Clinical trials: Membranous
Bone Loss
Bone Transport Through Induced Membrane vs Conventional Bone Transport in Management of Bone Defects of Lower Limbs
This is a prospective randomised controlled comparative study comparing bone transport through induced membrane (BTM) and conventional bone transport (BT) in management of bone defects in infected non united fractures of long…
- Trial name
- NCT05631951
- Testing
- bone transport through induced membrane, bone transport
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Bone Augmentation
Reconstruction of Atrophic Maxillary Ridges Using Mandibular Blocks With and Without Coverage Using Collagen Membrane
Is the use of collagen membrane on top of particulate bone mixture covered by onlay bone block in Maxilla better than the use of mixture of particulate bone covered by onlay bone block without the use of collagen membrane, in…
- Trial name
- NCT04462575
- Testing
- Onlay bone block covered using collagen membrane, Onlay bone block without collagen membrane
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Severe Forms of Mucous Membrane Pemphigoid
Randomized Clinical Trial Comparing the Safety and Efficacy of Rituximab Versus Oral Cyclophosphamide in Severe Forms of Mucous Membrane Pemphigoid
Mucous membrane pemphigoid (MMP) describes a group of chronic auto-immune bullous diseases (AIBD) of the basement membrane zone (BMZ), characterized by predominant or exclusive mucosal involvement, including oral…
- Trial name
- RITUX-MMP (NCT03295383)
- Testing
- Rituximab 1g IV, Cyclophosphamide 50Mg Oral Tablet
- Where
- 27 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Rouen
Inflammatory Response, Erythrocyte Destruction
Electric Polarization of Red Blood Cells : A Cohort Study to Assess the Erythrocytes Membrane Integrity Through Charge Conservation, Following Cardiac Surgery.
An immediate perioperative parameter that assess the integrity of the Erythrocytes Membrane and therefore their structural quality isn't available in clinical practice and medical diagnostics except through indirect clinical…
- Conditions
- Inflammatory Response, Erythrocyte Destruction, Red Blood Cell Disorder, Hemolysis
- Trial name
- Polaris (NCT05754294)
- Testing
- Polarization of red blood cells
- Where
- Italy
- Sponsor
- Anthea Hospital Bari
Anti-Glomerular Basement Membrane Disease, Anti-Glomerular Basement Membrane Antibody Disease
A Study With Imlifidase in Anti-GBM Disease
An open-label, controlled, randomised, multi-centre Phase 3 trial evaluating renal function in patients with severe anti-GBM disease comparing imlifidase and standard of care (SoC) with SoC alone.
- Conditions
- Anti-Glomerular Basement Membrane Disease, Anti-Glomerular Basement Membrane Antibody Disease, Goodpasture Syndrome, Good Pasture Syndrome
- Trial name
- GOOD-IDES-02 (NCT05679401)
- Testing
- Imlifidase, Plasma exchange (PLEX), Cyclophosphamide (CYC)
- Where
- 48 sites in United States, Austria and 11 more
- Volunteers
- 50 people
- Sponsor
- Hansa Biopharma AB
Prostate Cancer
Imaging Study to Investigate the Safety and Diagnostic Performance of rhPSMA 7.3 (18F) in Newly Diagnosed Prostate Cancer.
A prospective, Phase 3, multi center, single-arm, imaging study investigating the safety and diagnostic performance of Radio-hybrid Prostate Specific Membrane Antigen (rhPSMA) 7.3 (18F) Positron Emission Tomography (PET) ligand…
- Trial name
- NCT04186819
- Testing
- rhPSMA-7.3 (18F) Injection, Positron Emission Tomography scan
- Where
- 34 sites in United States, Finland and 2 more
- Volunteers
- 356 people
- Sponsor
- Blue Earth Diagnostics
Tooth Extraction
A Clinical Study on the Efficacy and Safety of Lando® Absorbable Collagen Membrane in Oral Bone Repair
This is a randomized, paralleled, control trial to validate the effectiveness and safety of Lando® absorbable collagen membrane for oral bone repair.
- Trial name
- NCT03464786
- Testing
- Lando® absorbable collagen membrane, Geistlich Bio-Gide resorbable bilayer membrane
- Where
- China
- Volunteers
- 119 people
- Sponsor
- Shenzhen Lando Biomaterials Co., Ltd.
Extracorporeal Membrane Oxygenation
Antithrombin Supplementation in ECMO
Bleeding is the most feared complication during extracorporeal membrane oxygenation (ECMO) and is associated with high dosing of heparin. There is no consensus on antithrombin (AT) supplementation during ECMO.
- Trial name
- NCT03208270
- Testing
- Antithrombin supplementation, No antithrombin supplementation
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Policlinico Hospital
Premature Rupture of Membranes
Rapid Immunoassay Tests for the Detection of Ruptured Membranes
The aim of the study is to demonstrate substantial equivalence of IGFBP-1/AFP tests with the "predicate device" Amnisure® in detecting pre labor rupture of membranes.
- Trial name
- NCT02495441
- Testing
- Use of Rapid Immunoassay Tests for the Detection of PROM
- Where
- Sri Lanka
- Volunteers
- 100 people
- Sponsor
- De Soysa Hospital for Women
Fuchs Endothelial Corneal Dystrophy
Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy
Fuchs endothelial corneal dystrophy (FECD) is the leading indication for corneal transplantation worldwide. It is characterized by the accumulation of guttae and progressive loss of corneal endothelial cells, leading to corneal…
- Trial name
- Fuchs Polishin (NCT07539012)
- Testing
- Fuchs Polishing
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Venous Leg Ulcers
Clinical Trial Evaluating an Amnion Membrane Allograft Intended for Use in the Management of Non- Healing Venous Leg Ulcers Versus Standard Of Care Alone
The main purpose of this research study is to compare the proportion of wound closure in subjects that receive E-GRAFT™ with SOC versus FIBRACOL™ with SOC.
- Trial name
- NCT06764953
- Testing
- E-GRAFT ™, FIBRACOL™
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Skye Biologics Holdings, LLC
Mesenchymal Stem Cells
Cartilage Tissue Engineering
In this study, the investigators explored the hypothesis that osteoarthritic cartilage fragments can promote chondrogenesis of MSCs.
- Trial name
- NCT01301664
- Testing
- total knee / hip replacement
- Sponsor
- Chin-Hung Chang
Catheter-Related Infections
Impact of Prophylactic Antibiotics on Bloodstream Infections After Liberation From Extracorporeal Membrane Oxygenation
The goal of this prospective interventional study is to evaluate the impact of antibiotic prophylaxis on bloodstream infections after liberation of extracorporeal membrane oxygenation therapy.
- Trial name
- IPANEMA-ECMO (NCT05651464)
- Testing
- Vancomycine
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- Universität des Saarlandes
Alveolar Bone Resorption
Lateral Ridge Augmentation Around Implants
The rehabilitation of dentoalveolar defects and tooth loss has seen remarkable advancements over time. Extraction of tooth leads to reduction in physiologic dimension of bone and it is imperative to evaluate the site before…
- Trial name
- NCT04197128
- Testing
- Resorbable Collagen membrane with bone graft for augmentation, Ribose cross linked collagen matrix for augmentation
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Healthy, Inflammation
Optimal Value Increase of Egg Products
The aim of this project is to evaluate daily intake of eggshell membrane taken as supplement (capsule), will reduce markers of inflammation in older people.
- Conditions
- Healthy, Inflammation, Aging
- Trial name
- OPTIEgg (NCT04606628)
- Testing
- Eggshell membrane (ESM)
- Where
- Norway
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Microcirculation, Extracorporeal Membrane Oxygenation
Effects of Microcirculation-assisted Adjustment of Blood Flow of VA-ECMO on Prognosis
One of the key factors of survival of patients with extra-corporeal membrane oxygenation (ECMO) life support system is whether the blood flow supplied by ECMO can meet the need of perfusion of each organ.
- Trial name
- NCT03470792
- Testing
- Microcirculation examination
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Carbon Dioxide
Validation of Continuous Transcutaneous Carbon Dioxide Monitoring in VA-ECMO Patients
Carbon dioxide in patients on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is eliminated via respirator as well as via the oxygenator's membrane of the ECMO machine.
- Trial name
- NCT04445909
- Testing
- VA-ECMO
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Alveolar Bone Loss, Alveolar Ridge Augmentation
Evaluation of Guided Tissue Regeneration With Autogenous Bone Chips and CGF During Implant Placement
CGF membranes will be prepared using a swing-lock centrifuge. A full-thickness mucoperiosteal flap will be elevated in a narrow alveolar ridge. Implants will be inserted.
- Conditions
- Alveolar Bone Loss, Alveolar Ridge Augmentation, Dental Implant
- Trial name
- CGF (NCT07521514)
- Testing
- concentrated growth factor (CGF) Membrane
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Cairo University
Epidermolysis Bullosa With Mitten Hands
Autologous Transplantation of Cultured Fibroblast on Amniotic Membrane in Patients With Epidermolysis Bullosa
Epidermolysis Bullosa (EB) is a blistering disease that is caused by defective anchoring fibrils and hemidesmosome in basement membrane of the skin layer. EB is inherited either autosomal or recessive and has 3 types.
- Trial name
- NCT01908088
- Testing
- Cell transplantation
- Where
- Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute
Idiopathic Membranous Nephropathy, Nephrotic Syndrome
Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome
Idiopathic membranous nephropathy (IMN) is one of the most common forms of nephrotic syndrome (NS) in adults and is usually treated by corticosteroids in combination with cytotoxic drugs especially cyclophosphamide or…
- Trial name
- NCT00362531
- Testing
- tacrolimus combined with prednisone
- Sponsor
- Peking University
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