Clinical trials: Memory Disorders, open to volunteers
Stroke
Efficacy of Music-Based Telerehabilitation After Stroke
The goal of this clinical trial is to learn if a music-based telerehabilitation intervention implemented at home works to treat different kinds of neurological deficits caused by stroke.
- Trial name
- NCT06804304
- Testing
- Music-based telerehabilitation
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Teppo Sarkamo
Cerebrovascular Disorders
Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals
The purpose of the study is to test the hypothesis of slowing the progression of White Matter Lesions (WML) by lowering blood pressure (BP) in patients with cognitive complaints and a moderate to high grade of WML on brain MRI.
- Trial name
- LEOPOLD (NCT02472028)
- Testing
- blood pressure lowering algorithm, usual strategy
- Where
- 2 sites in France
- Volunteers
- 820 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prodromal Alzheimer's Disease, Mild Cognitive Impairment
The Digital Memory Notebook
Compensatory aids (e.g., alarms, calendars) play an important supporting role when completing everyday tasks (e.g., appointments, medication management), and there is a growing body of scientific work suggesting that compensatory…
- Conditions
- Prodromal Alzheimer's Disease, Mild Cognitive Impairment, Subjective Cognitive Complaints
- Trial name
- DMN (NCT04240665)
- Testing
- Digital Memory Notebook (DMN) Application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Mild Cognitive Impairment, Alzheimer Dementia (AD)
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in older adults with and without cognitive impairment.
- Trial name
- NCT05907343
- Testing
- Closed-loop TBS, Open-loop TBS
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Post-traumatic Stress Disorder (PTSD), Intrusive Memories of Traumatic Event(s)
Tetris Intervention Following Subliminal Reactivation for Intrusive Memories
Intrusive memories of traumatic events are a core feature of Post-Traumatic Stress Disorder (PTSD) and can cause substantial distress and functional impairment.
- Trial name
- NCT07495917
- Testing
- Subliminal Reactivation Followed by Visuospatial Interference, Computer-based Visuospatial Task (Tetris)
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shaanxi Normal University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Transient Global Amnesia
PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome
Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at…
- Trial name
- PROTOS (NCT06903026)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Brain Diseases, Epilepsy
Amygdala Memory Enhancement
The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories.
- Conditions
- Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury
- Trial name
- NCT05065450
- Testing
- Intracranial Stimulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Washington University School of Medicine
Amnesia, Memory Disorder
How do Patients With Amnesia Acquire New Knowledge?
THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging…
- Trial name
- ASSAM (NCT07191197)
- Testing
- MRI, Psychometric
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Sleep Duration, Child Obesity
Effect of Sleep Extension on Body Weight and Learning in Children (More2Sleep)
More2Sleep is a randomized, controlled, parallel trial with two groups (sleep extension vs control) including 142 school-aged children (6-12 years) who have a BMI above average, defined as age- and sex-specific BMI Z-score above…
- Conditions
- Sleep Duration, Child Obesity, Child Development, Child Behavior
- Trial name
- More2Sleep (NCT06341179)
- Testing
- Sleep extension
- Where
- 3 sites in Denmark
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Mild Cognitive Impairment (MCI)
Working Memory Training in Patients with Mild Cognitive Impairment
The purpose of this study is to test whether a special memory training program, called CogMed, can help people with early memory problems.
- Trial name
- NCT06734286
- Testing
- CogMed
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Subjective Cognitive Decline, Alzheimer Disease
Using Artificial Intelligence to Detect Early Signs of Alzheimer's Disease in People With Memory Concerns
AHEAD is a prospective, longitudinal, risk-stratified single-arm interventional study enrolling 300 patients with Subjective Cognitive Decline (SCD) at IRCCS San Raffaele Hospital, Milan, Italy.
- Conditions
- Subjective Cognitive Decline, Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- AHEAD (NCT07652931)
- Testing
- High-frequency Transcranial Magnetic Stimulation (TMS), Digital Cognitive Training, Structured Physical Exercise
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- IRCCS San Raffaele
Epilepsy, Essential Tremor
Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation
This is a research study to determine how COBENFY KarXT (FDA approved), a drug which has been approved for treatment of certain disorders, affects brain activity and cognitive tasks which may be regulated by the cholinergic…
- Conditions
- Epilepsy, Essential Tremor, Seizures, Memory Consolidation
- Trial name
- NCT07721272
- Testing
- Cobenfy KarXT pill (50/20 mg)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas Southwestern Medical Center
Behavior, Health
Train Your Brain 2.0 - Improving Memory and Decision Making Among Youth
The goal of this clinical trial is to deliver a computer-based working memory training program to improve delay discounting (DD) and prevent substance misuse among at-risk adolescents in a traditionally underserved area.
- Trial name
- NCT06242704
- Testing
- Working Memory Training, Working Memory
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS)…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Amnestic Mild Cognitive Impairment, Mild Traumatic Brain Injury
- Trial name
- PATH (NCT05446584)
- Testing
- High Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Myeloid Leukemia, Leukemia
Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation
The purpose of this research study is to test the safety and efficacy of cytokine induced memory-like (CIML) natural killer (NK) cells expanded with Interleukin-2 (IL-2) at preventing relapse in acute myeloid leukemia (AML)…
- Conditions
- Acute Myeloid Leukemia, Leukemia, Leukemia, Myeloid, Myelodysplastic Syndromes
- Trial name
- NCT06138587
- Testing
- Cytokine Induced Memory-like Natural Killer Cells, Interleukin-2
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Dana-Farber Cancer Institute
Neurodegenerative Disease, Mild Cognitive Impairmen
Clinical Cohort of Memory Disorders
This observational study is designed as a multicenter clinical cohort to collect and bank blood specimens linked to clinical and brain imaging data for biomarker discovery and validation in memory disorders.
- Conditions
- Neurodegenerative Disease, Mild Cognitive Impairmen, Dementia, Alzheimer Disease
- Trial name
- NCT07880275
- Where
- South Korea
- Volunteers
- 1,550 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Mild Cognitive Impairment (MCI)
The Effects of Single Baduanjin and Elastic Band Exercises on VSWM in Elderly Individuals With MCI
Previous studies have confirmed that both acute (single) and long-term various exercise interventions can significantly improve the cognitive function of individuals with MCI.
- Trial name
- NCT07656480
- Testing
- baduanjin exercise, elastic band exercises
- Volunteers
- 60 people
- Sponsor
- qiu chen
Acquired Brain Injury (Including Stroke)
Stimulus Equivalence Learning in Acquired Brain Injury.
Stimulus Equivalence Learning (SEL) is a form of learning in which stimuli (such as words, pictures, or sounds) become linked to one another in memory, even though this specific connection has not been directly taught.
- Trial name
- NCT07345481
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Klimmendaal Revalidatiespecialisten
Traumatic Brain Injury (TBI) Patients
Transcutaneous Vagus Nerve Stimulation for Attention and Memory
This clinical trial aims to evaluate whether transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive brain stimulation method, can improve attention and memory in veterans with traumatic brain injury (TBI) and…
- Trial name
- taVNS (NCT06723743)
- Testing
- Transcutaneous vagus nerve stimulation for attention in veterans with TBI, Soterix Medical Vagus Nerve Stimulation mini-CT
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine