Clinical trials: Memory Deficits, open to volunteers
Mild Cognitive Impairment, Alzheimer Dementia (AD)
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in older adults with and without cognitive impairment.
- Trial name
- NCT05907343
- Testing
- Closed-loop TBS, Open-loop TBS
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
ADHD
Target ADHD Executive Working Memory Replication Study
The proposed study will replicate target engagement as assessed in the first phase while also determining if it correlates with clinically meaningful improvements in ADHD dysfunction
- Trial name
- NCT06446284
- Testing
- EWM Training
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Brain Cancer, Brain Tumor
HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-CA, to improve the quality of life and cognitive function in Service Members, Veterans and civilians who are survivors of brain cancer…
- Conditions
- Brain Cancer, Brain Tumor, Brain Neoplasms, Primary Brain Tumor
- Trial name
- HOBSCOTCH-CA (NCT06930846)
- Testing
- HOBSCOTCH-CA
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Amnestic
Deep Brain Stimulation Guided by Brain Mapping to Treat Cognitive Impairment
This trial is a 12-month safety and feasibility study, enrolling up to six participants. These participants will serve as their own controls, structured in multiple parts that follow an initial short-term stereo…
- Conditions
- Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Amnestic, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Memory Deficit
- Trial name
- NCT07887737
- Testing
- Abbott St Jude Medical Infinity™
- Volunteers
- 6 people
- Sponsor
- University of Texas Southwestern Medical Center
Healthy, Memory Problems
A Clinical Trial to Examine Lysoveta on Cognitive Function in Healthy Adults With Self-perceived Memory Problems
The study is a randomized, placebo-controlled, triple-blind, parallel group trial, in which the effect of krill oil is investigated in healthy volunteers with self-perceived memory problems.
- Trial name
- NCT07034794
- Testing
- Lysoveta
- Where
- Canada
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Aker BioMarine Human Ingredients AS
Memory Impairment
Predictive Factors and Autonomy Level Change
The Alzheimer's disease or related disorders (ADRD) are among the most disabling diseases because of their main features such as cognitive impairment, loss of functional autonomy and behavioural disorders.
- Trial name
- MEMORA (NCT02302482)
- Testing
- The Lawton Instrumental Activities of Daily Living score (IADL), and the disability assessment of dementia score (DAD-6
- Where
- 2 sites in France
- Volunteers
- 10,860 people
- Sponsor
- Hospices Civils de Lyon
T1DM, Sleep Disorders, Circadian Rhythm
Influence of Circadian Clock on Hormonal, Metabolic, Neurocognitive Markers in Adolescents With and Without Diabetes
Type 1 diabetes mellitus (T1DM), makes its appearance during childhood and youth, but management implications last till late adulthood.
- Conditions
- T1DM, Sleep Disorders, Circadian Rhythm, ADHD, Memory Impairment
- Trial name
- NCT04054934
- Testing
- Reversed Circadian Rhythm, Normal Circadian Rhythm
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Working Memory
NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits
Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes.
- Trial name
- NCT05662280
- Testing
- Active Intermittent Theta Burst Stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Bradley Hospital
Pediatric Iron Deficiency, Anemia
Choline and Iron Deficiency
BACKGROUND: Iron deficiency limits the neurodevelopmental potential of more than 200 million children each year. Iron therapy is typically started when iron deficiency anemia is first diagnosed after screening for anemia or…
- Trial name
- NCT06527391
- Testing
- choline bitartrate
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Minnesota
Psychotic Disorders, Cannabis Use Disorder
Investigating the Neural Correlates of Cognitive Function in Psychosis Patients and Non-Psychiatric Controls With Cannabis Use
Cognitive impairment is well established in people with psychosis and is associated with cannabis use. The current study will investigate the neurobiological basis of cognitive change associated with 28-days of cannabis…
- Conditions
- Psychotic Disorders, Cannabis Use Disorder, Cannabis Dependence, Cannabis Use
- Trial name
- NCT05445180
- Testing
- Contingency management
- Where
- Canada
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Schizophrenia, Schizoaffective Disorder
Brain Health and Exercise in Schizophrenia
To determine the effects of aerobic exercise on hippocampal volumes and severity of psychotic symptoms in a population of psychosis patients compared to healthy age/gender matched volunteers.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Poor Memory
- Trial name
- PEHP (NCT01392885)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BC Mental Health and Addictions Research Institute
Schizophrenia, Attention Deficit Disorder With Hyperactivity (ADHD)
Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior.
- Trial name
- NCT07217652
- Testing
- High-resolution fMRI during working memory, cognitive control, and decision-making tasks
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kai Hwang
Aging, Anxiety
Neurobiological Mechanisms of Aging and Stress on Prospective Navigation
Two hallmarks of both healthy aging and age-related disease are 1) memory and navigational deficits, particularly in orienting towards goal locations and planning how to navigate to them, and 2) increased susceptibility to stress…
- Conditions
- Aging, Anxiety, Memory Impairment
- Trial name
- NCT03896529
- Testing
- Anticipatory psychological stress
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Acquired Brain Injury (Including Stroke)
Implementation of a Home-based Computerized Cognitive Rehabilitation Program for Patients With ABI
Rationale: Patients with acquired brain injury (ABI) may suffer from persistent cognitive deficits and/or subjective cognitive complaints, especially in the domains of attention and working memory.
- Trial name
- CoRe@Home (NCT06749197)
- Testing
- Rehacom
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Alzheimer Disease, Neurodegenerative Diseases
Memory Deterioration in Alzheimer Disease
Semantic AD
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Magnetic Resonance Imaging, Memory Impairment
- Trial name
- MemAD (NCT07118137)
- Testing
- 7T MRI, EEG, Blood samples
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Memory Deficit
To Drill or Not to Drill: Do Memory Drills Help Train the Ability to "Remember to Remember" in Veterans
The goal of this clinical trial is to memory drilling works in improving the ability to remember to do something later in treatment-seeking veterans.
- Trial name
- PMIS (NCT06656637)
- Testing
- Memory Drilling, Compensatory Strategies, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Los Angeles
Sleep Disorder, Circadian Dysregulation
NIA_Improving Function and Well-being by Improving Patient Memory: Transdiagnostic Sleep and Circadian Treatment
Mental illness is often chronic, severe, and difficult to treat. Though there has been significant progress towards establishing effective and efficient interventions for psychological health problems, many individuals do not…
- Conditions
- Sleep Disorder, Circadian Dysregulation, Memory Impairment
- Trial name
- NCT05986604
- Testing
- Memory Support Intervention, Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Where
- United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
HIV Positive
Thinking and Memory Problems in People With HIV
Background: People with human immunodeficiency virus (HIV) can sometimes develop thinking and memory problems. These problems can vary widely, from few symptoms to severe problems with memory and concentration.
- Trial name
- NCT01875588
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cognition, Cognitive Performance
A Clinical Trial to Investigate the Safety and Efficacy of AP-Brain on Cognitive Performance at Varying Dosages in Healthy Middle-aged and Older Adults With Self-reported Memory Problems
The goal of this clinical trial is to investigate the safety and efficacy of AP-Brain on cognitive performance at varying dosages in healthy middle-aged and older adults with self-reported memory problems.
- Trial name
- NCT07388043
- Testing
- AP-Brain (1g), AP-Brain (3g), AP-Brain (5g)
- Where
- 2 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rousselot BVBA
Aging, Alzheimer Disease
Links Between Cognitive Deficits During Normal or Pathological Aging and Slow Waves Measured in EEG
With age, memory processes (encoding, consolidation and retrieval) as well as daytime vigilance are altered. Sleep is also impaired in older adults, notably slow waves that are known to play a key role in memory consolidation.
- Trial name
- MemoAge (NCT06501495)
- Testing
- video polysomnography, Attention task
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris