Clinical trials: Menopausal Hot Flashes
Hot Flashes
Understanding Experimentally Induced Hot Flushes
The purpose of the study is to examine the impact of hot flushes on sleep, mood, and well-being. The investigators will cause hot flushes by giving study participants the hormone medication, leuprolide (Lupron), which is a…
- Trial name
- NCT00455689
- Testing
- Leuprolide acetate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes
A Study to Learn if Elinzanetant Affects the Ability to Drive and Brain Function in Healthy Women
Researchers are looking for a better way to treat vasomotor symptoms (VMS), also known as hot flashes. Hot flashes are intense and sudden feelings of heat along with sweating and reddening of the skin.
- Trial name
- NCT06219902
- Testing
- Elinzanetant (BAY3427080), Zopiclone
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bayer
Postmenopausal Vasomotor Symptoms, Cardiovascular Disease
Comparison of Vascular Findings Between Symptomatic and Asymptomatic Postmenopausal Women Before and During Hormone Therapy (HRT)
Recent large randomized, placebo-controlled studies assessing the health effects of HT question the overall benefits of long term HT, especially with respect to cardiovascular disease.
- Trial name
- SYMPTOM (NCT00668603)
- Testing
- 17-b-estradiol, 17-b-estradiol + medroxyprogeterone acetate, 17-b-estradiol hemihydrate
- Where
- Finland
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Breast Cancer, Hot Flashes
Effect of Non-estrogenic Pollen Extract PCC-100 on Hot Flushes
Many postmenopausal women have vasomotor symptoms during adjuvant hormonal treatment for breast cancer. PCC-100 is a pollen extract used for alleviation of postmenopausal symptoms.
- Conditions
- Breast Cancer, Hot Flashes, Postmenopausal Symptoms
- Trial name
- NCT03684096
- Testing
- non-estrogenic pollen extract PCC-100
- Where
- Belgium
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Sleep
Hypnosis to Improve Sleep In Menopause
The purpose of this study is to determine feasibility and adherence to a hypnosis program to improve sleep. It is theorized (based on prior experience and pilot data) that one or more hypnosis program(s) will be feasible and will…
- Trial name
- NCT02187419
- Testing
- Hypnosis
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Baylor University
Hot Flashes
Flaxseed for the Treatment of Hot Flashes
Flaxseed, a phytoestrogen, is a natural food supplement rich in plant ligands, which have a very weak estrogen effect. In this study, flaxseed is being evaluated in regard to its capacity to safely and effectively treat hot…
- Trial name
- NCT00275704
- Testing
- Flaxseed
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Menopause Syndrome
Effect of Lavender Versus Primrose Oil on Menopause Symptom
there is a scanty of researches which integrate to investigate the comparing effect of evening primrose oil and lavender as the essential oil that affects on menopausal vasomotor symptoms especially hot flashes and night sweet…
- Trial name
- NCT05988242
- Testing
- Primrose oil, Lavender oil, placcebo
- Where
- Egypt
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Cairo University
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
A Study to Learn How Elinzanetant Moves Into, Through, and Out of the Body, How Safe it is, and How it Affects the Body in Participants With Kidneys That do Not Work as Well as They Should Compared to Participants Whose Kidneys Work Normally
Researchers are looking for a better way to treat people who have vasomotor symptoms (VMS). The symptoms of VMS are hot flashes. These symptoms can be caused by changes in sex hormone levels.
- Trial name
- NCT05071729
- Testing
- Elinzanetant (BAY3427080)
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Bayer
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes
A Study to Learn More About How the Study Treatment Elinzanetant (or BAY3427080) Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body After Taking Single and Multiple Doses in Healthy Women Aged 40 to 65 Years
Researchers are looking for a better way to treat men and women with vasomotor symptoms, a condition of having hot flashes caused by hormonal changes.
- Conditions
- Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes, Healthy Volunteers
- Trial name
- NCT05381142
- Testing
- Elinzanetant (BAY3427080)
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Menopausal Symptoms
Effects of Soy Isoflavones on Menopausal Hot Flashes
Hot flashes occur in three quarters of menopausal women, and can negatively impact quality of life. Interest has arisen in isoflavones, found in rich supply in soy products, as therapy for hot flashes.
- Trial name
- NCT00179556
- Testing
- Isoflavone supplement
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Risk Reduction, Breast Cancer
Phase IIB Trial of Bazedoxifene Plus Conjugated Estrogens
Women at risk for development of breast cancer and experiencing vasomotor menopausal symptoms (hot flashes) will be randomized to bazedoxifene (BZA) plus conjugated estrogens (CE) for 6 months versus a wait list control.
- Trial name
- NCT04821141
- Testing
- Bazedoxifene and Conjugated Estrogens
- Where
- 6 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Menopause
Getting Under the Skin of the Menopausal Hot Flush
The aim of this research is to 1) test how the skin blood vessels and sweat glands function in women who experience hot flushes by using skin microdialysis to deliver small amounts of substances to the skin that cause increased…
- Trial name
- NCT06222073
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Hot Flashes, Menopause
Investigation of the Usefulness of Omega 3 Vitamins in the Relief of Hot Flashes in Menopausal Women.
Hot flashes can be a disturbing symptom of menopause. Prescription medications are commonly used for symptom relief. Several non-prescription therapies are under investigation.
- Trial name
- NCT00599456
- Testing
- Omega 3 fatty acid vitamins
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Breast Cancer
Efficacy of Acupuncture for Hot Flashes in Women Treated With Hormonal Therapy for Breast Cancer
The purpose of this study is to determine if acupuncture is effective in relieving hot flashes in women treated with hormonal therapy for breast cancer.
- Trial name
- NCT00209001
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Emory University
Hot Flash, Stellate Ganglion Block
Stellate Ganglion Block to Reduce Hot Flushes
To assess the short-term efficacy of stellate ganglion block on hot flush reduction versus sham procedure
- Conditions
- Hot Flash, Stellate Ganglion Block, Postmenopausal, Hot Flushes
- Trial name
- NCT03756272
- Testing
- Bupivacaine block
- Where
- Netherlands
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Rijnstate Hospital
Hot Flashes
Black Cohosh Extract for the Management of Moderate to Severe Menopausal Symptoms in Thai Women
Cimicifuga racemosa (black cohosh) rhizome and root extract have been used to treat menopausal symptoms. To date, there are still scarce information about its efficacy in Thai women with menopausal symptoms.
- Trial name
- NCT01487694
- Testing
- cimicifuga racemosa
- Where
- Thailand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Hot Flashes
Womens Study to Alleviate Vasomotor Symptoms
This study tests the hypothesis that a low-fat, vegan diet including soybeans reduces the frequency and severity of menopausal hot flashes, and tests the hypothesis that total isoflavone intake is associated with the reduction in…
- Trial name
- WAVS (NCT04587154)
- Testing
- low-fat vegan diet with 1/2 cup soybeans daily
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Physicians Committee for Responsible Medicine
Hot Flashes, Menopause
MsFLASH-04: Pilot Trial: Telephone Behavioral Therapy for Menopause-related Sleep Disturbance
Self-reported sleep complaints are common in peri- and postmenopausal women and have been identified as a key symptom of the menopausal transition.
- Conditions
- Hot Flashes, Menopause, Vasomotor Disturbance, Sleep
- Trial name
- MsFLASH-04 (NCT01936441)
- Testing
- Cognitive Behavioral Therapy-Insomnia (CBT-I), Menopause Education Control (MEC)
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Breast Cancer, Handheld Fan
Use of Handheld Fans in Management of Hot Flashes in Women With Breast Cancer Receiving Hormonetherapy
Hot flushes are a common symptom in women with breast cancer receiving hormone therapy. It can lead to conditions that reduce quality of life such as sleep quality deterioration, sexual problems and discomfort in daily life.
- Conditions
- Breast Cancer, Handheld Fan, Hot Flashes, Hormonetherapy
- Trial name
- Breast Cancer (NCT07054957)
- Testing
- Handheld fan, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Hot Flashes, Menopause
MsFLASH-03: Comparative Efficacy of Low-Dose Estradiol and Venlafaxine XR for Treatment of Menopausal Symptoms
The primary objective of this study is to determine the efficacy of both low-dose oral (by mouth) 17-ß-estradiol and the non-hormonal drug venlafaxine XR compared to placebo in reducing hot flashes.
- Conditions
- Hot Flashes, Menopause, Vasomotor Disturbance
- Trial name
- NCT01418209
- Testing
- Low-dose 17-ß-estradiol with progesterone taper, Venlafaxine XR
- Where
- 4 sites in United States
- Volunteers
- 339 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center