Clinical trials: Memory Consolidation
Healthy
The Effects of TMS on Memory-consolidation in Human Primary Visual Cortex
Rapid Transcranial Magnetic Stimulation will be used in order to examine whether the human primary visual cortex is essential to visual memory consolidation.
- Trial name
- NCT00480012
- Testing
- rTMS
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Healthy Volunteers (HV)
Electrical Nerve Stimulation During Sleep for Memory Consolidation
The purpose of this study is to investigate the effects of transcutaneous electrical nerve stimulation (eTNS) applied during sleep on memory consolidation and brain-body physiological coupling.
- Trial name
- NCT07658274
- Testing
- 120 Hz Transcutaneous Electrical Nerve Stimulation, 2 Hz Transcutaneous Electrical Nerve Stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xidian University
Alzheimer Disease, Early Onset
Epileptiform Activity During REM Sleep in Alzheimer's Disease
Recent clinical data showed that patients with Alzheimer Disease (AD) might present epilepsy at early stages of the disease (Cretin et al., 2016, Vossel et al., 2016).
- Trial name
- EREMAD (NCT03923569)
- Testing
- Overnight polysomnography, blood sample, high-resolution MRI scan
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Attention Deficit Disorder With Hyperactivity
Sleep and Memory Consolidation in Adults With Attention Deficit Hyperactivity.
Attention Deficit Disorder With Hyperactivity is associated with deficits in cognition and sleep. In healthy adults, memory consolidation processes are related to sleep spindle activity in the sleep electroencephalogram.
- Trial name
- HYPNOS (NCT05876286)
- Testing
- Neurological examinations
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Sleep
Memory Consolidation in Pharmacologically Enhanced Naps
This study will examine whether various drugs affecting sleep cycles can improve different kinds of memory.
- Trial name
- NCT00777829
- Testing
- zolpidem
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Memory Consolidation
The Impact of Reactivation During Sleep on the Consolidation of Abstract Information in Humans
In any given cognitive domain, representations of individual elements are not independent but are organized by means of structured relations.
- Trial name
- NCT05746299
- Testing
- Congruent vs. Incongruent, Immediate vs. Awake vs. Asleep, Targeted memory reactivation (TMR)
- Where
- United States
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic
Acoustic Stimulation During Sleep: Effects on Memory and p-tau217 in MCI
The goal of this clinical trial is to determine whether acoustic stimulation during sleep can enhance slow-wave sleep (SWS), improve cognitive function, and reduce AD-related pathology in individuals with mild cognitive…
- Conditions
- Alzheimer's Disease (AD), Mild Cognitive Impairment (MCI) Amnestic, Cognitively Unimpaired
- Trial name
- PAS-MCI (NCT07529015)
- Testing
- Plase-Locked Acoustic Stimulation during slow-wave sleep
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institut de Recerca Biomèdica de Lleida-Fundació Dr. Pifarré (IRBLleida)
Speech, Consolidation
Sensory Memory in Speech Motor Learning
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal…
- Trial name
- NCT04818268
- Testing
- Adaptation, cTBS
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Intrusive Memories
Behavioral Modulation of Intrusive Memories
The purpose of the study is to examine whether sleep affects the development of intrusive memories.
- Trial name
- NCT03227081
- Testing
- Sleep Deprivation
- Where
- Germany
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Social Anxiety Disorder, Sleep Laboratory
Augmentation of Exposure Therapy for High Levels of Social Anxiety Using Post-exposure Naps
Investigators will examine whether post-exposure naps can be used to strengthen therapeutic extinction memories formed during exposure therapy for extreme social anxiety.
- Trial name
- SANAP (NCT02325128)
- Testing
- Sleep-enhancement of extinction memory
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Claustrophobia, Obsessive-Compulsive Disorder
Efficacy of Targeted Memory Reactivation for Enhancing Exposure Therapy
This study evaluates whether a scent applied during exposure therapy and during subsequent sleep will increase the durability of treatment effects for individuals with fear of spiders, contamination, and enclosed spaces.
- Conditions
- Claustrophobia, Obsessive-Compulsive Disorder, Arachnophobia
- Trial name
- NCT04663672
- Testing
- Experimental Scent, Control Scent, No-Scent Control
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Texas at Austin
Healthy Aging
The Effect of Training on Brain Activity During Postural Tasks in Older Adults
Older people show deficits in dynamic weight-shifting, as the investigators found that more time is needed to perform weight-shifts and the movements became less fluent and accurate in older versus younger adults.
- Trial name
- NCT04594148
- Testing
- Weight-shift training
- Where
- Belgium
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Benign Epilepsy With Centro Temporal Spikes (BECTS), Atypical Benign Partial Epilepsy (ABPE)
Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.
Age related focal epilepsies in children encompasses, according to the ILAE criteria, benign epilepsy with centro temporal spikes (BECTS), atypical benign partial epilepsy (ABPE) and epileptic encephalopathy with continuous spike…
- Conditions
- Benign Epilepsy With Centro Temporal Spikes (BECTS), Atypical Benign Partial Epilepsy (ABPE), Epileptic Encephalopathy With Continuous Spike and Waves During Sleep (ECSWS)
- Trial name
- EPIMEM (NCT03865771)
- Testing
- Neuropsychological testing, Neuropsychological procedure, Video EEG and polysomnography
- Where
- 2 sites in France
- Volunteers
- 95 people
- Sponsor
- University Hospital, Strasbourg, France
Memory Impairment, Amnesia
Sedation and Memory Consolidation
The study of plasticity processes, in particular, memory, is one of the fundamental directions in anesthesiology. To date, there are different views on the impact of sedation and anesthesia on memory.
- Conditions
- Memory Impairment, Amnesia, Recall, Recognition
- Trial name
- NCT05045170
- Testing
- Influence of propofol sedation on memory consolidation and 'working memory', Influence of dexmedetomidine sedation on memory consolidation and 'working memory', Influence of spinal anesthesia on memory consolidation and 'working memory'
- Where
- Russia
- Volunteers
- 81 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Sleep
Effects of WiFi Exposure on Sleep in Women
Effects of Wifi exposure on sleep and sleep-related memory consolidation are investigated in a double-blind, sham-controlled fully counterbalanced study design in young healthy women.
- Trial name
- NCT04583397
- Testing
- radio frequency electromagnetic fields
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Sleep, Consolidation
Reactivating Specific Memories During Sleep in Conjunction with a Suppression Context
Forgetting is often perceived as the inability to retain information, but in fact at least some memory deterioration is due to active suppression processes, that are behaviorally adaptive.
- Trial name
- NCT04702750
- Testing
- Targeted memory reactivation (odors), Targeted memory reactivation (sounds)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Parkinson Disease
Facilitating Motor Skill Learning in Parkinson's Disease III
The study is designed to assess the effects of cardiovascular (aerobic) exercise on motor skill learning in Parkinson patients. Specifically, the investigators examine whether moderate-intense aerobic exercise, performed…
- Trial name
- FaST-PD-III (NCT04653285)
- Testing
- motor skill practice, aerobic exercise, rest
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University of Erlangen-Nürnberg
Mild Cognitive Impairment Due to Alzheimer's Disease, Subjective Cognitive Decline (SCD)
Autophagy-Enhancers to Reduce Sleep Disturbances
This clinical trial investigates the effects of spermidine supplementation on sleep quality and sleep-dependent memory consolidation in older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI), two…
- Trial name
- SpSleep (NCT07383311)
- Testing
- Spermidine Supplementation
- Where
- Germany
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Mild Cognitive Impairment (MCI), Amnestic Mild Cognitive Impairment - aMCI
Auditory Stimulation During Sleep to Enhance Long-Term Memory in Amnestic MCI
This study aims to evaluate the efficacy and safety of Elevvo AudiStim, a sleep auditory stimulation device, as a symptomatic treatment for patients with amnestic mild cognitive impairment (aMCI).
- Conditions
- Mild Cognitive Impairment (MCI), Amnestic Mild Cognitive Impairment - aMCI, Alzheimer or Mild Cognitive Impairment
- Trial name
- NCT07402590
- Testing
- Auditory Stimulation
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Bitbrain
Posttraumatic Stress Disorder
The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body.
- Trial name
- NCT01466127
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital