Clinical trials: Memory, Delayed
Behavior, Health
Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT06242704
- Testing
- Working Memory Training, Working Memory
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Alzheimer's Disease
A Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease Dementia
This study is an extension of study I8D-MC-AZES (NCT02245737), the AMARANTH study. The purpose of this study is to evaluate the effectiveness of the study drug lanabecestat in participants with early Alzheimer's disease dementia…
- Trial name
- NCT02972658
- Testing
- Lanabecestat
- Where
- 133 sites in United States, Australia and 12 more
- Volunteers
- 421 people
- Sponsor
- AstraZeneca
Dementia, Cognitive Decline
Ammonia Levels and Cognitive Impairment
The purpose and objective of this study is to determine the prevalence of elevated ammonia levels in subjects with cognitive impairment, and to observe if treating the cause of the elevated ammonia level improves mental status.
- Conditions
- Dementia, Cognitive Decline, Cognitive Impairment, Developmental Delay
- Trial name
- NCT02059356
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Schizophrenia, Psychotic Disorders
Study To Assess Differential Sensitivity Of 2 Spatial Working Memory Tests In Schizophrenics Treated With Risperidone
To assess the effect of risperidone 2 mg daily (QD) on the differential sensitivity of 2 spatial working memory tests (the GMLT and MDR) in non-agitated, drug-naive patients suffering from first-episode…
- Trial name
- NCT00174200
- Testing
- Risperidone 2 mg
- Where
- 3 sites in Canada, Russia
- Volunteers
- 20 people
- Sponsor
- Pfizer
Speech, Memory, Delayed
Effects of Clear Speech on Listening Effort and Memory in Sentence Processing
Sensorineural hearing loss (SNHL) is among the most prevalent chronic conditions in aging and has a profoundly negative effect on speech comprehension, leading to increased social isolation, reduced quality of life, and increased…
- Conditions
- Speech, Memory, Delayed, Sensorineural Hearing Loss
- Trial name
- NCT06053190
- Testing
- Sentence stimulus, Speaking style
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Utah
Insomnia Chronic, Anxiety
The Effects of Insomnia Treatment on Overnight Regulation of Emotional Memories and Risk for Mental Disorders
This project aims to elucidate whether CBCTi changes symptom severity or even remission of anxiety disorders as compared with a delayed-start control group.
- Trial name
- Restless (NCT06567210)
- Testing
- Immediate CBCTi, Delayed CBCTi
- Where
- Australia
- Volunteers
- 98 people
- Sponsor
- Woolcock Institute of Medical Research
Delay Discounting
An Assessment of Cognitive Improvement Training Among Mid-life Individuals
Many health-relevant decisions involve intertemporal (now vs. later) tradeoffs. Extensive literature indicates that many negative health and financial consequences suffered in mid-life are linked to adversity and disadvantage…
- Trial name
- RehabEF (NCT03501706)
- Testing
- Sequenced Recall of Digits--Auditory, Sequenced Reverse Recall of Digits--Auditory, Sequenced Recall of Words--Visual
- Where
- United States
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Brain Activity
Effects of USP Methylene Blue on Cognitive and fMRI Brain Activity
The purpose of the study is to evaluate whether low-dose USP methylene blue (MB) will: i) improve short-term memory retention in a delayed match-to-sample task, ii) reduce reaction time in a psychomotor vigilance test, and iii)…
- Trial name
- NCT01836094
- Testing
- Methylene Blue (USP grade, 280mg oral)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Behavior, Health
Parent-Child Memory Study: Improving Future Thinking Among Mothers
Parents of children from impoverished communities are disproportionately more likely to engage in harsh physical discipline, which can lead to serious clinical outcomes, including suicidal ideation and attempts.
- Trial name
- NCT06145919
- Testing
- Episodic Future Thinking (EFT), Episodic Recent Thinking (ERT)
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Alzheimer Disease, Cognition Disorders
Investigation Into Delay to Diagnosis of Alzheimer's Disease With Exelon (InDDEx)
This phase IIIb trial is a prospective, randomized, double-blind, placebo-controlled, 36-month study comparing the length of time of progression from mild cognitive impairment (MCI) to a clinical diagnosis of Alzheimer's disease…
- Trial name
- NCT00000174
- Testing
- Rivastigmine
- Where
- 15 sites in United States
- Sponsor
- Novartis
Alzheimer Disease
Memory Impairment Study (Mild Cognitive Impairment Study)
The National Institute on Aging (NIA) is launching a nationwide treatment study targeting individuals with mild cognitive impairment (MCI), a condition characterized by a memory deficit, but not dementia.
- Trial name
- NCT00000173
- Testing
- Donepezil, Vitamin E
- Where
- 72 sites in United States, Canada
- Sponsor
- National Institute on Aging (NIA)
Solid Organ Transplant Complications, Solid Organ Transplant Recipients
Phase I Trial on the Safety of Delayed Infusion of a Naïve T Cell-Depleted Hematopoietic Graft With Memory T Cells in Solid Organ Transplant Recipients
The goal of this clinical trial is to evaluate the safety and feasibility of inducing hematopoietic mixed chimerism to promote immune tolerance and potentially reduce the need for lifelong immunosuppression in pediatric and adult…
- Conditions
- Solid Organ Transplant Complications, Solid Organ Transplant Recipients, Solid Organ Transplant Rejection
- Trial name
- DUALGRAFT (NCT06997471)
- Testing
- Investigational cellular therapy consisting on a HSCT using a graft enriched in CD34+, depleted of naïve T-lymphocytes and supplemented with memory lymphocytes
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Francisco Hernández Oliveros
Memory, Delayed
Neural Correlates of Real World Spatial Navigation in Humans
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world…
- Trial name
- NCT04874220
- Testing
- Deep Brain Stimulation, Memory and spatial navigation tasks, Physiological Signals
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Duke University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Behavior, Health
Train Your Brain: A Pilot Project to Improve Memory and Decision Making
The goal of this clinical trial is to pilot a computer-based working memory training program to improve delay discounting (DD) and prevent substance use among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT05879198
- Testing
- Computer-based Intervention
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Henry Ford Health System
Alzheimer's Disease
A Study of Lanabecestat (LY3314814) in Participants With Mild Alzheimer's Disease Dementia
The main purpose of this study is to evaluate the efficacy of the study drug known as lanabecestat in participants with mild Alzheimer's disease (AD) dementia.
- Trial name
- DAYBREAK-ALZ (NCT02783573)
- Testing
- Lanabecestat
- Where
- 262 sites in United States, Canada and 16 more
- Volunteers
- 1,722 people
- Sponsor
- AstraZeneca
Tobacco Use Disorder/Cigarette Smoking
Working Memory Training on Delay Discounting Among Cigarette Smokers
Despite widespread awareness of significant negative health consequences, cigarette smoking remains the leading cause of preventable morbidity and mortality in the US (Creamer et al., 2019; Jamal, 2018).
- Trial name
- RTA (NCT05210608)
- Testing
- Working Memory Training + Behavioral Intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Kansas Medical Center
Post-Traumatic Stress Disorder in Old Age
Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects
In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.
- Trial name
- I-TSPT-R (NCT03897855)
- Testing
- Post Traumatic Stress Disorder
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier de Niort
Memory, Delayed
Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized…
- Trial name
- NCT05452122
- Testing
- Auditory and Electrical Stimulation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment, Memory Disorders
Behavioral Interventions to Prevent or Delay Dementia
This study will compare the effectiveness of different combinations of 5 types of behavioral interventions across patient-centered outcomes. It will also evaluate which outcomes (e.g.
- Conditions
- Mild Cognitive Impairment, Memory Disorders, Mild Dementia, Impaired Cognition
- Trial name
- NCT02265757
- Testing
- Cognitive Rehabilitation, Computer Brain Fitness Training, Support Group (patient and partner)
- Where
- 3 sites in United States
- Volunteers
- 272 people
- Sponsor
- Mayo Clinic