- NCT02703480
- Testing
- d-PTFE, Ti-mesh
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Tufts University
Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion
Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury Biomarkers
The AMNIO-BRAIN Trial is a research study looking at whether a simple treatment during labor can help protect a baby's brain. Some newborns develop a condition called hypoxic-ischemic encephalopathy (HIE), which happens when the…
- Conditions
- Chorioamnionitis Affecting Fetus or Newborn, Amnioinfusion, Neonatal Brain Injury
- Trial name
- AMNIO-BRAIN (NCT07610642)
- Testing
- Intrauterine Pressure Catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
Retinal Detachment
Peeling of the Internal Limiting Membrane During Primary Vitrectomy for Retinal Detachment Repair
Primary vitrectomy for retinal detachment repair is one of the current methods for surgical treatment of retinal detachment. Additional peeling of the internal limiting membrane (ILM) was reported to successfully prevent…
- Trial name
- NCT07438210
- Testing
- ILM-Peeling, No Peeling
- Where
- Austria
- Volunteers
- 21 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Sinus Lift Surgery Complications, Maxillary Sinus Elevation
Predictors For Transosseous Maxillary Sinus Lift Complications
This prospective cohort study aims to identify clinical and anatomical predictors for complications following transosseous maxillary sinus lift procedures using the Versah (Densah burs) technique.
- Trial name
- PMSL (NCT07017413)
- Testing
- Transosseous Maxillary Sinus Lift using Osseodensification
- Where
- 2 sites in Iraq
- Volunteers
- 60 people
- Sponsor
- University of Baghdad
Diabetic Foot Ulcer, Diabetic Foot
Modified Platform Trial Evaluating PpLHACM and SOC Versus SOC Alone in the Treatment of Nonhealing DFUs
This study will evaluate two human amnion/chorion membrane (ppLHACM) products and Standard of Care (SOC) versus SOC alone in the closure of nonhealing diabetic foot ulcers (DFUs).
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Foot Ulcer Due to Type 2 Diabetes Mellitus, Foot Ulcer, Diabetic
- Trial name
- CAMPAIGN (NCT06600724)
- Testing
- Standard of Care, EPIEFFECT, EPIXPRESS
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- MiMedx Group, Inc.
Difficult Intubation
Study Assessing the Position of Cricothyroid Membrane in Relation to Movement of Neck From Neutral to Extended Position
Ability to provide oxygen to patients undergoing general anaesthesia is crucial. This is traditionally provided using face mask, supraglottic airway (breathing tube above voice box) or endotracheal tube (breathing tube in wind…
- Trial name
- ULOC (NCT03178318)
- Testing
- ultrasound
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Northampton General Hospital NHS Trust
COVID-19
Registry of CytoSorb Therapy in COVID-19 ICU Patients
The CTC Registry collects patient-level clinical data on CytoSorb hemoadsorption provided to COVID-19 ICU patients via integration of the CytoSorb device into ECMO, CRRT, or hemoperfusion extracorporeal circuits.
- Trial name
- CTC REGISTRY (NCT04391920)
- Testing
- CytoSorb 300 mL device
- Where
- 7 sites in United States
- Volunteers
- 138 people
- Sponsor
- CytoSorbents, Inc
Epithelial Basement Membrane Dystrophy
Manual Debridement vs Phototherapeutic Keratectomy in the Treatment of Corneal Basement Membrane Dystrophy
Of the few comparisons made in the existing literature, the results of PTK are comparable to those documented for manual debridement (MD).
- Trial name
- NCT06618508
- Testing
- Manual debridement, Phototherapeutic keratectomy
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Idiopathic Membranous Nephropathy
Evaluate Rituximab Treatment for Idiopathic Membranous Nephropathy
The Membranous Nephropathy is one of the most common cause of Nephrotic Syndrome of adults. In 2/3 of patients the cause of the disease is idiopathic.
- Trial name
- GEMRITUX (NCT01508468)
- Testing
- symptomatic treatment (Converting Enzyme inhibitor, Angiotensin II, Anti-renin, Aldosterone antagonist diuretic, Beta blocker, Calcium inhibitor, statin), experimental (Non Immunosuppressive Symptomatic Treatment (NIST) and Rituximab)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Periodontal Attachment Loss, Periodontal Bone Loss
Platelet-Rich Fibrin and Anorganic Bovine Bone vs Collagen Membrane and Anorganic Bovine Bone in Intrabony Defects
The primary outcome of periodontal reconstructive therapy is to regenerate all tissues of the periodontium including a functional periodontal ligament, alveolar bone and cementum.
- Conditions
- Periodontal Attachment Loss, Periodontal Bone Loss, Periodontal Diseases
- Trial name
- NCT03715374
- Testing
- Periodontal Surgery with PRF+ABB, Periodontal Surgery with Collagen Membrane +ABB
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- G. d'Annunzio University
Retinal Detachment, Macular Pucker
Zeiss RESIGHT Disposable Lenses Evaluation Study
To evaluate the intra-operative efficacy of a new intra-operative viewing device.
- Conditions
- Retinal Detachment, Macular Pucker, Macular Holes, Vitreomacular Traction
- Trial name
- RESIGHT (NCT05860985)
- Testing
- ZEISS disposable
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Intraocular Implants, Extended Depth of Focus
Quality of Vision After Implantation of EDOF Implants Versus Monofocal Implants in Patients Who Underwent Epiretinal Membrane and Cataract Surgery
Phacoexistence, the first surgical procedure performed in France, naturally raises the question of lens replacement. In recent years, the choice of intraocular lenses has expanded considerably.
- Trial name
- MACAEDOF (NCT07789249)
- Testing
- Questionnaires, Intermediate visual acuity, Optical coherence tomography
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Almaviva Sante
Infant, Premature, Diseases, Birth, Preterm
The NEU - CAP Trial
The aim of NEU-CAP is to investigate the clinical impact of using a colorimetric carbon dioxide (CO₂) detector during non-invasive ventilation (NIV). Infants born before 32 weeks of gestation will be included in this trial.
- Conditions
- Infant, Premature, Diseases, Birth, Preterm, Respiratory Distress Neonatal
- Trial name
- NEU-CAP (NCT07754032)
- Testing
- Local standard care of monitoring non-invasive ventilation, CO₂-guided Non-Invasive Ventilation
- Volunteers
- 1,860 people
- Sponsor
- Leiden University Medical Center
Extracorporeal Membrane Oxygenation Complication
TEG Anticoagulation Monitoring During ECMO
The best anticoagulation strategy during Extracorporeal Membrane Oxygenation (ECMO) is unknown. Actual recommendations suggest to use unfractionated heparin infusion and monitor the effect with either activated Partial…
- Trial name
- NCT02271126
- Testing
- TEG monitoring, APTT monitoring, Heparin
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Policlinico Hospital
Idiopathic Epiretinal Membranes
Clinical Evaluation of With or Without Internal Limiting Membrane Peeling for Idiopathic Epiretinal Membrane Surgery: A Randomized Controlled Trial
Idiopathic epiretinal membrane (ERM) is an age-related degenerative retinal condition. One of the primary treatment approaches is vitrectomy combined with epiretinal membrane peeling.
- Trial name
- NCT07142785
- Testing
- Epiretinal membrane peeling, Epiretinal membrane peeling combined with internal limiting membrane peeling
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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