Clinical trials: Memory Functions, open to volunteers
Exercise, Sleep
Effects of Exercise and Sleep on Motor Learning and Functional Abilities in Multiple Sclerosis
The ExSiMS study is a randomized, controlled crossover study including 20 individuals (18-70 years) diagnosed with relapsing remitting Multiple Sclerosis (MS) This project investigates, through behavioral and neurophysiological…
- Conditions
- Exercise, Sleep, Motor Learning, Memory
- Trial name
- ExSiMS (NCT07304375)
- Testing
- Aerobic Exercise, Daytime Sleep - Nap
- Where
- 2 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- Zealand University Hospital
Stress Disorders, Post-Traumatic
Enhancing Memory in Cognitive Processing Therapy for PTSD
Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans.
- Trial name
- MSCPTPTSD (NCT06000475)
- Testing
- Cognitive Processing Therapy, Cognitive Processing Therapy (CPT) + Memory Support
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
THC
Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks
The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.
- Trial name
- THC-MEG (NCT05641766)
- Testing
- THC
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Hematologic Malignancy
CD45RA Depleted DLI After TCRα/β Depleted Haploidentical HCT
The purpose of this clinical trial is to examine safety and toxicity of CD45RA depleted donor lymphocyte infusion (DLI) after transplantation of TCRα/β/CD19 depleted peripheral blood stem cells.
- Trial name
- CD45RADLIHaplo (NCT05943067)
- Testing
- CD45RA depleted donor lymphocyte infusion (DLI)
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Memory, Delayed
Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized…
- Trial name
- NCT05452122
- Testing
- Auditory and Electrical Stimulation
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
Long-Term Memory, Inhibitory Control
BID LTM Digital Intervention in Aging
Healthy aging is typically accompanied by diminished capability for learning and retrieval of high-fidelity long-term memory (LTM).
- Conditions
- Long-Term Memory, Inhibitory Control, Mild Cognitive Impairment
- Trial name
- NCT06916221
- Testing
- Long Term Memory, Worder
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Closed-Loop tACS
This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen…
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07722598
- Testing
- Peak Frequency, Phase Lag, Peak Frequency + Phase Lag
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Alzheimer Disease, Caregivers of Alzheimer's Disease or Memory Problem Patients
Psychological Counseling Program for Alzheimer's Patients' Caregivers
Purpose: To investigate the effects of a psychological counseling program (PsychoCP) applied to caregivers of Alzheimer's patients on perceived stress, psychological well-being and care burden.
- Conditions
- Alzheimer Disease, Caregivers of Alzheimer's Disease or Memory Problem Patients, Perceived Stress, Well-Being (Psychological Flourishing)
- Trial name
- PsychoCP (NCT06755476)
- Testing
- Psychological Counseling Program
- Volunteers
- 80 people
- Sponsor
- Aydan Akkurt Yalçıntürk
Healthy
Modulation of Working Memory by an Alternating Magnetic Field in Humans
Many studies have examined the effects of transcranial alternating current stimulation (tACS) on working memory, showing that low-intensity stimulation can enhance cognitive performance by modulating neuronal activity…
- Trial name
- MEMOCHAM (NCT07398833)
- Testing
- Electrical stimulation, Magnetic stimulation, No stimulation
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Clinique Beau Soleil
Schizophrenia, Cognitive Impairment
Eye-Movement Intervention for Cognitive Impairment Across Schizophrenia Spectrum
The goal of this clinical trial is to determine whether a gamified eye-movement intervention can improve cognitive function in individuals across the schizophrenia spectrum, including clinical high-risk individuals, first-episode…
- Conditions
- Schizophrenia, Cognitive Impairment, Clinical High Risk for Psychosis
- Trial name
- NCT07702526
- Testing
- Eye-Movement Training, Finger-Controlled Game Training
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Acute Myeloid Leukemia
Cytokine-Induced Memory-Like Natural Killer Cells (CIML-NK) for Relapsed & Refractory Acute Myeloid Leukemia (AML)
The objective of this study is to demonstrate that cytokine-induced memory-like natural killer cells can be generated from donor cells and infused safely into patients with relapsed or refractory acute myeloid leukemia (AML).
- Trial name
- NCT05580601
- Testing
- CIML-NK Cells
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Developmental Language Disorder, Healthy Subjects
The Short-term Verbal Memory Endophenotype for Developmental Language Disorder Language Disorder
The goal of this clinical trial is to determine how memory and attention affect the ability of children with developmental language disorder (DLD) to learn and use new vocabulary.
- Trial name
- NCT06968169
- Testing
- Supportive learning, Cascades
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Alcohol Use Disorder
Self-Concept and Autobiographical Memory in Alcohol Use Disorder
This study has two objectives. First, to evaluate the effectiveness of psychotherapy sessions based on self-concept and autobiographical memory in patients suffering from alcohol use disorders (AUD).
- Trial name
- CoSMA (NCT06985927)
- Testing
- psychotherapeutic sessions
- Where
- France
- Volunteers
- 100 people
- Sponsor
- CHU de Reims
Alzheimer Disease, Biomarkers / Blood
Blood Biomarkers for Early and Accurate Diagnosis of Alzheimer's Disease in Primary Care
Alzheimer's disease is a degenerative condition affecting the brain and is the most common form of dementia in older adults. Dementia is currently a major healthcare issue in the UK, affecting approximately a million people.
- Conditions
- Alzheimer Disease, Biomarkers / Blood, Biomarker in Early Diagnosis, Mild Cognitive Impairment (MCI)
- Trial name
- BEAD-PC (NCT07401849)
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Mild Cognitive Impairment, Alzheimer Disease
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive Decline
- Trial name
- SMART (NCT05877196)
- Testing
- Moderate Intensity Continuous Training (MICT), Chair-based Stretch, High-Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Memory, Short-Term
The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans
Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders.
- Trial name
- NCT06072378
- Testing
- Value-manipulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Rutgers, The State University of New Jersey
Mild Cognitive Impairment
Olfactory Training in Mild Cognitive Impairment
Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline.
- Trial name
- OTMCI (NCT06825403)
- Testing
- Olfactory Memory Training, Visual Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jeffrey Motter
Stoke
Treating New Learning and Memory Deficits Following Stroke
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons following stroke
- Trial name
- NCT07127367
- Testing
- Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Memory Disorders, Mild Cognitive Impairment
A Mobile Informatics Solution to Assist Caregivers in Care Coordination and Monitoring Social Engagement
This study will evaluate the Social Reminder System, a mobile informatics system designed to support persons with memory concerns and their care partners.
- Conditions
- Memory Disorders, Mild Cognitive Impairment, Dementia, Social Isolation
- Trial name
- NCT07773493
- Testing
- Social Reminder System
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Minnesota